Revealing pharmacodynamics of medicinal plants using in silico approach: A case study with wet lab validation

Computers in Biology and Medicine

Volumn 47, Issue 1, 2014, Pages 1-6

  Singh, Damanpreet ^a   Gawande, Dinesh Y ^a   Singh, Tanveer ^a   Poroikov, Vladimir ^b   Goel, Rajesh Kumar ^a  

^a PUNJABI UNIVERSITY   (India)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Anticonvulsant; Ficus religiosa L. (Moraceae); GABA aminotransferase; In silico predictions; Medicinal plants; Prediction of Activity Spectra for Substances (PASS)

Indexed keywords

ANTICONVULSANT; GABA AMINOTRANSFERASE; IN-SILICO; MEDICINAL PLANTS; MORACEAE;

BIOACTIVITY; METABOLITES; PHARMACODYNAMICS; PLANT EXTRACTS;

ENZYME INHIBITION;

4 AMINOBUTYRATE AMINOTRANSFERASE; ANTICONVULSIVE AGENT; BERGAPTEN; BERGAPTOL; DIAZEPAM; FICUS RELIGIOSA EXTRACT; METHYL OLEONATE; PENTETRAZOLE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BARK; CLONIC SEIZURE; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; FICUS RELIGIOSA; IC 50; IN VITRO STUDY; LATENT PERIOD; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; VALIDATION STUDY;

ANTICONVULSANT; FICUS RELIGIOSA L. (MORACEAE); GABA AMINOTRANSFERASE; IN SILICO PREDICTIONS; MEDICINAL PLANTS; PREDICTION OF ACTIVITY SPECTRA FOR SUBSTANCES (PASS);

4-AMINOBUTYRATE TRANSAMINASE; ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CONVULSANTS; FICUS; MALE; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, STATISTICAL; PENTYLENETETRAZOLE; PLANT EXTRACTS; PLANTS, MEDICINAL; REPRODUCIBILITY OF RESULTS; SEIZURES;

EID: 84893492245     PISSN: 00104825     EISSN: 18790534     Source Type: Journal    
DOI: 10.1016/j.compbiomed.2014.01.003     Document Type: Article

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