Dose response analysis of monophthalates in the murine embryonic stem cell test assessed by cardiomyocyte differentiation and gene expression

Reproductive Toxicology

Volumn 35, Issue 1, 2013, Pages 81-88

  Schulpen, Sjors H W ^a,b   Robinson, Joshua F ^a,c   Pennings, Jeroen L A ^a   van Dartel, Dorien A M ^a,c,d   Piersma, Aldert H ^a,b  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Cardiomyocyte differentiation; Developmental toxicity; Embryonic stem cell test; Mouse embryonic stem cells; Phthalate monoesters; Potency ranking; Transcriptomics

Indexed keywords

MONOBENZYLPHTHALATE; MONOBUTYLPHTHALATE; MONOMETHYLPHTHALATE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; EMBRYONIC STEM CELL TEST; GENE EXPRESSION; HEART MUSCLE CELL; MOUSE; NONHUMAN; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING; TRANSCRIPTOMICS;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICE; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHTHALIC ACIDS; PLASTICIZERS;

MURINAE;

EID: 84871921072     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.07.002     Document Type: Article

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