메뉴 건너뛰기




Volumn 60, Issue 4, 2013, Pages 607-612

Metformin reduces NAD(P)H oxidase activity in mouse cultured podocytes through purinergic dependent mechanism by increasing extracellular ATP concentration

Author keywords

AMP activated kinase; Free radicals; Metformin; NAD(P)H oxidase; Podocytes; Purinoceptors

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMP ACTIVATED PROTEIN KINASE KINASE; AMP-ACTIVATED PROTEIN KINASE KINASE; FREE RADICAL; METFORMIN; PROTEIN KINASE; PURINERGIC P2 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 84893374127     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (29)
  • 2
    • 0034464263 scopus 로고    scopus 로고
    • The short-term effect of a switch from glibenclamide to metformin on blood pressure and microalbuminuria in patients with type 2 diabetes mellitus
    • Amador-Licona N, Guízar-Mendoza J, Vargas E, Sánchez-Camargo G, Zamora-Mata L (2000) The short-term effect of a switch from glibenclamide to metformin on blood pressure and microalbuminuria in patients with type 2 diabetes mellitus Arch Med Res 31: 571-575.
    • (2000) Arch Med Res , vol.31 , pp. 571-575
    • Amador-Licona, N.1    Guízar-Mendoza, J.2    Vargas, E.3    Sánchez-Camargo, G.4    Zamora-Mata, L.5
  • 4
    • 34248576759 scopus 로고    scopus 로고
    • Physiology and pathophysiology of purinergic neurotransmission
    • Burnstock G (2007) Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87: 659-797.
    • (2007) Physiol Rev , vol.87 , pp. 659-797
    • Burnstock, G.1
  • 5
    • 80053052721 scopus 로고    scopus 로고
    • Podocytopathy in diabetes: a metabolic and endocrine disorder
    • Diez-Sampedro A, Lenz O, Fornoni A (2011) Podocytopathy in diabetes: a metabolic and endocrine disorder. Am J Kidney Dis 58: 637-646.
    • (2011) Am J Kidney Dis , vol.58 , pp. 637-646
    • Diez-Sampedro, A.1    Lenz, O.2    Fornoni, A.3
  • 6
    • 65549157823 scopus 로고    scopus 로고
    • Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases
    • Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE (2009) Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. Diabetes 58: 1201-1211.
    • (2009) Diabetes , vol.58 , pp. 1201-1211
    • Eid, A.A.1    Gorin, Y.2    Fagg, B.M.3    Maalouf, R.4    Barnes, J.L.5    Block, K.6    Abboud, H.E.7
  • 7
    • 84864144168 scopus 로고    scopus 로고
    • Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register
    • doi: e001076.
    • Ekström N, Schiöler L, Svensson AM, Eeg-Olofsson K, Jonasson MJ, Zethelius B, Cederholm J, Eliasson B, Gudbjörnsdottir S (2012) Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register. BMJ Open 2; doi: e001076.
    • (2012) BMJ Open , vol.2
    • Ekström, N.1    Schiöler, L.2    Svensson, A.M.3    Eeg-Olofsson, K.4    Jonasson, M.J.5    Zethelius, B.6    Cederholm, J.7    Eliasson, B.8    Gudbjörnsdottir, S.9
  • 9
    • 79952693613 scopus 로고    scopus 로고
    • Regulation of hepatic metabolism by AMPK
    • Foretz M, Viollet B (2011) Regulation of hepatic metabolism by AMPK. J Hepatol 54: 827-829.
    • (2011) J Hepatol , vol.54 , pp. 827-829
    • Foretz, M.1    Viollet, B.2
  • 11
    • 64049086421 scopus 로고    scopus 로고
    • Purinergic regulation of glomerular microvasculature and tubular function
    • Jankowski M (2008) Purinergic regulation of glomerular microvasculature and tubular function, J Physiol Pharmacol 59 (Suppl 9): 121-135.
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL. 9 , pp. 121-135
    • Jankowski, M.1
  • 12
  • 13
    • 0037904408 scopus 로고    scopus 로고
    • Third-generation betablockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action
    • Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, Jankowski M, Martyniec L, Angielski S, Malinski T (2003) Third-generation betablockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action. Circulation 107: 2747-2752.
    • (2003) Circulation , vol.107 , pp. 2747-2752
    • Kalinowski, L.1    Dobrucki, L.W.2    Szczepanska-Konkel, M.3    Jankowski, M.4    Martyniec, L.5    Angielski, S.6    Malinski, T.7
  • 14
    • 34347407361 scopus 로고    scopus 로고
    • The relationship between constitutive ATP release and its extracellular metabolism in isolated rat kidney glomeruli
    • Karczewska J, Martyniec M, Dzierzko G, Stepinski J, Angielski S (2007) The relationship between constitutive ATP release and its extracellular metabolism in isolated rat kidney glomeruli. J Physiol Pharmacol 58: 321-333.
    • (2007) J Physiol Pharmacol , vol.58 , pp. 321-333
    • Karczewska, J.1    Martyniec, M.2    Dzierzko, G.3    Stepinski, J.4    Angielski, S.5
  • 16
    • 84867814558 scopus 로고    scopus 로고
    • Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin
    • 210821
    • Kim J, Shon E, Kim CS, Kim JS (2012) Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin. Exp Diabetes Res 2012: 210821.
    • (2012) Exp Diabetes Res , vol.2012
    • Kim, J.1    Shon, E.2    Kim, C.S.3    Kim, J.S.4
  • 17
    • 0016573116 scopus 로고
    • Assay of picomole amounts of ATP, ADP, and AMP using the luciferase enzyme
    • Kimmich GA, Randles J, Brand JA (1975) Assay of picomole amounts of ATP, ADP, and AMP using the luciferase enzyme. Anal Biochem 69: 187-206.
    • (1975) Anal Biochem , vol.69 , pp. 187-206
    • Kimmich, G.A.1    Randles, J.2    Brand, J.A.3
  • 19
    • 33746548445 scopus 로고    scopus 로고
    • Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
    • Masuda S, Terada T, Yonezawa A, Tanihara Y, Kishimoto K, Katsura T, Ogawa O, Inui K (2006) Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 17: 2127-2135.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2127-2135
    • Masuda, S.1    Terada, T.2    Yonezawa, A.3    Tanihara, Y.4    Kishimoto, K.5    Katsura, T.6    Ogawa, O.7    Inui, K.8
  • 20
    • 0037207471 scopus 로고    scopus 로고
    • Cell biology of the glomerular podocytes
    • Pavenstädt H, Kriz W, Kretzler M (2003) Cell biology of the glomerular podocytes. Physiol Rev 83: 253-307.
    • (2003) Physiol Rev , vol.83 , pp. 253-307
    • Pavenstädt, H.1    Kriz, W.2    Kretzler, M.3
  • 22
    • 79959339572 scopus 로고    scopus 로고
    • Extracellular ATP through P2 receptors activates AMP-activated protein kinase and suppresses superoxide generation in cultured mouse podocytes
    • Piwkowska A, Rogacka D, Jankowski M, Angielski S (2011) Extracellular ATP through P2 receptors activates AMP-activated protein kinase and suppresses superoxide generation in cultured mouse podocytes. Exp Cell Res 317: 1904-1913.
    • (2011) Exp Cell Res , vol.317 , pp. 1904-1913
    • Piwkowska, A.1    Rogacka, D.2    Jankowski, M.3    Angielski, S.4
  • 23
    • 37349120735 scopus 로고    scopus 로고
    • The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy?
    • Reddy GR, Kotlyarevska K, Ransom RF, Menon RK (2008) The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy? Curr Opin Nephrol Hypertens 17: 32-36.
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 32-36
    • Reddy, G.R.1    Kotlyarevska, K.2    Ransom, R.F.3    Menon, R.K.4
  • 24
    • 33645319245 scopus 로고    scopus 로고
    • Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters
    • da Silva CG, Jarzyna R, Specht A, Kaczmarek E (2006) Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters. Circ Res 98: 39-47.
    • (2006) Circ Res , vol.98 , pp. 39-47
    • da Silva, C.G.1    Jarzyna, R.2    Specht, A.3    Kaczmarek, E.4
  • 25
    • 82455209029 scopus 로고    scopus 로고
    • Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
    • Stephenne X, Foretz M, Taleux N, van der Zon GC, Sokal E, Hue L, Viollet B, Guigas B (2011) Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia 54: 3101-3110.
    • (2011) Diabetologia , vol.54 , pp. 3101-3110
    • Stephenne, X.1    Foretz, M.2    Taleux, N.3    van der Zon, G.C.4    Sokal, E.5    Hue, L.6    Viollet, B.7    Guigas, B.8
  • 28
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: an emerging drug target for diabetes and the metabolic syndrome
    • Zhang BB, Zhou G, Li C (2009) AMPK: an emerging drug target for diabetes and the metabolic syndrome, Cell Metab 9: 407-416.
    • (2009) Cell Metab , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.