Extracellular ATP through P2 receptors activates AMP-activated protein kinase and suppresses superoxide generation in cultured mouse podocytes

Experimental Cell Research

Volumn 317, Issue 13, 2011, Pages 1904-1913

  Piwkowska, Agnieszka ^a   Rogacka, Dorota ^a   Jankowski, Maciej ^a,b   Angielski, Stefan ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

AMP activated protein kinase; Extracellular ATP; NAD(P)H oxidase; P2 receptors; Podocytes

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PURINERGIC P2 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STO 609; SUPEROXIDE; SURAMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR SPACE; HOMEOSTASIS; IMMUNOBLOTTING; MOUSE; NONHUMAN; OXIDATIVE STRESS; PODOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 79959339572     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.04.009     Document Type: Article

References (40)

1. Pavenstädt H., Kriz W., Kretzler M. Cell biology of the glomerular podocyte. Physiol. Rev. 2003, 83:253-307.
2. Faul C., Asanuma K., Yanagida-Asanuma E., Kim K., Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol. 2007, 17:428-437.
3. + (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. Mol. Pharmacol. 2009, 75:466-477.
4. Saleem M.A., Zavadil J., Bailly M., McGee K., Witherden I.R., Pavenstadt H., Hsu H., Sanday J., Satchell S.C., Lennon R., Ni L., Bottinger E.P., Mundel P., Mathieson P.W. The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells. Am. J. Physiol. Renal Physiol. 2008, 295:F959-F970.
5. Jankowski M., Szczepańska-Konkel M., Kalinowski L., Angielski S. Bidirectional action of extracellular ATP on intracapillary volume of isolated rat renal glomeruli. J. Physiol. Pharmacol. 2000, 51:491-496.
6. Jankowski M., Szczepanska-Konkel M., Kalinowski L., Angielski S. Cyclic GMP-dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP. J. Physiol. 2001, 530:123-130.
7. Burnstock G. Purine and pyrimidine receptors. Cell. Mol. Life Sci. 2007, 64:1471-1483.
8. Komlosi P., Fintha A., Bell P.D. Renal cell-to-cell communication via extracellular ATP. Physiology (Bethesda) 2005, 20:86-90.
9. Vallon V. P2 receptors in the regulation of renal transport mechanisms. Am. J. Physiol. Renal Physiol. 2008, 294:F10-F27.
10. Bailey M.A., Turner C.M., Hus-Citharel A., Marchetti J., Imbert-Teboul M., Milner P., Burnstock G., Unwin R.J. P2Y receptors present in the native and isolated rat glomerulus. Nephron Physiol. 2004, 96:79-90.
11. Fischer K.G., Saueressig U., Jacobshagen C., Wichelmann A., Pavenstädt H. Extracellular nucleotides regulate cellular functions of podocytes in culture. Am. J. Physiol. Renal Physiol. 2001, 281:F1075-F1081.
12. Vonend O., Oberhauser V., von Kügelgen I., Apel T.W., Amann K., Ritz E., Rump L.C. ATP release in human kidney cortex and its mitogenic effects in visceral glomerular epithelial cells. Kidney Int. 2002, 61:1617-1626.
13. Köles L., Gerevich Z., Oliveira J.F., Zadori Z.S., Wirkner K., Illes P. Interaction of P2 purinergic receptors with cellular macromolecules. Naunyn Schmiedebergs Arch. Pharmacol. 2008, 377:1-33.
14. da Silva C.G., Jarzyna R., Specht A., Kaczmarek E. Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters. Circ. Res. 2006, 98:e39-e47.
15. Guerra A.N., Gavala M.L., Chung H.S., Bertics P.J. Nucleotide receptor signalling and the generation of reactive oxygen species. Purinergic Signal. 2007, 3:39-51.
16. Eid A.A., Gorin Y., Fagg B.M., Maalouf R., Barnes J.L., Block K., Abboud H.E. Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. Diabetes 2009, 58:1201-1211.
17. Greiber S., Münzel T., Kästner S., Müller B., Schollmeyer P., Pavenstädt H. NAD(P)H oxidase activity in cultured human podocytes: effects of adenosine triphosphate. Kidney Int. 1998, 53:654-663.
18. Sharma K., Ramachandrarao S., Qiu G., Usui H.K., Zhu Y., Dunn S.R., Ouedraogo R., Hough K., McCue P., Chan L., Falkner B., Goldstein B.J. Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest. 2008, 118:1645-1656.
19. Hardie D.G. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int. J. Obes. (Lond.) 2008, 32:S7-S12.
20. Zeqiraj E., Filippi B.M., Deak M., Alessi D.R., van Aalten D.M. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 2009, 326:1707-1711.
21. Lage R., Diéguez C., Vidal-Puig A., López M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol. Med. 2008, 14:539-549.
22. Cammisotto P.G., Bendayan M. Adiponectin stimulates phosphorylation of AMP-activated protein kinase alpha in renal glomeruli. J. Mol. Histol. 2008, 39(2008):579-584.
23. Lee M.J., Feliers D., Mariappan M.M., Sataranatarajan K., Mahimainathan L., Musi N., Foretz M., Viollet B., Weinberg J.M., Choudhury G.G., Kasinath B.S. A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. Am. J. Physiol. Renal Physiol. 2007, 292:F617-F627.
24. Mundel P., Reiser J., Zúñiga Mejía Borja A., Pavenstädt H., Davidson G.R., Kriz W., Zeller R. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp. Cell Res. 1997, 236:248-258.
25. Lee E.Y., Chung C.H., Khoury C.C., Yeo T.K., Pyagay P.E., Wang A., Chen S. The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-β, increases podocyte motility and albumin permeability. Am. J. Physiol. Renal Physiol. 2009, 297:F85-F94.
26. Münzel T., Afanas'ev I.B., Kleschyov A.L., Harrison D.G. Detection of superoxide in vascular tissue. Arterioscler. Thromb. Vasc. Biol. 2002, 22:1761-1768.
27. Piwkowska A., Rogacka D., Jankowski M., Dominiczak M.H., Stepiński J.K., Angielski S. Metformin induces suppression of NAD(P)H oxidase activity in podocytes. Biochem. Biophys. Res. Commun. 2010, 393:268-273.
28. Hawley S.A., Davison M., Woods A., Davies S.P., Beri R.K., Carling D., Hardie D.G. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J. Biol. Chem. 1996, 271:27879-27887.
29. Vekaria R.M., Shirley D.G., Sévigny J., Unwin R.J. Immunolocalization of ectonucleotidases along the rat nephron. Am. J. Physiol. 2006, 290:F550-F560.
30. Yegutkin G.G. Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 2008, 178:673-694.
31. Karczewska J., Martyniec L., Dzierzko G., Stepiński J., Angielski S. The relationship between constitutive ATP release and its extracellular metabolism in isolated rat kidney glomeruli. J. Physiol. Pharmacol. 2007, 58:321-333.
32. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch. Pharmacol. 2000, 362:299-309.
33. Alba G., El Bekay R., Alvarez-Maqueda M., Chacón P., Vega A., Monteseirín J., Santa María C., Pintado E., Bedoya F.J., Bartrons R., Sobrino F. Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. FEBS Lett. 2004, 573:219-225.
34. Schuhmacher S., Foretz M., Knorr M., Jansen T., Hortmann M., Wenzel P., Oelze M., Kleschyov A.L., Daiber A., Jr Keaney J.F., Wegener G., Lackner K., Münzel T., Viollet B., Schulz E. α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler. Thromb. Vasc. Biol. 2011, 31:560-566.
35. Fisslthaler B., Fleming I. Activation and signaling by the AMP-activated protein kinase in endothelial cells. Circ. Res. 2009, 105:114-127.
36. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., Moller D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 2001, 108:1167-1174.
37. Lazarowski E.R., Boucher R.C., Harden K. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol. Pharmacol. 2003, 64:785-795.
38. 2+ fluxes in J774 macrophages by two distinct mechanisms. J. Biol. Chem. 1988, 263:10337-10343.
39. Viana F., de Smedt H., Droogmans G., Nilius B. Calcium signalling through nucleotide receptor P2Y2 in cultured human vascular endothelium. Cell Calcium 1998, 24:117-127.
40. 2+/calmodulin-dependent protein kinase kinase. J. Biol. Chem. 2002, 277:15813-15818.