Oxidative stress-inducible truncated serine/arginine-rich splicing factor 3 regulates interleukin-8 production in human colon cancer cells

American Journal of Physiology - Cell Physiology

Volumn 306, Issue 3, 2014, Pages

  Kano, Shizuka ^a   Nishida, Kensei ^a   Kurebe, Hiroyuki ^a   Nishiyama, Chihiro ^a   Kita, Kentaro ^a   Akaike, Yoko ^a   Kajita, Keisuke ^a   Kurokawa, Ken ^a   Masuda, Kiyoshi ^a   Kuwano, Yuki ^a   Tanahashi, Toshihito ^a   Rokutan, Kazuhito ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Alternative splicing; IL 8; Nonsense mediated mRNA decay; Oxidative stress; SRSF3 gene

Indexed keywords

ARSENITE SODIUM; INTERLEUKIN 8; ISOPROTEIN; MESSENGER RNA; PROTEIN C JUN; SERINE ARGININE RICH PROTEIN; SERINE ARGININE RICH SPLICING FACTOR 3; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHEMOLUMINESCENCE; COLON CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

ALTERNATIVE SPLICING; IL-8; NONSENSE-MEDIATED MRNA DECAY; OXIDATIVE STRESS; SRSF3 GENE;

ALTERNATIVE SPLICING; ARSENITES; BINDING SITES; CELL LINE, TUMOR; CODON, NONSENSE; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; INTERLEUKIN-8; NONSENSE MEDIATED MRNA DECAY; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-JUN; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SODIUM COMPOUNDS; TRANSCRIPTION FACTOR AP-1;

EID: 84893370362     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00091.2013     Document Type: Article

References (35)

1. Angel P, Hattori K, Smeal T, Karin M. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55: 875-885, 1988.
2. Bejerano G, Lowe CB, Ahituv N, King B, Siepel A, Salama SR, Rubin EM, Kent WJ, Haussler D. A distal enhancer and an ultraconserved exon are derived from a novel retroposon. Nature 441: 87-90, 2006.
3. Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay. Biochem Biophys Res Commun 349: 186-191, 2006.
4. Caceres JF, Misteli T, Screaton GR, Spector DL, Krainer AR. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J Cell Biol 138: 225-238, 1997.
5. Caceres JF, Screaton GR, Krainer AR. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev 12: 55-66, 1998.
6. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12: 215-229, 2007.
7. Chen M, Manley JL. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 10: 741-754, 2009.
8. Gardner LB. Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response. Mol Cell Biol 28: 3729-3741, 2008.
9. Gardner LB. Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis. Mol Cancer Res 8: 295-308, 2010.
10. He X, Arslan AD, Pool MD, Ho TT, Darcy KM, Coon JS, Beck WT. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer. Oncogene 30: 356-365, 2011.
11. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol 72: 847-855, 2002.
12. Jumaa H, Guenet JL, Nielsen PJ. Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle. Mol Cell Biol 17: 3116-3124, 1997.
13. Jumaa H, Nielsen PJ. Regulation of SRp20 exon 4 splicing. Biochim Biophys Acta 1494: 137-143, 2000.
14. Jumaa H, Nielsen PJ. The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation. EMBO J 16: 5077-5085, 1997.
15. Khanjani S, Terzidou V, Johnson MR, Bennett PR. NFkappaB and AP-1 drive human myometrial IL8 expression. Mediators Inflamm 2012: 504952, 2012.
16. Kurokawa K, Akaike Y, Masuda K, Kuwano Y, Nishida K, Yamagishi N, Kajita K, Tanahashi T, Rokutan K. Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells. Oncogene (March 18, 2013). doi: 10. 1038/onc. 2013. 86.
17. Kuwano Y, Kawahara T, Yamamoto H, Teshima-Kondo S, Tominaga K, Masuda K, Kishi K, Morita K, Rokutan K. Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells. Am J Physiol Cell Physiol 290: C433-C443, 2006.
18. Kuwano Y, Pullmann R Jr, Marasa BS, Abdelmohsen K, Lee EK, Yang X, Martindale JL, Zhan M, Gorospe M. NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif. Nucleic Acids Res 38: 225-238, 2010.
19. Lareau LF, Inada M, Green RE, Wengrod JC, Brenner SE. Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements. Nature 446: 926-929, 2007.
20. Lewis BP, Green RE, Brenner SE. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci USA 100: 189-192, 2013.
21. Li SJ, Qi Y, Zhao JJ, Li Y, Liu XY, Chen XH, Xu P. Characterization of nuclear localization signals (NLSs) and function of NLSs and phosphorylation of serine residues in subcellular and subnuclear localization of Transformer-2beta(Tra2beta). J Biol Chem 288: 8898-8909, 2013.
22. Lin S, Coutinho-Mansfield G, Wang D, Pandit S, Fu XD. The splicing factor SC35 has an active role in transcriptional elongation. Nat Struct Mol Biol 15: 819-826, 2008.
23. Loomis RJ, Naoe Y, Parker JB, Savic V, Bozovsky MR, Macfarlan T, Manley JL, Chakravarti D. Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Mol Cell 33: 450-461, 2009.
24. Manley JL, Krainer AR. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev 24: 1073-1074, 2010.
25. Maquat LE, Kinniburgh AJ, Rachmilewitz EA, Ross J. Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia. Cell 27: 543-553, 1981.
26. McGlincy NJ, Smith CW. Alternative splicing resulting in nonsensemediated mRNA decay: what is the meaning of nonsense? Trends Biochem Sci 33: 385-393, 2008.
27. Mendell JT, Sharifi NA, Meyers JL, Martinez-Murillo F, Dietz HC. Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat Genet 36: 1073-1078, 2004.
28. Moura-Alves P, Neves-Costa A, Raquel H, Pacheco TR, D'Almeida B, Rodrigues R, Cadima-Couto I, Chora A, Oliveira M, Gama-Carvalho M, Hacohen N, Moita LF. An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1beta secretion. PLoS One 6: e19829, 2011.
29. Nicholson P, Yepiskoposyan H, Metze S, Zamudio Orozco R, Kleinschmidt N, Muhlemann O. Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci 67: 677-700, 2010.
30. Palacios IM. Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health. Brief Funct Genomics 12: 25-36, 2013.
31. Sanford JR, Gray NK, Beckmann K, Caceres JF. A novel role for shuttling SR proteins in mRNA translation. Genes Dev 18: 755-768, 2004.
32. Sapra AK, Anko ML, Grishina I, Lorenz M, Pabis M, Poser I, Rollins J, Weiland EM, Neugebauer KM. SR protein family members display diverse activities in the formation of nascent and mature mRNPs in vivo. Mol Cell 34: 179-190, 2009.
33. Thermann R, Neu-Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE. Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J 17: 3484-3494, 1998.
34. Thompson C, Cloutier A, Bosse Y, Thivierge M, Gouill CL, Larivee P, McDonald PP, Stankova J, Rola-Pleszczynski M. CysLT1 receptor engagement induces activator protein-1-and NF-kappaB-dependent IL-8 expression. Am J Respir Cell Mol Biol 35: 697-704, 2006.
35. Wang D, Zavadil J, Martin L, Parisi F, Friedman E, Levy D, Harding H, Ron D, Gardner LB. Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Mol Cell Biol 31: 3670-3680, 2011.