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Volumn 33, Issue 11, 2014, Pages 1407-1417

Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells

Author keywords

alternative splicing; apoptosis; G1 arrest; HIPK2; SRSF3 (SRp20)

Indexed keywords

AMINO ACID; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E1; CYCLINE; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; MESSENGER RNA; MESSENGER RNA PRECURSOR; NUCLEOTIDE; PROTEIN P53; RETINOBLASTOMA PROTEIN; SERINE ARGININE RICH PROTEIN; SERINE ARGININE RICH SPLICING FACTOR 3; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F7; UNCLASSIFIED DRUG;

EID: 84896395111     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.86     Document Type: Article
Times cited : (87)

References (44)
  • 1
    • 77953030317 scopus 로고    scopus 로고
    • A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)
    • Manley JL, Krainer AR. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev 2010; 24: 1073-1074.
    • (2010) Genes Dev , vol.24 , pp. 1073-1074
    • Manley, J.L.1    Krainer, A.R.2
  • 2
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches
    • Chen M, Manley JL. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 2009; 10: 741-754.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 5
    • 64749099643 scopus 로고    scopus 로고
    • SR protein family members display diverse activities in the formation of nascent and mature mRNPs in vivo
    • Sapra AK, Anko ML, Grishina I, Lorenz M, Pabis M, Poser I et al. SR protein family members display diverse activities in the formation of nascent and mature mRNPs in vivo. Mol Cell 2009; 34: 179-190.
    • (2009) Mol Cell , vol.34 , pp. 179-190
    • Sapra, A.K.1    Anko, M.L.2    Grishina, I.3    Lorenz, M.4    Pabis, M.5    Poser, I.6
  • 6
    • 8844219677 scopus 로고    scopus 로고
    • Involvement of SR proteins in mRNA surveillance
    • DOI 10.1016/j.molcel.2004.10.031, PII S1097276504006562
    • Zhang Z, Krainer AR. Involvement of SR proteins in mRNA surveillance. Mol Cell 2004; 16: 597-607. (Pubitemid 39531882)
    • (2004) Molecular Cell , vol.16 , Issue.4 , pp. 597-607
    • Zhang, Z.1    Krainer, A.R.2
  • 7
    • 1842632326 scopus 로고    scopus 로고
    • A novel role for shuttling SR proteins in mRNA translation
    • DOI 10.1101/gad.286404
    • Sanford JR, Gray NK, Beckmann K, Caceres JF. A novel role for shuttling SR proteins in mRNA translation. Genes Dev 2004; 18: 755-768. (Pubitemid 38480888)
    • (2004) Genes and Development , vol.18 , Issue.7 , pp. 755-768
    • Sanford, J.R.1    Gray, N.K.2    Beckmann, K.3    Caceres, J.F.4
  • 8
    • 84863393843 scopus 로고    scopus 로고
    • The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
    • Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R et al. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol 2012; 19: 220-228.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 220-228
    • Anczuków, O.1    Rosenberg, A.Z.2    Akerman, M.3    Das, S.4    Zhan, L.5    Karni, R.6
  • 9
    • 0032534232 scopus 로고    scopus 로고
    • Altered expression of heterogeneous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas
    • Ghigna C, Moroni M, Porta C, Riva S, Biamonti G. Altered expression of heterogeneous nuclear ribonucleoproteins and SR factors in human colon adenocarci-nomas. Cancer Res 1998; 58: 5818-5824. (Pubitemid 29006424)
    • (1998) Cancer Research , vol.58 , Issue.24 , pp. 5818-5824
    • Ghigna, C.1    Moroni, M.2    Porta, C.3    Riva, S.4    Biamonti, G.5
  • 11
    • 23744455164 scopus 로고    scopus 로고
    • Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability
    • DOI 10.1016/j.cell.2005.06.008, PII S0092867405005544
    • Li X, Manley JL. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 2005; 122: 365-378. (Pubitemid 41127139)
    • (2005) Cell , vol.122 , Issue.3 , pp. 365-378
    • Li, X.1    Manley, J.L.2
  • 12
    • 27744441269 scopus 로고    scopus 로고
    • Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation
    • DOI 10.1101/gad.1359305
    • Li X, Wang J, Manley JL. Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. Genes Dev 2005; 19: 2705-2714. (Pubitemid 41627937)
    • (2005) Genes and Development , vol.19 , Issue.22 , pp. 2705-2714
    • Li, X.1    Wang, J.2    Manley, J.L.3
  • 13
    • 34547190674 scopus 로고    scopus 로고
    • Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis
    • DOI 10.1128/MCB.00288-07
    • Xiao R, Sun Y, Ding J, Lin S, Rose D, Rosenfeld M et al. Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organo-genesis. Mol Cell Biol 2007; 27: 5393-5402. (Pubitemid 47124393)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.15 , pp. 5393-5402
    • Xiao, R.1    Sun, Y.2    Ding, J.-H.3    Lin, S.4    Rose, D.W.5    Rosenfeld, M.G.6    Fu, X.-D.7    Li, X.8
  • 14
    • 77955662560 scopus 로고    scopus 로고
    • An alternative splicing network links cell-cycle control to apoptosis
    • Moore MJ, Wang Q, Kennedy CJ, Silver PA. An alternative splicing network links cell-cycle control to apoptosis. Cell 2010; 142: 625-636.
    • (2010) Cell , vol.142 , pp. 625-636
    • Moore, M.J.1    Wang, Q.2    Kennedy, C.J.3    Silver, P.A.4
  • 15
    • 33746927884 scopus 로고    scopus 로고
    • The connection between splicing and cancer
    • DOI 10.1242/jcs.03053
    • Srebrow A, Kornblihtt A. The connection between splicing and cancer. J Cell Sci 2006; 119: 2635-2641. (Pubitemid 44184000)
    • (2006) Journal of Cell Science , vol.119 , Issue.13 , pp. 2635-2641
    • Srebrow, A.1    Kornblihtt, A.R.2
  • 16
    • 3242659798 scopus 로고    scopus 로고
    • Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional spice variants and is associated with increased expression of the spiking factors PTB and SRp20
    • DOI 10.1158/1078-0432.CCR-03-0439
    • He X, Ee P, Coon J, Beck W. Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20. Clin Cancer Res 2004; 10: 4652-4660. (Pubitemid 38955515)
    • (2004) Clinical Cancer Research , vol.10 , Issue.14 , pp. 4652-4660
    • He, X.1    Ee, P.L.R.2    Coon, J.S.3    Beck, W.T.4
  • 17
    • 78751647679 scopus 로고    scopus 로고
    • Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer
    • He X, Arslan AD, Pool MD, Ho TT, Darcy KM, Coon JS et al. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer. Oncogene 2011; 30: 356-365.
    • (2011) Oncogene , vol.30 , pp. 356-365
    • He, X.1    Arslan, A.D.2    Pool, M.D.3    Ho, T.T.4    Darcy, K.M.5    Coon, J.S.6
  • 18
    • 0033578006 scopus 로고    scopus 로고
    • Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis
    • DOI 10.1038/sj.onc.1202671
    • Stickeler E, Kittrell F, Medina D, Berget SM. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis. Oncogene 1999; 18: 3574-3582. (Pubitemid 29322382)
    • (1999) Oncogene , vol.18 , Issue.24 , pp. 3574-3582
    • Stickeler, E.1    Kittrell, F.2    Medina, D.3    Berget, S.M.4
  • 19
    • 0033607012 scopus 로고    scopus 로고
    • Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20
    • DOI 10.1016/S0960-9822(99)80394-7
    • Jumaa H, Wei G, Nielsen PJ. Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20. Curr Biol 1999; 9: 899-902. (Pubitemid 29456007)
    • (1999) Current Biology , vol.9 , Issue.16 , pp. 899-902
    • Jumaa, H.1    Wei, G.2    Nielsen, P.J.3
  • 20
    • 77955416143 scopus 로고    scopus 로고
    • Global analysis reveals SRp20-and SRp75-specific mRNPs in cycling and neural cells
    • Änkö ML, Morales L, Henry I, Beyer A, Neugebauer KM. Global analysis reveals SRp20-and SRp75-specific mRNPs in cycling and neural cells. Nat Struct Mol Biol 2010; 17: 962-970.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 962-970
    • Änkö, M.L.1    Morales, L.2    Henry, I.3    Beyer, A.4    Neugebauer, K.M.5
  • 21
    • 78649726635 scopus 로고    scopus 로고
    • Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress
    • Hailemariam K, Iwasaki K, Huang BW, Sakamoto K, Tsuji Y. Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. J Cell Sci 2010; 123: 3863-3871.
    • (2010) J Cell Sci , vol.123 , pp. 3863-3871
    • Hailemariam, K.1    Iwasaki, K.2    Huang, B.W.3    Sakamoto, K.4    Tsuji, Y.5
  • 23
    • 18244379872 scopus 로고    scopus 로고
    • Home-odomain-interacting protein kinase-2 phosphorylates p53 at ser 46 and mediates apoptosis
    • D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S et al. Home-odomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 2002; 4: 11-19.
    • (2002) Nat Cell Biol , vol.4 , pp. 11-19
    • D'Orazi, G.1    Cecchinelli, B.2    Bruno, T.3    Manni, I.4    Higashimoto, Y.5    Saito, S.6
  • 26
    • 33847365838 scopus 로고    scopus 로고
    • MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
    • DOI 10.1016/j.molcel.2007.02.008, PII S1097276507000883
    • Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F et al. MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 2007; 25: 739-750. (Pubitemid 46341925)
    • (2007) Molecular Cell , vol.25 , Issue.5 , pp. 739-750
    • Rinaldo, C.1    Prodosmo, A.2    Mancini, F.3    Iacovelli, S.4    Sacchi, A.5    Moretti, F.6    Soddu, S.7
  • 27
    • 41949130508 scopus 로고    scopus 로고
    • Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1
    • Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ et al. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J Biol Chem 2008; 283: 4682-4689.
    • (2008) J Biol Chem , vol.283 , pp. 4682-4689
    • Choi, D.W.1    Seo, Y.M.2    Kim, E.A.3    Sung, K.S.4    Ahn, J.W.5    Park, S.J.6
  • 28
    • 58149354210 scopus 로고    scopus 로고
    • An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
    • Calzado MA, de la Vega L, Moller A, Bowtell DD, Schmitz ML. An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol 2009; 11: 85-91.
    • (2009) Nat Cell Biol , vol.11 , pp. 85-91
    • Calzado, M.A.1    De La Vega, L.2    Moller, A.3    Bowtell, D.D.4    Schmitz, M.L.5
  • 29
    • 66749097258 scopus 로고    scopus 로고
    • Stabilization of HIPK2 by escape from pro-teasomal degradation mediated by the E3 ubiquitin ligase Siah1
    • Kim SY, Choi DW, Kim EA, Choi CY. Stabilization of HIPK2 by escape from pro-teasomal degradation mediated by the E3 ubiquitin ligase Siah1. Cancer Lett 2009; 279: 177-184.
    • (2009) Cancer Lett , vol.279 , pp. 177-184
    • Kim, S.Y.1    Choi, D.W.2    Kim, E.A.3    Choi, C.Y.4
  • 30
    • 58249110508 scopus 로고    scopus 로고
    • How cells switch HIPK2 on and off
    • Sombroek D, Hofmann TG. How cells switch HIPK2 on and off. Cell Death Differ 2009; 16: 187-194.
    • (2009) Cell Death Differ , vol.16 , pp. 187-194
    • Sombroek, D.1    Hofmann, T.G.2
  • 31
    • 77955470408 scopus 로고    scopus 로고
    • Regulation of p53 activity by HIPK2: Molecular mechanisms and therapeutical implications in human cancer cells
    • Puca R, Nardinocchi L, Givol D, D'Orazi G. Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. Oncogene 2010; 29: 4378-4387.
    • (2010) Oncogene , vol.29 , pp. 4378-4387
    • Puca, R.1    Nardinocchi, L.2    Givol, D.3    D'Orazi, G.4
  • 32
    • 67649671966 scopus 로고    scopus 로고
    • SR proteins in vertical integration of gene expression from transcription to RNA processing to translation
    • Zhong XY, Wang P, Han J, Rosenfeld MG, Fu XD. SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell 2009; 35: 1-10.
    • (2009) Mol Cell , vol.35 , pp. 1-10
    • Zhong, X.Y.1    Wang, P.2    Han, J.3    Rosenfeld, M.G.4    Fu, X.D.5
  • 33
    • 60549110477 scopus 로고    scopus 로고
    • Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation
    • Loomis RJ, Naoe Y, Parker JB, Savic V, Bozovsky MR, Macfarlan T et al. Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Mol Cell 2009; 33: 450-461.
    • (2009) Mol Cell , vol.33 , pp. 450-461
    • Loomis, R.J.1    Naoe, Y.2    Parker, J.B.3    Savic, V.4    Bozovsky, M.R.5    Macfarlan, T.6
  • 34
    • 21244439380 scopus 로고    scopus 로고
    • Regulation of apoptosis by alternative pre-mRNA splicing
    • DOI 10.1016/j.molcel.2005.05.026, PII S1097276505013754
    • Schwerk C, Schulze-Osthoff K. Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 2005; 19: 1-13. (Pubitemid 40884653)
    • (2005) Molecular Cell , vol.19 , Issue.1 , pp. 1-13
    • Schwerk, C.1    Schulze-Osthoff, K.2
  • 35
    • 0345898928 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors
    • DOI 10.1074/jbc.273.40.25875
    • Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y. Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem 1998; 273: 25875-25879. (Pubitemid 28475817)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.40 , pp. 25875-25879
    • Kim, Y.H.1    Choi, C.Y.2    Lee, S.-J.3    Conti, M.A.4    Kim, Y.5
  • 36
    • 1542317686 scopus 로고    scopus 로고
    • US11 of Herpes Simplex Virus Type 1 Interacts with HIPK2 and Antagonizes HIPK2-Induced Cell Growth Arrest
    • DOI 10.1128/JVI.78.6.2984-2993.2004
    • Giraud S, Diaz-Latoud C, Hacot S, Textoris J, Bourette RP, Diaz JJ. US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest. J Virol 2004; 78: 2984-2993. (Pubitemid 38314356)
    • (2004) Journal of Virology , vol.78 , Issue.6 , pp. 2984-2993
    • Giraud, S.1    Diaz-Latoud, C.2    Hacot, S.3    Textoris, J.4    Bourette, R.P.5    Diaz, J.-J.6
  • 37
    • 0142258245 scopus 로고    scopus 로고
    • Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
    • DOI 10.1016/S0092-8674(03)00802-X
    • Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the tran-scriptional corepressor CtBP. Cell 2003; 115: 177-186. (Pubitemid 37329581)
    • (2003) Cell , vol.115 , Issue.2 , pp. 177-186
    • Zhang, Q.1    Yoshimatsu, Y.2    Hildebrand, J.3    Frisch, S.M.4    Goodman, R.H.5
  • 39
    • 33748372107 scopus 로고    scopus 로고
    • Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
    • DOI 10.1038/sj.emboj.7601273, PII 7601273
    • Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML et al. Roles of HIPK1 and HIPK2 in AML1-and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J 2006; 25: 3955-3965. (Pubitemid 44338738)
    • (2006) EMBO Journal , vol.25 , Issue.17 , pp. 3955-3965
    • Aikawa, Y.1    Nguyen, L.A.2    Isono, K.3    Takakura, N.4    Tagata, Y.5    Schmitz, M.L.6    Koseki, H.7    Kitabayashi, I.8
  • 40
    • 77957876629 scopus 로고    scopus 로고
    • Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification
    • Hikasa H, Ezan J, Itoh K, Li X, Klymkowsky MW, Sokol SY. Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell 2010; 19: 521-532.
    • (2010) Dev Cell , vol.19 , pp. 521-532
    • Hikasa, H.1    Ezan, J.2    Itoh, K.3    Li, X.4    Klymkowsky, M.W.5    Sokol, S.Y.6
  • 41
    • 82455209036 scopus 로고    scopus 로고
    • HIPK2 phosphorylates DNp63a and promotes its degradation in response to DNA damage
    • Lazzari C, Prodosmo A, Siepi F, Rinaldo C, Galli F, Gentileschi M et al. HIPK2 phosphorylates DNp63a and promotes its degradation in response to DNA damage. Oncogene 2011; 30: 4802-4813.
    • (2011) Oncogene , vol.30 , pp. 4802-4813
    • Lazzari, C.1    Prodosmo, A.2    Siepi, F.3    Rinaldo, C.4    Galli, F.5    Gentileschi, M.6
  • 42
    • 84864803434 scopus 로고    scopus 로고
    • Updates on HIPK2: A resourceful oncosuppressor for clearing cancer
    • D'Orazi G, Rinaldo C, Soddu S. Updates on HIPK2: a resourceful oncosuppressor for clearing cancer. J Exp Clin Cancer Res 2012; 31: 63.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 63
    • D'Orazi, G.1    Rinaldo, C.2    Soddu, S.3
  • 43
    • 80052865785 scopus 로고    scopus 로고
    • Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children
    • Kuwano Y, Kamio Y, Kawai T, Katsuura S, Inada N, Takaki A et al. Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children. PLoS One 2011; 6: e24723.
    • (2011) PLoS One , vol.6
    • Kuwano, Y.1    Kamio, Y.2    Kawai, T.3    Katsuura, S.4    Inada, N.5    Takaki, A.6
  • 44
    • 77956872861 scopus 로고    scopus 로고
    • Brief naturalistic stress induces an alternative splice variant of SMG-1 lacking exon 63 in peripheral leukocytes
    • Kurokawa K, Kuwano Y, Tominaga K, Kawai T, Katsuura S, Yamagishi N et al. Brief naturalistic stress induces an alternative splice variant of SMG-1 lacking exon 63 in peripheral leukocytes. Neurosci Lett 2010; 484: 128-132.
    • (2010) Neurosci Lett , vol.484 , pp. 128-132
    • Kurokawa, K.1    Kuwano, Y.2    Tominaga, K.3    Kawai, T.4    Katsuura, S.5    Yamagishi, N.6


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