18F-Glyco-RGD peptides for PET imaging of integrin expression: Efficient radiosynthesis by click chemistry and modulation of biodistribution by glycosylation

Molecular Pharmaceutics

Volumn 11, Issue 2, 2014, Pages 505-515

  Maschauer, Simone ^a   Haubner, Roland ^b   Kuwert, Torsten ^a   Prante, Olaf ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

click chemistry; fluorine 18; glycosylation; positron emission tomography; RGD peptide

Indexed keywords

6 GLUCOSYLARGINYLGLYCYLASPARTIC ACID F 18; ALKYNE; ARGINYLGLYCYLASPARTIC ACID; CARBOHYDRATE DERIVATIVE; CELLOBIOSYLARGINYLGLYCYLASPARTIC ACID F 18; DISACCHARIDE; FLUORINE 18; GALACTOSYLARGINYLGLYCYLASPARTIC ACID F 18; GLYCOPEPTIDE; INTEGRIN; INTEGRIN RECEPTOR; MALTOSYLARGINYLGLYCYLASPARTIC ACID F 18; MONOSACCHARIDE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; ARGINYL-GLYCYL-ASPARTIC ACID; FLUORINE; OLIGOPEPTIDE; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL LINE; CHEMICAL REACTION; CLICK CHEMISTRY; CONTROLLED STUDY; DEACETYLATION; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG PURITY; DRUG RETENTION; DRUG SYNTHESIS; DRUG UPTAKE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY TUBULE ABSORPTION; LIVER METABOLISM; MOLECULAR IMAGING; MOUSE; NONHUMAN; ONE POT SYNTHESIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN TARGETING; RADIOCHEMISTRY; REACTION OPTIMIZATION; TISSUE DISTRIBUTION; ANIMAL; CHEMISTRY; DIAGNOSTIC USE; GENETICS; GLYCOSYLATION; METABOLISM; NUDE MOUSE; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CLICK CHEMISTRY; FLUORINE RADIOISOTOPES; GLYCOSYLATION; HUMANS; INTEGRINS; MICE; MICE, NUDE; OLIGOPEPTIDES; PEPTIDES; POSITRON-EMISSION TOMOGRAPHY; TISSUE DISTRIBUTION;

EID: 84893333017     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4004817     Document Type: Article

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