Modulation of pharmacokinetics of radioiodinated sugar-conjugated somatostatin analogues by variation of peptide net charge and carbohydration chemistry

Bioconjugate Chemistry

Volumn 16, Issue 2, 2005, Pages 429-437

  Schottelius, Margret ^a   Rau, Friederike ^a   Reubi, Jean Claude ^b   Schwaiger, Markus ^a   Wester, Hans Jürgen ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; MEDICAL IMAGING; NUCLEAR MEDICINE; PEPTIDES; TUMORS;

COMPARATIVES STUDIES; IN-VIVO; LIPOPHILICITY; MALTOTRIOSE; NET CHARGES; RENAL EXCRETION; SOMATOSTATIN RECEPTORS; STRUCTURAL REQUIREMENTS; TUMOR ACCUMULATION; TUMOR UPTAKE;

PHARMACOKINETICS;

1 S (2,3,4,6 TETRAACETYLGALACTOPYRANOSYL) 3 MERCAPTOPROPIONATE; 1 S (2,3,4,6 TETRAACETYLGLUCOPYRANOSYL) 3 MERCAPTOPROPIONATE; GLUCORONIC ACID OCTREOTATE THYROSINE I 125; GLYCOSIDE; MALTOTRIOSE OCTREOTATE THYROSINE I 125; OCTREOTATE THYROXINE I 125; OCTREOTIDE THYROXINE I 125; RADIOISOTOPE; SOMATOSTATIN 28; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOLATERAL MEMBRANE; BINDING AFFINITY; BIOACCUMULATION; CELL TRANSPORT; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG UPTAKE; FEMALE; GENETIC TRANSFECTION; INTERNALIZATION; INTESTINE; ISOTOPE LABELING; KIDNEY; LIPOPHILICITY; LIVER; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; RADIOIODINATION; RAT;

MUS MUSCULUS;

EID: 15244355051     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0499228     Document Type: Article

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