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Volumn 6, Issue 1, 2014, Pages

Active immunotherapy options for Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AADVAC1 VACCINE; ACI 24 VACCINE; ACI 35 VACCINE; AFFITOPE VACCINE; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; BAPINEUZUMAB; CAD106 VACCINE; DNA; LU AF20513 VACCINE; PEPTIDE VACCINE; SOLANEZUMAB; TAU PROTEIN; UB 311 VACCINE; UNCLASSIFIED DRUG; V950 VACCINE; VANUTIDE CRIDIFICAR; VIRUS PROTEIN;

EID: 84893295027     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/alzrt237     Document Type: Review
Times cited : (70)

References (56)
  • 2
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • Clinical diagnosis of alzheimer's disease: report of the NINCDS-adrda work group under the auspices of department of health and human services task force on alzheimer's disease. G McKhann, D Drachman, M Folstein, R Katzman, D Price, EM Stadlan, Neurology 1984 34 939 944 10.1212/WNL.34.7.939 6610841 (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 3
    • 84872109456 scopus 로고    scopus 로고
    • The global prevalence of dementia: A systematic review and metaanalysis
    • 10.1016/j.jalz.2012.11.007 23305823
    • The global prevalence of dementia: a systematic review and metaanalysis. M Prince, R Bryce, E Albanese, A Wimo, W Ribeiro, CP Ferri, Alzheimers Dement 2013 9 63 75 10.1016/j.jalz.2012.11.007 23305823
    • (2013) Alzheimers Dement , vol.9 , pp. 63-75
    • Prince, M.1    Bryce, R.2    Albanese, E.3    Wimo, A.4    Ribeiro, W.5    Ferri, C.P.6
  • 4
    • 84872119357 scopus 로고    scopus 로고
    • The worldwide economic impact of dementia 2010
    • 10.1016/j.jalz.2012.11.006 23305821
    • The worldwide economic impact of dementia 2010. A Wimo, L Jonsson, J Bond, M Prince, B Winblad, Alzheimers Dement 2013 9 1 11 10.1016/j.jalz.2012.11. 006 23305821
    • (2013) Alzheimers Dement , vol.9 , pp. 1-11
    • Wimo, A.1    Jonsson, L.2    Bond, J.3    Prince, M.4    Winblad, B.5
  • 5
    • 0028856460 scopus 로고
    • An english translation of alzheimer's 1907 paper, 'Uber eine eigenartige Erkankung der Hirnrinde'
    • 10.1002/ca.980080612 8713166
    • An english translation of alzheimer's 1907 paper, 'Uber eine eigenartige Erkankung der Hirnrinde'. A Alzheimer, RA Stelzmann, HN Schnitzlein, FR Murtagh, Clin Anat 1995 8 429 431 10.1002/ca.980080612 8713166
    • (1995) Clin Anat , vol.8 , pp. 429-431
    • Alzheimer, A.1    Stelzmann, R.A.2    Schnitzlein, H.N.3    Murtagh, F.R.4
  • 6
    • 84859584667 scopus 로고    scopus 로고
    • The genetics of alzheimer's disease
    • 22482448
    • The genetics of alzheimer's disease. L Bertram, RE Tanzi, Prog Mol Biol Transl Sci 2012 107 79 100 22482448
    • (2012) Prog Mol Biol Transl Sci , vol.107 , pp. 79-100
    • Bertram, L.1    Tanzi, R.E.2
  • 7
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • 1763432
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease. J Hardy, D Allsop, Trends Pharmacol Sci 1991 12 383 388 1763432
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 8
    • 80052501210 scopus 로고    scopus 로고
    • Resolving controversies on the path to Alzheimer's therapeutics
    • 10.1038/nm.2460 21900936
    • Resolving controversies on the path to Alzheimer's therapeutics. DJ Selkoe, Nat Med 2011 17 1060 1065 10.1038/nm.2460 21900936
    • (2011) Nat Med , vol.17 , pp. 1060-1065
    • Selkoe, D.J.1
  • 9
    • 84874853965 scopus 로고    scopus 로고
    • Mechanisms of protein seeding in neurodegenerative diseases
    • 10.1001/jamaneurol.2013.1453 23599928
    • Mechanisms of protein seeding in neurodegenerative diseases. LC Walker, MI Diamond, KE Duff, BT Hyman, JAMA Neurol 2013 70 304 310 10.1001/jamaneurol. 2013.1453 23599928
    • (2013) JAMA Neurol , vol.70 , pp. 304-310
    • Walker, L.C.1    Diamond, M.I.2    Duff, K.E.3    Hyman, B.T.4
  • 13
    • 84877254025 scopus 로고    scopus 로고
    • Passive anti-amyloid immunotherapy in alzheimer's disease: What are the most promising targets?
    • 10.1186/1742-4933-10-18 23663286
    • Passive anti-amyloid immunotherapy in alzheimer's disease: what are the most promising targets? J Moreth, C Mavoungou, K Schindowski, Immun Ageing 2013 10 18 10.1186/1742-4933-10-18 23663286
    • (2013) Immun Ageing , vol.10 , pp. 18
    • Moreth, J.1    Mavoungou, C.2    Schindowski, K.3
  • 18
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: A case report
    • DOI 10.1038/nm840
    • Neuropathology of human alzheimer disease after immunization with amyloid-beta peptide: a case report. JA Nicoll, D Wilkinson, C Holmes, P Steart, H Markham, RO Weller, Nat Med 2003 9 448 452 10.1038/nm840 12640446 (Pubitemid 36460079)
    • (2003) Nature Medicine , vol.9 , Issue.4 , pp. 448-452
    • Nicolll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 20
    • 84856479445 scopus 로고    scopus 로고
    • Targeting beta amyloid: A clinical review of immunotherapeutic approaches in alzheimer's disease
    • 22292124
    • Targeting beta amyloid: a clinical review of immunotherapeutic approaches in alzheimer's disease. K Lobello, JM Ryan, E Liu, G Rippon, R Black, Int J Alzheimers Dis 2012 2012 628070 22292124
    • (2012) Int J Alzheimers Dis , vol.2012 , pp. 628070
    • Lobello, K.1    Ryan, J.M.2    Liu, E.3    Rippon, G.4    Black, R.5
  • 21
    • 84862331908 scopus 로고    scopus 로고
    • Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: Randomised, double-blind, placebo-controlled, first-in-human study
    • 10.1016/S1474-4422(12)70140-0 22677258
    • Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study. B Winblad, N Andreasen, L Minthon, A Floesser, G Imbert, T Dumortier, RP Maguire, K Blennow, J Lundmark, M Staufenbiel, JM Orgogozo, A Graf, Lancet Neurol 2012 11 597 604 10.1016/S1474-4422(12)70140-0 22677258
    • (2012) Lancet Neurol , vol.11 , pp. 597-604
    • Winblad, B.1    Andreasen, N.2    Minthon, L.3    Floesser, A.4    Imbert, G.5    Dumortier, T.6    Maguire, R.P.7    Blennow, K.8    Lundmark, J.9    Staufenbiel, M.10    Orgogozo, J.M.11    Graf, A.12
  • 27
    • 85011828039 scopus 로고    scopus 로고
    • The Aβ peptide conjugate vaccine, ACC-001, generates N-terminal anti-Aβ antibodies in the absence of Aβ directed T-cell responses [abstract]
    • The Aβ peptide conjugate vaccine, ACC-001, generates N-terminal anti-Aβ antibodies in the absence of Aβ directed T-cell responses [abstract]. M Hagen, P Seubert, S Jacobsen, D Schenk, M Pride, R Arumugham, G Warner, G Kinney, Alzheimers Dement 2011 7 460 S461
    • (2011) Alzheimers Dement , vol.7
    • Hagen, M.1    Seubert, P.2    Jacobsen, S.3    Schenk, D.4    Pride, M.5    Arumugham, R.6    Warner, G.7    Kinney, G.8
  • 28
    • 85081804780 scopus 로고    scopus 로고
    • Safety, tolerability, and immunogenicity of an immunotherapeutic vaccine (vanutide cridificar [ACC-001]) and the QS-21 adjuvant in Japanese subjects with mild to moderate Alzheimer's disease: A phase 2a, multicenter, randomized, adjuvant- and placebo-controlled, multiple-ascending-dose study [abstract P1-338]
    • Boston, MA, USA 21808935
    • Safety, tolerability, and immunogenicity of an immunotherapeutic vaccine (vanutide cridificar [ACC-001]) and the QS-21 adjuvant in Japanese subjects with mild to moderate Alzheimer's disease: a phase 2a, multicenter, randomized, adjuvant- and placebo-controlled, multiple-ascending-dose study [abstract P1-338]. H Arai, S Hideo, Y Tamotsu, K Lobello, P Yahong, L Enchi, K Nzeera, R Margolin, N Jackson, Y Fujimoto, Presented at the International Conference on Alzheimer's Disease (ICAD) Boston, MA, USA 2013 21808935
    • (2013) Presented at the International Conference on Alzheimer's Disease (ICAD)
    • Arai, H.1    Hideo, S.2    Tamotsu, Y.3    Lobello, K.4    Yahong, P.5    Enchi, L.6    Nzeera, K.7    Margolin, R.8    Jackson, N.9    Fujimoto, Y.10
  • 31
    • 63249137056 scopus 로고    scopus 로고
    • Development of AFFITOPE vaccines for Alzheimer's disease (AD) - From concept to clinical testing
    • 10.1007/s12603-009-0070-5 19262965
    • Development of AFFITOPE vaccines for Alzheimer's disease (AD)-from concept to clinical testing. A Schneeberger, M Mandler, O Otawa, W Zauner, F Mattner, W Schmidt, J Nutr Health Aging 2009 13 264 267 10.1007/s12603-009-0070- 5 19262965
    • (2009) J Nutr Health Aging , vol.13 , pp. 264-267
    • Schneeberger, A.1    Mandler, M.2    Otawa, O.3    Zauner, W.4    Mattner, F.5    Schmidt, W.6
  • 32
    • 84887878796 scopus 로고    scopus 로고
    • Development of AFFITOPE alzheimer vaccines: Results of phase i studies with AD01 and AD02 [abstract]
    • Development of AFFITOPE alzheimer vaccines: results of phase I studies with AD01 and AD02 [abstract]. M Mandler, W Schmidt, F Mattner, Alzheimers Dement 2011 7 793
    • (2011) Alzheimers Dement , vol.7 , pp. 19793
    • Mandler, M.1    Schmidt, W.2    Mattner, F.3
  • 33
    • 84893308581 scopus 로고    scopus 로고
    • The MimoVax vaccine: A novel alzheimer treatment strategy targeting truncated Aβ40/42 by active immunization [abstract]
    • 10.1016/j.jalz.2009.01.008 19328438
    • The MimoVax vaccine: a novel alzheimer treatment strategy targeting truncated Aβ40/42 by active immunization [abstract]. M Mandler, R Santic, H Weninger, E Kopinits, W Schmidt, F Mattner, Alzheimers Dement 2009 5 114 10.1016/j.jalz.2009.01.008 19328438
    • (2009) Alzheimers Dement , vol.5 , pp. 114
    • Mandler, M.1    Santic, R.2    Weninger, H.3    Kopinits, E.4    Schmidt, W.5    Mattner, F.6
  • 35
    • 84856454638 scopus 로고    scopus 로고
    • A novel multivalent Aβ peptide vaccine with preclinical evidence of a central immune response that generates antisera recognizing a wide range of abeta peptide species [abstract]
    • A novel multivalent Aβ peptide vaccine with preclinical evidence of a central immune response that generates antisera recognizing a wide range of abeta peptide species [abstract]. JM Savage, G Wu, A McCampbell, RK Wessner, M Citron, X Liang, S Hsieh, AL Wolfe, GG Kinney, BL Rosen, JJ Renger, Alzheimers Dement 2010 6 142
    • (2010) Alzheimers Dement , vol.6 , pp. 19142
    • Savage, J.M.1    Wu, G.2    McCampbell, A.3    Wessner, R.K.4    Citron, M.5    Liang, X.6    Hsieh, S.7    Wolfe, A.L.8    Kinney, G.G.9    Rosen, B.L.10    Renger, J.J.11
  • 40
    • 85027951959 scopus 로고    scopus 로고
    • DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation
    • 10.1007/s10571-011-9680-7 21625960
    • DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation. D Lambracht-Washington, BX Qu, M Fu, LD Anderson Jr, O Stuve, TN Eagar, RN Rosenberg, Cell Mol Neurobiol 2011 31 867 874 10.1007/s10571-011-9680-7 21625960
    • (2011) Cell Mol Neurobiol , vol.31 , pp. 867-874
    • Lambracht-Washington, D.1    Qu, B.X.2    Fu, M.3
  • 43
    • 84884679996 scopus 로고    scopus 로고
    • Development of a new DNA vaccine for Alzheimer disease targeting a wide range of abeta species and amyloidogenic peptides
    • 10.1371/journal.pone.0075203 24086465
    • Development of a new DNA vaccine for Alzheimer disease targeting a wide range of abeta species and amyloidogenic peptides. Y Matsumoto, N Niimi, K Kohyama, PLoS One 2013 8 75203 10.1371/journal.pone.0075203 24086465
    • (2013) PLoS One , vol.8 , pp. 575203
    • Matsumoto, Y.1    Niimi, N.2    Kohyama, K.3
  • 44
    • 79959370222 scopus 로고    scopus 로고
    • Disease-modifying treatments for Alzheimer's disease
    • 10.1177/1756285611404470 21765871
    • Disease-modifying treatments for Alzheimer's disease. D Galimberti, E Scarpini, Ther Adv Neurol Disord 2011 4 203 216 10.1177/1756285611404470 21765871
    • (2011) Ther Adv Neurol Disord , vol.4 , pp. 203-216
    • Galimberti, D.1    Scarpini, E.2
  • 45
    • 0023640751 scopus 로고
    • Intraneuronal IgG in the central nervous system: Uptake by retrograde axonal transport
    • Intraneuronal IgG in the central nervous system: uptake by retrograde axonal transport. RH Fabian, G Petroff, Neurology 1987 37 1780 1784 10.1212/WNL.37.11.1780 2444904 (Pubitemid 17163722)
    • (1987) Neurology , vol.37 , Issue.11 , pp. 1780-1784
    • Fabian, R.H.1    Petroff, G.2
  • 46
    • 0028963740 scopus 로고
    • Uptake of systemically administered human anticerebellar antibody by rat Purkinje cells following blood-brain barrier disruption
    • 10.1007/BF00309627 7610765
    • Uptake of systemically administered human anticerebellar antibody by rat Purkinje cells following blood-brain barrier disruption. JE Greenlee, JB Burns, JW Rose, KA Jaeckle, S Clawson, Acta Neuropathol 1995 89 341 345 10.1007/BF00309627 7610765
    • (1995) Acta Neuropathol , vol.89 , pp. 341-345
    • Greenlee, J.E.1    Burns, J.B.2    Rose, J.W.3    Jaeckle, K.A.4    Clawson, S.5
  • 47
    • 54249156984 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies
    • 18953105
    • Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. EM Sigurdsson, J Alzheimers Dis 2008 15 157 168 18953105
    • (2008) J Alzheimers Dis , vol.15 , pp. 157-168
    • Sigurdsson, E.M.1
  • 48
    • 84885783467 scopus 로고    scopus 로고
    • Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
    • 10.1016/j.neuron.2013.07.046 24075978
    • Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. K Yanamandra, N Kfoury, H Jiang, TE Mahan, S Ma, SE Maloney, DF Wozniak, MI Diamond, DM Holtzman, Neuron 2013 80 402 414 10.1016/j.neuron.2013.07.046 24075978
    • (2013) Neuron , vol.80 , pp. 402-414
    • Yanamandra, K.1    Kfoury, N.2    Jiang, H.3    Mahan, T.E.4    Ma, S.5    Maloney, S.E.6    Wozniak, D.F.7    Diamond, M.I.8    Holtzman, D.M.9
  • 49
    • 34548146119 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    • DOI 10.1523/JNEUROSCI.2361-07.2007
    • Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. AA Asuni, A Boutajangout, D Quartermain, EM Sigurdsson, J Neurosci 2007 27 9115 9129 10.1523/JNEUROSCI.2361-07.2007 17715348 (Pubitemid 47312068)
    • (2007) Journal of Neuroscience , vol.27 , Issue.34 , pp. 9115-9129
    • Asuni, A.A.1    Boutajangout, A.2    Quartermain, D.3    Sigurdsson, E.M.4
  • 50
    • 77954656871 scopus 로고    scopus 로고
    • Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
    • 10.1016/j.expneurol.2010.05.010 20546729
    • Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. M Boimel, N Grigoriadis, A Lourbopoulos, E Haber, O Abramsky, H Rosenmann, Exp Neurol 2010 224 472 485 10.1016/j.expneurol. 2010.05.010 20546729
    • (2010) Exp Neurol , vol.224 , pp. 472-485
    • Boimel, M.1    Grigoriadis, N.2    Lourbopoulos, A.3    Haber, E.4    Abramsky, O.5    Rosenmann, H.6
  • 51
    • 78650065372 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
    • 10.1523/JNEUROSCI.4363-10.2010 21147995
    • Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. A Boutajangout, D Quartermain, EM Sigurdsson, J Neurosci 2010 30 16559 16566 10.1523/JNEUROSCI.4363-10.2010 21147995
    • (2010) J Neurosci , vol.30 , pp. 16559-16566
    • Boutajangout, A.1    Quartermain, D.2    Sigurdsson, E.M.3
  • 53
    • 77952549757 scopus 로고    scopus 로고
    • Targeting Aβ and tau in Alzheimer's disease, an early interim report
    • 10.1016/j.expneurol.2009.07.035 19716367
    • Targeting Aβ and tau in Alzheimer's disease, an early interim report. TE Golde, L Petrucelli, J Lewis, Exp Neurol 2010 223 252 266 10.1016/j.expneurol.2009.07.035 19716367
    • (2010) Exp Neurol , vol.223 , pp. 252-266
    • Golde, T.E.1    Petrucelli, L.2    Lewis, J.3
  • 54
    • 85081802215 scopus 로고    scopus 로고
    • Tau immunotherapy - The way how to crack the immune code of misfolded protein tau [abstract S4-02-02]
    • Boston, MA, USA 21808935
    • Tau immunotherapy-the way how to crack the immune code of misfolded protein tau [abstract S4-02-02]. M Novak, Presented at the International Conference on Alzheimer's Disease (ICAD) Boston, MA, USA 2013 21808935
    • (2013) Presented at the International Conference on Alzheimer's Disease (ICAD)
    • Novak, M.1


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