The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite

Current Medicinal Chemistry

Volumn 21, Issue 3, 2014, Pages 365-376

  Schildknecht, S ^a   Weber, A ^a   Gerding, H R ^a   Pape, R ^a   Robotta, M ^a   Drescher, M ^a   Marquardt, A ^a   Daiber, A ^b   Ferger, B ^c   Leist, M ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Alpha synuclein; GKT136901; LUHMES; NADPH oxidase; NOX; Peroxynitrite

Indexed keywords

[2 (2 CHLOROPHENYL) 4 METHYL 5 (PYRIDIN 2 YLMETHYL) 1H PYRAZOLO[4,3 C]PYRIDINE 3,6(2H,5H) DIONE]; ALPHA SYNUCLEIN; ASCORBIC ACID; DIHYDRORHODAMINE 123; GKT 136901; GLUTATHIONE; HYDROXYL RADICAL; NITRIC OXIDE; OXIDOREDUCTASE INHIBITOR; OXYGEN; PEROXYNITRITE; UNCLASSIFIED DRUG; URIC ACID; VAS 2870;

ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DIMERIZATION; DOPAMINERGIC NERVE CELL; DRUG ACTIVITY; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG SELECTIVITY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NERVE CELL; NERVE CELL DEGENERATION; NEURITE; NEUROPROTECTION; PARKINSON DISEASE; PATHOGENESIS;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; CELL LINE; FREE RADICAL SCAVENGERS; HUMANS; MOLECULAR SEQUENCE DATA; NADPH OXIDASE; NEURODEGENERATIVE DISEASES; NITRIC OXIDE; PEROXYNITROUS ACID; PYRAZOLES; PYRIDONES;

EID: 84893255323     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990179     Document Type: Article

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