Mechanisms of intestinal absorption of carotenoids: Insights from in vitro systems

Carotenoids: Physical, Chemical, and Biological Functions and Properties

Volumn , Issue , 2009, Pages 367-380

  Harrison, Earl H ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; PLANTS (BOTANY);

BETA CAROTENE; GREEN LEAFY VEGETABLES; HUMAN BLOODS; HUMAN BODIES; INTESTINAL ABSORPTION; MARINE ANIMALS; NATURAL SOURCES; RED PEPPERS;

PIGMENTS;

EID: 84893238283     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420052312     Document Type: Chapter

References (62)

1. T. L. Bierer, N. R. Merchen, and J. W. Erdman, Comparative absorption and transport of five common carotenoids in preruminant calves, J. Nutr. 125 (1995) 1569-1577.
2. G. Britton, Structure and properties of carotenoids in relation to function, FASEB J. 9 (1995) 1551-1558.
3. G. S. Bullerjahn and L. A. Sherman, Identification of a carotenoid-binding protein in the cytoplasmic membrane from the heterotrophic cyanobacterium Synechocystis sp. Strain PCC6714, J. Bacteriol. 167 (1986) 396-399.
4. R. M. Clark, L. Yao, L. She, and H. C. Furr, A comparison of lycopene and canthaxanthin absorption: Using the rat to study the absorption of non-provitamin A carotenoids, Lipids 33 (1998) 159-163.
5. A. During and E. H. Harrison, Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cell, J. Lipid Res. 48 (2007) 2284-2294.
6. A. During, M. M. Hussain, D. W. Morel, and E. H. Harrison, Carotenoid uptake and secretion by Caco-2 cells: b-Carotene isomer selectivity and carotenoid interactions, J. Lipid Res. 43 (2002) 1086-1095.
7. A. During, H. Dawson, and E. H. Harrison, Carotenoid transport is decreased and the expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is down-regulated in CACO-2 cells treated with ezetimibe, J. Nutr. 135 (2005) 2305-2312.
8. A. J. Edwards, C.-S. You, J. E. Swanson, and R. S. Parker, A novel extrinsic reference method for assessing the vitamin A value of plant foods, Am. J. Clin. Nutr. 74 (2001) 348-355.
9. M. I. El-Gorab, B. A. Underwood, and J. D. Loerch, The roles of bile salts in the uptake of b-carotene and retinol by everted gut sacs, Biochim. Biophys. Acta 401 (1975) 265-277.
10. J. W. Erdman, T. L. Bierer, and E. T. Gugger, Absorption and transport of carotenoids, Ann. N. Y. Acad. Sci. 691 (1993) 76-85.
11. H. R. Furr and R. M. Clark, Intestinal absorption and tissue distribution of carotenoids, J. Nutr. Biochem. 8 (1997) 364-377.
12. D. A. Garrett, M. L. Failla, and R. J. Sarama, Development of an in vitro digestion method to assess carotenoid bioavailability from meals, J. Agric. Food Chem. 47 (1999) 4301-4309.
13. D. A. Garrett, M. L. Failla, and R. J. Sarama, Estimation of carotenoid bioavailability from fresh stir-fried vegetables using ab in vitro digestion/Caco-2 cell culture model, J. Nutr. Biochem. 11 (2000) 574-580.
14. C. Gartner, W. Stahl, and H. Sies, Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human, Int. J. Vitam. Nutr. Res. 66 (1996) 119-125.
15. J. M. Gaziano, E. J. Johnson, R. M. Russell, J. E. Manson, M. J. Stampfer, P. M. Ridker, B. Frei, C. H. Hennekens, and N. I. Krinsky, Discrimination in absorption or transport of beta-carotene isomers after oral supplementation with either all-trans or 9-cis-b-carotene, Am. J. Clin. Nutr. 61 (1995) 1248-1252.
16. D. S. Goodman, R. Blomstrand, B. Werner, H. S. Huang, and T. Shiratori, The intestinal absorption and metabolism of vitamin A and beta-carotene in man, J. Clin. Invest. 45 (1966) 1615-1623.
17. E. T. Gugger and J. W. Erdman, Intracellular beta-carotene transport in bovine liver and intestine is not mediated by cytosolic proteins, J. Nutr. 126 (1996) 1470-1474.
18. D. Hollander and P. E. Ruble, Beta-carotene intestinal absorption: bile, fatty acid, pH, and flow rate effects on absorption, Am. J. Physiol. 235 (1978) E686-E691.
19. C. D. Jensen, T. W. Howes, G. A. Spiller, T. S. Pattison, J. H. Whittam, and J. Scala, Observations on the effects of ingesting cis-and trans-b-carotene isomers on human serum concentrations, Nutr. Rep. Int. 35 (1987) 413-422.
20. E. J. Johnson, J. Qin, N. I. Krinsky, and R. M. Russell, Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene, J. Nutr. 127 (1997) 1833-1837.
21. Z. E. Jouni and M. Wells, Purification of a carotenoid-binding protein from the midgut of the silkworm, Bombyx mori, Ann. N. Y. Acad. Sci. 691 (1993) 210-212.
22. C. Kiefer, E. Sumser, M. F. Wernet, and J. von Lintig, A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila, Proc. Natl. Acad. Sci. U. S. A. 16 (2002) 10581-10586.
23. H. Kläui and J. C. Bauernfeind, in: J. C. Bauernfeind (Ed.), Carotenoids as Colorants and Vitamin A Precursors: Technological and Nutritional Applications, Academic Press, Inc., New York (1981), pp. 58-63.
24. D. Kostic, W. S. White, and J. A. Olson, Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses, Am. J. Clin. Nutr. 62 (1995) 604-610.
25. M. R. Lakshman and M. N. Rao, Purification and characterization of cellular carotenoid-binding protein from mammalian liver, Methods Enzymol. 299 (1999) 441-456.
26. C. M. Lee, A. C. Boileau, T. W. Boileau, A. W. Williams, K. S. Swanson, K. A. Heintz, and J. W. Erdman, Review of animal models in carotenoid research, J. Nutr. 129 (1999) 2271-2277.
27. Y. Lin, S. R. Dueker, B. J. Burri, T. R. Neidlinger, and A. J. Clifford, Variability of the conversion of betacarotene to vitamin A in women measured by using a double-tracer design, Am. J. Clin. Nutr. 71 (2000) 1545-1554.
28. J. Luchoomun and M. M. Hussain, Assembly and secretion of chylomicrons by differentiated Caco-2 cells. Nascent triglycerides and preformed phospholipids are preferentially used for lipoprotein assembly, J. Biol. Chem. 274 (1999) 19565-19572.
29. A. R. Mangels, J. M. Holden, G. R. Beecher, M. R. Forman, and E. Lanza, Carotenoid content of fruits and vegetables: An evaluation of analytic data, J. Am. Diet. Assoc. 93 (1993) 284-296.
30. J. A. Novotny, S. R. Dueker, L. A. Zech, and A. J. Clifford, Compartmental analysis of the dynamics of beta-carotene metabolism in an adult volunteer, J. Lipid Res. 36 (1995) 1825-1838.
31. J. A. Olson, Carotenoids, in: M. E. Shils, J. A. Olson, M. Shike, A. C. Ross (Eds.), Modern Human Nutrition in Health and Disease, 9th ed., Lippincott Williams & Wilkins, Baltimore, MD (1998), pp. 525-541.
32. M. E. O’Neill and D. I. Thurnham, Intestinal absorption of beta-carotene, lycopene and lutein in men and women following a standard meal: Response curves in the triacylglycerol-rich lipoprotein fraction, Br. J. Nutr. 79 (1998) 149-159.
33. R. S. Parker, Carotenoids in human blood and tissues, J. Nutr. 119 (1989) 101-104.
34. R. S. Parker, Absorption, metabolism, and transport of carotenoids, FASEB J. 10 (1996) 542-551.
35. R. Peto, R. Doll, J. D. Buckley, and M. B. Sporn, Can dietary beta-carotene materially reduce human cancer rates? Nature 290 (1981) 201-208.
36. C. L. Poor, T. L. Bierer, N. R. Merchen, G. C. Fahey, M. R. Murphy, and J. W. Erdman, Evaluation of the preruminant calf as a model for the study of human carotenoid metabolism, J. Nutr. 122 (1992) 262-268.
37. J. Pollack, J. M. Campbell, S. M. Potter, and J. W. Erdman, Mongolian gerbils (Meriones unguiculatus) absorb beta-carotene intact from a test meal, J. Nutr. 124 (1994) 869-873.
38. J. M. Seddon, U. A. Ajani, R. D. Sperduto, R. Hiller, N. Blair, T. C. Burton, M. D. Farber, E. S. Gragoudas, J. Haller, D. T. Miller, L. A. Yanuzzi, and W. Willett, Dietary carotenoids, vitamins A, C, and E, and the advanced age-related macular degeneration. Eye disease case-control study group, J. Am. Med. Assoc. 272 (1994) 1413-1420.
39. W. G. Siems, O. Sommerburg, and F. J. van Kuijk, Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro, Biofactors 10 (1999) 105-113.
40. W. Stahl, W. Schwarz, J. von Laar, and H. Sies, All-trans beta-carotene preferentially accumulates in human chylomicrons and very low density lipoproteins compared with the 9-cis geometrical isomer, J. Nutr. 125 (1995) 2128-2133.
41. G. Tang, J. Qin, G. G. Dolnikowski, and R. M. Russell, Vitamin A equivalence of beta-carotene in a women as determined by a stable isotope reference method, Eur. J. Nutr. 39 (2000) 7-11.
42. V. Tyssandier, N. Cardinault, C. Caris-Veyrat, M.-J. Amiot, P. Grolier, C. Bouteloup, V. Azais-Braesco, and P. Borel, Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into cylomicrons, with no adverse effect on the medium term (3-wk) plasma status of carotenoids in humans, Am. J. Clin. Nutr. 75 (2002) 526-534.
43. V. Tyssandier, E. Reboul, J. F. Dumas, C. Bouteloup-Demange, M. Armand, J. Marcand, M. Sallas, and P. Borel, Processing of vegetable-borne carotenoids in the human stomach and duodenum, Am. J. Physiol. Gastrointest. Liver Physiol. 284 (2003) G913-G923.
44. A. van Bennekum, M. Werder, S. T. Thuahnai, C. H. Han, P. Duong, D. L. Williams, P. Wettstein, G. Schulthess, M. C. Phillips, and H. Hauser, Class B scavenger receptor-mediated intestinal absorption of dietary b-carotene and cholesterol, Biochemistry 44 (2005) 4517-4525.
45. H. van den Berg, Effect of lutein on beta-carotene absorption and cleavage, Int. J. Vitam. Nutr. Res. 68 (1998) 360-365.
46. H. van den Berg, Carotenoid interactions, Nutr. Rev. 57 (1999) 1-10.
47. H. van den Berg and T. van Vliet, Effect of simultaneous, single oral doses of beta-carotene with lutein or lycopene on the beta-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men, Am. J. Clin. Nutr. 68 (1998) 82-89.
48. K. H. van het Hof, I. A. Brouwer, C. E. West, E. Haddeman, R. P. Steegers-Theunissen, M. van Dusseldorp, J. A. Weststrate, T. K. Eskes, and J. G. Hautvast, Bioavailability of lutein from vegetables is 5 times higher than that of beta-carotene, Am. J. Clin. Nutr. 70 (1999) 261-268.
49. M. van Lieshout, C. E. West, Muhilal, D. Permaesih, Y. Wang, X. Xu, R. B. van Breemen, A. F. L. Creemers, M. A. Verhoeven, and J. Lugtenburg, Bioefficacy of beta-carotene dissolved in oil studied in children in Indonesia, Am. J. Clin. Nutr. 73 (2001) 949-958.
50. M. van Lieshout, C. E. West, and R. B. van Breemen, Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: A review, Am. J. Clin. Nutr. 77 (2003) 12-28.
51. G. Van Poppel, Epidemiological evidence for beta-carotene in prevention of cancer and cardiovascular disease, Eur. J. Clin. Nutr. 50 (1996) 55S-57S.
52. T. Van Vliet, Absorption of beta-carotene and other carotenoids in humans and animal models, Eur. J. Clin. Nutr. 50 (1996) S32-S37.
53. T. van Vliet, W. H. Schreurs, and H. van den Berg, Intestinal beta-carotene absorption and cleavage in men: Response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene, Am. J. Clin. Nutr. 62 (1995) 110-116.
54. T. van Vliet, F. van Schaik, W. H. Schreurs, and H. van den Berg, In vitro measurement of beta-carotene cleavage activity: Methodological considerations and the effect of other carotenoids on beta-carotene cleavage, Int. J. Vitam. Nutr. Res. 66 (1996) 77-85.
55. W. E. von Doering, C. Sotiriou-Leventis, and W. R. Roth, Thermal interconversions among 15-cis, 13-cis, and all-trans b-carotene: Kinetics, Arrhenius parameters, thermochemistry, and potential relevance to anticarcinogenicity of all-trans b-carotene, J. Am. Chem. Soc. 117 (1995) 2747-2757.
56. X.-D. Wang, N. I. Krinsky, R. P. Marini, G. Tang, J. Yu, R. Hurley, J. G. Fox, and R. M. Russell, Intestinal uptake and lymphatic absorption of beta-carotene in ferrets: a model for human beta-carotene metabolism, Am. J. Physiol. 263 (1992) G480-G486.
57. A. Y. Yemelyanov, N. B. Katz, and P. S. Bernstein, Ligand-binding characterization of xanthophyll carotenoids to solubilized membrane proteins derived from human retina, Exp. Eye Res. 72 (2001) 381-392.
58. K. J. Yeum and R. M. Russell, Carotenoid bioavailability and bioconversion, Annu. Rev. Nutr. 22 (2002) 483-504.
59. C.-S. You, R. S. Parker, K. J. Goodman, J. E. Swanson, and T. N. Corso, Evidence of cis-trans isomerization of 9-cis-beta-carotene during absorption in humans, Am. J. Clin. Nutr. 64 (1996) 177-183.
60. C.-S. You, R. S. Parker, and J. E. Swanson, Bioavailability and vitamin A value of carotenes from red palm oil assessed by an extrinsic isotope reference method, Asia Pac. J. Clin. Nutr. 11 (2002) S348-S442.
61. P. F. Zagalsky, E. E. Eliopoulos, and J. B. Findlay, The lobster carapace carotenoprotein, alpha-crustacyanin. A possible role for tryptophan in the bathchromic spectral shift of protein-bound astaxanthin, J. Biochem. 274 (1991) 79-83.
62. R. G. Ziegler, Vegetables, fruits, and carotenoids and the risk of cancer, Am. J. Clin. Nutr. 53 (1991) 251S-259S.