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Volumn 16, Issue 4, 2014, Pages

Targeted therapy in gliomas

Author keywords

Anaplastic gliomas; Central nervous system (CNS); Chemotherapeutic agents; Flioblastoma (GBM); Glioma patients; Gliomas; Malignant gliomas; Molecular targets; Neuro oncology; Oncology; Radiation therapy; Therapeutic agents

Indexed keywords

ANTINEOPLASTIC AGENT; DEATH RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN; HISTONE DEACETYLASE; INTEGRIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEASOME; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; VASCULOTROPIN;

EID: 84893207414     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-014-0379-z     Document Type: Review
Times cited : (30)

References (173)
  • 1
    • 0027301923 scopus 로고
    • The new WHO classification of brain tumours
    • Kleihues P, Burger PC, Scheithauer BW. The new WHO classification of brain tumours. Brain Pathol. 1993;3(3):255-68. (Pubitemid 23276692)
    • (1993) Brain Pathology , vol.3 , Issue.3 , pp. 255-268
    • Kleihues, P.1    Burger, P.C.2    Scheithauer, B.W.3
  • 4
    • 52649160344 scopus 로고    scopus 로고
    • EGFR family: Structure physiology signaling and therapeutic targets
    • Burgess AW. EGFR family: structure physiology signaling and therapeutic targets. Growth Factors. 2008;26:263-74.
    • (2008) Growth Factors , vol.26 , pp. 263-274
    • Burgess, A.W.1
  • 5
    • 0025790916 scopus 로고
    • Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo
    • Ekstrand AJ, James CD, Cavenee WK, et al. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 1991;51:2164-72.
    • (1991) Cancer Res , vol.51 , pp. 2164-2172
    • Ekstrand, A.J.1    James, C.D.2    Cavenee, W.K.3
  • 6
    • 34250892787 scopus 로고    scopus 로고
    • EGFRvIII status defines distinct subtypes of glioblastoma: An analysis of 649 cases
    • abstract. Abstract PA-26
    • Pelloski CE, Zhang L, Lin E, et al. EGFRvIII status defines distinct subtypes of glioblastoma: an analysis of 649 cases [abstract]. Neuro-Oncol. 2006;8:462. Abstract PA-26.
    • (2006) Neuro-Oncol , vol.8 , pp. 462
    • Pelloski, C.E.1    Zhang, L.2    Lin, E.3
  • 7
    • 34250803209 scopus 로고    scopus 로고
    • Molecularly targeted therapy for malignant glioma
    • Sathornsumetree S, Reardon DA, Desjardins A, et al. Molecularly targeted therapy for malignant glioma. Cancer. 2007;110:13 - 24.
    • (2007) Cancer , vol.110 , pp. 13-24
    • Sathornsumetree, S.1    Reardon, D.A.2    Desjardins, A.3
  • 10
    • 26044467362 scopus 로고    scopus 로고
    • Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme
    • DOI 10.1002/path.1823
    • Joensuu H, Puputti M, Sihto H, et al. Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme. J Pathol. 2005;207:224-31. (Pubitemid 41404153)
    • (2005) Journal of Pathology , vol.207 , Issue.2 , pp. 224-231
    • Joensuu, H.1    Puputti, M.2    Sihto, H.3    Tynninen, O.4    Nupponen, N.N.5
  • 12
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 13
    • 34547757537 scopus 로고    scopus 로고
    • Exogenous Platelet-Derived Growth Factor (PDGF) induces human astrocytoma cell line proliferation
    • Ranza E, Facoetti A, Morbini P, et al. Exogenous platelet-derived growth factor (PDGF) induces human astrocytoma cell line proliferation. Anticancer Res. 2007;27:2161-6. (Pubitemid 47228049)
    • (2007) Anticancer Research , vol.27 , Issue.4 B , pp. 2161-2166
    • Ranza, E.1    Facoetti, A.2    Morbini, P.3    Benericetti, E.4    Nano, R.5
  • 14
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature. 1992;359:845-8.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3
  • 15
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • DOI 10.1200/JCO.2005.01.186
    • Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol. 2005;23(5):1028-43. (Pubitemid 46202321)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2
  • 16
    • 0033818764 scopus 로고    scopus 로고
    • Angiogenesis in malignant primary and metastatic brain tumors
    • Reijneveld JC, Voest EE, Taphoorn MJ. Angiogenesis in malignant primary and metastatic brain tumors. J Neurol. 2000;247:597-608.
    • (2000) J Neurol , vol.247 , pp. 597-608
    • Reijneveld, J.C.1    Voest, E.E.2    Taphoorn, M.J.3
  • 17
    • 34249113455 scopus 로고    scopus 로고
    • Integrin inhibitors reaching the clinic
    • DOI 10.1200/JCO.2006.09.8376
    • Stupp R, Ruegg C. Integrin inhibitors reaching the clinic. J Clin Oncol. 2007;25:1637-8. (Pubitemid 46797938)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.13 , pp. 1637-1638
    • Stupp, R.1    Ruegg, C.2
  • 18
    • 0026574125 scopus 로고
    • Role of integrin alpha 4 beta 7/alpha 4 beta P inlymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering
    • Ruegg C, Postigo AA, Sikorski EE, et al. Role of integrin alpha 4 beta 7/alpha 4 beta P inlymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol. 1992;117: 179-89.
    • (1992) J Cell Biol , vol.117 , pp. 179-189
    • Ruegg, C.1    Postigo, A.A.2    Sikorski, E.E.3
  • 19
    • 35348866157 scopus 로고    scopus 로고
    • Integrins: Molecular determinants of glioma invasion
    • DOI 10.1016/j.jocn.2007.06.019, PII S0967586807003797
    • D'Abaco GM, Kaye AH. Integrins: molecular determinants of glioma invasion. J Clin Neurosci. 2007;14:1041-8. (Pubitemid 47588943)
    • (2007) Journal of Clinical Neuroscience , vol.14 , Issue.11 , pp. 1041-1048
    • D'Abaco, G.M.1    Kaye, A.H.2
  • 23
    • 0025790389 scopus 로고
    • Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro
    • Couldwell WT, Uhm JH, Antel JP, et al. Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro. Neurosurgery. 1991;29:880-7.
    • (1991) Neurosurgery , vol.29 , pp. 880-887
    • Couldwell, W.T.1    Uhm, J.H.2    Antel, J.P.3
  • 24
    • 0025363850 scopus 로고
    • Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor
    • Fields AP, Tyler G, Kraft AS, et al. Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor. J Cell Sci. 1990;96:107-14.
    • (1990) J Cell Sci , vol.96 , pp. 107-114
    • Fields, A.P.1    Tyler, G.2    Kraft, A.S.3
  • 25
    • 0032478610 scopus 로고    scopus 로고
    • Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
    • DOI 10.1126/science.280.5360.109
    • Marais R, Light Y, Mason C, et al. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science. 1998;280:109-12. (Pubitemid 28169093)
    • (1998) Science , vol.280 , Issue.5360 , pp. 109-112
    • Marais, R.1    Light, Y.2    Mason, C.3    Paterson, H.4    Olson, M.F.5    Marshall, C.J.6
  • 26
    • 0028073606 scopus 로고
    • Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation
    • Freed E, Symons M, Macdonald SG, et al. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science. 1994;265:1713-6. (Pubitemid 24314903)
    • (1994) Science , vol.265 , Issue.5179 , pp. 1713-1716
    • Freed, E.1    Symons, M.2    Macdonald, S.G.3    McCormick, F.4    Ruggieri, R.5
  • 27
    • 0026754369 scopus 로고
    • Activation of the MAP kinase pathway by the protein kinase raf
    • Howe L, Leevers S, Gómez N, et al. Activation of the MAP kinase pathway by the protein kinase raf. Cell. 1992;71:335-42.
    • (1992) Cell , vol.71 , pp. 335-342
    • Howe, L.1    Leevers, S.2    Gómez, N.3
  • 28
    • 8844252330 scopus 로고    scopus 로고
    • Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas
    • DOI 10.1007/s00401-004-0929-9
    • Knobbe CB, Reifenberger J, Reifenberger G. Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas. Acta Neuropathol (Berl). 2004;108:467-70. (Pubitemid 39534587)
    • (2004) Acta Neuropathologica , vol.108 , Issue.6 , pp. 467-470
    • Knobbe, C.B.1    Reifenberger, J.2    Reifenberger, G.3
  • 29
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • DOI 10.1038/nature04869, PII NATURE04869
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441:424-30. (Pubitemid 44050136)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 31
    • 70149112112 scopus 로고    scopus 로고
    • Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients
    • Lu KV, Zhu S, Cvrljevic A, et al. Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res. 2009;69:6889-98.
    • (2009) Cancer Res , vol.69 , pp. 6889-6898
    • Lu, K.V.1    Zhu, S.2    Cvrljevic, A.3
  • 32
    • 60149089005 scopus 로고    scopus 로고
    • Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
    • Du J, Bernasconi P, Clauser KR, et al. Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nat Biotechnol. 2009;27:77-83.
    • (2009) Nat Biotechnol , vol.27 , pp. 77-83
    • Du, J.1    Bernasconi, P.2    Clauser, K.R.3
  • 33
    • 58149147368 scopus 로고    scopus 로고
    • Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer
    • Toschi L, Janne PA. Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer. Clin Cancer Res. 2008;14:5941-6.
    • (2008) Clin Cancer Res , vol.14 , pp. 5941-5946
    • Toschi, L.1    Janne, P.A.2
  • 34
    • 58949099258 scopus 로고    scopus 로고
    • Prognostic significance of c-Met expression in glioblastomas
    • Kong DS, Song SY, Kim DH, et al. Prognostic significance of c-Met expression in glioblastomas. Cancer. 2009;115:140-8.
    • (2009) Cancer , vol.115 , pp. 140-148
    • Kong, D.S.1    Song, S.Y.2    Kim, D.H.3
  • 35
    • 0035862199 scopus 로고    scopus 로고
    • The human histone deacetylase family
    • DOI 10.1006/excr.2000.5080
    • Gray S, Ekström T. The human histone deacetylase family. Exp Cell Res. 2001;262:75-83. (Pubitemid 32980246)
    • (2001) Experimental Cell Research , vol.262 , Issue.2 , pp. 75-83
    • Gray, S.G.1    Ekstrom, T.J.2
  • 36
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
    • Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst. 2000;92:1210-6. (Pubitemid 30627729)
    • (2000) Journal of the National Cancer Institute , vol.92 , Issue.15 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 37
    • 0029294663 scopus 로고
    • Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function
    • Yoshida M, Horinouchi S, Beppu T. Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays. 1995;17:423-30.
    • (1995) Bioessays , vol.17 , pp. 423-430
    • Yoshida, M.1    Horinouchi, S.2    Beppu, T.3
  • 39
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer. 2004;4:349-60. (Pubitemid 38579481)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 349-360
    • Adams, J.1
  • 40
    • 0036341291 scopus 로고    scopus 로고
    • Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
    • Fulda S, Wick W, Weller M, et al. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med. 2002;8:808-15.
    • (2002) Nat Med , vol.8 , pp. 808-815
    • Fulda, S.1    Wick, W.2    Weller, M.3
  • 43
    • 23144438578 scopus 로고    scopus 로고
    • Chaperone proteins and brain tumors: Potential targets and possible therapeutics
    • Graner MW, Bigner DD. Chaperone proteins and brain tumors: potential targets and possible therapeutics. Neuro Oncol. 2005;7: 260-78.
    • (2005) Neuro Oncol , vol.7 , pp. 260-278
    • Graner, M.W.1    Bigner, D.D.2
  • 44
    • 33646735616 scopus 로고    scopus 로고
    • Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth
    • Premkumar D, Arnold B, Pollack I. Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth. Mol Carcinog. 2006;45:288-301.
    • (2006) Mol Carcinog , vol.45 , pp. 288-301
    • Premkumar, D.1    Arnold, B.2    Pollack, I.3
  • 45
    • 77957944911 scopus 로고    scopus 로고
    • Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitizers
    • Powell C, Mikropoulos C, Kaye SB, et al. Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitizers. Cancer Treat Rev. 2010;36:566-75.
    • (2010) Cancer Treat Rev , vol.36 , pp. 566-575
    • Powell, C.1    Mikropoulos, C.2    Kaye, S.B.3
  • 46
    • 84864859391 scopus 로고    scopus 로고
    • PARP-1 protein expression in glioblastoma multiforme
    • Galia A, Calogero AE, Condorelli R, et al. PARP-1 protein expression in glioblastoma multiforme. Eur J Histochem. 2012;56(1):e9.
    • (2012) Eur J Histochem , vol.56 , Issue.1
    • Galia, A.1    Calogero, A.E.2    Condorelli, R.3
  • 47
    • 84880045561 scopus 로고    scopus 로고
    • RTOG 0913: A phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma
    • Chinnaiyan P, Won M, Wen PY, et al. RTOG 0913: a phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys. 2013;86(5):880-4.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , Issue.5 , pp. 880-884
    • Chinnaiyan, P.1    Won, M.2    Wen, P.Y.3
  • 48
    • 84875239034 scopus 로고    scopus 로고
    • RTOG 0211: A phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients
    • Chakravarti A, Wang M, Robins HI, et al. RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol Biol Phys. 2013;85(5):1206-11.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.5 , pp. 1206-1211
    • Chakravarti, A.1    Wang, M.2    Robins, H.I.3
  • 49
    • 84869189499 scopus 로고    scopus 로고
    • EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma
    • Franceschi E, Stupp R, van den Bent MJ, et al. EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma. Neuro Oncol. 2012;12(12):1503-10.
    • (2012) Neuro Oncol , vol.12 , Issue.12 , pp. 1503-1510
    • Franceschi, E.1    Stupp, R.2    Van Den Bent, M.J.3
  • 50
    • 84864400820 scopus 로고    scopus 로고
    • Phase I/II study of oral erlotinib for treatment of relapsed/refractory glioblastoma multiforme and anaplastic astrocytoma
    • Kesavabhotla K, Schlaff CD, Shin B, et al. Phase I/II study of oral erlotinib for treatment of relapsed/refractory glioblastoma multiforme and anaplastic astrocytoma. J Exp Ther Oncol. 2012;10(1):71-81.
    • (2012) J Exp Ther Oncol , vol.10 , Issue.1 , pp. 71-81
    • Kesavabhotla, K.1    Schlaff, C.D.2    Shin, B.3
  • 51
    • 84868561843 scopus 로고    scopus 로고
    • Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03
    • Lee EQ, Puduvalli VK, Reid JM, et al. Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03. Clin Cancer Res. 2012;18(21):6032-9.
    • (2012) Clin Cancer Res , vol.18 , Issue.21 , pp. 6032-6039
    • Lee, E.Q.1    Puduvalli, V.K.2    Reid, J.M.3
  • 52
    • 84863879018 scopus 로고    scopus 로고
    • A phase II trial with bevacizumab and irinotecan for patients with primary brain tumors and progression after standard therapy
    • Moller S, Grunnet K, Hansen S, et al. A phase II trial with bevacizumab and irinotecan for patients with primary brain tumors and progression after standard therapy. Acta Oncol. 2012;51(6): 797-804.
    • (2012) Acta Oncol , vol.51 , Issue.6 , pp. 797-804
    • Moller, S.1    Grunnet, K.2    Hansen, S.3
  • 53
    • 84859544365 scopus 로고    scopus 로고
    • A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054)
    • Rampling R, Sanson M, Gorlia T, et al. A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054). Neuro Oncol. 2012;14(3):344-50.
    • (2012) Neuro Oncol , vol.14 , Issue.3 , pp. 344-350
    • Rampling, R.1    Sanson, M.2    Gorlia, T.3
  • 54
    • 84875530192 scopus 로고    scopus 로고
    • A phase I study of temozolomide and everolimus (RAD001) in patients with newly diagnosed and progressive glioblastoma either receiving or not receiving enzyme-inducing anticonvulsants: An NCIC CTG study
    • Mason WP, Macneil M, Kavan P, et al. A phase I study of temozolomide and everolimus (RAD001) in patients with newly diagnosed and progressive glioblastoma either receiving or not receiving enzyme-inducing anticonvulsants: an NCIC CTG study. Invest New Drugs. 2012;30(6):2344-51.
    • (2012) Invest New Drugs , vol.30 , Issue.6 , pp. 2344-2351
    • Mason, W.P.1    Macneil, M.2    Kavan, P.3
  • 55
    • 84863595655 scopus 로고    scopus 로고
    • A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
    • Mason WP, Belanger K, Nicholas G, et al. A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression. J Neurooncol. 2012;107(2):343-9.
    • (2012) J Neurooncol , vol.107 , Issue.2 , pp. 343-349
    • Mason, W.P.1    Belanger, K.2    Nicholas, G.3
  • 56
    • 84861312289 scopus 로고    scopus 로고
    • Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma
    • Reardon DA, Desjardins A, Peters KB, et al. Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma. J Neurooncol. 2012;107(1):155-64.
    • (2012) J Neurooncol , vol.107 , Issue.1 , pp. 155-164
    • Reardon, D.A.1    Desjardins, A.2    Peters, K.B.3
  • 57
    • 84863011588 scopus 로고    scopus 로고
    • Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma
    • Butowski N, Chang SM, Lamborn KR, et al. Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. Neuro Oncol. 2011;13(12):1331-8.
    • (2011) Neuro Oncol , vol.13 , Issue.12 , pp. 1331-1338
    • Butowski, N.1    Chang, S.M.2    Lamborn, K.R.3
  • 58
    • 83055173043 scopus 로고    scopus 로고
    • Cilengitide in patients with recurrent glioblastoma: The results of NABTC 03-02, a phase II trial with measures of treatment delivery
    • Gilbert MR, Kuhn J, Lamborn KR, et al. Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery. J Neurooncol. 2012;106(1): 147-53.
    • (2012) J Neurooncol , vol.106 , Issue.1 , pp. 147-153
    • Gilbert, M.R.1    Kuhn, J.2    Lamborn, K.R.3
  • 59
    • 80855145598 scopus 로고    scopus 로고
    • Phase 2 study of carboplatin, irinotecan and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy
    • Reardon DA, Desjardins A, Peters KB, et al. Phase 2 study of carboplatin, irinotecan and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. Cancer. 2011;117(23): 5351-8.
    • (2011) Cancer , vol.117 , Issue.23 , pp. 5351-5358
    • Reardon, D.A.1    Desjardins, A.2    Peters, K.B.3
  • 60
    • 79959213028 scopus 로고    scopus 로고
    • The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide and irinotecan for newly diagnosed glioblastoma
    • Vredenburgh JJ, Desjardins A, Reardon DA, et al. The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide and irinotecan for newly diagnosed glioblastoma. Clin Cancer Res. 2011;17(12):4119-24.
    • (2011) Clin Cancer Res , vol.17 , Issue.12 , pp. 4119-4124
    • Vredenburgh, J.J.1    Desjardins, A.2    Reardon, D.A.3
  • 61
    • 79959956310 scopus 로고    scopus 로고
    • A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03
    • Iwamoto FM, Lamborn KR, Kuhn JG, et al. A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. Neuro Oncol. 2011;13(5):509-16.
    • (2011) Neuro Oncol , vol.13 , Issue.5 , pp. 509-516
    • Iwamoto, F.M.1    Lamborn, K.R.2    Kuhn, J.G.3
  • 62
    • 79955766450 scopus 로고    scopus 로고
    • A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma
    • Wen PY, Schiff D, Cloughesy TF, et al. A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol. 2011;13(4):437-46.
    • (2011) Neuro Oncol , vol.13 , Issue.4 , pp. 437-446
    • Wen, P.Y.1    Schiff, D.2    Cloughesy, T.F.3
  • 63
    • 79951602633 scopus 로고    scopus 로고
    • Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
    • Bogdahn U, Hau P, Stockhammer G, et al. Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro Oncol. 2011;13(1):132-42.
    • (2011) Neuro Oncol , vol.13 , Issue.1 , pp. 132-142
    • Bogdahn, U.1    Hau, P.2    Stockhammer, G.3
  • 64
    • 81855206303 scopus 로고    scopus 로고
    • A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma
    • Nghiemphu PL, Wen PY, Lamborn KR, et al. A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma. Int J Radiat Oncol Phys. 2011;81(5):1422-7.
    • (2011) Int J Radiat Oncol Phys , vol.81 , Issue.5 , pp. 1422-1427
    • Nghiemphu, P.L.1    Wen, P.Y.2    Lamborn, K.R.3
  • 65
    • 78349245231 scopus 로고    scopus 로고
    • Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risks
    • Sarkaria JN, Galanis E, Wu W, et al. Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risks. Clin Cancer Res. 2010;16(22):5573-80.
    • (2010) Clin Cancer Res , vol.16 , Issue.22 , pp. 5573-5580
    • Sarkaria, J.N.1    Galanis, E.2    Wu, W.3
  • 66
    • 80052820448 scopus 로고    scopus 로고
    • North Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme
    • Sarkaria JN, Galanis E, Wu W, et al. North Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2011;81(2):468-75.
    • (2011) Int J Radiat Oncol Biol Phys , vol.81 , Issue.2 , pp. 468-475
    • Sarkaria, J.N.1    Galanis, E.2    Wu, W.3
  • 67
    • 78049306732 scopus 로고    scopus 로고
    • Safety and efficacy of erlotinib in first-relapse glioblastoma: A phase II open-label study
    • Yung WK, Vredenburgh JJ, Cloughesy TF, et al. Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study. Neuro Oncol. 2010;12(10):1061-70.
    • (2010) Neuro Oncol , vol.12 , Issue.10 , pp. 1061-1070
    • Yung, W.K.1    Vredenburgh, J.J.2    Cloughesy, T.F.3
  • 68
    • 79955582712 scopus 로고    scopus 로고
    • Phase II evaluation of gefitinib in patients with newly diagnosed grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074
    • Uhm JH, Ballman KV, Wu W, et al. Phase II evaluation of gefitinib in patients with newly diagnosed grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074. Int J Radiat Oncol Biol Phys. 2011;80(2):347-53.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , Issue.2 , pp. 347-353
    • Uhm, J.H.1    Ballman, K.V.2    Wu, W.3
  • 69
    • 77954720781 scopus 로고    scopus 로고
    • Phase II study of Cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
    • Batchelor TT, Duda DG, di Tomaso E, et al. Phase II study of Cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 2010;28(17):2817-23.
    • (2010) J Clin Oncol , vol.28 , Issue.17 , pp. 2817-2823
    • Batchelor, T.T.1    Duda, D.G.2    Di Tomaso, E.3
  • 70
    • 77954924659 scopus 로고    scopus 로고
    • Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma
    • Stupp R, Hegi ME, Neyns B, et al. Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J Clin Oncol. 2010;28(16): 2712-8.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2712-2718
    • Stupp, R.1    Hegi, M.E.2    Neyns, B.3
  • 71
    • 77955633497 scopus 로고    scopus 로고
    • A Phase II study of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme
    • Li L, Quang TS, Gracely EJ, et al. A Phase II study of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme. J Neurosurg. 2010;113(2):192-8.
    • (2010) J Neurosurg , vol.113 , Issue.2 , pp. 192-198
    • Li, L.1    Quang, T.S.2    Gracely, E.J.3
  • 72
    • 79952194923 scopus 로고    scopus 로고
    • Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma
    • Phuphanich S, Supko JG, Carson KA, et al. Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma. J Neurooncol. 2010;100(1):95-103.
    • (2010) J Neurooncol , vol.100 , Issue.1 , pp. 95-103
    • Phuphanich, S.1    Supko, J.G.2    Carson, K.A.3
  • 73
    • 77957069911 scopus 로고    scopus 로고
    • Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: A phase I study
    • Butowski N, Chang SM, Lamborn KR, et al. Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study. Neuro Oncol. 2010;12(6):608-13.
    • (2010) Neuro Oncol , vol.12 , Issue.6 , pp. 608-613
    • Butowski, N.1    Chang, S.M.2    Lamborn, K.R.3
  • 74
    • 75849133697 scopus 로고    scopus 로고
    • A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas
    • Kreisl TN, Kotliarova S, Butman JA, et al. A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas. Neuro Oncol. 2010;12(2):181-9.
    • (2010) Neuro Oncol , vol.12 , Issue.2 , pp. 181-189
    • Kreisl, T.N.1    Kotliarova, S.2    Butman, J.A.3
  • 75
    • 75749122223 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy
    • Raizer JJ, Abrey LE, Lassman AB, et al. A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neuro Oncol. 2010;12(1):95-103.
    • (2010) Neuro Oncol , vol.12 , Issue.1 , pp. 95-103
    • Raizer, J.J.1    Abrey, L.E.2    Lassman, A.B.3
  • 76
    • 75749110539 scopus 로고    scopus 로고
    • A phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas
    • Raizer JJ, Abrey LE, Lassman AB, et al. A phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas. Neuro Oncol. 2010;12(1):87-94.
    • (2010) Neuro Oncol , vol.12 , Issue.1 , pp. 87-94
    • Raizer, J.J.1    Abrey, L.E.2    Lassman, A.B.3
  • 77
    • 79959812904 scopus 로고    scopus 로고
    • Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy
    • Reardon DA, Desjardins A, Peters K, et al. Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J Neurooncol. 2011;103(2):371-9.
    • (2011) J Neurooncol , vol.103 , Issue.2 , pp. 371-379
    • Reardon, D.A.1    Desjardins, A.2    Peters, K.3
  • 78
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • Lai A, Tran A, Nghiemphu PL, et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol. 2011;29(2):142-8.
    • (2011) J Clin Oncol , vol.29 , Issue.2 , pp. 142-148
    • Lai, A.1    Tran, A.2    Nghiemphu, P.L.3
  • 79
    • 78149254368 scopus 로고    scopus 로고
    • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    • Sampson JH, Heimberger AB, Archer GE, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol. 2010;28(31): 4722-9.
    • (2010) J Clin Oncol , vol.28 , Issue.31 , pp. 4722-4729
    • Sampson, J.H.1    Heimberger, A.B.2    Archer, G.E.3
  • 80
    • 84856806386 scopus 로고    scopus 로고
    • A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma
    • Narayana A, Gruber D, Kunnakkat S, et al. A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma. J Neurosurg. 2012;116(2):341-5.
    • (2012) J Neurosurg , vol.116 , Issue.2 , pp. 341-345
    • Narayana, A.1    Gruber, D.2    Kunnakkat, S.3
  • 81
    • 84857373272 scopus 로고    scopus 로고
    • Bevacizumab and daily temozolomide for recurrent glioblastoma
    • Desjardins A, Reardon DA, Coan A, et al. Bevacizumab and daily temozolomide for recurrent glioblastoma. Cancer. 2012;118(5): 1302-12.
    • (2012) Cancer , vol.118 , Issue.5 , pp. 1302-1312
    • Desjardins, A.1    Reardon, D.A.2    Coan, A.3
  • 82
    • 84868193304 scopus 로고    scopus 로고
    • A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)
    • Nabors LB, Mikkelsen T, Hegi ME, et al. A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306). Cancer. 2012;118(22):5601-7.
    • (2012) Cancer , vol.118 , Issue.22 , pp. 5601-5607
    • Nabors, L.B.1    Mikkelsen, T.2    Hegi, M.E.3
  • 83
    • 84866759977 scopus 로고    scopus 로고
    • Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma
    • Nagane M, Nishikawa R, Narita Y, et al. Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma. Jpn J Clin Oncol. 2012;42(10):887-95.
    • (2012) Jpn J Clin Oncol , vol.42 , Issue.10 , pp. 887-895
    • Nagane, M.1    Nishikawa, R.2    Narita, Y.3
  • 84
    • 77949891455 scopus 로고    scopus 로고
    • Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
    • Wick W, Puduvalli VK, Chamberlain MC, et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol. 2010;28(7):1168-74.
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1168-1174
    • Wick, W.1    Puduvalli, V.K.2    Chamberlain, M.C.3
  • 85
    • 77953617053 scopus 로고    scopus 로고
    • Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme
    • Peereboom DM, Shepard DR, Ahluwalia MS, et al. Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme. J Neurooncol. 2010;98(1):93-9.
    • (2010) J Neurooncol , vol.98 , Issue.1 , pp. 93-99
    • Peereboom, D.M.1    Shepard, D.R.2    Ahluwalia, M.S.3
  • 86
    • 71649094684 scopus 로고    scopus 로고
    • Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: A phase II study
    • Reardon DA, Desjardins A, Vredenburgh JJ, et al. Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. Br J Cancer. 2009;101(12):1986-94.
    • (2009) Br J Cancer , vol.101 , Issue.12 , pp. 1986-1994
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 87
    • 70350236627 scopus 로고    scopus 로고
    • An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme
    • Sampson JH, Archer GE, Mitchell DA, et al. An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Mol Cancer Ther. 2009;8(10):2773-9.
    • (2009) Mol Cancer Ther , vol.8 , Issue.10 , pp. 2773-2779
    • Sampson, J.H.1    Archer, G.E.2    Mitchell, D.A.3
  • 88
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009;27(28):4733-40.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3
  • 89
    • 70249128040 scopus 로고    scopus 로고
    • Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: A multicenter phase II trial
    • Grossman SA, Ye X, Chamberlain M, et al. Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. J Clin Oncol. 2009;27(25):4155-61.
    • (2009) J Clin Oncol , vol.27 , Issue.25 , pp. 4155-4161
    • Grossman, S.A.1    Ye, X.2    Chamberlain, M.3
  • 90
    • 71349088046 scopus 로고    scopus 로고
    • A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoam multiforme: Clinical outcomes, pharmacokinetics and molecular correlation
    • Thiessen B, Stewart C, Tsao M, et al. A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoam multiforme: clinical outcomes, pharmacokinetics and molecular correlation. Cancer Chemother Pharmacol. 2010;65(2):353-61.
    • (2010) Cancer Chemother Pharmacol , vol.65 , Issue.2 , pp. 353-361
    • Thiessen, B.1    Stewart, C.2    Tsao, M.3
  • 91
    • 65349141942 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in recurrent glioblastoma multiforme: A north central cancer treatment group study
    • Galanis E, Jaeckle KA, Maurer MJ, et al. Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study. J Clin Oncol. 2009;27(12):2052-8.
    • (2009) J Clin Oncol , vol.27 , Issue.12 , pp. 2052-2058
    • Galanis, E.1    Jaeckle, K.A.2    Maurer, M.J.3
  • 92
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 2009;27(5): 740-5.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 93
    • 67349138194 scopus 로고    scopus 로고
    • Phase I trial using proteasome inhibitor botezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies
    • Kubicek GJ, Werner-Wasik M, Machtay M, et al. Phase I trial using proteasome inhibitor botezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys. 2009;74(2):433-9.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , Issue.2 , pp. 433-439
    • Kubicek, G.J.1    Werner-Wasik, M.2    Machtay, M.3
  • 94
    • 59149086517 scopus 로고    scopus 로고
    • Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma
    • Prados MD, Chang SM, Butowski N, et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. J Clin Oncol. 2009;27(4):579-84.
    • (2009) J Clin Oncol , vol.27 , Issue.4 , pp. 579-584
    • Prados, M.D.1    Chang, S.M.2    Butowski, N.3
  • 95
    • 57149108506 scopus 로고    scopus 로고
    • Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme
    • Reardon DA, Fink KL, Mikkelsen T, et al. Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol. 2008;26(34):5610-7.
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5610-5617
    • Reardon, D.A.1    Fink, K.L.2    Mikkelsen, T.3
  • 96
    • 57149118473 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
    • Brown PD, Krishnan S, Sarkaria JN, et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol. 2008;26(34):5603-9.
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5603-5609
    • Brown, P.D.1    Krishnan, S.2    Sarkaria, J.N.3
  • 97
    • 50649118313 scopus 로고    scopus 로고
    • Ras pathway activation in gliomas: A strategic target for intranasal administration of perillyl alcohol
    • Warsz
    • da Fonseca CO, Linden R, Futuro D, et al. Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. Arch Immunol Ther Exp (Warsz). 2008;56(4):267-76.
    • (2008) Arch Immunol Ther Exp , vol.56 , Issue.4 , pp. 267-276
    • Da Fonseca, C.O.1    Linden, R.2    Futuro, D.3
  • 98
    • 60549100910 scopus 로고    scopus 로고
    • Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease
    • Lustig R, Mikkelsen T, Lesser G, et al. Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease. Neuro Oncol. 2008;10(6):1004-9.
    • (2008) Neuro Oncol , vol.10 , Issue.6 , pp. 1004-1009
    • Lustig, R.1    Mikkelsen, T.2    Lesser, G.3
  • 99
    • 50649103493 scopus 로고    scopus 로고
    • Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma
    • De Groot JF, Gilbert MR, Aldape K, et al. Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma. J Neurooncol. 2008;90(1):89-97.
    • (2008) J Neurooncol , vol.90 , Issue.1 , pp. 89-97
    • De Groot, J.F.1    Gilbert, M.R.2    Aldape, K.3
  • 100
    • 54049094871 scopus 로고    scopus 로고
    • Phase I safety study of escalating doses of atrasentan in adults with recurrent malignant glioma
    • Phuphanich S, Carson KA, Grossman SA, et al. Phase I safety study of escalating doses of atrasentan in adults with recurrent malignant glioma. Neuro Oncol. 2008;10(4):617-23.
    • (2008) Neuro Oncol , vol.10 , Issue.4 , pp. 617-623
    • Phuphanich, S.1    Carson, K.A.2    Grossman, S.A.3
  • 101
    • 45249097586 scopus 로고    scopus 로고
    • Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability
    • Lai A, Filka E, McGibbon B, et al. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys. 2008;71(5):1372-80.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , Issue.5 , pp. 1372-1380
    • Lai, A.1    Filka, E.2    McGibbon, B.3
  • 102
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy TF, Yoshimoto K, Nghiemphu P, et al. Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008;5(1):e8.
    • (2008) PLoS Med , vol.5 , Issue.1
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3
  • 109
    • 33745183568 scopus 로고    scopus 로고
    • Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: Results of North Central Cancer Treatment Group protocol N0177
    • Krishnan S, Brown PD, Ballman KV, et al. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys. 2006;65(4):1192-9.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , Issue.4 , pp. 1192-1199
    • Krishnan, S.1    Brown, P.D.2    Ballman, K.V.3
  • 110
    • 33646434844 scopus 로고    scopus 로고
    • Treatment of high-grade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h0R3: Report from a phase I/II trial
    • Ramos TC, Figueredo J, Catala M, et al. Treatment of high-grade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h0R3: report from a phase I/II trial. Cancer Biol Ther. 2006;5(4):375-9.
    • (2006) Cancer Biol Ther , vol.5 , Issue.4 , pp. 375-379
    • Ramos, T.C.1    Figueredo, J.2    Catala, M.3
  • 116
    • 0036499078 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme
    • DOI 10.1200/JCO.20.5.1383
    • Groves MD, Puduvalli VK, Hess KR, et al. Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J Clin Oncol. 2002;20(5):1383-8. (Pubitemid 34177446)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.5 , pp. 1383-1388
    • Groves, M.D.1    Puduvalli, V.K.2    Hess, K.R.3    Jaeckle, K.A.4    Peterson, P.5    Yung, W.K.A.6    Levin, V.A.7
  • 117
    • 0029931490 scopus 로고    scopus 로고
    • Multiple infusions of anti-epidermal growth factor recedptor (EGFR) monoclonal antibody (EMD 55,900) in patients with recurrent malignant gliomas
    • Stragliotto G, Vega F, Stasiecki P, et al. Multiple infusions of anti-epidermal growth factor recedptor (EGFR) monoclonal antibody (EMD 55,900) in patients with recurrent malignant gliomas. Eur J Cancer. 1996;32A(4):636-40.
    • (1996) Eur J Cancer , vol.32 A , Issue.4 , pp. 636-640
    • Stragliotto, G.1    Vega, F.2    Stasiecki, P.3
  • 118
    • 0029005809 scopus 로고
    • Epidermal growth factor receptor 425 monoclonal antibodies radiolabeled with iodine-125 in the adjuvant treatment of high-grade astrocytomas
    • Snelling L, Miyamoto CT, Bender H, et al. Epidermal growth factor receptor 425 monoclonal antibodies radiolabeled with iodine-125 in the adjuvant treatment of high-grade astrocytomas. Hybridoma. 1995;14(2):111-4.
    • (1995) Hybridoma , vol.14 , Issue.2 , pp. 111-114
    • Snelling, L.1    Miyamoto, C.T.2    Bender, H.3
  • 119
    • 0026599333 scopus 로고
    • Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: A phase II trial
    • Brady LW, Miyamoto C, Woo DV, et al. Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: a phase II trial. Int J Radiat Oncol Biol Phys. 1992;22(1):225-30.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , Issue.1 , pp. 225-230
    • Brady, L.W.1    Miyamoto, C.2    Woo, D.V.3
  • 120
    • 84883261716 scopus 로고    scopus 로고
    • Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: A phase II study
    • Zustovich F, Landi L, Lombardi G, et al. Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: a phase II study. Anticancer Res. 2013;33(8):3487-94.
    • (2013) Anticancer Res , vol.33 , Issue.8 , pp. 3487-3494
    • Zustovich, F.1    Landi, L.2    Lombardi, G.3
  • 121
    • 84876766342 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme
    • Lassen U, Sorensen M, Gaziel TB, et al. Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme. Anticancer Res. 2013;33(4):1657-60.
    • (2013) Anticancer Res , vol.33 , Issue.4 , pp. 1657-1660
    • Lassen, U.1    Sorensen, M.2    Gaziel, T.B.3
  • 122
    • 84874038379 scopus 로고    scopus 로고
    • A phase I/II trial of pazopanib in combination with lapatinib in adult patients with relapsed malignant glioma
    • Reardon DA, Groves MD, Wen PY, et al. A phase I/II trial of pazopanib in combination with lapatinib in adult patients with relapsed malignant glioma. Clin Cancer Res. 2013;19(4):900-8.
    • (2013) Clin Cancer Res , vol.19 , Issue.4 , pp. 900-908
    • Reardon, D.A.1    Groves, M.D.2    Wen, P.Y.3
  • 123
    • 84875740755 scopus 로고    scopus 로고
    • NABTT 0502: A phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme
    • Peereboom DM, Ahluwalia MS, Ye X, et al. NABTT 0502: a phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme. Neuro Oncol. 2013;15(4):490-6.
    • (2013) Neuro Oncol , vol.15 , Issue.4 , pp. 490-496
    • Peereboom, D.M.1    Ahluwalia, M.S.2    Ye, X.3
  • 124
    • 84879300467 scopus 로고    scopus 로고
    • Phase II open-label study of nintedanib in patients with recurrent glioblastoma multiforme
    • Muhic A, Poulsen HS, Sorensen M, et al. Phase II open-label study of nintedanib in patients with recurrent glioblastoma multiforme. J Neurooncol. 2013;111(2):205-12.
    • (2013) J Neurooncol , vol.111 , Issue.2 , pp. 205-212
    • Muhic, A.1    Poulsen, H.S.2    Sorensen, M.3
  • 125
    • 84872050000 scopus 로고    scopus 로고
    • Targeted therapy with bevacizumab and erlotinib tailored to the molecular profile of patients with recurrent glioblastoma. Preliminary experience
    • Wien
    • D'Alessandri QG, Montano N, Cenci T, et al. Targeted therapy with bevacizumab and erlotinib tailored to the molecular profile of patients with recurrent glioblastoma. Preliminary experience. Acta Neurochir (Wien). 2013;155(1):33-40.
    • (2013) Acta Neurochir , vol.155 , Issue.1 , pp. 33-40
    • D'Alessandri, Q.G.1    Montano, N.2    Cenci, T.3
  • 126
    • 84869155416 scopus 로고    scopus 로고
    • A phase I/II trial of vandetanib for patients with recurrent malignant glioma
    • Kreisl TN, McNeill KA, Sul J, et al. A phase I/II trial of vandetanib for patients with recurrent malignant glioma. Neuro Oncol. 2012;14(12):1519-26.
    • (2012) Neuro Oncol , vol.14 , Issue.12 , pp. 1519-1526
    • Kreisl, T.N.1    McNeill, K.A.2    Sul, J.3
  • 127
    • 84869188311 scopus 로고    scopus 로고
    • Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02
    • Lee EQ, Kuhn J, Lamborn KR, et al. Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02. Neuro Oncol. 2012;14(12):1511-8.
    • (2012) Neuro Oncol , vol.14 , Issue.12 , pp. 1511-1518
    • Lee, E.Q.1    Kuhn, J.2    Lamborn, K.R.3
  • 128
    • 84871816644 scopus 로고    scopus 로고
    • Continuous daily sunitinib for recurrent glioblastoma
    • Kreisl TN, Smith P, Sul J, et al. Continuous daily sunitinib for recurrent glioblastoma. J Neurooncol. 2013;111(1):41-8.
    • (2013) J Neurooncol , vol.111 , Issue.1 , pp. 41-48
    • Kreisl, T.N.1    Smith, P.2    Sul, J.3
  • 129
    • 84871818807 scopus 로고    scopus 로고
    • A phase II study of conventional radiation therapy and thalidomide for supratentorial, newly-diagnosed glioblastoma (RTOG 9806)
    • Alexander BM, Wang M, Yung WK, et al. A phase II study of conventional radiation therapy and thalidomide for supratentorial, newly-diagnosed glioblastoma (RTOG 9806). J Neurooncol. 2013;111(1):33-9.
    • (2013) J Neurooncol , vol.111 , Issue.1 , pp. 33-39
    • Alexander, B.M.1    Wang, M.2    Yung, W.K.3
  • 130
    • 84867854266 scopus 로고    scopus 로고
    • A dose escalation trial for the combination of erlotinib and sirolimus for recurrent malignant gliomas
    • Nghiemphu PL, Lai A, Green RM, et al. A dose escalation trial for the combination of erlotinib and sirolimus for recurrent malignant gliomas. J Neurooncol. 2012;110(2):245-50.
    • (2012) J Neurooncol , vol.110 , Issue.2 , pp. 245-250
    • Nghiemphu, P.L.1    Lai, A.2    Green, R.M.3
  • 131
    • 84866364645 scopus 로고    scopus 로고
    • A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma
    • Pan E, Yu D, Yue B, et al. A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma. J Neurooncol. 2012;110(1):111-8.
    • (2012) J Neurooncol , vol.110 , Issue.1 , pp. 111-118
    • Pan, E.1    Yu, D.2    Yue, B.3
  • 132
    • 84859628071 scopus 로고    scopus 로고
    • Phase II study of concurrent radiation therapy, temozolomide, and bevacizumab followed by bevacizumab/everolimus as first-line treatment for patients with glioblastoma
    • Hainsworth JD, Shih KC, Shepard GC, et al. Phase II study of concurrent radiation therapy, temozolomide, and bevacizumab followed by bevacizumab/everolimus as first-line treatment for patients with glioblastoma. Clin Adv Hematol Oncol. 2012;10(4): 240-6.
    • (2012) Clin Adv Hematol Oncol , vol.10 , Issue.4 , pp. 240-246
    • Hainsworth, J.D.1    Shih, K.C.2    Shepard, G.C.3
  • 133
    • 84863796631 scopus 로고    scopus 로고
    • Phase I study of AEE788, a novel multitarget inhibitor of ErbB and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients
    • Reardon DA, Conrad CA, Cloughesy T, et al. Phase I study of AEE788, a novel multitarget inhibitor of ErbB and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients. Cancer Chemother Pharmacol. 2012;69(6):1507-18.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.6 , pp. 1507-1518
    • Reardon, D.A.1    Conrad, C.A.2    Cloughesy, T.3
  • 134
    • 84859538161 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: A north central cancer treatment group study
    • Friday BB, Anderson SK, Buckner J, et al. Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study. Neuro Oncol. 2012;14(2):215-21.
    • (2012) Neuro Oncol , vol.14 , Issue.2 , pp. 215-221
    • Friday, B.B.1    Anderson, S.K.2    Buckner, J.3
  • 135
    • 84863321033 scopus 로고    scopus 로고
    • Phase 2 trial of irinotecan and thalidomide in adults with recurrent anaplastic glioma
    • Giglio P, Dhamne M, Hess KR, et al. Phase 2 trial of irinotecan and thalidomide in adults with recurrent anaplastic glioma. Cancer. 2012;118(14):3599-606.
    • (2012) Cancer , vol.118 , Issue.14 , pp. 3599-3606
    • Giglio, P.1    Dhamne, M.2    Hess, K.R.3
  • 136
    • 84856238982 scopus 로고    scopus 로고
    • Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma
    • Chinnaiyan P, Chowdhary S, Potthast L, et al. Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma. Neuro Oncol. 2012;14(1):93-100.
    • (2012) Neuro Oncol , vol.14 , Issue.1 , pp. 93-100
    • Chinnaiyan, P.1    Chowdhary, S.2    Potthast, L.3
  • 137
    • 82955232920 scopus 로고    scopus 로고
    • Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma
    • Reardon DA, Vredenburgh JJ, Coan A, et al. Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma. J Neurooncol. 2011;105(3):621-7.
    • (2011) J Neurooncol , vol.105 , Issue.3 , pp. 621-627
    • Reardon, D.A.1    Vredenburgh, J.J.2    Coan, A.3
  • 138
    • 79960111080 scopus 로고    scopus 로고
    • Phase II study of aflibercept in recurrent malignant glioma: A North American Brain Tumor Consortium study
    • De Groot JF, Lamborn KR, Chang SM, et al. Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol. 2011;29(19):2689-95.
    • (2011) J Clin Oncol , vol.29 , Issue.19 , pp. 2689-2695
    • De Groot, J.F.1    Lamborn, K.R.2    Chang, S.M.3
  • 139
    • 79959841782 scopus 로고    scopus 로고
    • Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide
    • Gerstner ER, Eichler AF, Plotkin SR, et al. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol. 2011;103(2):325-32.
    • (2011) J Neurooncol , vol.103 , Issue.2 , pp. 325-332
    • Gerstner, E.R.1    Eichler, A.F.2    Plotkin, S.R.3
  • 140
    • 78650148102 scopus 로고    scopus 로고
    • A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma
    • Gilbert MR, Gonzalez J, Hunter K, et al. A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma. Neuro Oncol. 2010;12(11):1167-72.
    • (2010) Neuro Oncol , vol.12 , Issue.11 , pp. 1167-1172
    • Gilbert, M.R.1    Gonzalez, J.2    Hunter, K.3
  • 141
    • 78650102866 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma
    • Sathornsumetee S, Dejardins A, Vredenburgh JJ, et al. Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol. 2010;12(12):1300-10.
    • (2010) Neuro Oncol , vol.12 , Issue.12 , pp. 1300-1310
    • Sathornsumetee, S.1    Dejardins, A.2    Vredenburgh, J.J.3
  • 142
    • 77955363593 scopus 로고    scopus 로고
    • Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme
    • Hainsworth JD, Ervin T, Friedman E, et al. Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme. Cancer. 2010;116(15):3663-9.
    • (2010) Cancer , vol.116 , Issue.15 , pp. 3663-3669
    • Hainsworth, J.D.1    Ervin, T.2    Friedman, E.3
  • 143
    • 77954748580 scopus 로고    scopus 로고
    • Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: A phase II trial
    • Hasselbalch B, Lassen U, Hansen S, et al. Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial. Neuro Oncol. 2010;12(5):508-16.
    • (2010) Neuro Oncol , vol.12 , Issue.5 , pp. 508-516
    • Hasselbalch, B.1    Lassen, U.2    Hansen, S.3
  • 144
    • 77749332056 scopus 로고    scopus 로고
    • A phase 1 trial of ABT-510 concurrent with standard chemoradiation for patients with newly diagnosed glioblastoma
    • Nabors LB, Fiveash JB, Markert JM, et al. A phase 1 trial of ABT-510 concurrent with standard chemoradiation for patients with newly diagnosed glioblastoma. Arch Neurol. 2010;67(3):313-9.
    • (2010) Arch Neurol , vol.67 , Issue.3 , pp. 313-319
    • Nabors, L.B.1    Fiveash, J.B.2    Markert, J.M.3
  • 145
    • 78149492402 scopus 로고    scopus 로고
    • Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02)
    • Iwamoto FM, Lamborn KR, Robins HI, et al. Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro Oncol. 2010;12(8):8555-61.
    • (2010) Neuro Oncol , vol.12 , Issue.8 , pp. 8555-8561
    • Iwamoto, F.M.1    Lamborn, K.R.2    Robins, H.I.3
  • 146
    • 77955922743 scopus 로고    scopus 로고
    • Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma
    • Drappatz J, Norden AD, Wong ET, et al. Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys. 2010;78(1):85-90.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , Issue.1 , pp. 85-90
    • Drappatz, J.1    Norden, A.D.2    Wong, E.T.3
  • 147
    • 72449155176 scopus 로고    scopus 로고
    • EORTC study 26041-22041: Phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma
    • Brandes AA, Stupp R, Hau P, et al. EORTC study 26041-22041: phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma. Eur J Cancer. 2010;46(2):348-54.
    • (2010) Eur J Cancer , vol.46 , Issue.2 , pp. 348-354
    • Brandes, A.A.1    Stupp, R.2    Hau, P.3
  • 148
    • 71649102124 scopus 로고    scopus 로고
    • Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
    • Reardon DA, Dresemann G, Taillibert S, et al. Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br J Cancer. 2009;101(12):1995-2004.
    • (2009) Br J Cancer , vol.101 , Issue.12 , pp. 1995-2004
    • Reardon, D.A.1    Dresemann, G.2    Taillibert, S.3
  • 149
    • 70349694368 scopus 로고    scopus 로고
    • Phase II study of neoadjuvant imatinib in glioblastoma: Evaluation of clinical and molecular effects of the treatment
    • Razis E, Selviaridis P, Labropoulos S, et al. Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecular effects of the treatment. Clin Cancer Res. 2009;15(19): 6258-66.
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6258-6266
    • Razis, E.1    Selviaridis, P.2    Labropoulos, S.3
  • 150
    • 75049085049 scopus 로고    scopus 로고
    • Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
    • Dresemann G, Weller M, Rosenthal MA, et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J Neurooncol. 2010;96(3):393-402.
    • (2010) J Neurooncol , vol.96 , Issue.3 , pp. 393-402
    • Dresemann, G.1    Weller, M.2    Rosenthal, M.A.3
  • 151
    • 75049084471 scopus 로고    scopus 로고
    • Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
    • Reardon DA, Desjardin A, Vredenburgh JJ, et al. Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. J Neurooncol. 2010;96(2):219-30.
    • (2010) J Neurooncol , vol.96 , Issue.2 , pp. 219-230
    • Reardon, D.A.1    Desjardin, A.2    Vredenburgh, J.J.3
  • 152
    • 65649146868 scopus 로고    scopus 로고
    • Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma
    • Reardon DA, Egorin MJ, Desjardins A, et al. Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma. Cancer. 2009;115(10):2188-98.
    • (2009) Cancer , vol.115 , Issue.10 , pp. 2188-2198
    • Reardon, D.A.1    Egorin, M.J.2    Desjardins, A.3
  • 153
    • 59349089499 scopus 로고    scopus 로고
    • A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM)
    • Kreisl TN, Lassman AB, Mischel PS, et al. A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM). J Neurooncol. 2009;92(1):99-105.
    • (2009) J Neurooncol , vol.92 , Issue.1 , pp. 99-105
    • Kreisl, T.N.1    Lassman, A.B.2    Mischel, P.S.3
  • 154
    • 53349117686 scopus 로고    scopus 로고
    • A phase II study of thalidomide and irinotecan for treatment of glioblastoma multiforme
    • Fadul CE, Kingman LS, Meyer LP, et al. A phase II study of thalidomide and irinotecan for treatment of glioblastoma multiforme. J Neurooncol. 2008;90(2):229-35.
    • (2008) J Neurooncol , vol.90 , Issue.2 , pp. 229-235
    • Fadul, C.E.1    Kingman, L.S.2    Meyer, L.P.3
  • 155
    • 57649110848 scopus 로고    scopus 로고
    • A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme
    • Drappatz J, Wong ET, Schiff D, et al. A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Phys. 2009;73(1):222-7.
    • (2009) Int J Radiat Oncol Phys , vol.73 , Issue.1 , pp. 222-227
    • Drappatz, J.1    Wong, E.T.2    Schiff, D.3
  • 156
    • 55849093794 scopus 로고    scopus 로고
    • Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults
    • Kesari S, Schiff D, Henson JW, et al. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol. 2008;10(3):300-8.
    • (2008) Neuro Oncol , vol.10 , Issue.3 , pp. 300-308
    • Kesari, S.1    Schiff, D.2    Henson, J.W.3
  • 157
    • 45349093651 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: Phase 1 trial in adults with malignant glioma
    • Reardon DA, Desjardins A, Vredenburgh JJ, et al. Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: phase 1 trial in adults with malignant glioma. Neuro Oncol. 2008;10(3):330-40.
    • (2008) Neuro Oncol , vol.10 , Issue.3 , pp. 330-340
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 158
    • 44849144705 scopus 로고    scopus 로고
    • Phase II trial of irinotecan and thalidomide in adults with recurrent glioblastoma multiforme
    • Puduvalli VK, Giglio P, Groves MD, et al. Phase II trial of irinotecan and thalidomide in adults with recurrent glioblastoma multiforme. Neuro Oncol. 2008;10(2):216-22.
    • (2008) Neuro Oncol , vol.10 , Issue.2 , pp. 216-222
    • Puduvalli, V.K.1    Giglio, P.2    Groves, M.D.3
  • 165
    • 33644830094 scopus 로고    scopus 로고
    • Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme
    • Reardon DA, Egorin MJ, Quinn JA, et al. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol. 2005;23(36):9359-68.
    • (2005) J Clin Oncol , vol.23 , Issue.36 , pp. 9359-9368
    • Reardon, D.A.1    Egorin, M.J.2    Quinn, J.A.3
  • 168
    • 3543132551 scopus 로고    scopus 로고
    • Thalidomide prolongs disease stabilization after conventional therapy in patients with recurrent glioblastoma
    • Morabito A, Fanelli M, Carillio G, et al. Thalidomide prolongs disease stabilization after conventional therapy in patients with recurrent glioblastoma. Oncol Rep. 2004;11(1):93-5.
    • (2004) Oncol Rep , vol.11 , Issue.1 , pp. 93-95
    • Morabito, A.1    Fanelli, M.2    Carillio, G.3
  • 172
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455:1061-8.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 173
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res. 2002;62(1):200-7. (Pubitemid 34074005)
    • (2002) Cancer Research , vol.62 , Issue.1 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3


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