메뉴 건너뛰기




Volumn 33, Issue 49, 2014, Pages 5626-5636

MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1

Author keywords

DEPTOR; differentiation; MPNST; Neurofibromatosis; resistance; Schwann

Indexed keywords

MAF PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; NEUROFIBROMIN; RAS PROTEIN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTOME;

EID: 84893202143     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.506     Document Type: Article
Times cited : (35)

References (49)
  • 1
    • 0027468594 scopus 로고
    • Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis
    • Legius E, Marchuk DA, Collins FS, Glover TW. Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. Nat Genet 1993; 3: 122-126.
    • (1993) Nat Genet , vol.3 , pp. 122-126
    • Legius, E.1    Marchuk, D.A.2    Collins, F.S.3    Glover, T.W.4
  • 2
    • 65349086151 scopus 로고    scopus 로고
    • Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1
    • Brems H, Beert E, De Ravel T, Legius E. Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1. Lancet Oncol 2009; 10: 508-515.
    • (2009) Lancet Oncol , vol.10 , pp. 508-515
    • Brems, H.1    Beert, E.2    De Ravel, T.3    Legius, E.4
  • 3
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research N. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012; 489: 519-525.
    • (2012) Nature , vol.489 , pp. 519-525
  • 5
    • 77955038485 scopus 로고    scopus 로고
    • NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome
    • Holzel M, Huang S, Koster J, Ora I, Lakeman A, Caron H et al. NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell 2010; 142: 218-229.
    • (2010) Cell , vol.142 , pp. 218-229
    • Holzel, M.1    Huang, S.2    Koster, J.3    Ora, I.4    Lakeman, A.5    Caron, H.6
  • 6
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer cell 2010; 17: 98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 9
    • 0347725620 scopus 로고    scopus 로고
    • Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells
    • Donovan S, See W, Bonifas J, Stokoe D, Shannon KM. Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells. Cancer cell 2002; 2: 507-514.
    • (2002) Cancer Cell , vol.2 , pp. 507-514
    • Donovan, S.1    See, W.2    Bonifas, J.3    Stokoe, D.4    Shannon, K.M.5
  • 10
    • 0026521070 scopus 로고
    • Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
    • Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature 1992; 356: 713-715.
    • (1992) Nature , vol.356 , pp. 713-715
    • Basu, T.N.1    Gutmann, D.H.2    Fletcher, J.A.3    Glover, T.W.4    Collins, F.S.5    Downward, J.6
  • 11
    • 0026528368 scopus 로고
    • Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
    • DeClue JE, Papageorge AG, Fletcher JA, Diehl SR, Ratner N, Vass WC et al. Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell 1992; 69: 265-273.
    • (1992) Cell , vol.69 , pp. 265-273
    • Declue, J.E.1    Papageorge, A.G.2    Fletcher, J.A.3    Diehl, S.R.4    Ratner, N.5    Vass, W.C.6
  • 14
    • 49849084685 scopus 로고    scopus 로고
    • Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors
    • Johansson G, Mahller YY, Collins MH, Kim MO, Nobukuni T, Perentesis J et al. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Mol Cancer Ther 2008; 7: 1237-1245.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1237-1245
    • Johansson, G.1    Mahller, Y.Y.2    Collins, M.H.3    Kim, M.O.4    Nobukuni, T.5    Perentesis, J.6
  • 15
    • 80052557069 scopus 로고    scopus 로고
    • Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors
    • De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer cell 2011; 20: 400-413.
    • (2011) Cancer Cell , vol.20 , pp. 400-413
    • De Raedt, T.1    Walton, Z.2    Yecies, J.L.3    Li, D.4    Chen, Y.5    Malone, C.F.6
  • 16
    • 74949090309 scopus 로고    scopus 로고
    • The therapeutic promise of the cancer stem cell concept
    • Frank NY, Schatton T, Frank MH. The therapeutic promise of the cancer stem cell concept. J Clin Invest 2010; 120: 41-50.
    • (2010) J Clin Invest , vol.120 , pp. 41-50
    • Frank, N.Y.1    Schatton, T.2    Frank, M.H.3
  • 17
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003; 3: 895-902.
    • (2003) Nat Rev Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 18
    • 84857028067 scopus 로고    scopus 로고
    • Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions
    • Buchstaller J, McKeever PE, Morrison SJ. Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer cell 2012; 21: 240-252.
    • (2012) Cancer Cell , vol.21 , pp. 240-252
    • Buchstaller, J.1    McKeever, P.E.2    Morrison, S.J.3
  • 19
    • 56749175521 scopus 로고    scopus 로고
    • Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential
    • Williams JP, Wu J, Johansson G, Rizvi TA, Miller SC, Geiger H et al. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell 2008; 3: 658-669.
    • (2008) Cell Stem Cell , vol.3 , pp. 658-669
    • Williams, J.P.1    Wu, J.2    Johansson, G.3    Rizvi, T.A.4    Miller, S.C.5    Geiger, H.6
  • 20
    • 84863593847 scopus 로고    scopus 로고
    • PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors
    • Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ et al. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer Res 2012; 72: 3405-3413.
    • (2012) Cancer Res , vol.72 , pp. 3405-3413
    • Keng, V.W.1    Rahrmann, E.P.2    Watson, A.L.3    Tschida, B.R.4    Moertel, C.L.5    Jessen, W.J.6
  • 21
    • 84891940023 scopus 로고    scopus 로고
    • EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors
    • Wu J, Patmore DM, Jousma E, Eaves DW, Breving K, Patel AV et al. EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene 2013; 33: 173-180.
    • (2013) Oncogene , vol.33 , pp. 173-180
    • Wu, J.1    Patmore, D.M.2    Jousma, E.3    Eaves, D.W.4    Breving, K.5    Patel, A.V.6
  • 22
    • 78649284957 scopus 로고    scopus 로고
    • Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development
    • Pytel P, Karrison T, Can G, Tonsgard JH, Krausz T, Montag AG. Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development. Int J Surg Pathol 2010; 18: 449-457.
    • (2010) Int J Surg Pathol , vol.18 , pp. 449-457
    • Pytel, P.1    Karrison, T.2    Can, G.3    Tonsgard, J.H.4    Krausz, T.5    Montag, A.G.6
  • 24
    • 75449103584 scopus 로고    scopus 로고
    • Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene
    • Miller SJ, Jessen WJ, Mehta T, Hardiman A, Sites E, Kaiser S et al. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO molecular medicine 2009; 1: 236-248.
    • (2009) EMBO Molecular Medicine , vol.1 , pp. 236-248
    • Miller, S.J.1    Jessen, W.J.2    Mehta, T.3    Hardiman, A.4    Sites, E.5    Kaiser, S.6
  • 25
    • 0346121540 scopus 로고    scopus 로고
    • Neural crest development is regulated by the transcription factor Sox9
    • Cheung M, Briscoe J. Neural crest development is regulated by the transcription factor Sox9. Development 2003; 130: 5681-5693.
    • (2003) Development , vol.130 , pp. 5681-5693
    • Cheung, M.1    Briscoe, J.2
  • 27
    • 84858333682 scopus 로고    scopus 로고
    • The transcription factor c-Maf controls touch receptor development and function
    • Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A et al. The transcription factor c-Maf controls touch receptor development and function. Science 2012; 335: 1373-1376.
    • (2012) Science , vol.335 , pp. 1373-1376
    • Wende, H.1    Lechner, S.G.2    Cheret, C.3    Bourane, S.4    Kolanczyk, M.E.5    Pattyn, A.6
  • 28
    • 0028154038 scopus 로고
    • Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun
    • Kerppola TK, Curran T. Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. Oncogene 1994; 9: 675-684.
    • (1994) Oncogene , vol.9 , pp. 675-684
    • Kerppola, T.K.1    Curran, T.2
  • 29
    • 0037184963 scopus 로고    scopus 로고
    • A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene
    • Huang W, Lu N, Eberspaecher H, De Crombrugghe B. A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene. J Biol Chem 2002; 277: 50668-50675.
    • (2002) J Biol Chem , vol.277 , pp. 50668-50675
    • Huang, W.1    Lu, N.2    Eberspaecher, H.3    De Crombrugghe, B.4
  • 31
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009; 137: 873-886.
    • (2009) Cell , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3    Sancak, Y.4    Kang, S.A.5    Kuehl, W.M.6
  • 32
    • 84861697039 scopus 로고    scopus 로고
    • An evolving role for DEPTOR in tumor development and progression
    • Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH et al. An evolving role for DEPTOR in tumor development and progression. Neoplasia 2012; 14: 368-375.
    • (2012) Neoplasia , vol.14 , pp. 368-375
    • Wang, Z.1    Zhong, J.2    Inuzuka, H.3    Gao, D.4    Shaik, S.5    Sarkar, F.H.6
  • 33
    • 75149150217 scopus 로고    scopus 로고
    • Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
    • Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM et al. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene 2010; 29: 368-379.
    • (2010) Oncogene , vol.29 , pp. 368-379
    • Miller, S.J.1    Lan, Z.D.2    Hardiman, A.3    Wu, J.4    Kordich, J.J.5    Patmore, D.M.6
  • 34
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995; 270: 16483-16486.
    • (1995) J Biol Chem , vol.270 , pp. 16483-16486
    • Karin, M.1
  • 35
    • 78449304547 scopus 로고    scopus 로고
    • The role of neurofibromin in N-Ras mediated AP-1 regulation in malignant peripheral nerve sheath tumors
    • Kraniak JM, Sun D, Mattingly RR, Reiners Jr JJ, Tainsky MA. The role of neurofibromin in N-Ras mediated AP-1 regulation in malignant peripheral nerve sheath tumors. Mol Cell Biochem 2010; 344: 267-276.
    • (2010) Mol Cell Biochem , vol.344 , pp. 267-276
    • Kraniak, J.M.1    Sun, D.2    Mattingly, R.R.3    Reiners, J.J.4    Tainsky, M.A.5
  • 36
    • 0030802419 scopus 로고    scopus 로고
    • A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis
    • Olive M, Krylov D, Echlin DR, Gardner K, Taparowsky E, Vinson C. A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis. J Biol Chem 1997; 272: 18586-18594.
    • (1997) J Biol Chem , vol.272 , pp. 18586-18594
    • Olive, M.1    Krylov, D.2    Echlin, D.R.3    Gardner, K.4    Taparowsky, E.5    Vinson, C.6
  • 37
    • 0035823540 scopus 로고    scopus 로고
    • Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds
    • Kataoka K, Handa H, Nishizawa M. Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds. J Biol Chem 2001; 276: 34074-34081.
    • (2001) J Biol Chem , vol.276 , pp. 34074-34081
    • Kataoka, K.1    Handa, H.2    Nishizawa, M.3
  • 38
    • 0030604714 scopus 로고    scopus 로고
    • The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
    • Ho IC, Hodge MR, Rooney JW, Glimcher LH. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 1996; 85: 973-983.
    • (1996) Cell , vol.85 , pp. 973-983
    • Ho, I.C.1    Hodge, M.R.2    Rooney, J.W.3    Glimcher, L.H.4
  • 39
    • 79958026380 scopus 로고    scopus 로고
    • The Ras-ERK and PI3K-mTOR pathways: Cross-talk and compensation
    • Mendoza MC, Er EE, Blenis J. The Ras-ERK and PI3K-mTOR pathways: Cross-talk and compensation. Trends Biochem Sci 2011; 36: 320-328.
    • (2011) Trends Biochem Sci , vol.36 , pp. 320-328
    • Mendoza, M.C.1    Er, E.E.2    Blenis, J.3
  • 40
    • 79952123613 scopus 로고    scopus 로고
    • A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression
    • Annunziata CM, Hernandez L, Davis RE, Zingone A, Lamy L, Lam LT et al. A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression. Blood 2011; 117: 2396-2404.
    • (2011) Blood , vol.117 , pp. 2396-2404
    • Annunziata, C.M.1    Hernandez, L.2    Davis, R.E.3    Zingone, A.4    Lamy, L.5    Lam, L.T.6
  • 41
    • 84879300153 scopus 로고    scopus 로고
    • RAS/MEK-Independent Gene Expression Reveals BMP2-Related Malignant Phenotypes in the Nf1-Deficient MPNST
    • Sun D, Haddad R, Kraniak JM, Horne SD, Tainsky MA. RAS/MEK-Independent Gene Expression Reveals BMP2-Related Malignant Phenotypes in the Nf1-Deficient MPNST. Mol Cancer Res 2013; 11: 616-627.
    • (2013) Mol Cancer Res , vol.11 , pp. 616-627
    • Sun, D.1    Haddad, R.2    Kraniak, J.M.3    Horne, S.D.4    Tainsky, M.A.5
  • 42
    • 2442707675 scopus 로고    scopus 로고
    • Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer
    • Watson JE, Doggett NA, Albertson DG, Andaya A, Chinnaiyan A, Van Dekken H et al. Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer. Oncogene 2004; 23: 3487-3494.
    • (2004) Oncogene , vol.23 , pp. 3487-3494
    • Watson, J.E.1    Doggett, N.A.2    Albertson, D.G.3    Andaya, A.4    Chinnaiyan, A.5    Van Dekken, H.6
  • 43
    • 84872546604 scopus 로고    scopus 로고
    • Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors
    • Endo M, Yamamoto H, Setsu N, Kohashi K, Takahashi Y, Ishii T et al. Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors. Clin Cancer Res 2013; 19: 450-461.
    • (2013) Clin Cancer Res , vol.19 , pp. 450-461
    • Endo, M.1    Yamamoto, H.2    Setsu, N.3    Kohashi, K.4    Takahashi, Y.5    Ishii, T.6
  • 44
    • 0033799930 scopus 로고    scopus 로고
    • Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma
    • Lau N, Feldkamp MM, Roncari L, Loehr AH, Shannon P, Gutmann DH et al. Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. J Neuropathol Exp Neurol 2000; 59: 759-767.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 759-767
    • Lau, N.1    Feldkamp, M.M.2    Roncari, L.3    Loehr, A.H.4    Shannon, P.5    Gutmann, D.H.6
  • 45
    • 66849131261 scopus 로고    scopus 로고
    • Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor
    • Zou CY, Smith KD, Zhu QS, Liu J, McCutcheon IE, Slopis JM et al. Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther 2009; 8: 1157-1168.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1157-1168
    • Zou, C.Y.1    Smith, K.D.2    Zhu, Q.S.3    Liu, J.4    McCutcheon, I.E.5    Slopis, J.M.6
  • 46
    • 81855167585 scopus 로고    scopus 로고
    • DEPTOR an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy
    • Zhao Y, Xiong X, Sun Y. DEPTOR an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell 2011; 44: 304-316.
    • (2011) Mol Cell , vol.44 , pp. 304-316
    • Zhao, Y.1    Xiong, X.2    Sun, Y.3
  • 47
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008; 118: 3065-3074.
    • (2008) J Clin Invest , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3    Rojo, F.4    Salmena, L.5    Alimonti, A.6
  • 48
    • 33644974752 scopus 로고    scopus 로고
    • Nfl gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways
    • Yin B, Morgan K, Hasz DE, Mao Z, Largaespada DA. Nfl gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways. Leukemia 2006; 20: 151-154.
    • (2006) Leukemia , vol.20 , pp. 151-154
    • Yin, B.1    Morgan, K.2    De, H.3    Mao, Z.4    Largaespada, D.A.5
  • 49
    • 84863643200 scopus 로고    scopus 로고
    • A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1
    • Stowe IB, Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernandez H et al. A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev 2012; 26: 1421-1426.
    • (2012) Genes Dev , vol.26 , pp. 1421-1426
    • Stowe, I.B.1    Mercado, E.L.2    Stowe, T.R.3    Bell, E.L.4    Oses-Prieto, J.A.5    Hernandez, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.