Neoplasms with Schwannian differentiation express transcription factors known to regulate normal Schwann cell development

International Journal of Surgical Pathology

Volumn 18, Issue 6, 2010, Pages 449-457

  Pytel, Peter ^a   Karrison, Theodore ^a   Can Gong, ^a   Tonsgard, James H ^a   Krausz, Thomas ^a   Montag, Anthony G ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

FoxD3; MPNST; neurofibroma; schwannoma; Sox10; Sox9; transcription factor

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2ALPHA; TRANSCRIPTION FACTOR FOXD3; TRANSCRIPTION FACTOR PAX7; TRANSCRIPTION FACTOR SOX10; TRANSCRIPTION FACTOR SOX5; TRANSCRIPTION FACTOR SOX9; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; NERVE CELL DIFFERENTIATION; NEURILEMOMA; NEUROFIBROMA; PERIPHERAL NERVE TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHWANN CELL; SPINDLE CELL; SPINDLE CELL CARCINOMA; SPINDLE CELL MELANOMA; SYNOVIAL SARCOMA; TISSUE MICROARRAY; TUMOR DIFFERENTIATION; UPREGULATION;

CELL DIFFERENTIATION; HUMANS; IMMUNOHISTOCHEMISTRY; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; SCHWANN CELLS; TISSUE ARRAY ANALYSIS; TRANSCRIPTION FACTORS;

EID: 78649284957     PISSN: 10668969     EISSN: 19402465     Source Type: Journal    
DOI: 10.1177/1066896909351698     Document Type: Article

References (61)

1. Jessen KR, Mirsky R. The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci. 2005 ; 6: 671-682.
2. Morales AV, Barbas JA, Nieto MA How to become neural crest: from segregation to delamination. Semin Cell Dev Biol. 2005 ; 16: 655-662.
3. Heeg-Truesdell E., LaBonne C. A slug, a fox, a pair of sox: transcriptional responses to neural crest inducing signals. Birth Defects Res C Embryo Today. 2004 ; 72: 124-139.
4. Sakai D., Wakamatsu Y. Regulatory mechanisms for neural crest formation. Cells Tissues Organs. 2005 ; 179 (1-2). 24-35.
5. Ferner RE, O'Doherty MJ Neurofibroma and schwannoma. Curr Opin Neurol. 2002 ; 15: 679-684.
6. Weiss SW, Goldblum JR Soft Tissue Tumours. 5th ed. St Louis, MO: C V Mosby ; 2008.
7. Pytel P., Taxy JB, Krausz T. Divergent differentiation in malignant soft tissue neoplasms: the paradigm of liposarcoma and malignant peripheral nerve sheath tumor. Int J Surg Pathol. 2005 ; 13: 19-28.
8. Lee MJ, Stephenson DA Recent developments in neurofibromatosis type 1. Curr Opin Neurol. 2007 ; 20: 135-141.
9. McClatchey AI Merlin and ERM proteins: unappreciated roles in cancer development ? Nat Rev Cancer. 2003 ; 3: 877-883.
10. Xiao GH, Chernoff J., Testa JR NF2: the wizardry of merlin. Genes Chromosomes Cancer. 2003 ; 38: 389-399.
11. Yohay K. Neurofibromatosis types 1 and 2. Neurologist. 2006 ; 12: 86-93.
12. Morotti RA, Nicol KK, Parham DM, et al. An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience. Am J Surg Pathol. 2006 ; 30: 962-968.
13. Goding CR Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage. Genes Dev. 2000 ; 14: 1712-1728.
14. Marino S. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med. 2005 ; 11: 17-22.
15. Gershon TR, Oppenheimer O., Chin SS, Gerald WL Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation. Neoplasia. 2005 ; 7: 575-584.
16. Harder A., Mautner VF, Friedrich RE, Harder T., Plagemann A., von Deimling A. Transcription factor AP-2 is expressed in human Schwann cell-derived tumours. Histopathology. 2006 ; 49: 441-443.
17. MacCollin M., Chiocca EA, Evans DG, et al. Diagnostic criteria for schwannomatosis. Neurology. 2005 ; 64: 1838-1845.
18. Hulsebos TJ, Plomp AS, Wolterman RA, Robanus-Maandag EC, Baas F., Wesseling P. Germline mutation of INI1/SMARCB1 in familial schwannomatosis. Am J Hum Genet. 2007 ; 80: 805-810.
19. Thompson J., Lovicu F., Ziman M. The role of Pax7 in determining the cytoarchitecture of the superior colliculus. Dev Growth Differ. 2004 ; 46: 213-218.
20. Buckingham M., Relaix F. The role of pax genes in the development of tissues and organs: pax3 and pax7 regulate muscle progenitor cell functions. Annu Rev Cell Dev Biol. 2007 ; 23: 645-673.
21. Gallego Melcon S., Sanchez de Toledo Codina J. Molecular biology of rhabdomyosarcoma. Clin Transl Oncol. 2007 ; 9: 415-419.
22. Basch ML, Bronner-Fraser M., Garcia-Castro MI Specification of the neural crest occurs during gastrulation and requires Pax7. Nature. 2006 ; 441: 218-222.
23. Lacosta AM, Canudas J., Gonzalez C., Muniesa P., Sarasa M., Dominguez L. Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during zebrafish development. Int J Dev Biol. 2007 ; 51: 327-331.
24. Smits P., Li P., Mandel J., et al. The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 ; 1: 277-290.
25. Smits P., Lefebvre V. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development. 2003 ; 130: 1135-1148.
26. Perez-Alcala S., Nieto MA, Barbas JA LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest. Development. 2004 ; 131: 4455-4465.
27. Hong CS, Saint-Jeannet JP Sox proteins and neural crest development. Semin Cell Dev Biol. 2005 ; 16: 694-703.
28. Sauka-Spengler T., Bronner-Fraser M. Development and evolution of the migratory neural crest: a gene regulatory perspective. Curr Opin Genet Dev. 2006 ; 16: 360-366. (Pubitemid 43994443)
29. Kobayashi A., Chang H., Chaboissier MC, Schedl A., Behringer RR Sox9 in testis determination. Ann N Y Acad Sci. 2005 ; 1061: 9-17.
30. Seymour PA, Freude KK, Tran MN, et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007 ; 104: 1865-1870.
31. Mori-Akiyama Y., van den Born M., van Es JH, et al. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology. 2007 ; 133: 539-546.
32. Barrionuevo F., Taketo MM, Scherer G., Kispert A. Sox9 is required for notochord maintenance in mice. Dev Biol. 2006 ; 295: 128-140.
33. Sakai D., Suzuki T., Osumi N., Wakamatsu Y. Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development. Development. 2006 ; 133: 1323-1333.
34. Britsch S., Goerich DE, Riethmacher D., et al. The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 2001 ; 15: 66-78.
35. Aoki Y., Saint-Germain N., Gyda M., et al. Sox10 regulates the development of neural crest-derived melanocytes in Xenopus. Dev Biol. 2003 ; 259: 19-33.
36. Kordes U., Hagel C. Expression of SOX9 and SOX10 in central neuroepithelial tumor. J Neurooncol. 2006 ; 80: 151-155.
37. Zhao C., Bratthauer GL, Barner R., Vang R. Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis. Int J Gynecol Pathol. 2007 ; 26: 1-9.
38. Wehrli BM, Huang W., De Crombrugghe B., Ayala AG, Czerniak B. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol. 2003 ; 34: 263-269.
39. Nonaka D., Chiriboga L., Rubin BP Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008 ; 32: 1291-1298.
40. Miller SJ, Rangwala F., Williams J., et al. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res. 2006 ; 66: 2584-2591.
41. Levy P., Vidaud D., Leroy K., et al. Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR. Mol Cancer. 2004 ; 3: 20.
42. Tompers DM, Foreman RK, Wang Q., Kumanova M., Labosky PA Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo. Dev Biol. 2005 ; 285: 126-137.
43. Yaklichkin S., Steiner AB, Lu Q., Kessler DS FoxD3 and Grg4 physically interact to repress transcription and induce mesoderm in Xenopus. J Biol Chem. 2007 ; 282: 2548-2557.
44. Kos R., Reedy MV, Johnson RL, Erickson CA The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. Development. 2001 ; 128: 1467-1479.
45. Lister JA, Cooper C., Nguyen K., Modrell M., Grant K., Raible DW Zebrafish Foxd3 is required for development of a subset of neural crest derivatives. Dev Biol. 2006 ; 290: 92-104.
46. Pohl BS, Knochel W. Overexpression of the transcriptional repressor FoxD3 prevents neural crest formation in Xenopus embryos. Mech Dev. 2001 ; 103 (1-2). 93-106.
47. Katoh M., Katoh M. Human FOX gene family (review). Int J Oncol. 2004 ; 25: 1495-1500.
48. Luo T., Zhang Y., Khadka D., Rangarajan J., Cho KW, Sargent TD Regulatory targets for transcription factor AP2 in Xenopus embryos. Dev Growth Differ. 2005 ; 47: 403-413.
49. Luo T., Lee YH, Saint-Jeannet JP, Sargent TD Induction of neural crest in Xenopus by transcription factor AP2alpha. Proc Natl Acad Sci U S A. 2003 ; 100: 532-537.
50. O'Brien EK, d'Alencon C., Bonde G., et al. Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Dev Biol. 2004 ; 265: 246-261.
51. Orso F., Fassetta M., Penna E., et al. The AP-2alpha transcription factor regulates tumor cell migration and apoptosis. Adv Exp Med Biol. 2007 ; 604: 87-95.
52. Stabach PR, Thiyagarajan MM, Woodfield GW, Weigel RJ AP2alpha alters the transcriptional activity and stability of p53. Oncogene. 2006 ; 25: 2148-2159.
53. Pellikainen J., Kataja V., Ropponen K., et al. Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer. Clin Cancer Res. 2002 ; 8: 3487-3495.
54. Tellez C., McCarty M., Ruiz M., Bar-Eli M. Loss of activator protein-2alpha results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma. J Biol Chem. 2003 ; 278: 46632-46642.
55. Heimberger AB, McGary EC, Suki D., et al. Loss of the AP-2alpha transcription factor is associated with the grade of human gliomas. Clin Cancer Res. 2005 ; 11: 267-272.
56. Stewart RA, Arduini BL, Berghmans S., et al. Zebrafish foxd3 is selectively required for neural crest specification, migration and survival. Dev Biol. 2006 ; 292: 174-188.
57. Holtkamp N., Reuss DE, Atallah I., et al. Subclassification of nerve sheath tumors by gene expression profiling. Brain Pathol. 2004 ; 14: 258-264.
58. Birindelli S., Perrone F., Oggionni M., et al. Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors. Lab Invest. 2001 ; 81: 833-844.
59. Watson MA, Perry A., Tihan T., et al. Gene expression profiling reveals unique molecular subtypes of neurofibromatosis type I-associated and sporadic malignant peripheral nerve sheath tumors. Brain Pathol. 2004 ; 14: 297-303.
60. Burger PC, Scheithauer BW Tumors of the Central Nervous System. 4 th ed. Washington, DC: American Registry of Pathology ; 2007.
61. Louis DN, Ohgaki H., Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 ; 114: 97-109.