Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma

Journal of Neuropathology and Experimental Neurology

Volumn 59, Issue 9, 2000, Pages 759-767

  Lau, Nelson ^a   Feldkamp, Matthias M ^a,b   Roncari, Luba ^a   Loehr, Allison H ^c   Shannon, Patrick ^b   Gutmann, David H ^c   Guha, Abhijit ^a,b,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Astrocytoma; Neurofibromin; NF1; Ras; Signal transduction; Tumor suppressor gene

Indexed keywords

CELL ENZYME; ENZYME AKT; GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; NEUROFIBROMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P120; PROTEIN P16; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTROCYTOMA; CANCER SUSCEPTIBILITY; CASE REPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; NEUROFIBROMATOSIS; NEUROPATHOLOGY; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE MATTER;

EID: 0033799930     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/59.9.759     Document Type: Article

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