메뉴 건너뛰기




Volumn 56, Issue 6, 2013, Pages 971-979

Isolation and purification of bromelain from waste peel of pineapple for therapeutic application

Author keywords

Bromelain; Downstream processing; Enzymatic activity; Pineapple peel; Therapeutic applications; Waste

Indexed keywords


EID: 84893175671     PISSN: 15168913     EISSN: 16784324     Source Type: Journal    
DOI: 10.1590/S1516-89132013000600012     Document Type: Article
Times cited : (47)

References (40)
  • 1
    • 0023276067 scopus 로고
    • Enzymatic frostbite eschar debridement by bromelain
    • Ahle NW, Hamlet MP. Enzymatic frostbite eschar debridement by bromelain. Ann Emerg Med. 1987; 16: 1063-1065.
    • (1987) Ann Emerg Med. , vol.16 , pp. 1063-1065
    • Ahle, N.W.1    Hamlet, M.P.2
  • 2
    • 35448929407 scopus 로고    scopus 로고
    • Liquidliquid extraction of bromelain and polyphenol oxidase using aqueous two-phase system
    • Babu BR, Rastogi NK, Raghavarao KSMS. Liquidliquid extraction of bromelain and polyphenol oxidase using aqueous two-phase system. Chem Eng Process. 2008; 47: 83-89.
    • (2008) Chem Eng Process. , vol.47 , pp. 83-89
    • Babu, B.R.1    Rastogi, N.K.2    Raghavarao, K.S.M.S.3
  • 5
    • 67649968417 scopus 로고    scopus 로고
    • Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumorinitiation triggering mitochondrial death pathway
    • Bhui K, Prasad S, George J, Shukla Y. Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumorinitiation triggering mitochondrial death pathway. Cancer Lett. 2009; 282: 167-176.
    • (2009) Cancer Lett. , vol.282 , pp. 167-176
    • Bhui, K.1    Prasad, S.2    George, J.3    Shukla, Y.4
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72: 248-254.
    • (1976) Anal Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 80054980807 scopus 로고    scopus 로고
    • IgG purification by negative chromatography in amine-based ligands: A comparison of L-lysine and poly-L-lysine
    • Bresolin ITL, Fioritti RF, Bueno SMA. IgG purification by negative chromatography in amine-based ligands: A comparison of L-lysine and poly-L-lysine. Proc Biochem. 2011; 46: 2277-2285.
    • (2011) Proc Biochem. , vol.46 , pp. 2277-2285
    • Bresolin, I.T.L.1    Fioritti, R.F.2    Bueno, S.M.A.3
  • 9
    • 77955058243 scopus 로고    scopus 로고
    • A new process of IgG purification by negative chromatography: Adsorption aspects of human serum proteins onto w-aminodecyl-agarose
    • Bresolin ITL, Souza MCM, Bueno SMA. A new process of IgG purification by negative chromatography: Adsorption aspects of human serum proteins onto w-aminodecyl-agarose. J Chromatogr B. 2010; 878: 2087-2093.
    • (2010) J Chromatogr B. , vol.878 , pp. 2087-2093
    • Bresolin, I.T.L.1    Souza, M.C.M.2    Bueno, S.M.A.3
  • 10
    • 84858340203 scopus 로고    scopus 로고
    • Pineapple fruit bromelain affinity to different protein substrates
    • Corzo CA, Waliszewski KN, Welti-Chanes J. Pineapple fruit bromelain affinity to different protein substrates. Food Chem. 2012; 133: 631-635.
    • (2012) Food Chem. , vol.133 , pp. 631-635
    • Corzo, C.A.1    Waliszewski, K.N.2    Welti-Chanes, J.3
  • 12
    • 33749946901 scopus 로고
    • Colorimetric method for determination of sugars and related substances
    • Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F. Colorimetric method for determination of sugars and related substances. Anal Chem. 1956; 28: 350-356.
    • (1956) Anal Chem. , vol.28 , pp. 350-356
    • Dubois, M.1    Gilles, K.A.2    Hamilton, J.K.3    Rebers, P.A.4    Smith, F.5
  • 14
    • 79952858023 scopus 로고    scopus 로고
    • The Effect of pH on Bromelain Partition from Ananas comosus by PEG4000/Phosphate ATPS
    • Ferreira JF, Santana JCC, Tambourgi EB. The Effect of pH on Bromelain Partition from Ananas comosus by PEG4000/Phosphate ATPS. Braz Arch Biol Technol. 2011; 54: 125-132.
    • (2011) Braz Arch Biol Technol. , vol.54 , pp. 125-132
    • Ferreira, J.F.1    Santana, J.C.C.2    Tambourgi, E.B.3
  • 15
    • 77956240883 scopus 로고    scopus 로고
    • Comparative study of extraction, purification and estimation of bromelain from stem and fruit of pineapple plant
    • Gautam SS, Mishra SK, Dash V, Goya AK, Rath G. Comparative study of extraction, purification and estimation of bromelain from stem and fruit of pineapple plant. Thai J Pharm Sci. 2010; 34: 67-76.
    • (2010) Thai J Pharm Sci. , vol.34 , pp. 67-76
    • Gautam, S.S.1    Mishra, S.K.2    Dash, V.3    Goya, A.K.4    Rath, G.5
  • 16
    • 13844289324 scopus 로고    scopus 로고
    • Proteinase activity and stability of natural bromelain preparations
    • Hale LP, Greer PK, Trinh CT, James CL. Proteinase activity and stability of natural bromelain preparations. Int Immunopharmacol 2005; 5: 783-793.
    • (2005) Int Immunopharmacol , vol.5 , pp. 783-793
    • Hale, L.P.1    Greer, P.K.2    Trinh, C.T.3    James, C.L.4
  • 18
    • 0029637138 scopus 로고
    • Multipoint binding and heterogeneity in immobilized metal affinity chromatography
    • Johnson RD, Arnold FH. Multipoint binding and heterogeneity in immobilized metal affinity chromatography. Biotechnol Bioeng. 1995; 48: 437-443.
    • (1995) Biotechnol Bioeng. , vol.48 , pp. 437-443
    • Johnson, R.D.1    Arnold, F.H.2
  • 19
    • 0000979197 scopus 로고    scopus 로고
    • Bromelain: A literature review and discussion of its therapeutic applications
    • Kelly GS. Bromelain: A literature review and discussion of its therapeutic applications. Altern Med Rev. 1996; 1: 243-257.
    • (1996) Altern Med Rev. , vol.1 , pp. 243-257
    • Kelly, G.S.1
  • 20
    • 77957933142 scopus 로고    scopus 로고
    • Two phase partitioning and collagen hydrolysis of bromelain from pineapple peel Nang Lae cultivar
    • Ketnawa S, Rawdkuen S, Chaiwut P. Two phase partitioning and collagen hydrolysis of bromelain from pineapple peel Nang Lae cultivar. Biochem Eng J. 2010; 47: 205-211.
    • (2010) Biochem Eng J. , vol.47 , pp. 205-211
    • Ketnawa, S.1    Rawdkuen, S.2    Chaiwut, P.3
  • 21
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during assembly of head of bacteriophage-T4
    • Laemmli UK. Cleavage of structural proteins during assembly of head of bacteriophage-T4. Nature. 1970; 227: 680-685.
    • (1970) Nature. , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 22
    • 0034843751 scopus 로고    scopus 로고
    • Bromelain: biochemistry, pharmacology and medical use
    • Maurer, HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001; 58: 1234-1245.
    • (2001) Cell Mol Life Sci. , vol.58 , pp. 1234-1245
    • Maurer, H.R.1
  • 23
    • 0019800463 scopus 로고
    • Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity
    • Morrissey JH. Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity. Anal Biochem. 1981; 117: 307-310.
    • (1981) Anal Biochem. , vol.117 , pp. 307-310
    • Morrissey, J.H.1
  • 24
    • 0017219079 scopus 로고
    • Bromelain enzymes
    • Murachi T. Bromelain enzymes. Methods Enzymol. 1976; 45: 475-485.
    • (1976) Methods Enzymol. , vol.45 , pp. 475-485
    • Murachi, T.1
  • 25
    • 0036547751 scopus 로고    scopus 로고
    • Cloning of cold-active alkaline phosphatase gene of a psychrophile, Shewanella sp., and expression of the recombinant enzyme
    • Murakawa T, Yamagata H, Tsuruta H, Aizono Y. Cloning of cold-active alkaline phosphatase gene of a psychrophile, Shewanella sp., and expression of the recombinant enzyme. Biosci Biotechnol Biochem. 2002; 66: 754-761.
    • (2002) Biosci Biotechnol Biochem. , vol.66 , pp. 754-761
    • Murakawa, T.1    Yamagata, H.2    Tsuruta, H.3    Aizono, Y.4
  • 26
    • 0028109020 scopus 로고
    • Purification and characterization of multiple forms of the pineapplestem-derived cysteine proteinases ananain and comosain
    • Napper AD, Bennett SP, Borowski M, Holdridge MB, Leonard MJ, Rogers EE et al. Purification and characterization of multiple forms of the pineapplestem-derived cysteine proteinases ananain and comosain. Biochem J. 1994; 301: 727-735.
    • (1994) Biochem J. , vol.301 , pp. 727-735
    • Napper, A.D.1    Bennett, S.P.2    Borowski, M.3    Holdridge, M.B.4    Leonard, M.J.5    Rogers, E.E.6
  • 27
    • 0015342868 scopus 로고
    • Fractionation and some properties of the proteolytically active components of bromelains in the stem and the fruit of the pineapple plant
    • Ota S, Horie K, Hagino F, Hashimoto C, Date H. Fractionation and some properties of the proteolytically active components of bromelains in the stem and the fruit of the pineapple plant. J Biochem. 1972; 71: 817-830.
    • (1972) J Biochem. , vol.71 , pp. 817-830
    • Ota, S.1    Horie, K.2    Hagino, F.3    Hashimoto, C.4    Date, H.5
  • 28
    • 2642511370 scopus 로고    scopus 로고
    • Bromelain partitioning in two-phase aqueous systems containing PEO-PPO-PEO block copolymers
    • Rabelo APB, Tambourgi EB, Pessoa Jr A, Bromelain partitioning in two-phase aqueous systems containing PEO-PPO-PEO block copolymers. J Chromatogr B. 2004; 807: 61-68.
    • (2004) J Chromatogr B. , vol.807 , pp. 61-68
    • Rabelo, A.P.B.1    Tambourgi, E.B.2    Pessoa Jr., A.3
  • 32
    • 79952349490 scopus 로고    scopus 로고
    • Design of automatic control system for the precipitation of bromelain from the extract of pineapple wastes
    • Silva FV, Santos RLA, Fujiki TL, Leite MS, Fileti AMF. Design of automatic control system for the precipitation of bromelain from the extract of pineapple wastes. Cienc Tecnol Aliment. 2010; 30: 1033-1040.
    • (2010) Cienc Tecnol Aliment. , vol.30 , pp. 1033-1040
    • Silva, F.V.1    Santos, R.L.A.2    Fujiki, T.L.3    Leite, M.S.4    Fileti, A.M.F.5
  • 34
    • 0016638261 scopus 로고
    • Characterization of the pineapple stem proteases (bromelain)
    • Silverstein RM, Kezdy FJ. Characterization of the pineapple stem proteases (bromelain). Arch Biochem Biophys. 1975; 167: 678-686.
    • (1975) Arch Biochem Biophys. , vol.167 , pp. 678-686
    • Silverstein, R.M.1    Kezdy, F.J.2
  • 35
    • 1542378234 scopus 로고    scopus 로고
    • Purification and Characterization of a Pineapple Crown Leaf Thiol Protease
    • Singh LR, Devi TP, Devi SK. Purification and Characterization of a Pineapple Crown Leaf Thiol Protease. Prep Biochem Biotech. 2004; 34: 25-43.
    • (2004) Prep Biochem Biotech. , vol.34 , pp. 25-43
    • Singh, L.R.1    Devi, T.P.2    Devi, S.K.3
  • 37
    • 79952382862 scopus 로고    scopus 로고
    • Affinity adsorption of bromelain on Reactive Red 120 immobilized magnetic composite particles
    • Song MM, Nie HL, Zhou YT, Zhu LM, Bao JY, Affinity adsorption of bromelain on Reactive Red 120 immobilized magnetic composite particles. Separ Sci Technol. 2011; 46: 473-482.
    • (2011) Separ Sci Technol. , vol.46 , pp. 473-482
    • Song, M.M.1    Nie, H.L.2    Zhou, Y.T.3    Zhu, L.M.4    Bao, J.Y.5
  • 38
    • 0015911270 scopus 로고
    • Multiple molecular forms of stem bromelain. Isolation and characterization of two closely related components, SB1 and SB2
    • Takahashi N, Yasuda Y, Goto K, Miyake T, Murachi T. Multiple molecular forms of stem bromelain. Isolation and characterization of two closely related components, SB1 and SB2. J Biochem. 1973; 74: 355-373.
    • (1973) J Biochem. , vol.74 , pp. 355-373
    • Takahashi, N.1    Yasuda, Y.2    Goto, K.3    Miyake, T.4    Murachi, T.5
  • 39
    • 0024620848 scopus 로고
    • Pseudobiospecific ligand affinity chromatography
    • Vijayalakshmi MA. Pseudobiospecific ligand affinity chromatography. Trends Biotechnol. 1989; 7: 71-76.
    • (1989) Trends Biotechnol. , vol.7 , pp. 71-76
    • Vijayalakshmi, M.A.1
  • 40
    • 0016320911 scopus 로고
    • The structure and mechanism of stem bromelain: Evaluation of the homogeneity of purified stem bromelain, determination of the molecular weight and kinetic analysis of the bromelaincatalysed hydrolysis of N-benzyloxy-carbonyl-Lphenylalanyl-L-serine methyl ester
    • Wharton CW. The structure and mechanism of stem bromelain: Evaluation of the homogeneity of purified stem bromelain, determination of the molecular weight and kinetic analysis of the bromelaincatalysed hydrolysis of N-benzyloxy-carbonyl-Lphenylalanyl-L-serine methyl ester. Biochem J. 1974; 143: 575-586.
    • (1974) Biochem J. , vol.143 , pp. 575-586
    • Wharton, C.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.