Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro

International Immunopharmacology

Volumn 9, Issue 3, 2009, Pages 340-346

  Secor Jr , Eric R ^a   Singh, Anurag ^a   Guernsey, Linda A ^a   McNamara, Jeff T ^a   Zhan, Lijun ^a   Maulik, Nilanjana ^a   Thrall, Roger S ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Bromelain; CD25; CD4+ T cells; Cysteine protease; Natural product

Indexed keywords

BROMELAIN; CD3 ANTIBODY; INTERLEUKIN 2 RECEPTOR ALPHA; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL SURFACE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; INFLAMMATION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PINEAPPLE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANANAS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BROMELAINS; CD4-POSITIVE T-LYMPHOCYTES; CELL EXTRACTS; CELL SURVIVAL; FEMALE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL;

EID: 60249083774     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.12.012     Document Type: Article

References (39)

1. Akkoc T., de Koning P.J., Ruckert B., Barlan I., Akdis M., and Akdis C.A. Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases. J Allergy Clin Immunol 121 3 (2008) 652-658 [e1]
2. Cope A.P., Schulze-Koops H., and Aringer M. The central role of T cells in rheumatoid arthritis. Clin Exp Rheumatol 25 5 Suppl 46 (2007) S4-S11
3. Steinman R.M., and Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311 (2006) 17-58
4. Corthay A. A three-cell model for activation of naive T helper cells. Scand J Immunol 64 2 (2006) 93-96
5. Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4 9 (2004) 665-674
6. + T cells and regulation of allergen-induced responses. Curr Allergy Asthma Rep 5 1 (2005) 35-41
7. Hoeger P.H., Niggemann B., Ganschow R., Dammann C., and Haeuser G. Serum levels of sCD23 and sCD25 in children with asthma and in healthy controls. Allergy 49 4 (1994) 217-221
8. Brassard P., Larbi A., Grenier A., Frisch F., Fortin C., Carpentier A.C., et al. Modulation of T-cell signalling by non-esterified fatty acids. Prostaglandins Leukot Essent Fatty Acids 77 5-6 (2007) 337-343
9. Biondo P.D., Goruk S., Ruth M.R., O'Connell E., and Field C.J. Effect of CVT-E002 (COLD-fX) versus a ginsenoside extract on systemic and gut-associated immune function. Int Immunopharmacol 8 8 (2008) 1134-1142
10. Varalakshmi C., Ali M., Pardhasaradhi B.V., Srivastava R.M., Singh S., and Khar A. Immunomodulatory effects of curcumin: in-vivo. Int Immunopharmacol 8 5 (2008) 688-700
11. Hale L.P., Fitzhugh D.J., and Staats H.F. Oral immunogenicity of the plant proteinase bromelain. Int Immunopharmacol 6 13-14 (2006) 2038-2046
12. Harrach T., Eckert K., Maurer H.R., Machleidt I., Machleidt W., and Nuck R. Isolation and characterization of two forms of an acidic bromelain stem proteinase. J Protein Chem 17 4 (1998) 351-361
13. Roep B.O., van den Engel N.K., van Halteren A.G., Duinkerken G., and Martin S. Modulation of autoimmunity to beta-cell antigens by proteases. Diabetologia 45 5 (2002) 686-692
14. Kleef R., Delohery T.M., and Bovbjerg D.H. Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5. Pathobiology 64 6 (1996) 339-346
15. Hale L.P., and Haynes B.F. Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation. J Immunol 149 12 (1992) 3809-3816
16. Targoni O.S., Tary-Lehmann M., and Lehmann P.V. Prevention of murine EAE by oral hydrolytic enzyme treatment. J Autoimmun 12 3 (1999) 191-198
17. Secor Jr. E.R., Carson IV W.F., Cloutier M.M., Guernsey L.A., Schramm C.M., Wu C.A., et al. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol 237 1 (2005) 68-75
18. Hale L.P., Greer P.K., Trinh C.T., and Gottfried M.R. Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. Clin Immunol 116 2 (2005) 135-142
19. Secor E.R., Carson IV W.F., Singh A., Pensa M., Guernsey L.A., Schramm C.M., et al. Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma. Evid Based Complement Alternat Med 5 1 (2008) 61-69
20. Mynott T.L., Ladhams A., Scarmato P., and Engwerda C.R. Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells. J Immunol 163 5 (1999) 2568-2575
21. + cells and the interferon-gamma response in Peyer's patches and spleen in endotoxemic balb/c mice. Cell Immunol 215 2 (2002) 113-119
22. Murachi T., and Neurath H. Fractionation and specificity studies on stem bromelain. J Biol Chem 235 (1960) 99-107
23. Knill-Jones R.P., Pearce H., Batten J., and Williams R. Comparative trial of Nutrizym in chronic pancreatic insufficiency. Br Med J 4 5726 (1970) 21-24
24. Felton G.E. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses 6 11 (1980) 1123-1133
25. Bouwstra J.B., Spoelstra E.C., De Waard P., Leeflang B.R., Kamerling J.P., and Vliegenthart J.F. Conformational studies on the N-linked carbohydrate chain of bromelain. Eur J Biochem 190 1 (1990) 113-122
26. Barnes J. Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part II: Efficacy and safety. Br J Clin Pharmacol 55 4 (2003) 331-340
27. Khan I.A. Issues related to botanicals. Life Sci 78 18 (2006) 2033-2038
28. Fitzhugh D.J., Shan S., Dewhirst M.W., and Hale L.P. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clin Immunol 128 1 (2008) 66-74
29. Engwerda C.R., Andrew D., Ladhams A., and Mynott T.L. Bromelain modulates T cell and B cell immune responses in vitro and in vivo. Cell Immunol 210 1 (2001) 66-75
30. Lehmann P.V. Immunomodulation by proteolytic enzymes. Nephrol Dial Transplant 11 6 (1996) 952-955
31. El Houda Agueznay N., Badoual C., Hans S., Gey A., Vingert B., Peyrard S., et al. Soluble interleukin-2 receptor and metalloproteinase-9 expression in head and neck cancer: prognostic value and analysis of their relationships. Clin Exp Immunol 150 1 (2007) 114-123
32. Murakami S. Soluble interleukin-2 receptor in cancer. Front Biosci 9 (2004) 3085-3090
33. +(high) T cell apoptosis after the diagnosis of type 1 diabetes. Clin Exp Immunol 150 1 (2007) 75-82
34. Hubeau C., Apostolou I., and Kobzik L. Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice. J Immunol 178 3 (2007) 1477-1487
35. Maeta M., Saito H., Katano K., Kondo A., Tsujitani S., Makino M., et al. A progressive postoperative increase in the serum level of soluble receptors for interleukin-2 is an indicator of a poor prognosis in patients with gastric cancer. Int J Mol Med 1 1 (1998) 113-116
36. Kaito K., Otsubo H., Ogasawara Y., Kimura H., Kurihara E., Koike M., et al. Serum soluble interleukin-2 receptor in eosinophilia. Acta Haematol 109 1 (2003) 23-28
37. Schulz O., Sewell H.F., and Shakib F. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. J Exp Med 187 2 (1998) 271-275
38. Lamhamedi-Cherradi S.E., Martin R.E., Ito T., Kheradmand F., Corry D.B., Liu Y.J., et al. Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J Immunol 180 9 (2008) 6000-6009
39. Sokol C.L., Barton G.M., Farr A.G., and Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 21 (2007) 21