Immunological activity of ginseng is enhanced by solid-state culture with ganoderma lucidum mycelium

Journal of Medicinal Food

Volumn 17, Issue 1, 2014, Pages 150-160

  Kim, Hoon ^a   Suh, Hyung Joo ^a   Kang, Choong Min ^b   Lee, Kyung Haeng ^c   Hwang, Jong Hyun ^c   Yu, Kwang Won ^c  

^a Korea University   (South Korea)

^b CALIFORNIA STATE UNIVERSITY   (United States)

^c Chungju National University   (South Korea)

Author keywords

Fermented ginseng; Ganoderma lucidum; Immunomodulating activity; Polysaccharide; Solid state culture

Indexed keywords

2 DIETHYLAMINOETHANOL; ARABINOSE; GALACTOSE; GINSENG EXTRACT; GLUCOSE; MANNOSE; POLYSACCHARIDE; SEPHAROSE; URONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FERMENTED PRODUCT; FRACTIONATION; FREEZE DRYING; FUNGUS CULTURE; GANODERMA LUCIDUM; IMMUNE SYSTEM; IMMUNOMODULATION; MACROPHAGE; METHYLATION; MITOGENESIS; MOLECULAR WEIGHT; MOUSE; MYCELIUM; NONHUMAN; OXIDATION; PEYER PATCH; PRIORITY JOURNAL; SOLID STATE;

ANIMALS; FEMALE; FERMENTATION; IMMUNOLOGIC FACTORS; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED ICR; MOLECULAR WEIGHT; MYCELIUM; PANAX; PLANT EXTRACTS; POLYSACCHARIDES; REISHI;

EID: 84893143750     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2013.3063     Document Type: Article

References (47)

1. Lee HS, Lee HJ, Yu HJ, Ju DW, Kim Y, Kim CT, Kim CJ, Cho YJ, Kim N, Choi SY, Suh HJ: A comparison between high hydrostatic pressure extraction and heat extraction of ginsenosides from ginseng (Panax ginseng CA Meyer). J Sci Food Agric 2011;91:1466-1473.
2. Bae EA, Han, MJ, Choo MK, Park SY, Kim DH: Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 2002;25:58-63.
3. Kim BG, Choi SY, Kim MR, Suh HJ, Park HJ: Changes of ginsenosides in Korean red ginseng (Panax ginseng) fermented by Lactobacillus plantarum M1. Process Biochem 2010;45: 1319-1324.
4. Ryu JS, Lee HJ, Bae SH, Kim SY, Park Y, Suh HJ, Jeong YH: The bioavailability of red ginseng extract fermented by Phellinus linteus. J Ginseng Res 2013;37:108-116.
5. Park CK, Kim H, Tu Q, Yu KW, Jeong HS, Lee HY, Jeong JH: Chemical composition and immunomodulating activity of the fermented Korean ginseng (Panax ginseng C.A. Meyer) with mushroom mycelium by solid culture. J Korean Soc Food Sci Nutr 2009;38:1145-1152.
6. Pandey A, Soccol CR, Mitchell D: New developments in solidstate fermentation: I-bioprocesses and products. Process Biochem 2000;35:1153-1169.
7. Wagner R, Mitchell DA, Sassaki GI, De Almeida Amazonas MAI, Berovi-c M: Current techniques for the cultivation of Ganoderma lucidum for the production of biomass, ganoderic acid and polysaccharides. Food Technol Biotechnol 2003;41:371-382.
8. Zhong JJ, Xiao JH: Secondary metabolites from higher fungi: discovery, bioactivity, and bioproduction. Adv Biochem Eng Biotechnol 2009;113:79-150.
9. Shiao MS, Lee KR, Lin LJ, Wang CT: Natural-products and biological-activities of the Chinese medicinal fungus Ganoderma lucidum. In: Food Phytochemicals for Cancer Prevention II- Teas, Spices, and Herbs. (Ho CT, Osawa T, Huang MT, Rosen RT, eds.) American Chemical Society, Washington, DC, 1994, pp. 342-354.
10. Han JR, An CH, Yuan JM: Solid-state fermentation of cornmeal with the basidiomycetes Ganoderma lucidum for degrading starch and upgrading nutritional value. J Appl Microbiol 2005;99:910-915.
11. Dubois M, Gilles KA, Hamilton JK, Rebers RA, Smith F: Colorimetric method for determination of sugars and related substances. Anal Chem 1956;28:350-356.
12. Blumenkrantz N, Asboe-Hansen G: New method for quantitative determination of uronic acid. Anal Biochem 1973;54:484-489.
13. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
14. Johnes TM, Albersheim P: A gas chromatographic method for the determination of aldose and uronic acid constituents of plant cell wall polysaccharide. Plant Physiol 1972;49:926-936.
15. Zhao JF, Kiyohara H, Yamada H, Takemoto N, Kawamura H: Heterogeneity and characterization of mitogenic and anticomplementary pectic polysaccharides from roots of Glycyrrhiza uralensis Fisch et DC. Carbohydr Res 1991;219:149-172.
16. Yamada H, Kiyohara H, Cyong JC, Takemoto N, Komatsu Y, Kawamura H, Aburada M, Hosoya E: Fractionation and characterization of mitogenic and anti-complementary active fraction from Kampo ( Japanese herbal) medicine 'Juzen-taiho-to'. Planta Med 1990;56:386-391.
17. Hakomori S: A rapid permethylation of glycolipid, and polysaccharide catalyzed by methylsulfinyl carbanion in dimethyl sulfoxide. J Biochem 1964;55:205-208.
18. Waeghe TJ, Darvill AG, McNeil M, Albersheim P: Determination by methylation analysis of the glycosyl linkage compositions of microgram quantities of complex carbohydrate. Carbohydr Res 1983;123:281-304.
19. York WS, Darvill AG, McNeil M, Stevenson TT, Albersheim P: Isolation and characterization of plant cell walls and cell wall components. Methods Enzymol 1986;118:3-40.
20. Sweet DP, Shapiro RH, Albersheim P: Quantitative analysis by various GLC response-factor theories for partially methylated and partially ethylated alditol acetates. Carbohydr Res 1975;40: 217-225.
21. Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K: A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, netural red and crystal violet. Biol Pharm Bull 1996;19:1518-1520.
22. Conrad RE: Induction and collection of peritoneal exudates macrophages. In: Manual of Macrophage Methodolgy (Herscowitz BH, Holden HT, Bellanti JA, Ghaffar A, eds.). Marcel Dekker, Inc., New York, 1981, pp. 5-11.
23. Suzuki I, Tanaka H, Kinoshita A, Oikawa S, Osawa M, Yadomae T: Effect of orally administered-glucan on macrophage function in mice. Int J Immunopharmacol 1990;12:675-684.
24. Yu KW, Kiyohara H, Matsumoto T, Yang HC, Yamada H: Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea DC. Planta Med 1998;64:714-719.
25. Yu KW, Kim YS, Shin KS, Kim JM, Suh HJ: Macrophagestimulating activity of exo-biopolymer from cultured rice bran with Monascus pilosus. Appl Biochem Biotechnol 2005;126:35-48
26. Nam KY: The comparative understanding between red ginseng and white ginseng. J Ginseng Res 2005;29:1-18.
27. Beak NI, Kim DS, Lee YH, Park JD, Kim SI: Ginsenosides Rh4, a genuine dammarane glycoside from Korean red ginseng. Planta Med 1996;62:86-87.
28. Du XW, Wills RBH, Stuart DL: Changes in neutral malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction. Food Chem 2004;86: 155-159.
29. Martins S, Mussatto SI, Martínez-Avila G, Montañez-Saenz J, Aguilar CN, Teixeira JA: Bioactive phenolic compounds: Production and extraction by solid-state fermentation. A review. Biotechnol Adv 2011;29:365-373.
30. Hölker U, Lenz J: Solid-state fermentation: are there any biotechnological advantages? Curr Opin Microbiol 2005;8:301-306.
31. Nigam PS: Production of bioactive secondary metabolites. In: Biotechnology for Agro-industrial Residues Utilization, 1st edition. (Nigam PS, Pandey A, eds.) Springer, Netherlands, 2009, pp. 129-145.
32. Christensen LP: Chapter 1 Ginsenosides: chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2008;55:1-99.
33. Yoon SR, Lee GD, Park JH, Lee IS, Kwon JH: Ginsenoside composition and antiproliferative activities of explosively puffed ginseng (Panax ginseng CA Meyer). J Food Sci 2010;75:C378- C382.
34. Zhao HF, Li Q, Li Y: Long-term ginsenoside administration prevents memory loss in aged female C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus. Neuroscience 2011;183:189-202.
35. Attele AS, Wu JA, Yuan CS: Ginseng pharmacology; multiple constituents and multiple action. Biochem Pharmacol 1999;58:1685-1693.
36. Choi KT: Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C.A. Meyer. Acta Pharmacol Sin 2008;29:1109-1118.
37. Sun Y: Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: an overview. Carbohydr Polym 2011;85:490-499.
38. Wang J, Li S, Fan Y, Chen Y, Liu D, Cheng H, Gao X, Zhou Y: Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C.A. Meyer. J Ethnopharmacol 2010; 130:421-423.
39. Shiao MS: Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions. Chem Rec 2003;3:172-180.
40. Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH: Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem 2004;12:5595-5601.
41. Lin ZB: Cellular andmolecularmechanismsof immuno-modulation by Ganoderma lucidum. J Pharmacol Sci 2005;99:144-153.
42. Lee SY, Kim YK, Park NI, Kim CS, Lee CY, Park SU: Chemical constituents and biological activities of the berry of Panax ginseng. J Med Plant Res 2010;4:349-353.
43. Zhang SD, Yin YX, Wei Q: Immunopotentiation on murine spleen lymphocytes induced by polysaccharide fraction of Panax ginseng via upregulating calcineurin activity. APMIS 2010;118: 288-296.
44. Tomoda M, Takeda K, Shimizu N, Gonda R, Ohara N, Takada K, Hirabayashi K: Characterization of two acidic polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 1993;16:22-25.
45. Tomoda M, Hirabayashi K, Shimizu N, Gonda R, Ohara N, Takada K: Characterization of two novel polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 1993;16:1087-1090.
46. Gao QP, Kiyohara H, Cyong JC, Yamada H: Chemical properties and anti-complementary activities of polysaccharide fractions from roots and leaves of Panax ginseng. Planta Med 1989;55:9-12.
47. Zhang X, Yu L, Bi H, Li X, Ni W, Han H, Li N, Wang B, Zhou Y, Tai G: Total fractionation and characterization of the watersoluble polysaccharides isolated from Panax ginseng C.A. Meyer. Carbohydr Polym 2009;77:544-552.