Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples

Journal of Pharmaceutical and Biomedical Analysis

Volumn 75, Issue , 2013, Pages 33-40

  Shalev, Moran ^a   Kandasamy, Jeyakumar ^a   Skalka, Nir ^b   Belakhov, Valery ^a   Rosin Arbesfeld, Rina ^b   Baasov, Timor ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Aminoglycosides; Enzyme linked immunosorbent assay; Generic antibody; Genetic diseases; Nonsense mutations; Residue monitoring

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE DERIVATIVE; ANTIBIOTIC G 418; FRAMYCETIN; GENTAMICIN; KANAMYCIN A; NB124; NB82; NB84; NEAMINE; PAROMAMINE; PAROMOMYCIN; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; CROSS REACTION; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; GENETIC DISORDER; IMMUNIZATION; IN VIVO STUDY; LIMIT OF DETECTION; MALE; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; TREATMENT DURATION;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODY AFFINITY; BINDING, COMPETITIVE; CALIBRATION; CODON, NONSENSE; CODON, TERMINATOR; CROSS REACTIONS; DRUG DISCOVERY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC DISEASES, INBORN; HAPTENS; INJECTIONS, INTRAPERITONEAL; LIMIT OF DETECTION; MALE; MICE; MICE, INBRED C57BL; REPRODUCIBILITY OF RESULTS;

EID: 84871758875     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.11.014     Document Type: Article

References (35)

1. Davis B.D. Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev. 1987, 51:341-350.
2. Jana S., Deb J.K. Molecular understanding of aminoglycoside action and resistance. Appl. Microbiol. Biotechnol. 2006, 70:140-150.
3. Burke J.F., Mogg A.E. Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin. Nucleic Acids Res. 1985, 13:6265-6272.
4. Manuvakhova M., Keeling K., Bedwell D.M. Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system. RNA 2000, 6:1044-1055.
5. Kerem E. Pharmacologic therapy for stop mutations: how much CFTR activity is enough?. Curr. Opin. Pulm. Med. 2004, 10:547-552.
6. Online Mendelian Inheritance in Man, OMIM®, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, 2012, World Wide Web URL: http://omim.org/OMIM.
7. Atkinson J., Martin R. Mutations to nonsense codons in human genetic disease: implications for gene therapy by nonsense suppressor tRNAs. Nucleic Acids Res. 1994, 22:1327-1334.
8. Keeling K.M., Bedwell D.M. Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases. Wiley Interdiscip. Rev. RNA 2011, 2:837-852.
9. Nudelman I., Rebibo-Sabbah A., Cherniavsky M., Belakhov V., Hainrichson M., Chen F., Schacht J., Pilch D.S., Ben-Yosef T., Baasov T. Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations. J. Med. Chem. 2009, 52:2836-2845.
10. Nudelman I., Glikin D., Smolkin B., Hainrichson M., Belakhov V., Baasov T. Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations. Bioorg. Med. Chem. 2010, 18:3735-3746.
11. Kandasamy J., Atia-Glikin D., Belakhov V., Baasov T. Repairing faulty genes by aminoglycosides: identification of new pharmacophore with enhanced suppression of disease-causing nonsense mutations. Med. Chem. Commun. 2011, 2:165-171.
12. T. Baasov, D. Atia-Glikin, J. Kandasamy, V. Belakhov, Aminoglycosides and uses thereof in targeting genetic disorders, PTC/IL2011/000889 [WO 2012/066546 A1], Israel, 2011.
13. Wang D., Belakhov V., Kandasamy J., Baasov T., Li S.C., Li Y.T., Bedwell D.M., Keeling K.M. The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse. Mol. Genet. Metab. 2012, 105:116-125.
14. Brendel C., Belakhov V., Werner H., Wegener E., Gartner J., Nudelman I., Baasov T., Huppke P. Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model. J. Mol. Med. (Berl.) 2011, 89:389-398.
15. Solomun B., Bilandzic N., Varenina I., Scortichini G. Validation of an enzyme-linked immunosorbent assay for qualitative screening of neomycin in muscle, liver, kidney, eggs and milk. Food Addit. Contam. Part A: Chem. Anal. Control Expo. Risk Assess. 2011, 28:11-18.
16. Jin Y., Jang J.W., Lee M.H., Han C.H. Development of competitive direct enzyme-linked immunosorbent assay for the detection of gentamicin residues in the plasma of live animals. Asian-Australas. J. Anim. Sci. 2005, 18:1498-1504.
17. Xu N.F., Qu C.L., Ma W., Xu L.G., Liu L.Q., Kuang H., Xu C.L. Development and application of one-step ELISA for the detection of neomycin in milk. Food Agric. Immunol. 2011, 22:259-269.
18. Galvidis I.A., Burkin M.A. Monoclonal antibody-based enzyme-linked immunosorbent assay for the aminoglycoside antibiotic kanamycin in foodstuffs. Russ. J. Bioorg. Chem. 2010, 36:722-729.
19. Preu M., Guyot D., Petz M. Development of a gas chromatography mass spectrometry method for the analysis of aminoglycoside antibiotics using experimental design for the optimisation of the derivatisation reactions. J. Chromatogr. A 1998, 818:95-108.
20. Hubicka U., Krzek J., Woltynska H., Stachacz B. Simultaneous identification and quantitative determination of selected aminoglycoside antibiotics by thin-layer chromatography and densitometry. J. AOAC Int. 2009, 92:1068-1075.
21. Kaufmann A., Butcher P., Maden K. Determination of aminoglycoside residues by liquid chromatography and tandem mass spectrometry in a variety of matrices. Anal. Chim. Acta 2012, 711:46-53.
22. El-Attug M.N., Hoogmartens J., Adams E., Van Schepdael A. Optimization of capillary electrophoresis method with contactless conductivity detection for the analysis of tobramycin and its related substances. J. Pharm. Biomed. Anal. 2012, 58:49-57.
23. Adams E., Liu L., Dierick K., Guyomard S., Nabet P., Rico S., Louis P., Roets E., Hoogmartens J. Neomycin: microbiological assay or liquid chromatography?. J. Pharm. Biomed. Anal. 1998, 17:757-766.
24. Oeltgen P.R., Hamann S.R., Blouin R.A. Comparison of radioimmunoassay (RIA) and enzyme-immunoassay (EMIT) for the determination of serum gentamicin. Clin. Chem. 1980, 26:970.
25. Du M., Jones J.R., Lanier J., Keeling K.M., Lindsey J.R., Tousson A., Bebok Z., Whitsett J.A., Dey C.R., Colledge W.H., Evans M.J., Sorscher E.J., Bedwell D.M. Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene. J. Mol. Med. (Berl.) 2002, 80:595-604.
26. Du M., Keeling K.M., Fan L., Liu X., Kovacs T., Sorscher E., Bedwell D.M. Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model. J. Mol. Med. (Berl.) 2006, 84:573-582.
27. Raz S.R., Bremer M.G.E.G., Haasnoot W., Norde W. Label-free and multiplex detection of antibiotic residues in milk using imaging surface plasmon resonance-based immunosensor. Anal. Chem. 2009, 81:7743-7749.
28. Zhu Y., Son J.I., Shim Y.B. Amplification strategy based on gold nanoparticle-decorated carbon nanotubes for neomycin immunosensors. Biosens. Bioelectron. 2010, 26:1002-1008.
29. Stead D.A. Current methodologies for the analysis of aminoglycosides. J. Chromatogr. B 2000, 747:69-93.
30. National Committee of Clinical Laboratory Services, EP5A2, Evaluation of Precision Performance of Quantitative Measurement Methods, Approved Guideline, 2nd ed., NCCLS, Wayne, PA, 2004.
31. Chen Y., Wang Z., Wang Z., Tang S., Zhu Y., Xiao X. Rapid enzyme-linked immunosorbent assay and colloidal gold immunoassay for kanamycin and tobramycin in swine tissues. J. Agric. Food Chem. 2008, 56:2944-2952.
32. Loomans E.E., Van W.J., Koets M., Van Amerongen A. Neamin as an immunogen for the development of a generic ELISA detecting gentamicin, kanamycin, and neomycin in milk. J. Agric. Food Chem. 2003, 51:587-593.
33. Turnidge J. Pharmacodynamics and dosing of aminoglycosides. Infect. Dis. Clin. North Am. 2003, 17:503-528.
34. Mehta M. PDR provides latest Food and Drug Administration - approved dosage guidelines. Arch. Intern. Med. 2001, 161:2622.
35. Sermet-Gaudelus I., Renouil M., Fajac A., Bidou L., Parbaille B., Pierrot S., Davy N., Bismuth E., Reinert P., Lenoir G., Lesure J.F., Rousset J.P., Edelman A. In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study. BMC Med. 2007, 5:5.