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Volumn 112, Issue 2, 2014, Pages 108-115

Biologic targeted therapy in allergic asthma

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ALTRAKINCEPT; AMG 317; ANRUKINZUMAB; BENRALIZUMAB; CINQUIL; ETANERCEPT; GOLIMUMAB; IMIQUIMOD; IMMUNOGLOBULIN E; IMMUNOLOGIC AGENT; INFLIXIMAB; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 5; LEBRIKIZUMAB; MEPOLIZUMAB; OMALIZUMAB; PASCOLIZUMAB; PITRAKINRA; PLACEBO; QBG 10; RESIQUIMOD; RESLIZUMAB; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRALOKINUMAB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIDUPIPRANT;

EID: 84893124137     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/j.anai.2013.12.013     Document Type: Review
Times cited : (49)

References (78)
  • 1
    • 84866378472 scopus 로고    scopus 로고
    • Biologic therapy
    • S. Eisenberg Biologic therapy J Infus Nurs 35 2012 301 313
    • (2012) J Infus Nurs , vol.35 , pp. 301-313
    • Eisenberg, S.1
  • 3
    • 84879105693 scopus 로고    scopus 로고
    • Stratified approaches to the treatment of asthma
    • S.T. Holgate Stratified approaches to the treatment of asthma Br J Clin Pharmacol 76 2013 277 291
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 277-291
    • Holgate, S.T.1
  • 4
    • 84862760305 scopus 로고    scopus 로고
    • Effects of adding omalizumab, an anti-immunoglobulin e antibody, on airway wall thickening in asthma
    • M. Hoshino, and J. Ohtawa Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma Respiration 83 2012 520 528
    • (2012) Respiration , vol.83 , pp. 520-528
    • Hoshino, M.1    Ohtawa, J.2
  • 5
    • 84863698582 scopus 로고    scopus 로고
    • Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patients
    • A.M. Riccio, R.W. Dal Negro, and C. Micheletto et al. Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patients Int J Immunopathol Pharmacol 25 2012 475 484
    • (2012) Int J Immunopathol Pharmacol , vol.25 , pp. 475-484
    • Riccio, A.M.1    Dal Negro, R.W.2    Micheletto, C.3
  • 6
    • 28044431859 scopus 로고    scopus 로고
    • Effects of omalizumab and budesonide on markers of inflammation in human bronchial epithelial cells
    • Y.-C. Huang, B. Leyko, and M. Frieri Effects of omalizumab and budesonide on markers of inflammation in human bronchial epithelial cells Ann Allergy Asthma Immunol 95 2005 443 451
    • (2005) Ann Allergy Asthma Immunol , vol.95 , pp. 443-451
    • Huang, Y.-C.1    Leyko, B.2    Frieri, M.3
  • 7
    • 78649331032 scopus 로고    scopus 로고
    • Anti-IgE therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma
    • Z. Zietkowski, R. Skiepko, M.M. Tomasiak-Lozowska, and A. Bodzenta-Lukaszyk Anti-IgE therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma Respiration 80 2010 534 542
    • (2010) Respiration , vol.80 , pp. 534-542
    • Zietkowski, Z.1    Skiepko, R.2    Tomasiak-Lozowska, M.M.3    Bodzenta-Lukaszyk, A.4
  • 8
    • 84870821942 scopus 로고    scopus 로고
    • The potential of biologics for the treatment of asthma
    • G. Pelaia, A. Vatrella, and R. Maselli The potential of biologics for the treatment of asthma Nat Rev Drug Discov 11 2012 958 972
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 958-972
    • Pelaia, G.1    Vatrella, A.2    Maselli, R.3
  • 9
    • 20044362008 scopus 로고    scopus 로고
    • Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    • M. Humbert, R. Beasley, and J. Ayres et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE Allergy 60 2005 309 316
    • (2005) Allergy , vol.60 , pp. 309-316
    • Humbert, M.1    Beasley, R.2    Ayres, J.3
  • 10
    • 84876883293 scopus 로고    scopus 로고
    • Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the EXTRA study
    • N.A. Hanania, S. Wenzel, and K. Rosén et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study Am J Respir Crit Care Med 187 2013 804 811
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 804-811
    • Hanania, N.A.1    Wenzel, S.2    Rosén, K.3
  • 11
    • 36448986847 scopus 로고    scopus 로고
    • Effectiveness of omalizumab (Xolair) in the first patients treated in real-life practice in France
    • M. Molimard, F. De Blay, A. Didier, and V. Le Gros Effectiveness of omalizumab (Xolair) in the first patients treated in real-life practice in France Respir Med 102 2008 71 76
    • (2008) Respir Med , vol.102 , pp. 71-76
    • Molimard, M.1    De Blay, F.2    Didier, A.3    Le Gros, V.4
  • 12
    • 85058905872 scopus 로고    scopus 로고
    • American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology Joint Task Force Report on omalizumab-associated anaphylaxis
    • L. Cox, T.A. Platts-Mills, and I. Finegold et al. American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology Joint Task Force Report on omalizumab-associated anaphylaxis J Allergy Clin Immunol 128 2007 210 212
    • (2007) J Allergy Clin Immunol , vol.128 , pp. 210-212
    • Cox, L.1    Platts-Mills, T.A.2    Finegold, I.3
  • 13
    • 78649673636 scopus 로고    scopus 로고
    • Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: A systematic review
    • G.J. Rodrigo, H. Neffen, and J.A. Castro-Rodriguez Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review Chest 139 2011 28 35
    • (2011) Chest , vol.139 , pp. 28-35
    • Rodrigo, G.J.1    Neffen, H.2    Castro-Rodriguez, J.A.3
  • 14
    • 0034847879 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts
    • T. Machino, S. Hashimoto, and Y. Gon et al. Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts Allergol Int 50 2001 197 202
    • (2001) Allergol Int , vol.50 , pp. 197-202
    • Machino, T.1    Hashimoto, S.2    Gon, Y.3
  • 15
    • 17844393640 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys
    • T.K. Hart, R.M. Cook, and P. Zia-Amirhosseini et al. Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys J Allergy Clin Immunol 108 2001 250 257
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 250-257
    • Hart, T.K.1    Cook, R.M.2    Zia-Amirhosseini, P.3
  • 16
    • 0036379740 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma
    • T.K. Hart, M.N. Blackburn, and M. Brigham-Burke et al. Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma Clin Exp Immunol 130 2002 93 100
    • (2002) Clin Exp Immunol , vol.130 , pp. 93-100
    • Hart, T.K.1    Blackburn, M.N.2    Brigham-Burke, M.3
  • 17
    • 4944230274 scopus 로고    scopus 로고
    • The safety and pharmacokinetics of SB240683 (anti-Il-4 humanized monoclonal antibody) in patients with mild to moderate asthma
    • R.S. Shames, V. Vexler, and N.M. Lane The safety and pharmacokinetics of SB240683 (anti-Il-4 humanized monoclonal antibody) in patients with mild to moderate asthma J Allergy Clin Immunol 107 2001 1030
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 1030
    • Shames, R.S.1    Vexler, V.2    Lane, N.M.3
  • 18
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
    • S. Wenzel, D. Wilbraham, R. Fuller, E.B. Getz, and M. Longphre Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies Lancet 370 2007 1422 1431
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 19
    • 0343502999 scopus 로고    scopus 로고
    • Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma
    • W.R. Henderson, E.Y. Chi, and C.R. Maliszewski Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma J Immunol 164 2000 1086 1095
    • (2000) J Immunol , vol.164 , pp. 1086-1095
    • Henderson, W.R.1    Chi, E.Y.2    Maliszewski, C.R.3
  • 20
    • 0033454115 scopus 로고    scopus 로고
    • Interleukin-4 receptor in moderate atopic asthma: A phase I/II randomized, placebo-controlled trial
    • L. Borish, H. Nelson, and M.J. Lanz et al. Interleukin-4 receptor in moderate atopic asthma: a phase I/II randomized, placebo-controlled trial Am J Respir Crit Care Med 160 1999 1816 1823
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1816-1823
    • Borish, L.1    Nelson, H.2    Lanz, M.J.3
  • 21
    • 0034995872 scopus 로고    scopus 로고
    • Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
    • L.C. Borish, H.S. Nelson, and J. Corren et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma J Allergy Clin Immunol 107 2001 963 970
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 963-970
    • Borish, L.C.1    Nelson, H.S.2    Corren, J.3
  • 22
    • 69949132843 scopus 로고    scopus 로고
    • Cytokine and anti-cytokine therapy in asthma: Ready for the clinic?
    • D. Desai, and C. Brightling Cytokine and anti-cytokine therapy in asthma: ready for the clinic? Clin Exp Immunol 158 2009 10 19
    • (2009) Clin Exp Immunol , vol.158 , pp. 10-19
    • Desai, D.1    Brightling, C.2
  • 23
    • 84879401471 scopus 로고    scopus 로고
    • Dupilumab in persistent asthma with elevated eosinophil levels
    • S. Wenzel, L. Ford, and D. Pearlman et al. Dupilumab in persistent asthma with elevated eosinophil levels N Engl J Med 368 2013 2455 2466
    • (2013) N Engl J Med , vol.368 , pp. 2455-2466
    • Wenzel, S.1    Ford, L.2    Pearlman, D.3
  • 24
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Z. Zhu, R.J. Homer, and Z. Wang et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production J Clin Invest 103 1999 779 788
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3
  • 25
    • 84875692522 scopus 로고    scopus 로고
    • Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab
    • M. Ultsch, J. Bevers, and G. Nakamura et al. Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab J Mol Biol 425 2013 1330 1339
    • (2013) J Mol Biol , vol.425 , pp. 1330-1339
    • Ultsch, M.1    Bevers, J.2    Nakamura, G.3
  • 26
    • 0030228818 scopus 로고    scopus 로고
    • Interleukin-13 and interleukin-4 are coexpressed in atopic asthma
    • T.C. Kotsimbos, P. Ernst, and Q.A. Hamid Interleukin-13 and interleukin-4 are coexpressed in atopic asthma Proc Assoc Am Phys 108 1996 368 373
    • (1996) Proc Assoc Am Phys , vol.108 , pp. 368-373
    • Kotsimbos, T.C.1    Ernst, P.2    Hamid, Q.A.3
  • 27
    • 40049099397 scopus 로고    scopus 로고
    • Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    • S.K. Saha, M.A. Berry, and D. Parker et al. Increased sputum and bronchial biopsy IL-13 expression in severe asthma J Allergy Clin Immunol 121 2008 685 691
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 685-691
    • Saha, S.K.1    Berry, M.A.2    Parker, D.3
  • 28
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • P.G. Woodruff, B. Modrek, and D.F. Choy et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma Am J Respir Crit Care Med 180 2009 388 395
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 388-395
    • Woodruff, P.G.1    Modrek, B.2    Choy, D.F.3
  • 30
    • 84865696394 scopus 로고    scopus 로고
    • Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
    • G. Jia, R.W. Erickson, and D.F. Choy et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients J Allergy Clin Immunol 130 2012 647 654
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 647-654
    • Jia, G.1    Erickson, R.W.2    Choy, D.F.3
  • 31
    • 0030934422 scopus 로고    scopus 로고
    • Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy
    • T. Naseer, E.M. Minshall, and D.Y. Leung et al. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy Am J Respir Crit Care Med 155 1997 845 851
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 845-851
    • Naseer, T.1    Minshall, E.M.2    Leung, D.Y.3
  • 32
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • J. Corren, R.F. Lemanske, and N.A. Hanania et al. Lebrikizumab treatment in adults with asthma N Engl J Med 365 2011 1088 1098
    • (2011) N Engl J Med , vol.365 , pp. 1088-1098
    • Corren, J.1    Lemanske, R.F.2    Hanania, N.A.3
  • 33
    • 84883256475 scopus 로고    scopus 로고
    • Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids
    • M. Noonan, P. Korenblat, and S. Mosesova et al. Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids J Allergy Clin Immunol 132 2013 567 574.e12
    • (2013) J Allergy Clin Immunol , vol.132
    • Noonan, M.1    Korenblat, P.2    Mosesova, S.3
  • 34
    • 27744558641 scopus 로고    scopus 로고
    • Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354)
    • C. Blanchard, A. Mishra, H. Saito-Akei, P. Monk, I. Anderson, and M.E. Rothenberg Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354) Clin Exp Allergy 35 2005 1096 1103
    • (2005) Clin Exp Allergy , vol.35 , pp. 1096-1103
    • Blanchard, C.1    Mishra, A.2    Saito-Akei, H.3    Monk, P.4    Anderson, I.5    Rothenberg, M.E.6
  • 35
    • 84873389433 scopus 로고    scopus 로고
    • A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
    • E. Piper, C. Brightling, and R. Niven et al. A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma Eur Respir J 41 2013 330 338
    • (2013) Eur Respir J , vol.41 , pp. 330-338
    • Piper, E.1    Brightling, C.2    Niven, R.3
  • 36
    • 79960415853 scopus 로고    scopus 로고
    • IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2
    • M.T. Kasaian, D. Raible, and K. Marquette et al. IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2 J Immunol 187 2011 561 569
    • (2011) J Immunol , vol.187 , pp. 561-569
    • Kasaian, M.T.1    Raible, D.2    Marquette, K.3
  • 37
    • 33847685713 scopus 로고    scopus 로고
    • Efficacy of IL-13 neutralization in a sheep model of experimental asthma
    • M.T. Kasaian, D.D. Donaldson, and L. Tchistiakova et al. Efficacy of IL-13 neutralization in a sheep model of experimental asthma Am J Respir Cell Mol Biol 36 2007 368 376
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 368-376
    • Kasaian, M.T.1    Donaldson, D.D.2    Tchistiakova, L.3
  • 38
    • 79954583416 scopus 로고    scopus 로고
    • Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
    • G.M. Gauvreau, L.P. Boulet, and D.W. Cockcroft et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma Am J Respir Crit Care Med 183 2011 1007 1014
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1007-1014
    • Gauvreau, G.M.1    Boulet, L.P.2    Cockcroft, D.W.3
  • 39
    • 0036839816 scopus 로고    scopus 로고
    • Effects of montelukast and budesonide on airway responses and airway inflammation in asthma
    • R. Leigh, D. Vethenayagam, and M. Yoshida et al. Effects of montelukast and budesonide on airway responses and airway inflammation in asthma Am J Respir Crit Care Med 166 2002 1212 1217
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1212-1217
    • Leigh, R.1    Vethenayagam, D.2    Yoshida, M.3
  • 40
    • 0035888724 scopus 로고    scopus 로고
    • Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma
    • R.G. Stirling, E.L. Van Rensen, P.J. Barnes, and K.F. Chung Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma Am J Respir Crit Care Med 164 2001 1403 1409
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1403-1409
    • Stirling, R.G.1    Van Rensen, E.L.2    Barnes, P.J.3    Chung, K.F.4
  • 41
    • 0025760379 scopus 로고
    • Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma
    • Q. Hamid, M. Azzawi, and S. Ying et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma J Clin Invest 87 1991 1541 1546
    • (1991) J Clin Invest , vol.87 , pp. 1541-1546
    • Hamid, Q.1    Azzawi, M.2    Ying, S.3
  • 43
    • 0027183057 scopus 로고
    • Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression
    • D. Robinson, Q. Hamid, and S. Yng et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression Am Rev Respir Dis 148 1993 401 406
    • (1993) Am Rev Respir Dis , vol.148 , pp. 401-406
    • Robinson, D.1    Hamid, Q.2    Yng, S.3
  • 44
    • 0033070962 scopus 로고    scopus 로고
    • Effects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation
    • C.G. Garlisi, T.T. Kung, and P. Wang et al. Effects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation Am J Respir Cell Mol Biol 20 1999 248 255
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 248-255
    • Garlisi, C.G.1    Kung, T.T.2    Wang, P.3
  • 45
    • 0029146701 scopus 로고
    • Effects of an antibody to interleukin-5 in a monkey model of asthma
    • P.J. Mauser, A.M. Pitman, and X. Fernandez et al. Effects of an antibody to interleukin-5 in a monkey model of asthma Am J Respir Crit Care Med 152 1995 467 472
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 467-472
    • Mauser, P.J.1    Pitman, A.M.2    Fernandez, X.3
  • 46
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • M.J. Leckie, A. ten Brinke, and J. Khan et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response Lancet 356 2000 2144 2148
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3
  • 47
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • P. Flood-Page, C. Swenson, and I. Faiferman et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma Am J Respir Crit Care Med 176 2007 1062 1071
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3
  • 48
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • P. Haldar, C.E. Brighling, and B. Hargadon et al. Mepolizumab and exacerbations of refractory eosinophilic asthma N Engl J Med 360 2009 973 984
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brighling, C.E.2    Hargadon, B.3
  • 49
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • P. Nair, M.M. Pizzichini, and M. Kjarsgaard et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia N Engl J Med 360 2009 985 993
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 50
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • I. Pavord, S. Korn, and P. Howarth et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial Lancet 380 2012 651 659
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.1    Korn, S.2    Howarth, P.3
  • 51
    • 84875467652 scopus 로고    scopus 로고
    • Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: A meta-analysis of randomized placebo-controlled trials
    • Y. Liu, S. Zhang, D. Li, and S. Jiang Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials PloS One 8 2013 e59872
    • (2013) PloS One , vol.8 , pp. 59872
    • Liu, Y.1    Zhang, S.2    Li, D.3    Jiang, S.4
  • 52
    • 8944227052 scopus 로고    scopus 로고
    • Structure and humanization of a rat monoclonal Fab to human interleukin-5
    • W.J. Cook, L.J. Walter, and N.J. Murgolo et al. Structure and humanization of a rat monoclonal Fab to human interleukin-5 Protein Eng 9 1996 623 628
    • (1996) Protein Eng , vol.9 , pp. 623-628
    • Cook, W.J.1    Walter, L.J.2    Murgolo, N.J.3
  • 53
    • 81455155725 scopus 로고    scopus 로고
    • Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
    • M. Castro, S. Mathur, and F. Hargreave et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study Am J Respir Crit Care Med 184 2011 1125 1132
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3
  • 55
    • 77952683218 scopus 로고    scopus 로고
    • Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase i study of subjects with mild asthma
    • W.W. Busse, R. Katial, and D. Gossage et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma J Allergy Clin Immunol 125 2010 1237 1244.e2
    • (2010) J Allergy Clin Immunol , vol.125
    • Busse, W.W.1    Katial, R.2    Gossage, D.3
  • 56
    • 84055199162 scopus 로고    scopus 로고
    • Benralizumab-a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity - A novel approach for the treatment of asthma
    • A. Ghazi, A. Trikha, and W.J. Calhoun Benralizumab-a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity-a novel approach for the treatment of asthma Expert Opin Biol Ther 12 2012 113 118
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 113-118
    • Ghazi, A.1    Trikha, A.2    Calhoun, W.J.3
  • 57
    • 22144438655 scopus 로고    scopus 로고
    • TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway
    • M.A. Lokuta, and A. Huttenlocher TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway J Leukocyte Biol 78 2005 210 219
    • (2005) J Leukocyte Biol , vol.78 , pp. 210-219
    • Lokuta, M.A.1    Huttenlocher, A.2
  • 58
    • 32644490529 scopus 로고    scopus 로고
    • Evidence of a role of tumor necrosis factor alpha in refractory asthma
    • M.A. Berry, B. Hargadon, and M. Shelley et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma N Engl J Med 354 2006 697 708
    • (2006) N Engl J Med , vol.354 , pp. 697-708
    • Berry, M.A.1    Hargadon, B.2    Shelley, M.3
  • 59
    • 28244479315 scopus 로고    scopus 로고
    • Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
    • P.H. Howarth, K.S. Babu, and A.S. Arshad et al. Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid dependent asthma Thorax 60 2005 1012 1018
    • (2005) Thorax , vol.60 , pp. 1012-1018
    • Howarth, P.H.1    Babu, K.S.2    Arshad, A.S.3
  • 60
    • 47049130758 scopus 로고    scopus 로고
    • The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: A double blind, randomised, placebo controlled trial
    • J.B. Morjaria, A.J. Chauhan, K.S. Babu, R. Polosa, D.E. Davies, and S.T. Holgate The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial Thorax 63 2008 584 591
    • (2008) Thorax , vol.63 , pp. 584-591
    • Morjaria, J.B.1    Chauhan, A.J.2    Babu, K.S.3    Polosa, R.4    Davies, D.E.5    Holgate, S.T.6
  • 61
    • 33749438560 scopus 로고    scopus 로고
    • The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma
    • E.M. Erin, B.R. Leaker, and G.C. Nicholson et al. The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma Am J Respir Crit Care Med 174 2006 753 762
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 753-762
    • Erin, E.M.1    Leaker, B.R.2    Nicholson, G.C.3
  • 62
    • 62549084077 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
    • S.E. Wenzel, P.J. Barnes, and E.R. Bleecker et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma Am J Respir Crit Care Med 179 2009 549 558
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 549-558
    • Wenzel, S.E.1    Barnes, P.J.2    Bleecker, E.R.3
  • 63
    • 84873407189 scopus 로고    scopus 로고
    • Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
    • W.W. Busse, S.E. Wenzel, and E.O. Meltzer et al. Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients J Allergy Clin Immunol 131 2013 339 345
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 339-345
    • Busse, W.W.1    Wenzel, S.E.2    Meltzer, E.O.3
  • 64
    • 84655167630 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma
    • N. Barnes, I. Pavord, and A. Chuchalin et al. A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma Clin Exp Allergy 42 2012 38 48
    • (2012) Clin Exp Allergy , vol.42 , pp. 38-48
    • Barnes, N.1    Pavord, I.2    Chuchalin, A.3
  • 65
    • 84873708317 scopus 로고    scopus 로고
    • Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis
    • A. Straumann, S. Hoesli, and C. Bussmann et al. Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis Allergy 68 2013 375 385
    • (2013) Allergy , vol.68 , pp. 375-385
    • Straumann, A.1    Hoesli, S.2    Bussmann, C.3
  • 66
    • 84875219804 scopus 로고    scopus 로고
    • The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma
    • K.M. Beeh, F. Kanneiss, and F. Wagner et al. The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma J Allergy Clin Immunol 131 2013 866 874
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 866-874
    • Beeh, K.M.1    Kanneiss, F.2    Wagner, F.3
  • 67
    • 79551468701 scopus 로고    scopus 로고
    • Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs
    • E.H. Kaufman, A.D. Fryer, and D.B. Jacoby Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs J Allergy Clin Immunol 127 2011 462 469
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 462-469
    • Kaufman, E.H.1    Fryer, A.D.2    Jacoby, D.B.3
  • 68
    • 84859313808 scopus 로고    scopus 로고
    • Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity
    • M. Biffen, H. Matsui, and S. Edwards et al. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity Br J Pharmacol 166 2012 573 586
    • (2012) Br J Pharmacol , vol.166 , pp. 573-586
    • Biffen, M.1    Matsui, H.2    Edwards, S.3
  • 69
    • 34347399259 scopus 로고    scopus 로고
    • Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
    • P.J. Pockros, D. Guyader, and H. Patton et al. Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies J Hepatol 47 2007 174 182
    • (2007) J Hepatol , vol.47 , pp. 174-182
    • Pockros, P.J.1    Guyader, D.2    Patton, H.3
  • 71
    • 84869100349 scopus 로고    scopus 로고
    • IL-13 in asthma and allergic disease: Asthma phenotypes and targeted therapies
    • J.L. Ingram, and M. Kraft IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies J Allergy Clin Immunol 130 2012 829 844
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 829-844
    • Ingram, J.L.1    Kraft, M.2
  • 72
    • 84864810492 scopus 로고    scopus 로고
    • Tissue-based and bronchoalveolar lavage-based biomarkers in asthma
    • S.E. Wenzel Tissue-based and bronchoalveolar lavage-based biomarkers in asthma Immunol Allergy Clin North Am 32 2012 401 411
    • (2012) Immunol Allergy Clin North Am , vol.32 , pp. 401-411
    • Wenzel, S.E.1
  • 73
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: The evolution from clinical to molecular approaches
    • S.E. Wenzel Asthma phenotypes: the evolution from clinical to molecular approaches Nat Med 18 2012 716 725
    • (2012) Nat Med , vol.18 , pp. 716-725
    • Wenzel, S.E.1
  • 75
    • 84857429187 scopus 로고    scopus 로고
    • A systematic review and meta-analysis: Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)
    • H.L. Petsky, C.J. Cates, and T.J. Lasserson et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils) Thorax 67 2012 199 208
    • (2012) Thorax , vol.67 , pp. 199-208
    • Petsky, H.L.1    Cates, C.J.2    Lasserson, T.J.3
  • 76
    • 79551468701 scopus 로고    scopus 로고
    • Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs
    • E.H. Kaufman, A.D. Fryer, and D.B. Jacoby Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs J Allergy Clin Immunol 127 2011 462 469
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 462-469
    • Kaufman, E.H.1    Fryer, A.D.2    Jacoby, D.B.3
  • 77
    • 84859313808 scopus 로고    scopus 로고
    • Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity
    • M. Biffen, H. Matsui, and S. Edwards et al. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity Br J Pharmacol 166 2012 573 586
    • (2012) Br J Pharmacol , vol.166 , pp. 573-586
    • Biffen, M.1    Matsui, H.2    Edwards, S.3
  • 78
    • 34548336791 scopus 로고    scopus 로고
    • Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C
    • Pockros PJ, Schiff ER, Shiffman ML, et al. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology. 2007;46:324-329.
    • (2007) Hepatology , vol.46 , pp. 324-329
    • Pockros, P.J.1    Schiff, E.R.2    Shiffman, M.L.3


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