Paxillin is an intrinsic negative regulator of platelet activation in mice

Thrombosis Journal

Volumn 12, Issue 1, 2014, Pages

  Sakata, Asuka ^a   Ohmori, Tsukasa ^a   Nishimura, Satoshi ^a,b   Suzuki, Hidenori ^c   Madoiwa, Seiji ^a   Mimuro, Jun ^a   Kario, Kazuomi ^a   Sakata, Yoichi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Glycoprotein; Platelet; Platelet aggregation; Release reaction

Indexed keywords

DEXTRAN; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN VI; LENTIVIRUS VECTOR; PADGEM PROTEIN; PAXILLIN; SHORT HAIRPIN RNA; THROMBOXANE A2;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; BLEEDING TIME; BLOOD CLOTTING; BONE MARROW CELL; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; FLOW CYTOMETRY; FOCAL ADHESION; IMMUNOBLOTTING; IN VITRO STUDY; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84893118036     PISSN: None     EISSN: 14779560     Source Type: Journal    
DOI: 10.1186/1477-9560-12-1     Document Type: Article

References (37)

1. Coller BS. Historical perspective and future directions in platelet research. J Thromb Haemost 2011, 9(Suppl 1):374-395. 3163479, 21781274.
2. Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost 2005, 3:1752-1762. 10.1111/j.1538-7836.2005.01429.x, 16102042.
3. Varga-Szabo D, Pleines I, Nieswandt B. Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol 2008, 28:403-412. 10.1161/ATVBAHA.107.150474, 18174460.
4. Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol 2010, 11:288-300. 10.1038/nrm2871, 20308986.
5. Siess W. Molecular mechanisms of platelet activation. Physiol Rev 1989, 69:58-178.
6. Guidetti GF, Torti M. The small GTPase rap1b: a bidirectional regulator of platelet adhesion receptors. J Signal Transduct 2012, 2012:412089. 3382407, 22745904.
7. Moser M, Legate KR, Zent R, Fassler R. The tail of integrins, talin, and kindlins. Science 2009, 324:895-899. 10.1126/science.1163865, 19443776.
8. Moser M, Nieswandt B, Ussar S, Pozgajova M, Fassler R. Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 2008, 14:325-330. 10.1038/nm1722, 18278053.
9. Nieswandt B, Moser M, Pleines I, Varga-Szabo D, Monkley S, Critchley D, Fassler R. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med 2007, 204:3113-3118. 10.1084/jem.20071827, 2150972, 18086864.
10. Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest 2007, 117:2250-2259. 10.1172/JCI31024, 1906732, 17627302.
11. Cantor JM, Ginsberg MH, Rose DM. Integrin-associated proteins as potential therapeutic targets. Immunol Rev 2008, 223:236-251. 10.1111/j.1600-065X.2008.00640.x, 18613840.
12. Glenney JR, Zokas L. Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton. J Cell Biol 1989, 108:2401-2408. 10.1083/jcb.108.6.2401, 2115592, 2472406.
13. Brown MC, Turner CE. Paxillin: adapting to change. Physiol Rev 2004, 84:1315-1339. 10.1152/physrev.00002.2004, 15383653.
14. Deakin NO, Turner CE. Paxillin comes of age. J Cell Sci 2008, 121:2435-2444. 10.1242/jcs.018044, 2522309, 18650496.
15. Hagmann J, Grob M, Welman A, Van Willigen G, Burger MM. Recruitment of the LIM protein hic-5 to focal contacts of human platelets. J Cell Sci 1998, 111(Pt 15):2181-2188.
16. Osada M, Ohmori T, Yatomi Y, Satoh K, Hosogaya S, Ozaki Y. Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2. Biochem J 2001, 355:691-697. 1221784, 11311131.
17. Rathore VB, Okada M, Newman PJ, Newman DK. Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J 2007, 403:275-281. 10.1042/BJ20061618, 1874248, 17233630.
18. Liu S, Slepak M, Ginsberg MH. Binding of Paxillin to the alpha 9 integrin cytoplasmic domain inhibits cell spreading. J Biol Chem 2001, 276:37086-37092. 10.1074/jbc.M105114200, 11477105.
19. Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH. Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature 1999, 402:676-681. 10.1038/45264, 10604475.
20. Coller BS, Anderson K, Weisman HF. New antiplatelet agents: platelet GPIIb/IIIa antagonists. Thromb Haemost 1995, 74:302-308.
21. Ohmori T, Kashiwakura Y, Ishiwata A, Madoiwa S, Mimuro J, Sakata Y. Silencing of a targeted protein in in vivo platelets using a lentiviral vector delivering short hairpin RNA sequence. Arterioscler Thromb Vasc Biol 2007, 27:2266-2272. 10.1161/ATVBAHA.107.149872, 17872456.
22. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Ihrig MM, McManus MT, Gertler FB, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003, 33:401-406. 10.1038/ng1117, 12590264.
23. Ohmori T, Kashiwakura Y, Ishiwata A, Madoiwa S, Mimuro J, Furukawa Y, Sakata Y. Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function. J Biol Chem 2010, 285:31763-31773. 10.1074/jbc.M109.099085, 2951248, 20663867.
24. Suzuki H, Okamura Y, Ikeda Y, Takeoka S, Handa M. Ultrastructural analysis of thrombin-induced interaction between human platelets and liposomes carrying fibrinogen gamma-chain dodecapeptide as a synthetic platelet substitute. Thromb Res 2011, 128:552-559. 10.1016/j.thromres.2011.07.031, 21840573.
25. Bergmeier W, Schulte V, Brockhoff G, Bier U, Zirngibl H, Nieswandt B. Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry 2002, 48:80-86. 10.1002/cyto.10114, 12116368.
26. Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, et al. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood 2012, 119:e45-e56. 10.1182/blood-2011-09-381400, 3351094, 22096246.
27. Smolenski A. Novel roles of cAMP/cGMP-dependent signaling in platelets. J Thromb Haemost 2012, 10:167-176. 10.1111/j.1538-7836.2011.04576.x, 22136590.
28. Ming Z, Hu Y, Xiang J, Polewski P, Newman PJ, Newman DK. Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. Blood 2011, 117:3903-3906. 10.1182/blood-2010-09-304816, 3083302, 21297004.
29. Wong C, Liu Y, Yip J, Chand R, Wee JL, Oates L, Nieswandt B, Reheman A, Ni H, Beauchemin N, Jackson DE. CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood 2009, 113:1818-1828. 10.1182/blood-2008-06-165043, 19008452.
30. Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood 2010, 116:6092-6100. 10.1182/blood-2010-05-283846, 3031394, 20852125.
31. Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, Imamoto A, Thomas SM. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 2002, 22:901-915. 10.1128/MCB.22.3.901-915.2002, 133539, 11784865.
32. Feral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg MH. Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest 2006, 116:715-723. 10.1172/JCI26091, 1361348, 16470243.
33. Dorsam RT, Kim S, Jin J, Kunapuli SP. Coordinated signaling through both G12/13 and G (i) pathways is sufficient to activate GPIIb/IIIa in human platelets. J Biol Chem 2002, 277:47588-47595. 10.1074/jbc.M208778200, 12297512.
34. Nieswandt B, Schulte V, Zywietz A, Gratacap MP, Offermanns S. Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. J Biol Chem 2002, 277:39493-39498. 10.1074/jbc.M207256200, 12183468.
35. Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bosl M, Nieswandt B. CLP36 Is a Negative Regulator of Glycoprotein VI Signaling in Platelets. Circ Res 2012, 111:1410-1420. 10.1161/CIRCRESAHA.112.264754, 22955732.
36. Kim-Kaneyama JR, Miyauchi A, Lei XF, Arita S, Mino T, Takeda N, Kou K, Eto K, Yoshida T, Miyazaki T, et al. Identification of Hic-5 as a novel regulatory factor for integrin alphaIIbbeta3 activation and platelet aggregation in mice. J Thromb Haemost 2012, 10:1867-1874. 10.1111/j.1538-7836.2012.04856.x, 22812543.
37. Chew V, Lam KP. Leupaxin negatively regulates B cell receptor signaling. J Biol Chem 2007, 282:27181-27191. 10.1074/jbc.M704625200, 17640867.