Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction

Nature Methods

Volumn 5, Issue 1, 2008, Pages 101-108

  Andersson, Malin ^a   Groseclose, M Reid ^a   Deutch, Ariel Y ^a   Caprioli, Richard M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTISIC ACID; SINAPIC ACID;

ANIMAL TISSUE; ARTICLE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEOMICS; RAT; THREE DIMENSIONAL IMAGING;

IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MASS SPECTROMETRY; PEPTIDE MAPPING; SYSTEMS INTEGRATION;

RATTUS;

EID: 37749010579     PISSN: 15487091     EISSN: 15491676     Source Type: Journal    
DOI: 10.1038/nmeth1145     Document Type: Article

References (9)

1. Caprioli, R.M., Farmer, T.B. & Gile, J. Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 69, 4751-4760 (1997).
2. Crecelius, A.C. et al. Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry. J. Am. Soc. Mass Spectrom. 16, 1093-1099 (2005).
3. Aerni, H.R., Cornett, D.S. & Caprioli, R.M. Automated acoustic matrix deposition for MALDI sample preparation. Anal. Chem. 78, 827-834 (2006).
4. Groseclose, M.R., Andersson, M., Hardesty, W.M. & Caprioli, R.M. Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry. J. Mass Spectrom. 42, 254-262 (2007).
5. Reyzer, M.L., Hsieh, Y.S., Ng, K., Korfmacher, W.A. & Caprioli, R.M. Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry. J. Mass Spectrom. 38 1081-1092 (2003).
6. Khatib-Shahidi, S., Andersson, M., Herman, J.L., Gillespie, T.A. & Caprioli, R.M. Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal. Chem. 78, 6448-6456 (2006).
7. Hankin, J.A., Barkley, R.M. & Murphy, R.C. Sublimation as a method of matrix application for mass spectrometry imaging. J. Am. Soc. Mass Spectrom. 18, 1646-1652 (2007).
8. Schwartz, S.A., Reyzer, M.L. & Caprioli, R.M. Direct tissue analysis using matrix-assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparation. J. Mass Spectrom. 38 699-708 (2003).
9. Chaurand, P., Norris, J.L., Cornett, D.S., Mobley, J.A. & Caprioli, R.M. New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry. J. Proteome Res. 5, 2889-2900 (2006).