Age-related macular degeneration - A genome scan in extended families

American Journal of Human Genetics

Volumn 73, Issue 3, 2003, Pages 540-550

  Majewski, Jacek ^a   Schultz, Dennis W ^b   Weleber, Richard G ^b   Schain, Mitchell B ^b   Edwards, Albert O ^c   Matise, Tara C ^a,d   Acott, Ted S ^b   Ott, Jurg ^a   Klein, Michael L ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ALLELE; ARTICLE; CHROMOSOME 10Q; CHROMOSOME 1Q; CHROMOSOME 3P; CHROMOSOME 9Q; CORRELATION ANALYSIS; FAMILY; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC EPISTASIS; GENETIC LINKAGE; GENOME; GENOME SCAN; GENOTYPE; GEOGRAPHY; HEREDITY; HUMAN; LINKAGE ANALYSIS; MUTATIONAL ANALYSIS; PARAMETRIC TEST; PEDIGREE; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; STATISTICAL ANALYSIS;

EID: 0041886495     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/377701     Document Type: Article

References (24)

1. Allikmets R, Shroyer NF, Singh N, Seddon JM, Lewis RA, Bernstein PS, Peiffer A, Zabriskie NA, Li Y, Hutchinson A, Dean M, Lupski JR, Leppert M (1997) Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277:1805-1807
2. Badner JA, Gershon ES, Goldin LR (1998) Optimal ascertainment strategies to detect linkage to common disease alleles. Am J Hum Genet 63:880-888
3. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 63:861-869
4. Cottingham RW Jr, Idury RM, Schäffer AA (1993) Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263
5. Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI, Kong A (1999) Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet 21:213-215
6. Evans J, Wormald R (1996) Is the incidence of registrable age-related macular degeneration increasing? Br J Ophthalmol 80:9-14
7. Gudbjartsson DF, Jonasson K, Frigge ML, Kong A (2000) Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25:12-13
8. Haines JL, Lamb JM, Schmidt S, Agarwal A, Postel E, De La Paz-Schmidlekofer M, Gilbert JR, Scott WK, Pericak-Vance MA (2002) Follow-up of genomic screen regions in age-related macular degeneration. Paper presented at Association for Research in Vision and Ophthalmology Meeting, Fort Lauderdale, FL, May 5-10
9. Iyengar SK, Schick J, Reading K, Milliard C, Brey N, Liptak R, Klein R, Klein B, Elston R (2002) A genomewide scan for age-related maculopathy and other ocular phenotypes in a sample from the Beaver Dam Eye Study (BDES). Paper presented at Association for Research in Vision and Ophthalmology Meeting, Fort Lauderdale, FL, May 5-10
10. Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D (2002) The Human Genome Browser at UCSC. Genome Res 12:996-1006
11. Klein ML, Schultz DW, Edwards A, Matise TC, Rust K, Berselli CB, Trzupek K, Weleber RG, Ott J, Wirtz MK, Acott TS (1998) Age-related macular degeneration: clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol 116:1082-1088
12. Klein R, Klein BE, Linton KL (1992) Prevalence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 99:933-943
13. Klein R, Klein BE, Tomany SC, Meuer SM, Huang GH (2002) Ten-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 109:1767-1779
14. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
15. Li YJ, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, Watts RL, et al (2002) Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 70:985-993
16. Majewski J, Li H, Ott J (2001) The Ising model in physics and statistical genetics. Am J Hum Genet 69:853-862
17. McPeek MS (1999) Optimal allele-sharing statistics for genetic mapping using affected relatives. Genet Epidemiol 16:225-249
18. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266
19. Ott J (1999) Analysis of human genetic linkage. Johns Hopkins University Press, Baltimore
20. Terwilliger J, Ott J (1994) Handbook of human genetic linkage. Johns Hopkins University Press, Baltimore
21. Weeks DE, Conley YP, Mah TS, Paul TO, Morse L, Ngo-Chang J, Dailey JP, Ferrell RE, Gorin MB (2000) A full genome scan for age-related maculopathy. Hum Mol Genet 9:1329-1349
22. Weeks DE, Conley YP, Tsai HJ, Mah TS, Rosenfeld PJ, Paul TO, Eller AW, Morse LS, Dailey JP, Ferrell RE, Gorin MB (2001) Age-related maculopathy: an expanded genomewide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions. Am J Ophthalmol 132:682-692
23. Whittemore AS, Halpern J (2001) Problems in the definition, interpretation, and evaluation of genetic heterogeneity. Am J Hum Genet 68:457-465
24. Williamson JA, Amos CI (1995) Guess LOD approach: sufficient conditions for robustness. Genet Epidemiol 12:163-176