ITCH deficiency protects from diet-induced obesity

Diabetes

Volumn 63, Issue 2, 2014, Pages 550-561

  Marino, Arianna ^a   Menghini, Rossella ^a   Fabrizi, Marta ^a   Casagrande, Viviana ^a   Mavilio, Maria ^a   Stoehr, Robert ^a   Candi, Eleonora ^a   Mauriello, Alessandro ^a   Moreno Navarrete, Jose M ^b   Gómez Serrano, María ^c   Peral, Belén ^c   Melino, Gerry ^a,d   Lauro, Renato ^a   Fernandez Real, Jose M ^b   Federici, Massimo ^a,e  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b HOSPITAL JOSEP TRUETA   (Spain)

^c INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^d MEDICAL RESEARCH COUNCIL   (United Kingdom)

^e TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; INSULIN; ITCH PROTEIN; PROTEIN M2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALORIMETRY; CELL POLARITY; CONTROLLED STUDY; DIETARY INTAKE; FATTY ACID OXIDATION; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INSULIN RESISTANCE; LIPID DIET; METABOLIC DISORDER; METABOLISM; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; TH2 CELL; WILD TYPE;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; BIOLOGICAL MARKERS; DIETARY FATS; GENE EXPRESSION REGULATION; HUMANS; LECTINS, C-TYPE; LIVER; MACROPHAGES, PERITONEAL; MANNOSE-BINDING LECTINS; MICE; MICE, KNOCKOUT; OBESITY; RECEPTORS, CELL SURFACE; UBIQUITIN-PROTEIN LIGASES;

EID: 84893046564     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0802     Document Type: Article

References (37)

1. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808
2. Stefan N, Häring HU. The metabolically benign and malignant fatty liver. Diabetes 2011;60:2011-2017
3. Fernández-Real JM, Pickup JC. Innate immunity, insulin resistance and type 2 diabetes. Diabetologia 2012;55:273-278
4. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011;29:415-445
5. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012;18:363-374
6. Biswas SK, Mantovani A. Orchestration of metabolism by macrophages. Cell Metab 2012;15:432-437
7. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012;122:787-795
8. Harford KA, Reynolds CM, McGillicuddy FC, Roche HM. Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue. Proc Nutr Soc 2011;70:408-417
9. Lacy-Hulbert A, Moore KJ. Designer macrophages: oxidative metabolism fuels inflammation repair. Cell Metab 2006;4:7-8
10. Perry WL, Hustad CM, Swing DA, O'Sullivan TN, Jenkins NA, Copeland NG. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet 1998;18:143-146
11. Melino G, Gallagher E, Aqeilan RI, et al. Itch: a HECT-type E3 ligase regulating immunity, skin and cancer. Cell Death Differ 2008;15:1103-1112
12. Fang D, Elly C, Gao B, et al. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol 2002;3:281-287
13. Parravicini V, Field AC, Tomlinson PD, Basson MA, Zamoyska R. Itch-/-alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice. Blood 2008;111:4273-7282
14. Casagrande V, Menghini R, Menini S, et al. Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 2012;32:74-81
15. Menghini R, Menini S, Amoruso R, et al. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 2009;136:663-672, e4
16. Menghini R, Casagrande V, Menini S, et al. TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. Diabetes 2012;61:454-462
17. Zhang X, Goncalves R, Mosser DM. The isolation and characterization of murine macrophages. Curr Protoc Immunol 2008;Chapter 14:Unit 14.1
18. Menghini R, Marchetti V, Cardellini M, et al. Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissuerelated inflammation: a novel pathway linking obesity to atherosclerosis. Circulation 2005;111:1946-1953
19. Karlmark KR, Zimmermann HW, Roderburg C, et al. The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepathology 2010;52:1769-1782
20. Odegaard JI, Chawla A. Alternative macrophage activation and metabolism. Annu Rev Pathol 2011;6:275-297
21. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007;447:1116-1120
22. Chawla A, Nguyen KD, Goh YP. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 2011;11:738-749
23. Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol 2012;13:707-712
24. Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013; 229:176-185
25. Nguyen KD, Qiu Y, Cui X, et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 2011;480: 104-108
26. Stanya KJ, Jacobi D, Liu S, et al. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest 2013;123:261-271
27. Yang Z, Grinchuk V, Smith A, et al. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infect Immun 2013;81:1905-1914
28. MacLean E, Madsen N, Vliagoftis H, Field C, Cameron L. n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. Br J Nutr 2013;109:990-1000
29. Maijó M, Miró L, Polo J, et al. Dietary plasma proteins modulate the adaptive immune response in mice with acute lung inflammation. J Nutr 2012;142:264-270
30. Monroy A, Kamath S, Chavez AO, et al. Impaired regulation of the TNFalpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Diabetologia 2009;52:2169-2181
31. Tripathy D, Daniele G, Fiorentino TV, et al. Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study. Diabetologia 2013;56:2153-2163
32. Oberst A, Rossi M, Salomoni P, et al. Regulation of the p73 protein stability and degradation. Biochem Biophys Res Commun 2005;331:707-712
33. Rossi M, De Laurenzi V, Munarriz E, et al. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 2005;24:836-848
34. Lapi E, Di Agostino S, Donzelli S, et al. PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. Mol Cell 2008;32:803-814
35. Ito K, Carracedo A, Weiss D, et al. A PML-PPAR-d pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med 2012; 18:1350-1358
36. Carracedo A, Weiss D, Leliaert AK, et al. A metabolic prosurvival role for PML in breast cancer. J Clin Invest 2012;122:3088-3100
37. Tomasini R, Secq V, Pouyet L, et al. TAp73 is required for macrophagemediated innate immunity and the resolution of inflammatory responses. Cell Death Differ 2013;20:293-301