α-Asarone ameliorates memory deficit in lipopolysaccharide-treated mice via suppression of pro-inflammatory cytokines and microglial activation

Biomolecules and Therapeutics

Volumn 22, Issue 1, 2014, Pages 17-26

  Shin, Jung Won ^a   Cheong, Young Jin ^a   Koo, Yong Mo ^a   Kim, Sooyong ^a   Noh, Chung Ku ^a   Son, Young Ha ^a   Kang, Chulhun ^a   Sohn, Nak Won ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Il 1 ; Memory deficit; Microglial activation; Neuroinflammation; Tnf ; Asarone

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; ALPHA ASARONE; BETA SECRETASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SIZE; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MORRIS WATER MAZE TEST; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; TASK PERFORMANCE; UPREGULATION;

EID: 84893027510     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2013.102     Document Type: Article

References (43)

1. Alvarez, A., Cacabelos, R., Sanpedro, C., Garcia-Fantini, M. and Aleixandre, M. (2007) Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease. Neurobiol. Aging 28, 533-536.
2. Baier, P. C., May, U., Scheller, J., Rose-John, S. and Schiffelholz, T. (2009) Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice. Behav. Brain Res. 200, 192-196.
3. Belarbi, K., Jopson, T., Tweedie, D., Arellano, C., Luo, W., Greig, N. H. and Rosi, S. (2012) TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J. Neuroinflammation 9, 23.
4. Blasko, I., Marx, F., Steiner, E., Hartmann, T. and Grubeck-Loebenstein, B. (1999) TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J. 13, 63-68.
5. Block, M. L., Zecca, L. and Hong, J. S. (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69.
6. Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas-Kramarski, R., Jaffe, E. A., Gandy, S. E. and Greengard, P. (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. U.S.A. 89, 10075-10078.
7. Chen, Q. X., Miao, J. K., Li, C., Li, X. W., Wu, X. M. and Zhang, X. P. (2013) Anticonvulsant activity of acute and chronic treatment with a-asarone from Acorus gramineus in seizure models. Biol. Pharm. Bull. 36, 23-30.
8. Cho, J., Kim, Y. H., Kong, J. Y., Yang, C. H. and Park, C. G. (2002) Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus. Life Sci. 71, 591-599.
9. Choi, M., Kwak, H., Kweon, K., Hwang, J., Shin, J. and Sohn, N. (2013) Effects of β-asarone on pro-inflammatory cytokines and learning and memory impairment in lipopolysaccharide-treated mice. Kor. J. Herbology 28, 119-127.
10. Gallagher, J. J., Minogue, A. M. and Lynch, M. A. (2013) Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Abeta accumulation and microglial activation. Neurodegener. Dis. 11, 33-41.
11. Geng, Y., Li, C., Liu, J., Xing, G., Zhou, L., Dong, M., Li, X. and Niu, Y. (2010) Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Biol. Pharm. Bull. 33, 836-843.
12. Graeber, M. B. and Streit, W. J. (2010) Microglia: biology and pathology. Acta Neuropathol. 119, 89-105.
13. Griffin, R., Nally, R., Nolan, Y., McCartney, Y., Linden, J. and Lynch, M. A. (2006) The age-related attenuation in long-term potentiation is associated with microglial activation. J. Neurochem. 99, 1263-1272.
14. Han, P., Han, T., Peng, W. and Wang, X. R. (2013) Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii. Pharm. Biol. 51, 589-594.
15. Harry, G. J. and Kraft, A. D. (2008) Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment. Expert Opin. Drug Metab. Toxicol. 4, 1265-1277.
16. Hein, A. M., Stutzman, D. L., Bland, S. T., Barrientos, R. M., Watkins, L. R., Rudy, J. W. and Maier, S. F. (2007) Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Neuroscience 150, 754-763.
17. Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T. and Van Leuven, F. (2005) Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J. Neuroinflammation 2, 22.
18. Huang, C., Li, W. G., Zhang, X. B., Wang, L., Xu, T. L., Wu, D. and Li, Y. (2013) a-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors. Neuropharmacology 65, 1-11.
19. Imamura, Y., Wang, H., Matsumoto, N., Muroya, T., Shimazaki, J., Ogura, H. and Shimazu, T. (2011) Interleukin-1beta causes longterm potentiation deficiency in a mouse model of septic encephalopathy. Neuroscience 187, 63-69.
20. Jeong, H. K., Jou, I. and Joe, E. H. (2010) Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Exp. Mol. Med. 42, 823-832.
21. Kim, J. H., Hahm, D. H., Lee, H. J., Pyun, K. H. and Shim, I. (2009) Acori graminei rhizoma ameliorated ibotenic acid-induced amnesia in rats. Evid. Based Complement. Alternat. Med. 6, 457-464.
22. Kumar, H., Kim, B. W., Song, S. Y., Kim, J. S., Kim, I. S., Kwon, Y. S., Koppula, S. and Choi, D. K. (2012) Cognitive enhancing effects of alpha asarone in amnesic mice by influencing cholinergic and antioxidant defense mechanisms. Biosci. Biotechnol. Biochem. 76, 1518-1522.
23. Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W. and Hong, J. T. (2008) Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J. Neuroinflammation 5, 37.
24. Li, C., Xing, G., Dong, M., Zhou, L., Li, J., Wang, G., Zou, D., Wang, R., Liu, J. and Niu, Y. (2010) Beta-asarone protection against beta amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins. Eur. J. Pharmacol. 635, 96-102.
25. Li, Z., Zhao, G., Qian, S., Yang, Z., Chen, X., Chen, J., Cai, C., Liang, X. and Guo, J. (2012) Cerebrovascular protection of beta-asarone in Alzheimer's disease rats: a behavioral, cerebral blood flow, biochemical and genic study. J. Ethnopharmacol. 144, 305-312.
26. Lien, E., Means, T. K., Heine, H., Yoshimura, A., Kusumoto, S., Fukase, K., Fenton, M. J., Oikawa, M., Qureshi, N., Monks, B., Finberg, R. W., Ingalls, R. R. and Golenbock, D. T. (2000) Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J. Clin. Invest. 105, 497-504.
27. Limon, I. D., Mendieta, L., Diaz, A., Chamorro, G., Espinosa, B., Zenteno, E. and Guevara, J. (2009) Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-beta(25-35). Neurosci. Lett. 453, 98-103.
28. Liu, M. C., Liu, X. Q., Wang, W., Shen, X. F., Che, H. L., Guo, Y. Y., Zhao, M. G., Chen, J. Y. and Luo, W. J. (2012a) Involvement of microglia activation in the lead induced long-term potentiation impairment. PLoS One 7, e43924.
29. Liu, S., Chen, S. W., Xu, N., Liu, X. H., Zhang, H., Wang, Y. Z. and Xu, X. D. (2012b). Anxiolytic-like effect of alpha-asarone in mice. Phytother. Res. 26, 1476-1481.
30. Liu, X., Wu, Z., Hayashi, Y. and Nakanishi, H. (2012c) Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation. Neuroscience 216, 133-142.
31. Manikandan, S. and Devi, R. S. (2005) Antioxidant property of alphaasarone against noise-stress-induced changes in different regions of rat brain. Pharmacol. Res. 52, 467-474.
32. Mishra, A., Kim, H. J., Shin, A. H. and Thayer, S. A. (2012) Synapse loss induced by interleukin-1beta requires pre- and post-synaptic mechanisms. J. Neuroimmune Pharmacol. 7, 571-578.
33. Pages, N., Maurois, P., Delplanque, B., Bac, P., Stables, J. P., Tamariz, J., Chamorro, G. and Vamecq, J. (2010) Activities of alpha-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties. Neurosci. Res. 68, 337-344.
34. Park, S. M., Choi, M. S., Sohn, N. W. and Shin, J. W. (2012) Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice. Biol. Pharm. Bull. 35, 1546-1552.
35. Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., van Leuven, F. and Heneka, M. T. (2003) Nonsteroidal antiinflammatory drugs and peroxisome proliferator-activated receptor- gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J. Neurosci. 23, 9796-9804.
36. Sastre, M., Walter, J. and Gentleman, S. M. (2008) Interactions between APP secretases and inflammatory mediators. J. Neuroinflammation 5, 25.
37. Shaw, K. N., Commins, S. and O'Mara, S. M. (2001) Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus. Behav. Brain Res. 124, 47-54.
38. Smith, D. H., Okiyama, K., Thomas, M. J. and McIntosh, T. K. (1993) Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury. J. Neurosci. 13, 5383-5392.
39. Thomson, L. M. and Sutherland, R. J. (2005) Systemic administration of lipopolysaccharide and interleukin-1beta have different effects on memory consolidation. Brain Res. Bull. 67, 24-29.
40. Wei, G., Chen, Y. B., Chen, D. F., Lai, X. P., Liu, D. H., Deng, R. D., Zhou, J. H., Zhang, S. X., Li, Y. W., Lii, H., Liu, L. F., Wang, Q. and Nie, H. (2013) beta-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AbetaPP/PS1 mice. J. Alzheimers Dis. 33, 863-880.
41. Wu, M. D., Montgomery, S. L., Rivera-Escalera, F., Olschowka, J. A. and O'Banion, M. K. (2013) Sustained IL-1beta expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells. Brain Behav. Immun. 32, 9-18.
42. Zhang, H., Han, T., Yu, C. H., Rahman, K., Qin, L. P. and Peng, C. (2007) Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice. J. Pharm. Pharmacol. 59, 301-309.
43. Zou, D. J., Wang, G., Liu, J. C., Dong, M. X., Li, X. M., Zhang, C., Zhou, L., Wang, R. and Niu, Y. C. (2011) Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells. Pharmazie 66, 44-51.