메뉴 건너뛰기




Volumn 92, Issue 2, 2014, Pages 240-248

CFD analysis of interphase mass transfer and energy dissipation in a milliliter-scale stirred-tank reactor for filamentous microorganisms

Author keywords

Computational fluid dynamics; Free surface; Gas liquid two phase flow; Oxygen mass transfer coefficient kLa; Unbaffled stirred tank

Indexed keywords

FILAMENTOUS MICROORGANISMS; FREE SURFACES; GAS-LIQUID TWO-PHASE FLOW; INTER-PHASE MASS TRANSFER; OXYGEN MASS TRANSFER; STIRRED TANK; STIRRED TANK BIOREACTORS; TRANSITIONAL FLOW REGIMES;

EID: 84893016258     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2013.07.024     Document Type: Article
Times cited : (16)

References (53)
  • 1
    • 14544268581 scopus 로고    scopus 로고
    • Large eddy simulation of turbulent flow in an unbaffled stirred tank driven by a Rushton turbine
    • Alcamo R., Micale G., Grisafi F., Brucato A., Ciofalo M. Large eddy simulation of turbulent flow in an unbaffled stirred tank driven by a Rushton turbine. Chem. Eng. Sci. 2005, 60:2303-2316.
    • (2005) Chem. Eng. Sci. , vol.60 , pp. 2303-2316
    • Alcamo, R.1    Micale, G.2    Grisafi, F.3    Brucato, A.4    Ciofalo, M.5
  • 3
    • 1942498795 scopus 로고    scopus 로고
    • Gas-liquid mass transfer coefficient in stirred tanks interpreted through bubble contamination kinetics
    • Alves S.S., Maia C.I., Vasconcelos J.M. Gas-liquid mass transfer coefficient in stirred tanks interpreted through bubble contamination kinetics. Chem. Eng. Process. 2004, 43:823-830.
    • (2004) Chem. Eng. Process. , vol.43 , pp. 823-830
    • Alves, S.S.1    Maia, C.I.2    Vasconcelos, J.M.3
  • 6
    • 0000902282 scopus 로고
    • Comparison of experimental and numerical fluid velocity distribution profiles in an unbaffled mixing vessel provided with pitched-blade turbine
    • Armenante P., Chou C.C., Hemrajani R.R. Comparison of experimental and numerical fluid velocity distribution profiles in an unbaffled mixing vessel provided with pitched-blade turbine. Inst. Chem. Eng. Symp. Ser. 1994, 136:349-356.
    • (1994) Inst. Chem. Eng. Symp. Ser. , vol.136 , pp. 349-356
    • Armenante, P.1    Chou, C.C.2    Hemrajani, R.R.3
  • 7
    • 0031255711 scopus 로고    scopus 로고
    • Velocity profiles in a closed, unbaffled vessel: comparison between experimental LDV data and numerical CFD predictions
    • Armenante P., Luo C., Chou C.C., Fort I., Medek J. Velocity profiles in a closed, unbaffled vessel: comparison between experimental LDV data and numerical CFD predictions. Chem. Eng. Sci. 1997, 52:3483-3492.
    • (1997) Chem. Eng. Sci. , vol.52 , pp. 3483-3492
    • Armenante, P.1    Luo, C.2    Chou, C.C.3    Fort, I.4    Medek, J.5
  • 9
    • 0028082793 scopus 로고
    • A computational model for the gas-liquid flow in stirred reactors
    • Bakker A., Van den Akker H.E.A. A computational model for the gas-liquid flow in stirred reactors. Trans. Inst. Chem. Eng. 1994, 72:594-606.
    • (1994) Trans. Inst. Chem. Eng. , vol.72 , pp. 594-606
    • Bakker, A.1    Van den Akker, H.E.A.2
  • 10
    • 0032215763 scopus 로고    scopus 로고
    • Numerical prediction of flow fields in baffled stirred vessels. A comparison of alternative modelling approached
    • Brucato A., Ciofalo M., Grisafi F., Micale G. Numerical prediction of flow fields in baffled stirred vessels. A comparison of alternative modelling approached. Chem. Eng. Sci. 1998, 53:3653-3684.
    • (1998) Chem. Eng. Sci. , vol.53 , pp. 3653-3684
    • Brucato, A.1    Ciofalo, M.2    Grisafi, F.3    Micale, G.4
  • 11
    • 0030176876 scopus 로고    scopus 로고
    • Turbulent flow in closed and free-surface unbaffled tanks stirred by radial impeller
    • Ciofalo M., Brucato A., Grisafi F., Torraca N. Turbulent flow in closed and free-surface unbaffled tanks stirred by radial impeller. Chem. Eng. Sci. 1996, 51:3557-3573.
    • (1996) Chem. Eng. Sci. , vol.51 , pp. 3557-3573
    • Ciofalo, M.1    Brucato, A.2    Grisafi, F.3    Torraca, N.4
  • 13
    • 2942565815 scopus 로고    scopus 로고
    • Flow generated by an aerated rushton impeller: two-phase PIV experiments and numerical simulations
    • Deen N.G., Solberg T., Hjertager B.H. Flow generated by an aerated rushton impeller: two-phase PIV experiments and numerical simulations. Can. J. Chem. Eng. 2002, 80:1-15.
    • (2002) Can. J. Chem. Eng. , vol.80 , pp. 1-15
    • Deen, N.G.1    Solberg, T.2    Hjertager, B.H.3
  • 14
    • 0030152087 scopus 로고    scopus 로고
    • Numerical computation of turbulent gas-liquid dispersion in mechanically agitated vessels
    • Djebbar R., Roustan M., Liné A. Numerical computation of turbulent gas-liquid dispersion in mechanically agitated vessels. Trans. Inst. Chem. Eng. 1996, 74:492-498.
    • (1996) Trans. Inst. Chem. Eng. , vol.74 , pp. 492-498
    • Djebbar, R.1    Roustan, M.2    Liné, A.3
  • 15
    • 0028519677 scopus 로고
    • Flow induced by an impeller in an unbaffled tank - II. Numerical modelling
    • Dong L., Johansen S.T., Engh T.A. Flow induced by an impeller in an unbaffled tank - II. Numerical modelling. Chem. Eng. Sci. 1994, 49:3511-3518.
    • (1994) Chem. Eng. Sci. , vol.49 , pp. 3511-3518
    • Dong, L.1    Johansen, S.T.2    Engh, T.A.3
  • 17
    • 34547137887 scopus 로고    scopus 로고
    • Biocatalytic ketone reduction - a powerful tool for the production of chiral alcohols - Part II. Whole-cell reductions
    • Goldberg K., Schroer K., Lutz S., Liese A. Biocatalytic ketone reduction - a powerful tool for the production of chiral alcohols - Part II. Whole-cell reductions. Appl. Microbiol. Biotechnol. 2007, 76:249-255.
    • (2007) Appl. Microbiol. Biotechnol. , vol.76 , pp. 249-255
    • Goldberg, K.1    Schroer, K.2    Lutz, S.3    Liese, A.4
  • 18
    • 33646371509 scopus 로고    scopus 로고
    • Modeling turbulent flows with free-surface in unbaffled agitated vessels
    • Haque J.N., Mahmud T., Roberts K.J., Rhodes D. Modeling turbulent flows with free-surface in unbaffled agitated vessels. Ind. Eng. Chem. Res. 2006, 45:2881-2891.
    • (2006) Ind. Eng. Chem. Res. , vol.45 , pp. 2881-2891
    • Haque, J.N.1    Mahmud, T.2    Roberts, K.J.3    Rhodes, D.4
  • 19
    • 0019367877 scopus 로고
    • Volume of fluid (VOF) method for the dynamics of free boundaries
    • Hirt C.W., Nichols B.D. Volume of fluid (VOF) method for the dynamics of free boundaries. J. Comput. Phys. 1981, 39:201-225.
    • (1981) J. Comput. Phys. , vol.39 , pp. 201-225
    • Hirt, C.W.1    Nichols, B.D.2
  • 20
    • 77956225483 scopus 로고    scopus 로고
    • Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16
    • Hoefel T., Wittmann E., Reinecke L., Weuster-Botz D. Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16. Appl. Microbiol. Biotechnol. 2010, 88:477-484.
    • (2010) Appl. Microbiol. Biotechnol. , vol.88 , pp. 477-484
    • Hoefel, T.1    Wittmann, E.2    Reinecke, L.3    Weuster-Botz, D.4
  • 21
    • 77953576190 scopus 로고    scopus 로고
    • New milliliter-scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms
    • Hortsch R., Stratmann A., Weuster-Botz D. New milliliter-scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms. Biotechnol. Bioeng. 2010, 106:443-451.
    • (2010) Biotechnol. Bioeng. , vol.106 , pp. 443-451
    • Hortsch, R.1    Stratmann, A.2    Weuster-Botz, D.3
  • 22
    • 77956132496 scopus 로고    scopus 로고
    • Milliliter-scale stirred tank reactors for the cultivation of microorganisms
    • Academic Press, Burlington
    • Hortsch R., Weuster-Botz D. Milliliter-scale stirred tank reactors for the cultivation of microorganisms. Advances in Applied Microbiology 2010, 73:61-82. Academic Press, Burlington.
    • (2010) Advances in Applied Microbiology , vol.73 , pp. 61-82
    • Hortsch, R.1    Weuster-Botz, D.2
  • 23
    • 79955933278 scopus 로고    scopus 로고
    • Process performance of parallel bioreactors for batch cultivation of Streptomyces tendae
    • Hortsch R., Krispin H., Weuster-Botz D. Process performance of parallel bioreactors for batch cultivation of Streptomyces tendae. Bioprocess Biosyst. Eng. 2011, 34:297-304.
    • (2011) Bioprocess Biosyst. Eng. , vol.34 , pp. 297-304
    • Hortsch, R.1    Krispin, H.2    Weuster-Botz, D.3
  • 25
    • 0026864050 scopus 로고
    • Liquid-phase mass transfer coefficients in bioreactors
    • Kawase Y., Halard B., Moo-Young M.B. Liquid-phase mass transfer coefficients in bioreactors. Biotechnol. Bioeng. 1992, 39:1133-1140.
    • (1992) Biotechnol. Bioeng. , vol.39 , pp. 1133-1140
    • Kawase, Y.1    Halard, B.2    Moo-Young, M.B.3
  • 26
    • 33846927258 scopus 로고    scopus 로고
    • Scale down and parallel operation of the riboflavin production process with Bacillus subtilis
    • Knorr B., Schlieker H., Hohman H.P., Weuster-Botz D. Scale down and parallel operation of the riboflavin production process with Bacillus subtilis. Biochem. Eng. J. 2007, 33:263-274.
    • (2007) Biochem. Eng. J. , vol.33 , pp. 263-274
    • Knorr, B.1    Schlieker, H.2    Hohman, H.P.3    Weuster-Botz, D.4
  • 27
    • 30344447253 scopus 로고    scopus 로고
    • Effect of internals on the flow pattern and mixing in stirred tanks
    • Kumaresan T., Nere N.K., Joshi J.B. Effect of internals on the flow pattern and mixing in stirred tanks. Ind. Eng. Chem. Res. 2005, 44:9951-9961.
    • (2005) Ind. Eng. Chem. Res. , vol.44 , pp. 9951-9961
    • Kumaresan, T.1    Nere, N.K.2    Joshi, J.B.3
  • 29
    • 25644455240 scopus 로고    scopus 로고
    • Validation of bubble breakage, coalescence and mass transfer models for gas-liquid dispersion in agitated vessels
    • Laakkonen M., Alopaeus V., Aittamaa J. Validation of bubble breakage, coalescence and mass transfer models for gas-liquid dispersion in agitated vessels. Chem. Eng. Sci. 2006, 61:218-228.
    • (2006) Chem. Eng. Sci. , vol.61 , pp. 218-228
    • Laakkonen, M.1    Alopaeus, V.2    Aittamaa, J.3
  • 31
    • 0014819677 scopus 로고
    • An eddy cell model of mass transfer into the surface of a turbulent liquid
    • Lamont J.C., Scott D.S. An eddy cell model of mass transfer into the surface of a turbulent liquid. AIChE J. 1970, 16:513-519.
    • (1970) AIChE J. , vol.16 , pp. 513-519
    • Lamont, J.C.1    Scott, D.S.2
  • 32
    • 0036474753 scopus 로고    scopus 로고
    • Predicting gas-liquid flow in a mechanically stirred tank
    • Lane G.L., Schwartz M.P., Evans G.M. Predicting gas-liquid flow in a mechanically stirred tank. Appl. Math. Model. 2002, 26:223-235.
    • (2002) Appl. Math. Model. , vol.26 , pp. 223-235
    • Lane, G.L.1    Schwartz, M.P.2    Evans, G.M.3
  • 33
    • 68949088150 scopus 로고    scopus 로고
    • Review of the shear-stress transport turbulence model experience from an industrial perspective
    • Menter F.R. Review of the shear-stress transport turbulence model experience from an industrial perspective. Int. J. Comput. Fluid Dynam. 2009, 23:305-316.
    • (2009) Int. J. Comput. Fluid Dynam. , vol.23 , pp. 305-316
    • Menter, F.R.1
  • 34
    • 33846083188 scopus 로고    scopus 로고
    • Modeling aerated fermenters with computational fluid dynamics
    • Moilanen P., Laakkonen M., Aittamaa J. Modeling aerated fermenters with computational fluid dynamics. Ind. Eng. Chem. Res. 2006, 45:8656-8663.
    • (2006) Ind. Eng. Chem. Res. , vol.45 , pp. 8656-8663
    • Moilanen, P.1    Laakkonen, M.2    Aittamaa, J.3
  • 35
    • 0036661460 scopus 로고    scopus 로고
    • CFD study of power and mixing time for paddle mixing in unbaffled vessels
    • Murthy Shekhar S., Jayanti S. CFD study of power and mixing time for paddle mixing in unbaffled vessels. Chem. Eng. Res. Des. 2002, 80:482-498.
    • (2002) Chem. Eng. Res. Des. , vol.80 , pp. 482-498
    • Murthy Shekhar, S.1    Jayanti, S.2
  • 39
    • 0034011574 scopus 로고    scopus 로고
    • Understanding the morphology of fungi
    • Pazouki M., Panda T. Understanding the morphology of fungi. Bioprocess. Eng. 2000, 22:127-143.
    • (2000) Bioprocess. Eng. , vol.22 , pp. 127-143
    • Pazouki, M.1    Panda, T.2
  • 40
    • 15944379153 scopus 로고    scopus 로고
    • Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD)
    • Puskeiler R., Kaufmann K., Weuster-Botz D. Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). Biotechnol. Bioeng. 2005, 89:512-523.
    • (2005) Biotechnol. Bioeng. , vol.89 , pp. 512-523
    • Puskeiler, R.1    Kaufmann, K.2    Weuster-Botz, D.3
  • 41
    • 28644436489 scopus 로고    scopus 로고
    • Miniature bioreactors for automated high-throughput bioprocess design (HTBD): reproducibility of parallel fed-batch cultivations with Escherichia coli
    • Puskeiler R., Kusterer A., John G.T., Weuster-Botz D. Miniature bioreactors for automated high-throughput bioprocess design (HTBD): reproducibility of parallel fed-batch cultivations with Escherichia coli. Biotechnol. Appl. Biochem. 2005, 42:227-235.
    • (2005) Biotechnol. Appl. Biochem. , vol.42 , pp. 227-235
    • Puskeiler, R.1    Kusterer, A.2    John, G.T.3    Weuster-Botz, D.4
  • 42
    • 0033165985 scopus 로고    scopus 로고
    • Gas-liquid flow in stirred reactors: trailing vortices and gas accumulation behind impeller blades
    • Ranade V.V., Deshpande V.R. Gas-liquid flow in stirred reactors: trailing vortices and gas accumulation behind impeller blades. Chem. Eng. Sci. 1999, 54:2305-2315.
    • (1999) Chem. Eng. Sci. , vol.54 , pp. 2305-2315
    • Ranade, V.V.1    Deshpande, V.R.2
  • 43
    • 0035520654 scopus 로고    scopus 로고
    • Influence of gas flowrate on the structure of trailing vortices of a rushton turbine: PIV measurements and CFD simulations
    • Ranade V.V., Perrard M., Xuereb C., Le Sauze N., Bertrand J. Influence of gas flowrate on the structure of trailing vortices of a rushton turbine: PIV measurements and CFD simulations. Trans. Inst. Chem. Eng. 2001, 79:957-964.
    • (2001) Trans. Inst. Chem. Eng. , vol.79 , pp. 957-964
    • Ranade, V.V.1    Perrard, M.2    Xuereb, C.3    Le Sauze, N.4    Bertrand, J.5
  • 44
    • 0000202520 scopus 로고
    • The deferred approach to the limit. Part I. Single lattice. Part II. Interpenetrating lattices
    • Richardson L.F., Gaunt J.A. The deferred approach to the limit. Part I. Single lattice. Part II. Interpenetrating lattices. Philos. T. Roy. Soc. A 1927, 226:299-361.
    • (1927) Philos. T. Roy. Soc. A , vol.226 , pp. 299-361
    • Richardson, L.F.1    Gaunt, J.A.2
  • 47
    • 0025420058 scopus 로고
    • The effect of agitation on the morphology and penicillin production of Penicillium chrysogenum
    • Smith J.J., Lilly M.D., Fox R.I. The effect of agitation on the morphology and penicillin production of Penicillium chrysogenum. Biotechnol. Bioeng. 1990, 35:1011-1023.
    • (1990) Biotechnol. Bioeng. , vol.35 , pp. 1011-1023
    • Smith, J.J.1    Lilly, M.D.2    Fox, R.I.3
  • 48
    • 33846859772 scopus 로고    scopus 로고
    • Modeling of oxygen mass transfer in a gas-liquid airlift reactor
    • Talvy S., Cockx A., Line A. Modeling of oxygen mass transfer in a gas-liquid airlift reactor. AIChE J. 2007, 53:316-326.
    • (2007) AIChE J. , vol.53 , pp. 316-326
    • Talvy, S.1    Cockx, A.2    Line, A.3
  • 49
    • 63649121527 scopus 로고    scopus 로고
    • An introduction to computational fluid dynamics
    • Pearson Education Ltd., Harlow
    • Versteeg H.K., Malalasekera W. An introduction to computational fluid dynamics. The Finite Volume Method 2007, Pearson Education Ltd., Harlow. 2nd ed.
    • (2007) The Finite Volume Method
    • Versteeg, H.K.1    Malalasekera, W.2
  • 50
    • 68349085774 scopus 로고    scopus 로고
    • Discrimination of riboflavin producing Bacillus subtilis strains based on their fed-batch process performances on a milliliter-scale
    • Vester A., Hans M., Hohmann H.P., Weuster-Botz D. Discrimination of riboflavin producing Bacillus subtilis strains based on their fed-batch process performances on a milliliter-scale. Appl. Microbiol. Biotechnol. 2009, 84:71-76.
    • (2009) Appl. Microbiol. Biotechnol. , vol.84 , pp. 71-76
    • Vester, A.1    Hans, M.2    Hohmann, H.P.3    Weuster-Botz, D.4
  • 51
    • 0034752042 scopus 로고    scopus 로고
    • How many antibiotics are produced by the genus Streptomycesα
    • Watve M.G., Tickoo R., Jog M.M., Bhole B.D. How many antibiotics are produced by the genus Streptomycesα. Arch. Microbiol. 2001, 176:386-390.
    • (2001) Arch. Microbiol. , vol.176 , pp. 386-390
    • Watve, M.G.1    Tickoo, R.2    Jog, M.M.3    Bhole, B.D.4
  • 53
    • 1042278473 scopus 로고    scopus 로고
    • Scale-up from Miniplants
    • Zlokarnik M. Scale-up from Miniplants. Chem. Eng. Technol. 2004, 27:23-27.
    • (2004) Chem. Eng. Technol. , vol.27 , pp. 23-27
    • Zlokarnik, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.