Discrimination of riboflavin producing Bacillus subtilis strains based on their fed-batch process performances on a millilitre scale

Applied Microbiology and Biotechnology

Volumn 84, Issue 1, 2009, Pages 71-76

  Vester, Andrea ^a   Hans, Michael ^b   Hohmann, Hans Peter ^b   Weuster Botz, Dirk ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

Bacillus subtilis; Bioreaction block; Discrimination; Fermentation; Parallel; Riboflavin

Indexed keywords

BACILLUS SUBTILIS; BIOREACTION BLOCK; DISCRIMINATION; PARALLEL; RIBOFLAVIN;

BACTERIOLOGY; FERMENTATION; FOOD ADDITIVES; LAW ENFORCEMENT;

BATCH DATA PROCESSING;

RIBOFLAVIN;

BACTERIUM; FERMENTATION; PERFORMANCE ASSESSMENT; VITAMIN;

ARTICLE; AUTOMATION; BACILLUS SUBTILIS; BACTERIAL STRAIN; CONTROLLED STUDY; FED BATCH FERMENTATION; FERMENTATION MONITORING; NONHUMAN; STIRRED REACTOR;

BACILLUS SUBTILIS; BIOREACTORS; CULTURE TECHNIQUES; FERMENTATION; RIBOFLAVIN;

BACILLUS SUBTILIS;

EID: 68349085774     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-1966-z     Document Type: Article

References (15)

1. J Betts S Doig F Baganz 2006 Characterization and application of a miniature 10 mL stirred-tank bioreactor, showing scale-down equivalence with a conventional 7 L reactor Biotechnol Prog 22 681 688
2. P Harms Y Kostov J French M Soliman M Anjanappa A Ram G Rao 2006 Design and performance of a 24-station high throughput microbioreactor Biotechnol Bioeng 93 6 13
3. M Hümbelin V Griesser T Keller W Schurter M Haiker H-P Hohmann H Ritz G Richter A Bacher APGM van Loon 1999 GTP cyclohydrolase II and 3, 4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production J Indust Microbiol Biotechnol 22 1 7
4. B Knorr H Schlieker H-P Hohmann D Weuster-Botz 2007 Scale-down and parallel operation of the riboflavin production process with Bacillus subtilis Biochem Eng J 33 263 274
5. Y Kostov P Harms L Randers-Eichhorn G Rao 2001 Low-cost microbioreactor for high-throughput bioprocessing Biotechnol Bioeng 72 346 352
6. A Kusterer C Krause K Kaufmann M Arnold D Weuster-Botz 2008 Fully automated single-use stirred-tank bioreactors for parallel microbial cultivations Bioproc Biosyst Eng 31 207 215
7. SR Lamping H Zhang B Allen PA Shamlou 2003 Design of a prototype miniature bioreactor for high throughput automated bioprocessing Chem Eng Sci 58 747 758
8. Lehmann M (2007): Modified transketolase and use thereof. European patent number WO 2007/051552 A1).
9. H Link D Weuster-Botz 2006 Genetic algorithm for multi-objective experimental optimization Bioproc Biosyst Eng 29 385 390
10. J Perkins A Sloma T Hermann K Thieriault E Zachgo T Erdenberger N Hannet N Chatterjee V Williams G Rufo R Hatch J Pero 1999 Genetic engineering of Bacillus subtilis for the commercial production of riboflavin J Indust Microbiol Biotechnol 22 8 12
11. R Puskeiler K Kaufmann D Weuster-Botz 2005 Development, parallelization and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD) Biotechnol Bioeng 89 512 523
12. R Puskeiler A Kusterer G John D Weuster-Botz 2005 Miniature bioreactors for automated high-throughput bioprocess design (HTBD): Reproducibility of parallel fed-batch cultivations with Escherichia coli Biotechnol Appl Biochem 42 227 235
13. Rudolf M, Kulisch W (2008) Biostatistik. Pearson Studium, München
14. J Vallejos Y Kostov A Ram J French M Marten G Rao 2006 Optical analysis of liquid mixing in a minibioreactor Biotechnol Bioeng 93 906 911
15. D Weuster-Botz R Puskeiler A Kusterer K Kaufmann G John M Arnold 2005 Methods and milliliter scale devices for high-throughput bioprocess design Bioproc Biosyst Eng 28 109 119