Process performance of parallel bioreactors for batch cultivation of Streptomyces tendae

Bioprocess and Biosystems Engineering

Volumn 34, Issue 3, 2011, Pages 297-304

  Hortsch, Ralf ^a   Krispin, Harald ^a   Weuster Botz, Dirk ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Milliliter bioreactor; Nikkomycin Z; Rheology; Shear rate; Viscosity

Indexed keywords

APPARENT VISCOSITY; BATCH CULTIVATION; BIOPROCESSES; BIOREACTOR SYSTEM; CULTURE BROTHS; DIFFERENT SCALE; DRY CELLS; ENGINEERING CHARACTERISTICS; LOWER AVERAGE; MICROTITER PLATES; MILLILITER BIOREACTOR; NIKKOMYCIN; NIKKOMYCIN Z; NON-NEWTONIAN; OXYGEN LIMITATION; PROCESS DEVELOPMENT; PROCESS PERFORMANCE; PROCESS TIME; PRODUCT CONCENTRATION; PRODUCT FORMATION; REACTOR SYSTEMS; RHEOLOGICAL BEHAVIORS; SCALE-UP; SHAKE FLASK CULTIVATIONS; SHAKE FLASKS; SHEAR RATE; SHEAR-THINNING BEHAVIOR; SIMPLE METHOD; STIRRED TANK REACTORS; STREPTOMYCES TENDAE;

BACTERIA; BATCH REACTORS; BIOCONVERSION; BOTTLES; CELL CULTURE; NON NEWTONIAN FLOW; RHEOLOGY; SHEAR DEFORMATION; TANKS (CONTAINERS); VISCOSITY;

BIOREACTORS;

NIKKOMYCIN Z;

ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; BATCH REACTOR; BIOPROCESS; BIOREACTOR DESIGN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; INTERMETHOD COMPARISON; MICROBIAL ACTIVITY; MICROTITER PLATE ASSAY; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; REACTOR OPERATION; SHEAR RATE; SPECIES CULTIVATION; STIRRED REACTOR; STREPTOMYCES; STREPTOMYCES TENDAE; VALIDATION PROCESS;

AMINOGLYCOSIDES; BIOREACTORS; BIOTECHNOLOGY; CULTURE TECHNIQUES; EQUIPMENT DESIGN; KINETICS; RHEOLOGY; SHEAR STRENGTH; STREPTOMYCES; VISCOSITY;

STREPTOMYCES TENDAE;

EID: 79955933278     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-010-0471-1     Document Type: Article

References (39)

1. Watve MG, Tickoo R, Jog MM, Bhole BD (2001) How many antibiotics are produced by the genus Streptomyces? Arch Microbiol 176:386-390
2. Ishige T, Honda K, Shimizu S (2005) Whole organism biocatalysis. Curr Opin Biotechnol 9:174-180 (Pubitemid 40462487)
3. Goldberg K, Schroer K, Lütz S, Liese A (2007) Biocatalytic ketone reduction - a powerful tool for the production of chiral alcohols - part II: whole-cell reductions. Appl Microbiol Biotechnol 76:249-255 (Pubitemid 47101672)
4. Papagianni M (2004) Fungal morphology and metabolite production in submerged mycelial processes. Biotechnol Adv 22:189-259
5. Nevalainen KMH, Te'o VSJ, Bergquist PL (2005) Heterologous protein expression in filamentous fungi. TIBTECH 23:468-474
6. Weuster-Botz D (2005) Parallel reactor systems for bioprocess development. In: Scheper T (ed) Advances in biochem engineering/biotechnology 92. Springer, Berlin, pp 125-144
7. Hortsch R, Weuster-Botz D (2010) Milliliter-scale stirred tank reactors for the cultivation of microorganisms. Adv Appl Microbiol 73:61-82
8. Hortsch R, Stratmann A, Weuster-Botz D (2010) New milliliterscale stirred tank bioreactors for the cultivation of mycelium forming microorganisms. Biotechnol Bioeng 106:443-451
9. Pollard DJ, Hunt G, Kirschner TK, Salmon PM (2002) Rheological characterization of a fungal fermentation for the production of pneumocandins. Bioprocess Biosys Eng 24:373-383
10. Riley GL, Tucker KG, Paul GC, Thomas CR (2000) Effect of biomass concentration and mycelial morphology on fermentation broth rheology. Biotechnol Bioeng 68:161-172
11. Nienow AW (1990) Agitators for mycelial fermentations. TIBTECH 8:224-233
12. La) in batch cultivations involving non-Newtonian broths. Biochem Eng J 8:111-119
13. Junker B, Walker A, Hesse M, Lester M, Vesey D, Christensen J, Burgess B, Connors N (2008) Pilot-scale process development and scale up for antifungal production. Bioprocess Biosyst Eng 32:445-458
14. Nix DE, Swezey RR, Hector R, Galgiani JN (2009) Pharmacokinetics of nikkomycin Z after single rising oral doses. Antimicrob Agents Chemother 53:2517-2521
15. Weuster-Botz D, Puskeiler R, Kusterer A, Kaufmann K, John GT, Arnold M (2005) Methods and milliliter scale devices for highthroughput bioprocess design. Bioprocess Biosyst Eng 28:109-119 (Pubitemid 41749732)
16. Büchs J, Lotter S, Milbradt C (2001) Out-of-phase operating conditions, a hitherto unknown phenomenon in shaking bioreactors. Biochem Eng J 7:135-141 (Pubitemid 32162701)
17. Peter CP, Lotter S, Maier U, Büchs J (2004) Impact of out-ofphase conditions on screening results in shaking flask experiments. Biochem Eng J 17:205-215 (Pubitemid 38201457)
18. Galindo E, Flores C, Larralde-Corona P, Corkidi-Blanco G, Rocha-Valadez JA, Serrano-Carreon L (2004) Production of 6- pentyl-α-pyrone by Trichoderma harzianum cultured in unbaffled and baffled shake flasks. Biochem Eng J 18:1-8 (Pubitemid 38317122)
19. Metzner AB, Otto RE (1957) Agitation of non-Newtonian fluids. AIChE J 3:3-10
20. Hortsch R, Weuster-Botz D (2010) Power consumption and maximum energy dissipation in a milliliter-scale bioreactor. Biotechnol Prog 26:595-599
21. Hermann R, Lehmann M, Büchs J (2003) Characterization of gas - liquid mass transfer phenomena in microtiter plates. Biotechnol Bioeng 81:178-186 (Pubitemid 36077294)
22. Zhang H, Lamping SR, Pickering SCR, Lye GJ, Shamlou PA (2008) Engineering characterisation of a single well from 24-well and 96-well microtitre plates. Biochem Eng J 40:138-149
23. Barrett TA, Wu A, Zhang H, Levy MS, Lye GJ (2010) Microwell engineering characterization for mammalian cell culture process development. Biotechnol Bioeng 105:260-275
24. Schüz T, Fiedler HP, Zähner H (1993) Optimized nikkomycin production by fed-batch and continuous fermentation. Appl Microbiol Biotechnol 39:433-437
25. Bruntner C, Lauer B, Schwarz W, Möhrle V, Bormann C (1999) Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety of the peptidyl nucleoside antibiotic nikkomycin. Mol Gen Genet 262:102-114 (Pubitemid 29423907)
26. John GT, Klimant I, Wittmann C, Heinzle E (2003) Integrated optical sensing of dissolved oxygen in microtiter plates: a novel tool for microbial cultivation. Biotechnol Bioeng 81:829-836 (Pubitemid 36313721)
27. Samorski M, Müller-Newen G, Büchs J (2005) Quasi-continuous combined scattered light and fluorescence measurements: a novel measurement technique for shaken microtiter plates. Biotechnol Bioeng 92:61-68 (Pubitemid 41657588)
28. Allen DG, Robinson CW (1990) Measurement of rheological properties of filamentous fermentation broths. Chem Eng Sci 45:37-48
29. Olsvik E, Kristiansen B (1994) Rheology of filamentous fermentations. Biotechnol Adv 12:1-39
30. Warren SJ, Keshavaz-Moore E, Shamlou PA, Lilly MD, Thomas CR, Dixon K (1995) Rheologies and morphologies of three actinomycetes in submerged culture. Biotechnol Bioeng 45:80-85
31. Kelly W, Gigas B (2003) Using CFD to predict the behaviour of power law fluids near axial-flow impellers operation in the transitional flow regime. Chem Eng Sci 58:2141-2152 (Pubitemid 36610895)
32. Perez JAS, Porcel EMR, López JLC, Sevilla JMF, Chisti Y (2006) Shear rate in stirred tank and bubble column bioreactors. Chem Eng J 124:1-5
33. Campesi A, Cerri MO, Hokka CO, Badino A (2008) Determination of the average shear rate in a stirred and aerated tank bioreactor. Bioprocess Biosys Eng 32:241-248
34. Funke M, Diederichs S, Kensy F, Müller C, Büchs J (2009) The baffled microtiter plate: increased oxygen transfer and improved online monitoring in small scale fermentations. Biotechnol Bioeng 103:1118-1128
35. Kottmeier K, Weber J, Müller C, Bley T, Büchs J (2009) Asymmetric division of Hansenula polymorpha reflected by a drop of light scatter intensity measured in batch microtiter plate cultivations at phosphate limitation. Biotechnol Bioeng 104:554-561
36. Kensy F, Zimmermann HF, Knabben I, Anderlei T, Trauthwein H, Dingerdissen U, Büchs J (2005) Oxygen transfer phenomena in 48-well microtiter plates: determination by optical monitoring of sulfite oxidation and verification by real-time measurement during microbial growth. Biotechnol Bioeng 89:698-708 (Pubitemid 40470358)
37. Duetz WA (2007) Microtiter plates as mini-bioreactors: miniaturization of fermentation methods. Trends Microbiol 15:469-475
38. La. Biotechnol Bioeng 99:1128-1139
39. Büchs J, Maier U, Milbradt C, Zoels B (2000) Power consumption in shaking flasks on rotary shaking machines: I. Power consumption measurement in unbaffled flasks at low liquid viscosity. Biotechnol Bioeng 68:589-593