Miniature bioreactors for automated high-throughput bioprocess design (HTBD): Reproducibility of parallel fed-batch cultivations with Escherichia coli

Biotechnology and Applied Biochemistry

Volumn 42, Issue 3, 2005, Pages 227-235

  Puskeiler, Robert ^a   Kusterer, Andreas ^a   John, Gernot T ^b   Weuster Botz, Dirk ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b PRESENS PRECISION SENSING GMBH   (Germany)

Author keywords

Aerobic process; Automation; Bioprocess design; Fed batch cultivation; High throughput; Oxygen transfer

Indexed keywords

COMPUTATIONAL FLUID DYNAMICS; ESCHERICHIA COLI; FLUOROMETERS; GLUCOSE; OXYGEN; PH EFFECTS;

AEROBIC PROCESS; BIOPROCESS DESIGN; HIGH THROUGHPUT; OXYGEN TRANSFER;

BIOREACTORS;

GLUCOSE; OXYGEN;

ARTICLE; AUTOMATION; BIOREACTOR; CALCULATION; ESCHERICHIA COLI; FEEDING; FLUORESCENCE; FLUOROMETRY; HIGH THROUGHPUT BIOPROCESS DESIGN; IMMOBILIZATION; LIQUID; NONHUMAN; OXYGEN TENSION; PH; REPRODUCIBILITY; SAMPLING; SCALE UP; SENSOR; SIMULATION; TECHNIQUE; TIME; TITRIMETRY; VELOCITY;

AUTOMATION; BIOMASS; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; CULTURE MEDIA; EQUIPMENT DESIGN; ESCHERICHIA COLI; FERMENTATION; FLUOROMETRY; GLUCOSE; HYDROGEN-ION CONCENTRATION; OXYGEN; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

ESCHERICHIA COLI;

EID: 28644436489     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20040197     Document Type: Article

References (20)

1. Elmahdi, I., Baganz, F., Dixon, K., Harrop, T., Sugden, D. and Lye, G. J. (2003) Biochem. Eng. J. 16, 299-310
2. Lye, G. J., Ayazi-Shamlou, P., Baganz, F., Dalby, P. A. and Woodley J. M. (2003) Trends Biotechnol. 21, 29-37
3. Maharbiz, M. M., Holtz, W. J., Howe, R. T. and Keasling, J. D. (2004) Biotechnol. Bioeng. 85, 376-381
4. Weuster-Botz, D., Stevens, S. and Hawrylenko, A. (2002) Biochem. Eng. J. 11, 69-72
5. Duetz, W. A., Ruedi, L., Hermann, R., O'Connor, K., Buchs, J. and Witholt, B. (2000) Appl. Environ. Microbiol. 66, 2641-2646
6. Hermann, R., Lehmann, M. and Buchs, J. (2003) Biotechnol. Bioeng. 81, 178-186
7. Maier, U., Losen, M. and Buchs, J. (2004) Biochem. Eng. J. 17, 155-167
8. Buchs, J., Maier, U., Milbradt, C. and Zoels, B. (2000) Biotechnol. Bioeng. 68, 589-593
9. Weuster-Botz, D., Altenbach-Rehm, J. and Arnold, M. (2001) Biochem. Eng. J. 7, 163-170
10. Dilsen, S., Paul, W., Herforth, D., Sandgathe, A., Altenbach-Rehm, J., Rreudl, R., Wandrey, C. and Weuster-Botz, D. (2001) J. Biotechnol. 88, 77-84
11. Lamping, S. R., Zhang, H., Allen, B. and Shamlou, P. A. (2003) Chem. Eng. Sci. 58, 747-758
12. Weis, S., John, G. T., Klimant, I. and Heinzle, E. (2002) Biotechnol. Prog. 18, 821-830
13. Puskeiler, R., Zacher, H. K. and Weuster-Botz, D. (2003) Eur. Pat. Appl. PCT EP03/14752
14. Puskeiler, R., Kaufmann, K. and Weuster-Botz, D. (2004) Biotechnol. Bioeng. 89, 512-523
15. Riesenberg, D., Schulz, V., Knorre, W. A., Pohl, H. D., Korz, D., Sanders, E. A., Ross, A. and Deckwer, W. D. (1991) J. Biotechnol. 20, 17-28
16. Gentric, C., Mignon, D., Bousquet, J. and Tanguy, P. A. (2005) Chem. Eng. Sci. 60, 2253-2272
17. Vrabel, P., van der Lans, R. G. J. M., van der Schot, F. N., Luyben, K. C. A. M., Xu, B. and Enfors, S. O. (2001) Chem. Eng. J. 84, 463-474
18. Puskeiler, R. (2004) Ph.D. Thesis, Munich University of Technology
19. Schumpe, A. (1993) Chem. Eng. Sci. 48, 153-158
20. Korz, D. J., Rinas, U., Hellmuth, K., Sanders, E. A. and Deckwer W. D. (1995) J. Biotechnol. 39, 59-65