Algal sterols are as effective as β-sitosterol in reducing plasma cholesterol concentration

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 3, 2014, Pages 675-681

  Chen, Jingnan ^a   Jiao, Rui ^b   Jiang, Yue ^c   Bi, Yanlan ^a   Chen, Zhen Yu ^d  

^a HENAN UNIVERSITY OF TECHNOLOGY   (China)

^b JINAN UNIVERSITY   (China)

^c JIANGNAN UNIVERSITY   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

sitosterol; ACAT2; algal sterol; cholesterol; HMG CoA reductase; LDL receptor

Indexed keywords

ACAT2; ACYL-COA:CHOLESTEROL ACYLTRANSFERASE; ALGAL STEROL; CHOLESTEROL ABSORPTION; HMG-COA-REDUCTASE; LDL RECEPTORS; LOW DENSITY LIPOPROTEINS; PLASMA CHOLESTEROL; CHOLESTEROL LOWERING; HMG-COA REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTORS;

ALCOHOLS; GENE EXPRESSION; LIPIDS; NUTRITION; PHYSIOLOGY; PLASMAS;

CHOLESTEROL;

ALGAE; CRICETINAE; SCHIZOCHYTRIUM;

CHOLESTEROL; GAMMA-SITOSTEROL; HYPOCHOLESTEROLEMIC AGENT; SITOSTEROL DERIVATIVE;

ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; DOWN REGULATION; DRUG EFFECTS; FUNCTIONAL FOOD; HAMSTER; MALE; MESOCRICETUS; MICROALGA;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CRICETINAE; DOWN-REGULATION; FUNCTIONAL FOOD; MALE; MESOCRICETUS; MICROALGAE; SITOSTEROLS;

EID: 84892987559     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf404955n     Document Type: Article

References (30)

1. Chen, Z. Y.; Jiao, R.; Ma, K. Y. Cholesterol-lowering nutraceuticals and functional foods J. Agric. Food Chem. 2008, 56, 8761-8773
2. Chen, Z. Y.; Ma, K. Y.; Liang, Y.; Peng, C.; Zuo, Y. Role and classification of cholesterol-lowering functional foods J. Funct. Food 2011, 3, 61-69
3. Andersson, S. W.; Skinner, J.; Ellegard, L. Intake of dietary plant sterols is inversely related to serum cholesterol concentration in men and women in the EPIC Norfolk population: a cross-sectional study Eur. J. Clin. Nutr. 2004, 58, 1378-1385
4. Kim, S. K.; Ta, Q. V. Potential benefical effects of marine algal sterols on human health Adv. Food Nutr. Res. 2011, 64, 191-198
5. Law, M. Plant sterols and stanol margarine and health West. J. Med. 2000, 173, 43-47
6. Plat, J.; van Onselen, E. N.; van Heugten, M. M.; Mensink, R. P. Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters Eur. J. Clin. Nutr. 2000, 54, 671-677
7. Plat, J.; Mensink, R. P. Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects Am. J. Cardiol. 2005, 96, 15-22
8. Chen, J. N.; Jiang, Y.; Ma, K. Y.; Chen, F.; Chen, Z. Y. Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1, hepatic LDL receptor, and HMG-CoA reductase J. Agric. Food Chem. 2011, 59, 6790-6797
9. Chen, J. N.; Jiang, Y.; Liang, Y. T.; Tian, X. Y.; Peng, C.; Ma, K. Y.; Liu, J.; Huang, Y.; Chen, Z. Y. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and vascular function in hamsters fed a high cholesterol diet Atherosclerosis 2012, 221, 397-404
10. Markus, S.; Walter, V. Investigation of unsaponifiable matter of plant oils and isolation of eight phytosterols by means of high-speed counter-current chromatography J. Chromatogr., A 2012, 1237, 96-105
11. Haas, D.; Morgenthaler, J.; Lacbawan, F.; Long, B.; Runz, H.; Garbade, S. F.; Zschocke, J.; Kelley, R. I.; Okun, J. G.; Hoffmann, G. F.; Muenke, M. Abnormal sterol metabolism in holoprosencephaly: studies in cultured lymphoblasts J. Med. Genet. 2007, 44, 298-305
12. Weete, J. D.; Kim, H.; Gandhi, S. R.; Wang, Y.; Dute, R. Lipids and ultrastructure of Thraustochytrium sp. ATCC 26185 Lipids 1997, 32, 839-845
13. Yang, B. R.; Koponen, J.; Tahvonen, R.; Kallio, H. Plant sterols in seeds of two species of Vaccinium (V. myrtillus and V. vitis-idaea) naturally distributed in Finland Eur. Food Res. Technol. 2003, 216, 34-38
14. Ma, K. Y.; Yang, N.; Jiao, R.; Peng, C.; Guan, L.; Huang, Y.; Chen, Z. Y. Dietary calcium decreases plasma cholesterol by down-regulation of intestinal NPC1L1 and MTP and up-regulation of CYP7A1 and ABCG 5/8 in hamsters Mol. Nutr. Food Res. 2011, 55, 247-258
15. Lam, C. K.; Chen, J. N.; Cao, Y.; Yang, L.; Wong, Y. M.; Yeung, S. Y.; Yao, X.; Huang, Y.; Chen, Z. Y. Conjugated and non-conjugated octadecaenoic acids affect differently intestinal acyl coenzyme A:cholesterol acyltransferase activity Atherosclerosis 2008, 198, 85-93
16. Chan, P. T.; Fong, W. P.; Cheung, Y. L.; Huang, Y.; Ho, W. K.; Chen, Z. Y. Jasmine green epicatechins are hypolipidemic in hamsters fed a high fat diet J. Nutr. 1999, 129, 1094-1101
17. Alasek, M. A. J.; Repa, J. J.; Quan, G.; Dietschy, J. M.; Turley, S. D. Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters Am. J. Physiol. Gastrointest. Liver. Physiol. 2008, 295, 813-822
18. Field, F. J.; Born, E.; Mathur, S. N. Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression J. Lipid Res. 2004, 45, 2252-2259
19. Qin, B.; Qiu, W.; Avramoglu, R. K.; Adeli, K. Tumor necrosis factor-α induces intestinal insulin resistance and stimulates the overproduction of intestinal apolipoprotein B48-containing lipoproteins Diabetes 2007, 56, 450-461
20. Plat, J.; Brufau, G.; Dallinga-Thie, G. M.; Dasselaar, M.; Mensink, R. P. A plant stanol yogurt drink alone or combined with a low-dose stains lowers serum triacylglycerol and non-HDL-choleterol in metabolic syndrome patients J. Nutr. 2009, 139, 1143-1149
21. Klingberg, S.; EllegaÌŠrd, L.; Johansson, I.; Hallmans, G.; Weinehall, L.; Andersson, H.; Winkvist, A. Inverse relation between dietary intake of naturally occurring plant sterols and serum cholesterol in northern Sweden Am. J. Clin. Nutr. 2008, 87, 993-1001
22. Ostlund, R. E., Jr.; Lin, X. Regulation of cholesterol absorption by phytosterols Curr. Atheroscler. Rep. 2006, 8, 487-491
23. Jones, P. J.; AbuMweis, S. S. Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer Curr. Opin. Clin. Nutr. Metab. Care 2009, 12, 147-151
24. Vanhanen, H. T.; Miettinen, T. A. Effects of unsaturated and saturated dietary plant sterols on their serum contents Clin. Chim. Acta 1992, 205, 97-107
25. Gylling, H.; Miettinen, T. A. Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men J. Lipid Res. 1996, 37, 1776-1785
26. Becker, M.; Staab, D.; Bergmann, K. V. Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol J. Pediatr. 1993, 122, 292-296
27. Kritchevsky, D.; Chen, S. C. Phytosterols-health benefits and potential concerns: a review J. Nutr. Res. 2005, 25, 413-428
28. Swell, L.; Trout, E. C., Jr.; Field, H., Jr.; Treadwell, C. R. Absorption of H3-β-sitosterol in the lymph fistula rat Proc. Soc. Exp. Biol. Med. 1959, 100, 140-142
29. Bhattacharyya, A. K.; Lopez, L. A. Absorbability of plant sterols and their distribution in rabbit tissues Biochim. Biophys. Acta 1979, 574, 146-153
30. Altmann, S. W.; Davis, H. R.; Zhu, L. J.; Yao, X.; Hoos, L. M.; Tetzloff, G.; Iyer, S. P.; Maguire, M.; Golovko, A.; Zeng, M.; Wang, L.; Murgolo, N.; Graziano, M. Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption Science 2004, 303, 1201-1204