PEG as a spacer arm markedly increases the immunogenicity of meningococcal group Y polysaccharide conjugate vaccine

Journal of Controlled Release

Volumn 172, Issue 1, 2013, Pages 382-389

  Huang, Qingrui ^a,d   Li, Dongxia ^a   Kang, Aijun ^c   An, Wenqi ^b   Fan, Bei ^b   Ma, Xiaowei ^b   Ma, Guanghui ^a   Su, Zhiguo ^a   Hu, Tao ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b Hualan Biological Engineering Inc   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Conjugate vaccine; Immunogenicity; Neisseria meningitidis; Polyethylene glycol; Spacer arm

Indexed keywords

ANTIGENS; EPITOPES; FUNCTIONAL POLYMERS; POLYETHYLENE GLYCOLS; POLYETHYLENES; PROTEINS; SHIELDING;

CAPSULAR POLYSACCHARIDES; CLINICAL MANIFESTATION; CONJUGATE VACCINE; HETEROBIFUNCTIONAL POLYETHYLENE GLYCOLS; IMMUNOGENICITY; MENINGOCOCCAL DISEASE; NEISSERIA MENINGITIDIS; SPACER ARM;

VACCINES;

IMMUNOGLOBULIN G; MACROGOL; MENINGOCOCCUS VACCINE; POLYSACCHARIDE VACCINE; TETANUS TOXOID;

ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; COMPETITIVE INHIBITION; CONTROLLED STUDY; CROSS LINKING; DRUG CONJUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNOGENICITY; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

CONJUGATE VACCINE; IMMUNOGENICITY; NEISSERIA MENINGITIDIS; POLYETHYLENE GLYCOL; SPACER ARM;

ANIMALS; ANTIBODY AFFINITY; FEMALE; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN G; MENINGITIS, MENINGOCOCCAL; MICE; MICE, INBRED BALB C; NEISSERIA MENINGITIDIS; POLYETHYLENE GLYCOLS; POLYSACCHARIDES, BACTERIAL; VACCINES, CONJUGATE;

EID: 84892949847     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.03.008     Document Type: Article

References (37)

1. N.E. Rosenstein, B.A. Perkins, D.S. Stephens, T. Popovic, J.M. Hughes, Meningococcal disease, N. Engl. J. Med. 344 (2001) 1378-1388.
2. Q. Chang, Y.L. Tzeng, D.S. Stephens, Meningococcal disease: changes in epidemiology and prevention, Clin. Epidemiol. 4 (2012) 237-245.
3. R. Yogev, T. Tan, Meningococcal disease: the advances and challenges of meningococcal disease prevention, Hum. Vaccin. 7 (2011) 828-837.
4. P.L. Shao, L.Y. Chang, S.M. Hsieh, S.C. Chang, S.C. Pan, C.Y. Lu, Y.C. Hsieh, C.Y. Lee, K. Dobbelaere, D. Boutriau, H. Tang, H.L. Bock, L.M. Huang, Safety and immunogenicity of a tetravalent polysaccharide vaccine against meningococcal disease, J. Formos. Med. Assoc. 108 (2009) 539-547.
5. C. Vipond, R. Care, I.M. Feavers, History of meningococcal vaccines and their serological correlates of protection, Vaccine 30 (Suppl. 2) (2011) B10-B17.
6. J.F.G. Vliegenthart, Carbohydrates based vaccines, FEBS Lett. 580 (2006) 2945-2950.
7. H. Kayhty, V. Karanko, H. Peltola, P.H. Makela, Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory, Pediatrics 74 (1984) 857-865. (Pubitemid 15203456)
8. D.V. Bertolini, L.S. Costa, I.M. van der Heijden, H.K. Sato, H.H. Marques, Immunogenicity of a meningococcal serogroup C conjugate vaccine in HIV-infected children, adolescents, and young adults, Vaccine 30 (2012) 5482-5486.
9. G. Dbaibo, M. Van der Wielen, M. Reda, F. Medlej, C. Tabet, D. Boutriau, A. Sumbul, S. Anis, J.M. Miller, The tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic with a clinically acceptable safety profile in subjects previously vaccinated with a tetravalent polysaccharide vaccine, Int. J. Infect. Dis. 16 (2012) e608-e615.
10. V. Papaevangelou, N. Spyridis, MenACWY-TT vaccine for active immunization against invasive meningococcal disease, Expert Rev. Vaccines 11 (2012) 523-537.
11. A. Finn, Bacterial polysaccharide-protein conjugate vaccines, Br. Med. Bull. 70 (2004) 1-14. (Pubitemid 40069369)
12. E.D. Deeks, Meningococcal quadrivalent (serogroups A, C, W135, and Y) conjugate vaccine (Menveo(®)): profile report, Paediatr. Drugs 14 (2012) 63-65.
13. A. Bartoloni, F. Norelli, C. Ceccarini, R. Rappuoli, P. Costantino, Immunogenicity of meningococcal B polysaccharide conjugated to tetanus toxoid or CRM197 via adipic acid dihydrazide, Vaccine 13 (1995) 463-470.
14. N.S. Wilson, J.A. Villadangos, Regulation of antigen presentation and crosspresentation in the dendritic cell network: facts, hypothesis, and immunological implications, Adv. Immunol. 86 (2005) 241-305. (Pubitemid 40215695)
15. R.M. Steinman, D. Hawiger, K. Liu, L. Bonifaz, D. Bonnyay, K. Mahnke, T. Iyoda, J. Ravetch, M. Dhodapkar, K. Inaba, M. Nussenzweig, Dendritic cell function in vivo during the steady state: a role in peripheral tolerance, Ann. N. Y. Acad. Sci. 987 (2003) 15-25. (Pubitemid 36584003)
16. G. Ragupathi, R.R. Koganty, D. Qiu, K.O. Lloyd, P.O. Livingston, A novel and efficient method for synthetic carbohydrate conjugate vaccine preparation: synthesis of sialyl Tn-KLH conjugate using a 4-(4-N-maleimidomethyl) cyclohexane-1-carboxyl hydrazide (MMCCH) linker arm, Glycoconj. J. 15 (1998) 217-221. (Pubitemid 28121373)
17. C. Peeters, P.R. Lagerman, O. de Weers, L.A. Oomen, P. Hoogerhout, M. Beurret, J.T. Poolman, Preparation of polysaccharide-conjugate vaccines, Methods Mol. Med. 87 (2003) 153-174.
18. S.K. Singh, P.S. Bisen, Adjuvanticity of stealth liposomes on the immunogenicity of synthetic gp41 epitope of HIV-1, Vaccine 24 (2006) 4161-4166.
19. Y. Wang, S. Hao, Y. Liu, T. Hu, G. Zhang, X. Zhang, Q. Qi, G. Ma, Z. Su, PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: a comparison with glycosylated erythropoietin, J. Control. Release 145 (2010) 306-313.
20. G. Pasut, F.M. Veronese, State of the art in PEGylation: the great versatility achieved after forty years of research, J. Control. Release 161 (2010) 461-472.
21. T. Hu, B.N. Manjula, D. Li, M. Brenowitz, A.S. Acharya, Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated hemoglobin, Biochem. J. 402 (2007) 143-151.
22. C.L. Trotter, H. Findlow, R. Borrow, Seroprevalence of serum bactericidal antibodies against group W135 and Y meningococci in England in 2009, Clin. Vaccine Immunol. 19 (2012) 219-222.
23. L. Svennerholm, Quantitative estimation of sialic acids, Biochim. Biophys. Acta 24 (1957) 604-611.
24. W. Zhu, S.L. Yu, W.Y. Zhu, X. Wang, G.Y. Huang, F.X. Li, Y.N. Li, A method for quantitative test of unconjugated meningoccocal polysaccharide (PS) in PS-tetanus toxoid conjugate preparations, Chin. Prog. Microbiol. Immunol. 30 (2002) 29-32.
25. S. Liu, L. Sun, J. Wang, G. Ma, Z. Su, T. Hu, Mono-PEGylation of ribonuclease A: high PEGylation efficiency by thiolation with small molecular weight reagent, Process Biochem. 47 (2012) 1364-1370.
26. X. Suo, X. Lu, T. Hu, G. Ma, Z. Su, A solid phase adsorption method for PEGylation of human serum albumin and staphylokinase: preparation, purification and biochemical characterization, Biotechnol. Lett. 31 (2009) 1191-1196.
27. R. Liu, D. Li, J. Wang, R. Qiu, Q. Lin, G. Zhang, G. Ma, Z. Su, T. Hu, Preparation, characterization and in vitro bioactivity of N-terminally PEGylated staphylokinase dimers, Process Biochem. 47 (2012) 41-46.
28. J. Wang, T. Hu, Y. Liu, G. Zhang, G. Ma, Z. Su, Kinetic and stoichiometric analysis of the modification process for N-terminal PEGylation of staphylokinase, Anal. Biochem. 412 (2011) 114-116.
29. T. Hu, D. Li, J. Wang, Q. Wang, Y. Liang, Y. Su, G. Ma, Z. Su, S. Wang, Propylbenzmethylation at Val-1(α) markedly increases the tetramer stability of the PEGylated hemoglobin: a comparison with propylation at Val-1(α), Biochim. Biophys. Acta 1820 (2012) 2044-2051.
30. T. Hu, D. Li, F. Meng, M. Prabhakaran, S.A. Acharya, Increased inter dimeric interaction of oxy hemoglobin is necessary for attenuation of reductive Pegylation promoted dissociation of tetramer, Artif. Cells Blood Substit. Immobil. Biotechnol. 39 (2011) 69-78.
31. R. Schneerson, O. Barrera, A. Sutton, J.B. Robbins, Preparation, characterization, and immunogenicity of Haemophilus Influenzae type b polysaccharide-protein conjugates, J. Exp. Med. 152 (1980) 361-376. (Pubitemid 10037059)
32. I.A. Silverira, R.C. Bastos, M.S. Neto, A.P. Laranjeira, E.F. Assis, I.A. Silveira, S.A. Fernandes, M.L. Leal, W.C. Silva, C.H. Lee, C.E. Frasch, J.M. Peralta, E. Jessouroun, Characterization and immunogenicity of meningococcal group C conjugate vaccine prepared using hydrazide-activated tetanus toxoid, Vaccine 25 (2007) 7261-7270. (Pubitemid 47464664)
33. A. Bardotti, G. Averani, F. Berti, S. Berti, C. Galli, S. Giannini, B. Fabbri, D. Proietti, N. Ravenscroft, S. Ricci, Size determination of bacterial capsular oligosaccharides used to prepare conjugate vaccines against Neisseria meningitidis groups Y and W135, Vaccine 23 (2005) 1887-1899. (Pubitemid 40289059)
34. B.N. Manjula, A.G. Tsai, M. Intaglietta, C. Tsai, C. Ho, P.K. Smith, K. Perumalsamy, N.D. Kanika, J.M. Friedman, S.A. Acharya, Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function, Protein J. 24 (2005) 133-146. (Pubitemid 41159991)
35. R. Dagan, D. Goldblatt, J. Maleckar, M. Yaïch, J. Eskola, Reduction of antibody response to an 11-valent pneumococcal vaccine coadministered with a vaccine containing acellular pertussis components, Infect. Immun. 72 (2004) 5383-5391. (Pubitemid 39223427)
36. R. Dagan, J. Eskola, C. Leclerc, O. Leroy, Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants, Infect. Immun. 66 (1998) 2093-2098. (Pubitemid 28194107)
37. B. Slütter, P.C. Soema, Z. Ding, R. Verheul, W. Hennink, W. Jiskoot, Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen, J. Control. Release 143 (2010) 207-214.