Mono-PEGylation of ribonuclease A: High PEGylation efficiency by thiolation with small molecular weight reagent

Process Biochemistry

Volumn 47, Issue 9, 2012, Pages 1364-1370

  Liu, Shenxiang ^a,b   Sun, Lijing ^a   Wang, Jun ^a   Ma, Guanghui ^a   Su, Zhiguo ^a   Hu, Tao ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Mono PEGylation; PEGylation; Polyethylene glycol; Ribonuclease A; Thiolation

Indexed keywords

2-IMINOTHIOLANE; AMINO GROUP; ANALYTICAL CHARACTERIZATION; ANTI-PROLIFERATIVE; CANCER CHEMOTHERAPEUTIC AGENTS; ENZYMATIC ACTIVITIES; INDUSTRIAL PRODUCTION; MALEIMIDES; MONO-PEGYLATION; N-HYDROXYSUCCINIMIDE; PEGYLATED PROTEINS; PEGYLATION; PHARMACEUTICAL PRODUCTION; RIBONUCLEASE A; RNASE A; SOLVENT ACCESSIBILITY; THERAPEUTIC POTENTIALS; THERAPEUTIC PROTEIN; THIOL GROUPS; THIOLATION;

FUNCTIONAL GROUPS; POLYETHYLENE GLYCOLS; STOICHIOMETRY;

PROTEINS;

EID: 84862846674     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2012.05.003     Document Type: Article

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