Reduced responsiveness of hypercholesterolemic rabbit aortic smooth muscle cells to nitric oxide

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 2, 1997, Pages 394-402

  Weisbrod, Robert M ^a   Griswold, Mark C ^a   Du, Yue ^a   Bolotina, Victoria M ^a   Cohen, Richard A ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

atherosclerosis; calcium; cholesterol; cyclic GMP; nitric oxide; smooth muscle cell

Indexed keywords

ACETYLCHOLINE; CALCIUM ION; CHOLESTEROL; CYCLIC GMP; FURA 2; MANGANESE; NITRIC OXIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; ATHEROSCLEROSIS; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHOLESTEROL INTAKE; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; VASODILATATION;

EID: 0031038132     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.2.394     Document Type: Article

References (15)

1. Cohen RA. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Dis. 1995;38:105-128.
2. Najibi S, Cohen RA. Enhanced role of potassium channels in relaxation of hypercholesterolemic rabbit carotid artery to nitric oxide and sodium nitroprusside. Am J Physiol. 1995;269:H805-H811.
3. Verbeuren TJ, Jordaens FH, Van Hove CE, Van Hoydonck AE, Herman AG. Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta. Eur J Pharmacol. 1990; 191:173-184.
4. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, Harrison DG. Dietinduced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest. 1990;86:2109-2116.
5. Lincoln TM, Comwell TL. Intracellular cyclic GMP receptor proteins. FASEB J. 1993:7:328-338.
6. i in vascular smooth muscle by inhibition of calcium current. Cell Calcium. 1994;15:122-131.
7. Godfraind T. EDRF and cGMP control gating of receptor-operated calcium channels in vascular smooth muscle. Eur J Pharmacol. 1986:126:341-343.
8. 2+ exchange in vascular smooth muscle cells in primary culture. J Biol Chem. 1991;266:12337-12341.
9. Ruth P, Wang GX, Boekhoff I, May B, Pfeifer A, Penner R, Korth M, Breer H, Huffman F. Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production. Proc Natl Acad Sci U S A. 1993:90:2623-2627.
10. Robertson BE, Schubert R, Hescheler J, Nelson MT. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol. 1993;265:C299-C303.
11. Archer SL, Huang JMC, Hampl V, Nelson DP, Shultz PJ, Weir EK. Nitric oxide and cGMP cause vasorelaxation by cGMP kinase-dependent activation of a charybdotoxin-sensitive K channel. Proc Natl Acad Sci U S A. 1994;91:7583-7587.
12. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle cells. Nature. 1994;368:850-853.
13. Stepp DW, Tulenko TN. Alterations in basal and serotonin-stimulated calcium permeability and vasoconstriction in atherosclerotic aorta. Arterioscler Thromb. 1994;14:1854-1859.
14. Bialecki RA, Tulenko TN, Colucci WS. Cholesterol enrichment increases basal and agonist-stimulated calcium influx in rat vascular smooth muscle cells. J Clin Invest. 1991;88:1894-1900.
15. Larson DM, Fujiwara K, Alexander RW, Gimbrone MA Jr. Heterogeneity of myosin antigenic expression in vascular smooth muscle in vivo. Lab Invest. 1984;50:401-407.