메뉴 건너뛰기




Volumn 110, Issue 2, 2014, Pages 450-458

MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4

Author keywords

colorectal cancer; KLF4; metastasis; miR 29a

Indexed keywords

GELATINASE A; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MICRORNA 29A; UVOMORULIN;

EID: 84892903184     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.724     Document Type: Article
Times cited : (165)

References (50)
  • 2
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2): 215-233.
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 7
    • 80053593567 scopus 로고    scopus 로고
    • MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer
    • Cui Y, Su WY, Xing J, Wang YC, Wang P, Chen XY, Shen ZY, Cao H, Lu YY, Fang JY (2011) MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer. PLoS One 6(10): e25872.
    • (2011) PLoS One , vol.6 , Issue.10
    • Cui, Y.1    Su, W.Y.2    Xing, J.3    Wang, Y.C.4    Wang, P.5    Chen, X.Y.6    Shen, Z.Y.7    Cao, H.8    Lu, Y.Y.9    Fang, J.Y.10
  • 8
    • 0037780740 scopus 로고    scopus 로고
    • Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
    • Dang DT, Chen X, Feng J, Torbenson M, Dang LH, Yang VW (2003) Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene 22(22): 3424-3430.
    • (2003) Oncogene , vol.22 , Issue.22 , pp. 3424-3430
    • Dang, D.T.1    Chen, X.2    Feng, J.3    Torbenson, M.4    Dang, L.H.5    Yang, V.W.6
  • 9
    • 0035833319 scopus 로고    scopus 로고
    • Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2
    • Dang DT, Mahatan CS, Dang LH, Agboola IA, Yang VW (2001) Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene 20(35): 4884-4890.
    • (2001) Oncogene , vol.20 , Issue.35 , pp. 4884-4890
    • Dang, D.T.1    Mahatan, C.S.2    Dang, L.H.3    Agboola, I.A.4    Yang, V.W.5
  • 10
    • 33646576169 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tumour metastasis
    • Deryugina EI, Quigley JP (2006) Matrix metalloproteinases and tumour metastasis. Cancer Metast Rev 25(1): 9-34.
    • (2006) Cancer Metast Rev , vol.25 , Issue.1 , pp. 9-34
    • Deryugina, E.I.1    Quigley, J.P.2
  • 11
    • 77954647669 scopus 로고    scopus 로고
    • The tumoursuppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML
    • Eyholzer M, Schmid S, Wilkens L, Mueller BU, Pabst T (2010) The tumoursuppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML. Br J Cancer 103(2): 275-284.
    • (2010) Br J Cancer , vol.103 , Issue.2 , pp. 275-284
    • Eyholzer, M.1    Schmid, S.2    Wilkens, L.3    Mueller, B.U.4    Pabst, T.5
  • 12
    • 0036224749 scopus 로고    scopus 로고
    • The APC gene in colorectal cancer
    • Fodde R (2002) The APC gene in colorectal cancer. Eu J Cancer 38(7): 867-871.
    • (2002) Eu J Cancer , vol.38 , Issue.7 , pp. 867-871
    • Fodde, R.1
  • 13
    • 84862200068 scopus 로고    scopus 로고
    • Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis
    • Fu J, Tang W, Du P, Wang G, Chen W, Li J, Zhu Y, Gao J, Cui L (2012) Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis. BMC Systems Biol 6: 68.
    • (2012) BMC Systems Biol , vol.6 , pp. 68
    • Fu, J.1    Tang, W.2    Du, P.3    Wang, G.4    Chen, W.5    Li, J.6    Zhu, Y.7    Gao, J.8    Cui, L.9
  • 14
    • 84863072876 scopus 로고    scopus 로고
    • Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis
    • Gamper AM, Qiao X, Kim J, Zhang L, DeSimone MC, Rathmell WK, Wan Y (2012) Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis. Mol Cell 45(2): 233-243.
    • (2012) Mol Cell , vol.45 , Issue.2 , pp. 233-243
    • Gamper, A.M.1    Qiao, X.2    Kim, J.3    Zhang, L.4    Desimone, M.C.5    Rathmell, W.K.6    Wan, Y.7
  • 15
    • 64049107465 scopus 로고    scopus 로고
    • MiR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis
    • Gebeshuber CA, Zatloukal K, Martinez J (2009) miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep 10(4): 400-405.
    • (2009) EMBO Rep , vol.10 , Issue.4 , pp. 400-405
    • Gebeshuber, C.A.1    Zatloukal, K.2    Martinez, J.3
  • 16
    • 34547642699 scopus 로고    scopus 로고
    • Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis
    • Ghaleb AM, McConnell BB, Nandan MO, Katz JP, Kaestner KH, Yang VW (2007) Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res 67(15): 7147-7154.
    • (2007) Cancer Res , vol.67 , Issue.15 , pp. 7147-7154
    • Ghaleb, A.M.1    McConnell, B.B.2    Nandan, M.O.3    Katz, J.P.4    Kaestner, K.H.5    Yang, V.W.6
  • 19
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5): 646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 23
    • 33751277288 scopus 로고    scopus 로고
    • Loss of Kruppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression
    • Kanai M, Wei D, Li Q, Jia Z, Ajani J, Le X, Yao J, Xie K (2006) Loss of Kruppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. Clin Cancer Res 12(21): 6395-6402.
    • (2006) Clin Cancer Res , vol.12 , Issue.21 , pp. 6395-6402
    • Kanai, M.1    Wei, D.2    Li, Q.3    Jia, Z.4    Ajani, J.5    Le, X.6    Yao, J.7    Xie, K.8
  • 24
    • 77955492538 scopus 로고    scopus 로고
    • MiR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop
    • Kapinas K, Kessler C, Ricks T, Gronowicz G, Delany AM (2010) miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. J Biol Chem 285(33): 25221-25231.
    • (2010) J Biol Chem , vol.285 , Issue.33 , pp. 25221-25231
    • Kapinas, K.1    Kessler, C.2    Ricks, T.3    Gronowicz, G.4    Delany, A.M.5
  • 25
    • 79955870017 scopus 로고    scopus 로고
    • Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model
    • Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X (2011) Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PLoS One 6(5): e19518.
    • (2011) PLoS One , vol.6 , Issue.5
    • Kong, G.1    Zhang, J.2    Zhang, S.3    Shan, C.4    Ye, L.5    Zhang, X.6
  • 26
    • 79957889846 scopus 로고    scopus 로고
    • KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis
    • Li D, Peng Z, Tang H, Wei P, Kong X, Yan D, Huang F, Li Q, Le X, Xie K (2011) KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res 17(11): 3558-3568.
    • (2011) Clin Cancer Res , vol.17 , Issue.11 , pp. 3558-3568
    • Li, D.1    Peng, Z.2    Tang, H.3    Wei, P.4    Kong, X.5    Yan, D.6    Huang, F.7    Li, Q.8    Le, X.9    Xie, K.10
  • 27
    • 84865487198 scopus 로고    scopus 로고
    • Dysregulated Kruppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma
    • e1-2
    • Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K (2012) Dysregulated Kruppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology 143(3): 799-810 e1-2.
    • (2012) Gastroenterology , vol.143 , Issue.3 , pp. 799-810
    • Li, Q.1    Gao, Y.2    Jia, Z.3    Mishra, L.4    Guo, K.5    Li, Z.6    Le, X.7    Wei, D.8    Huang, S.9    Xie, K.10
  • 28
    • 85027930332 scopus 로고    scopus 로고
    • Rethinking the metastatic cascade as a therapeutic target
    • Mina LA, Sledge Jr. GW (2011) Rethinking the metastatic cascade as a therapeutic target. Nat Rev Clin Oncol 8(6): 325-332.
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.6 , pp. 325-332
    • Mina, L.A.1    Sledge Jr., G.W.2
  • 29
    • 1942469421 scopus 로고    scopus 로고
    • Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells
    • Miyoshi A, Kitajima Y, Sumi K, Sato K, Hagiwara A, Koga Y, Miyazaki K (2004) Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 90(6): 1265-1273.
    • (2004) Br J Cancer , vol.90 , Issue.6 , pp. 1265-1273
    • Miyoshi, A.1    Kitajima, Y.2    Sumi, K.3    Sato, K.4    Hagiwara, A.5    Koga, Y.6    Miyazaki, K.7
  • 30
    • 70350596499 scopus 로고    scopus 로고
    • MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines
    • Muniyappa MK, Dowling P, Henry M, Meleady P, Doolan P, Gammell P, Clynes M, Barron N (2009) MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. Eur J Cancer 45(17): 3104-3118.
    • (2009) Eur J Cancer , vol.45 , Issue.17 , pp. 3104-3118
    • Muniyappa, M.K.1    Dowling, P.2    Henry, M.3    Meleady, P.4    Doolan, P.5    Gammell, P.6    Clynes, M.7    Barron, N.8
  • 32
    • 0023340925 scopus 로고
    • Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue
    • Remmele W, Stegner HE (1987) [Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue]. Der Pathologe 8(3): 138-140.
    • (1987) Der Pathologe , vol.8 , Issue.3 , pp. 138-140
    • Remmele, W.1    Stegner, H.E.2
  • 34
    • 0032813661 scopus 로고    scopus 로고
    • Klf4 is a transcription factor required for establishing the barrier function of the skin
    • Segre JA, Bauer C, Fuchs E (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nature Genet 22(4): 356-360.
    • (1999) Nature Genet , vol.22 , Issue.4 , pp. 356-360
    • Segre, J.A.1    Bauer, C.2    Fuchs, E.3
  • 35
    • 0029829236 scopus 로고    scopus 로고
    • Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest
    • Shields JM, Christy RJ, Yang VW (1996) Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem 271(33): 20009-20017.
    • (1996) J Biol Chem , vol.271 , Issue.33 , pp. 20009-20017
    • Shields, J.M.1    Christy, R.J.2    Yang, V.W.3
  • 36
    • 0037163902 scopus 로고    scopus 로고
    • Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway
    • Stone CD, Chen ZY, Tseng CC (2002) Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. FEBS Lett 530(1-3): 147-152.
    • (2002) FEBS Lett , vol.530 , Issue.1-3 , pp. 147-152
    • Stone, C.D.1    Chen, Z.Y.2    Tseng, C.C.3
  • 37
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4): 663-676.
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 39
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network
    • The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 487(7407): 330-337.
    • (2012) Nature , vol.487 , Issue.7407 , pp. 330-337
  • 40
    • 78049511518 scopus 로고    scopus 로고
    • Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells
    • Wang CJ, Stratmann J, Zhou ZG, Sun XF (2010) Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells. BMC Cancer 10: 616.
    • (2010) BMC Cancer , vol.10 , pp. 616
    • Wang, C.J.1    Stratmann, J.2    Zhou, Z.G.3    Sun, X.F.4
  • 41
    • 84855859459 scopus 로고    scopus 로고
    • Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis
    • Wang LG, Gu J (2012) Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis. Cancer Epidemiol 36(1): e61-e67.
    • (2012) Cancer Epidemiol , vol.36 , Issue.1
    • Wang, L.G.1    Gu, J.2
  • 42
    • 16844386207 scopus 로고    scopus 로고
    • Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression
    • Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT,Huang S, Xie K (2005) Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res 65(7): 2746-2754.
    • (2005) Cancer Res , vol.65 , Issue.7 , pp. 2746-2754
    • Wei, D.1    Gong, W.2    Kanai, M.3    Schlunk, C.4    Wang, L.5    Yao, J.C.6    Wu, T.T.7    Huang, S.8    Xie, K.9
  • 43
    • 49649101156 scopus 로고    scopus 로고
    • Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells
    • Wei D, Kanai M, Jia Z, Le X, Xie K (2008) Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res 68(12): 4631-4639.
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4631-4639
    • Wei, D.1    Kanai, M.2    Jia, Z.3    Le, X.4    Xie, K.5
  • 45
    • 77952768290 scopus 로고    scopus 로고
    • Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression
    • Yori JL, Johnson E, Zhou G, Jain MK, Keri RA (2010) Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. J Biol Chem 285(22): 16854-16863.
    • (2010) J Biol Chem , vol.285 , Issue.22 , pp. 16854-16863
    • Yori, J.L.1    Johnson, E.2    Zhou, G.3    Jain, M.K.4    Keri, R.A.5
  • 47
    • 84863050370 scopus 로고    scopus 로고
    • Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: Implications for colon cancer
    • Yu T, Chen X, ZhangW, Colon D, Shi J, Napier D, Rychahou P, LuW, Lee EY, Weiss HL, Evers BM, Liu C (2012) Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: implications for colon cancer. J Biol Chem 287(6): 3760-3768.
    • (2012) J Biol Chem , vol.287 , Issue.6 , pp. 3760-3768
    • Yu, T.1    Chen, X.2    Zhang, W.3    Colon, D.4    Shi, J.5    Napier, D.6    Rychahou, P.7    Lu, W.8    Lee, E.Y.9    Weiss, H.L.10    Evers, B.M.11    Liu, C.12
  • 48
    • 84863723167 scopus 로고    scopus 로고
    • MiR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer
    • Zhang J, Xiao Z, Lai D, Sun J, He C, Chu Z, Ye H, Chen S, Wang J (2012) miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer. Br J Cancer 107(2): 352-359.
    • (2012) Br J Cancer , vol.107 , Issue.2 , pp. 352-359
    • Zhang, J.1    Xiao, Z.2    Lai, D.3    Sun, J.4    He, C.5    Chu, Z.6    Ye, H.7    Chen, S.8    Wang, J.9
  • 49
    • 0034674712 scopus 로고    scopus 로고
    • The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter
    • Zhang W, Geiman DE, Shields JM, Dang DT, Mahatan CS, Kaestner KH, Biggs JR, Kraft AS, Yang VW (2000) The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem 275(24): 18391-18398.
    • (2000) J Biol Chem , vol.275 , Issue.24 , pp. 18391-18398
    • Zhang, W.1    Geiman, D.E.2    Shields, J.M.3    Dang, D.T.4    Mahatan, C.S.5    Kaestner, K.H.6    Biggs, J.R.7    Kraft, A.S.8    Yang, V.W.9
  • 50
    • 0842329848 scopus 로고    scopus 로고
    • Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
    • Zhao W, Hisamuddin IM, Nandan MO, Babbin BA, Lamb NE, Yang VW (2004) Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene 23(2): 395-402.
    • (2004) Oncogene , vol.23 , Issue.2 , pp. 395-402
    • Zhao, W.1    Hisamuddin, I.M.2    Nandan, M.O.3    Babbin, B.A.4    Lamb, N.E.5    Yang, V.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.