Dysregulated Krppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma

Gastroenterology

Volumn 143, Issue 3, 2012, Pages

  Li, Qi ^a,b   Gao, Yong ^a   Jia, Zhiliang ^b   Mishra, Lopa ^b   Guo, Kun ^b   Li, Zhiwei ^b   Le, Xiangdong ^b   Wei, Daoyan ^b   Huang, Suyun ^b   Xie, Keping ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

1,25 dihydroxyvitamin; Liver Cancer Progression; Nuclear Receptor; Transcriptional Regulation

Indexed keywords

COLECALCIFEROL; KRUPPEL LIKE FACTOR 4; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; KRUPPEL LIKE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER CELL CARCINOMA; LIVER METASTASIS; LYMPH NODE METASTASIS; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; RISK FACTOR; SIGNAL TRANSDUCTION; SURVIVAL RATE; TISSUE MICROARRAY; TUMOR CELL; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BINDING SITE; CANCER INVASION; CELL MOTION; CELL STRAIN HEPG2; DISEASE COURSE; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; LIVER TUMOR; METABOLISM; METASTASIS; METHODOLOGY; MORTALITY; NUDE MOUSE; PATHOLOGY; PROGNOSIS; PROMOTER REGION; TIME; TUMOR VOLUME;

ANIMALS; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER NEOPLASMS; LYMPHATIC METASTASIS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; PROMOTER REGIONS, GENETIC; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; TIME FACTORS; TISSUE ARRAY ANALYSIS; TRANSFECTION; TUMOR BURDEN;

EID: 84865487198     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.05.043     Document Type: Article

References (39)

1. A. Villanueva, B. Minguez, A. Forner Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy Annu Rev Med 61 2010 317 328
2. J.D. Yang, I. Nakamura, L.R. Roberts The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets Semin Cancer Biol 21 2011 35 43
3. S.S. Thorgeirsson, J.W. Grisham Molecular pathogenesis of human hepatocellular carcinoma Nat Genet 31 2002 339 346 (Pubitemid 35154440)
4. P. Laurent-Puig, P. Legoix, P. Bluteau Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis Gastroenterology 120 2001 1763 1773 (Pubitemid 32523494)
5. A. Tannapfel, C. Wittekind Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis Virchows Arch 440 2002 345 352 (Pubitemid 34328064)
6. S. Imbeaud, Y. Ladeiro, J. Zucman-Rossi Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma Semin Liver Dis 30 2010 75 86
7. S. Whittaker, R. Marais, A.X. Zhu The role of signaling pathways in the development and treatment of hepatocellular carcinoma Oncogene 29 2010 4989 5005
8. B. Minguez, Y. Hoshida, A. Villanueva Gene-expression signature of vascular invasion in hepatocellular carcinoma J Hepatol 55 2011 1325 1331
9. D.F. Calvisi, S. Ladu, A. Gorden Ubiquitous activation of Ras and Jak/Stat pathways in human HCC Gastroenterology 130 2006 1117 1128
10. D. Wei, W. Gong, M. Kanai Drastic down-regulation of Krppel-like factor 4 expression is critical in human gastric cancer development and progression Cancer Res 65 2005 2746 2754 (Pubitemid 40490076)
11. J.P. Katz, N. Perreault, B.G. Goldstein Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach Gastroenterology 128 2005 935 945 (Pubitemid 40523545)
12. B.B. McConnell, A.M. Ghaleb, M.O. Nandan The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology Bioessays 29 2007 549 557 (Pubitemid 46903942)
13. D. Wei, L. Wang, M. Kanai KLF4α up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer Gastroenterology 139 2010 2135 2145
14. D. Wei, M. Kanai, S. Huang Emerging role of KLF4 in human gastrointestinal cancer Carcinogenesis 27 2006 23 31 (Pubitemid 43032979)
15. Y. Sakai, M.B. Demay Evaluation of keratinocyte proliferation and differentiation in vitamin D receptor knockout mice Endocrinology 141 2000 2043 2049 (Pubitemid 32274354)
16. M.J. Larriba, N. Valle, S. Alvarez Vitamin D3 and colorectal cancer Adv Exp Med Biol 617 2008 271 280
17. M. Di Rosa, M. Malaguarnera, F. Nicoletti Vitamin D3: a helpful immuno-modulator Immunology 134 2011 123 139
18. C.S. Spina, L. Ton, M. Yao Selective vitamin D receptor modulators and their effects on colorectal tumor growth J Steroid Biochem Mol Biol 103 2007 757 762 (Pubitemid 46420525)
19. E.C. de Lyra, I.A. da Silva, M.L. Katayama 25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1α-hydroxylase, 24-hydroxylase and vitamin D receptor in women with and without breast cancer J Steroid Biochem Mol Biol 100 2006 184 192 (Pubitemid 44177771)
20. S. Shah, M.N. Islam, S. Dakshanamurthy The molecular basis of vitamin D receptor and β-catenin cross-regulation Mol Cell 21 2006 799 809 (Pubitemid 43376130)
21. M.J. Larriba, P. Ordez-Morn, I. Chicote Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer PLoS One 6 2011 e23524
22. M.E. Beildeck, M. Islam, S. Shah Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines PLoS One 4 2009 e7872
23. P.M. Evans, X. Chen, W. Zhang KLF4 interacts with β-catenin/TCF4 and blocks p300/CBP recruitment by β-catenin Mol Cell Biol 30 2010 372 381
24. D. Wei, M. Kanai, Z. Jia Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells Cancer Res 68 2008 4631 4639
25. X. Chen, E.M. Whitney, S.Y. Gao Transcriptional profiling of Krppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation J Mol Biol 326 2003 665 677 (Pubitemid 36279310)
26. M. Liu, M.H. Lee, M. Cohen Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937 Genes Dev 10 1996 142 153 (Pubitemid 26049905)
27. A. Saramki, C.M. Banwell, M.J. Campbell Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor Nucleic Acids Res 34 2006 543 554 (Pubitemid 43240242)
28. H.T. Cheng, J.Y. Chen, Y.C. Huang Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex J Cell Biochem 98 2006 1450 1456
29. G. Hager, M. Formanek, C. Gedlicka 1,25(OH)2 vitamin D3 induces elevated expression of the cell cycle-regulating genes P21 and P27 in squamous carcinoma cell lines of the head and neck Acta Otolaryngol 121 2001 103 109 (Pubitemid 32205033)
30. A. Caputo, M.H. Pourgholami, J. Akhter 1,25-Dihydroxyvitamin D(3) induced cell cycle arrest in the human primary liver cancer cell line HepG2 Hepatol Res 26 2003 34 39 (Pubitemid 36939929)
31. M.H. Pourgholami, J. Akhter, Y. Lu In vitro and in vivo inhibition of liver cancer cells by 1,25-dihydroxyvitamin D3 Cancer Lett 151 2000 97 102 (Pubitemid 30155590)
32. K. Dalhoff, J. Dancey, L. Astrup A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma Br J Cancer 89 2003 252 257 (Pubitemid 36976311)
33. R. Marik, M. Fackler, E. Gabrielson DNA methylation-related vitamin D receptor insensitivity in breast cancer Cancer Biol Ther 10 2010 44 53
34. M.J. Larriba, E. Martn-Villar, J.M. Garca Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer Carcinogenesis 30 2009 1459 1468
35. H. Yang, Y. Zhang, Z. Zhou Snail-1 regulates VDR signaling and inhibits 1,25(OH)-D(3) action in osteosarcoma Eur J Pharmacol 670 2011 341 346
36. M.H. Yang, C.L. Chen, G.Y. Chau Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma Hepatology 50 2009 1464 1474
37. K. Sugimachi, S. Tanaka, T. Kameyama Transcriptional repressor snail and progression of human hepatocellular carcinoma Clin Cancer Res 9 2003 2657 2664 (Pubitemid 36842110)
38. J.L. Yori, D.D. Seachrist, E. Johnson Krppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer Neoplasia 13 2011 601 610
39. P.M. Evans, X. Chen, W. Zhang KLF4 interacts with β-catenin/TCF4 and blocks p300/CBP recruitment by β-catenin Mol Cell Biol 30 2010 372 381