Gut-enriched Krüppel-like factor regulates colonic cell growth through APC/β-catenin pathway

FEBS Letters

Volumn 530, Issue 1-3, 2002, Pages 147-152

  Stone, Christian D ^a   Chen, Zhi Y ^a   Tseng, Chi Chuan ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell growth; Colonic cancer; Gene expression; Gut enriched Kr ppel like factor promoter

Indexed keywords

APC PROTEIN; BETA CATENIN; DNA; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GKLF; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL STRAIN HT29; COLON CARCINOGENESIS; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DNA TRANSFECTION; DOWN REGULATION; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE MUTATION; GENE OVEREXPRESSION; GROWTH REGULATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

BETA CATENIN; CELL DIVISION; COLON; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, APC; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0037163902     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)03449-X     Document Type: Article

References (20)

1. Vogelstein B., Kinzler K.W. The multistep nature of cancer. Trends Genet. 93:1993;138-141.
2. Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., Kinzler K.W. Activation of β-catenin-Tcf signaling in colon cancer by mutation in β-catenin or APC. Science. 275:1997;1787-1790.
3. He T.-C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T., Morin P.J., Vogelstein B., Kinzler K.W. Identification of c-Myc as a target of the APC pathway. Science. 281:1998;1509-1512.
4. Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 398:1999;422-426.
5. Shields J.M., Christy R.J., Yang V.W. Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem. 71:1996;20009-20017.
6. Shie J.L., Chen Z.Y., O'Brien M.J., Pestell R.G., Lee M.E., Tseng C.-C. Role of gut-enriched krüppel-like factor in colonic cell growth and differentiation. Am. J. Physiol. 279:2000;G806-G814.
7. Shie J.L., Chen Z.Y., Fu M., Pestell R.G., Tseng C.-C. Gut-enriched krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res. 28:2000;2969-2976.
8. Ton-That H., Kaestne K.H., Shields J.M., Mahatanakoon C.S., Yang V.W. Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis. FEBS Lett. 419:1997;239-243.
9. Morin P.J., Vogelstein B., Kinzler K.W. Apoptosis and APC in colorectal tumorigenesis. Proc. Natl. Acad. Sci. USA. 93:1996;7950-7954.
10. Shie J.L., Tseng C.-C. A nucleus-localization-deficient mutant serves as a dominant-negative inhibitor of gut-enriched krüppel-like factor function. Biochem. Biophys. Res. Commun. 283:2001;205-208.
11. Chomczynski P., Sacchi N. Single-step method of mRNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
12. Tseng C-C., Jarboe L.A., Wolfe M.M. Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal. Am. J. Physiol. 266:1994;G887-G891.
13. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
14. Chen, Z.Y., Shie, J.L. and Tseng, C.-C. (2002) STAT1 is required for IFN-g-mediated gut-enriched Kruppel-like factor expression. Exp. Cell Res. (in press).
15. Chen Z.Y., Shie J.L., Tseng C.-C. Up-regulation of gut-enriched krüppel-like factor by interferon-γ in human colon carcinoma cells. FEBS Lett. 477:2000;67-72.
16. Anderson K.P., Kern C.B., Crable S.C., Lingrel J.B. Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol. Cell. Biol. 15:1995;5957-5965.
17. Garrett-Sinha L.A., Eberspaecher H., Seldin M.F., Crombrugghe B.D. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem. 271:1996;31384-31390.
18. Nagase H., Nakamura Y. Mutations of the APC (adenomatous polyposis coli) gene. Hum. Mutat. 2:1993;425-434.
19. Kinzler K.W., Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 87:1996;159-170.
20. Rubinfeld B., Albert I., Porfiri E., Fiol C., Munemitsu S., Polakis P. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science. 272:1996;1023-1026.