Wound coverage technologies in burn care: Novel techniques

Journal of Burn Care and Research

Volumn 34, Issue 6, 2013, Pages 612-620

  Jeschke, Marc G ^a,b,c,d   Finnerty, Celeste C ^b,d   Shahrokhi, Shahriar ^b,d   Branski, Ludwik K ^d,e   Dibildox, Manuel ^b,d  

^a Canada   (Canada)

^b Division of Plastic Surgery   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d SHRINERS HOSPITALS FOR CHILDREN   (United States)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN GLUE; GROWTH FACTOR;

ARTICLE; BURN; FACIAL TRANSPLANTATION; GENE THERAPY; HUMAN; KERATINOCYTE; NONHUMAN; SKIN GRAFT; STEM CELL TRANSPLANTATION; SURGICAL TECHNIQUE; TISSUE ENGINEERING; WOUND CARE; WOUND HEALING;

ANIMALS; BANDAGES; BURNS; CICATRIX; CROSS INFECTION; FACIAL TRANSPLANTATION; FIBRIN TISSUE ADHESIVE; GRAFT REJECTION; HUMANS; SKIN CARE; SKIN TRANSPLANTATION; SKIN, ARTIFICIAL; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; WOUND HEALING;

EID: 84892822870     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e31829b0075     Document Type: Article

References (94)

1. Dyess DI, Blache C, Wright T, et al. The use of fibrin sealant in burn treatment. In: Schlag G, Holle J, editors. Fibrin sealing in surgical and non-surgical fields. 3. Berlin: Springer-Verlag; 1995. p. 120-7.
2. Mittermayr R, Wassermann E, Thurnher M, Simunek M, Redl H. Skin graft fixation by slow clotting fibrin sealant applied as a thin layer. Burns 2006;32:305-11.
3. Pomahac B, Pribaz J, Eriksson E, et al. Restoration of facial form and function after severe disfigurement from burn injury by a composite facial allograft. Am J Transplant 2011;11:386-93.
4. Natesan S, Wrice NL, Baer DG, Christy RJ. Debrided skin as a source of autologous stem cells for wound repair. Stem Cells 2011;29:1219-30.
5. Branski LK, Masters OE, Herndon DN, et al. Pre-clinical evaluation of liposomal gene transfer to improve dermal and epidermal regeneration. Gene Ther 2010;17:770-8.
6. Muller MJ, Herndon DN. Operative wound management. In: Herndon DN, editor. Total burn care. Philadelphia, PA: Saunders Elsevier; 2007. p. 177-95.
7. Pereira C, Murphy K, Herndon D. Outcome measures in burn care. Is mortality dead? Burns 2004;30:761-71.
8. Pereira CT, Barrow RE, Sterns AM, et al. Age-dependent differences in survival after severe burns: a unicentric review of 1,674 patients and 179 autopsies over 15 years. J Am Coll Surg 2006;202:536-48.
9. Herndon DN, Parks DH. Comparison of serial debridement and autografting and early massive excision with cadaver skin overlay in the treatment of large burns in children. J Trauma 1986;26:149-52.
10. Janzekovic Z. A new concept in the early excision and immediate grafting of burns. J Trauma 1970;10:1103-8.
11. Muller MJ, Herndon DN. Operative wound management. In: Herndon DN, editor. Total burn care. London: W. B. Saunders; 2001. p. 221-31.
12. Thompson P, Herndon DN, Abston S, Rutan T. Effect of early excision on patients with major thermal injury. J Trauma 1987;27:205-7.
13. Kulber DA, Bacilious N, Peters ED, Gayle LB, Hoffman L. The use of fibrin sealant in the prevention of seromas. Plast Reconstr Surg 1997;99:842-9; discussion 850-1.
14. Zederfeldt H. Does fibrin play an important role in wound healing? In: Schlag G, Redl H, editors. Fibrin sealing in surgical and nonsurgical fields. 1. Berlin: Springer-Verlag; 1994 p. 18-22.
15. Buchta C, Hedrich HC, Macher M, Höcker P, Redl H. Biochemical characterization of autologous fibrin sealants produced by CryoSeal and Vivostat in comparison to the homologous fibrin sealant product Tissucol/Tisseel. Biomaterials 2005;26:6233-41.
16. Furst W, Banerjee A, Redl H. Comparison of structure, strength and cytocompatibility of a fibrin matrix supplemented either with tranexamic acid or aprotinin. J Biomed Mater Res B Appl Biomater 2007;82:109-14.
17. Gibran N, Luterman A, Herndon D, et al.; FS 4IU Clinical Study Group. Comparison of fibrin sealant and staples for attaching split-thickness autologous sheet grafts in patients with deep partial- or full-thickness burn wounds: a phase 1/2 clinical study. J Burn Care Res 2007;28:401-8.
18. O'Grady KM, Agrawal A, Bhattacharyya TK, Shah A, Toriumi DM. An evaluation of fibrin tissue adhesive concentration and application thickness on skin graft survival. Laryngoscope 2000;110:1931-5.
19. Redl H. History of tissue adhesives. In: Saltz R, Toriumi DM, editors. Tissue glues in cosmetic surgery. St. Louis, MO: Quality Medical Publishing, Inc.; 2004. p. 4-27.
20. Currie LJ, Sharpe JR, Martin R. The use of fibrin glue in skin grafts and tissue-engineered skin replacements: a review. Plast Reconstr Surg 2001;108:1713-26.
21. Jabs AD Jr, Wider TM, DeBellis J, Hugo NE. The effect of fibrin glue on skin grafts in infected sites. Plast Reconstr Surg 1992;89:268-71.
22. Devauchelle B, Badet L, Lengelé B, et al. First human face allograft: early report. Lancet 2006;368:203-9.
23. Pomahac B, Nowinski D, Diaz-Siso JR, et al. Face transplantation. Curr Probl Surg 2011;48:293-357.
24. O'Neill H, Godden D. Ethical issues of facial transplantation. Br J Oral Maxillofac Surg 2009;47:443-5.
25. Soni CV, Barker JH, Pushpakumar SB, et al. Psychosocial considerations in facial transplantation. Burns 2010;36:959-64.
26. Pushpakumar SB, Barker JH, Soni CV, et al. Clinical considerations in face transplantation. Burns 2010;36:951-8.
27. Arno A, Barret JP, Harrison RA, Jeschke MG. Face allotransplantation and burns: a review. J Burn Care Res 2012;33:561-76.
28. Boyce ST, Glatter R, Kitzmiller WJ. Treatment of chronic wounds with cultured cells and biopolymers: a pilot study. Wounds 1995;24-9.
29. Boyce ST. Skin substitutes from cultured cells and collagen-GAG polymers. Med Biol Eng Comput 1998;36:791-800.
30. Hansbrough JF, Boyce ST, Cooper ML, Foreman TJ. Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate. JAMA 1989;262:2125-30.
31. Boyce ST, Williams ML. Lipid supplemented medium induces lamellar bodies and precursors of barrier lipids in cultured analogues of human skin. J Invest Dermatol 1993;101:180-4.
32. Prunieras M, Regnier M, Woodley DT. Methods for cultivation of keratinocytes with an air-liquid interface. J Invest Dermatol 1983;81:28s-33s.
33. Boyce ST, Supp AP, Swope VB, Warden GD. Vitamin C regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes. J Invest Dermatol 2002;118:565-72.
34. Swope VB, Supp AP, Cornelius JR, Babcock GF, Boyce ST. Regulation of pigmentation in cultured skin substitutes by cytometric sorting of melanocytes and keratinocytes. J Invest Dermatol 1997;109:289-95.
35. Supp DM, Boyce ST. Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes. J Burn Care Rehabil 2002;23:10-20.
36. Supp DM, Supp AP, Bell SM, Boyce ST. Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. J Invest Dermatol 2000;114:5-13.
37. Butler KL, Goverman J, Ma H, et al. Stem cells and burns: review and therapeutic implications. J Burn Care Res 2010;31:874-81.
38. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007;25:2648-59.
39. Burd A, Ahmed K, Lam S, Ayyappan T, Huang L. Stem cell strategies in burns care. Burns 2007;33:282-91.
40. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 2001;166:7556-62.
41. Körbling M, Estrov Z, Champlin R. Adult stem cells and tissue repair. Bone Marrow Transplant 2003;32(Suppl 1):S23-4.
42. Mansilla E, Marín GH, Drago H, et al. Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine. Transplant Proc 2006;38:967-9.
43. Weil BR, Markel TA, Herrmann JL, Abarbanell AM, Kelly ML, Meldrum DR. Stem cells in sepsis. Ann Surg 2009;250:19-27.
44. Guenou H, Nissan X, Larcher F, et al. Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study. Lancet 2009;374:1745-53.
45. Wood FM, Kolybaba ML, Allen P. The use of cultured epithelial autograft in the treatment of major burn injuries: a critical review of the literature. Burns 2006;32:395-401.
46. Reid MJ, Currie LJ, James SE, Sharpe JR. Effect of artificial dermal substitute, cultured keratinocytes and split thickness skin graft on wound contraction. Wound Repair Regen 2007;15:889-96.
47. James SE, Booth S, Dheansa B, et al. Sprayed cultured autologous keratinocytes used alone or in combination with meshed autografts to accelerate wound closure in difficultto-heal burns patients. Burns 2010;36:e10-20.
48. Zweifel CJ, Contaldo C, Köhler C, Jandali A, Künzi W, Giovanoli P. Initial experiences using non-cultured autologous keratinocyte suspension for burn wound closure. J Plast Reconstr Aesthet Surg 2008;61:e1-4.
49. Hernandez A, Evers BM. Functional genomics: clinical effect and the evolving role of the surgeon. Arch Surg 1999;134:1209-15.
50. Badillo AT, Chung S, Zhang L, Zoltick P, Liechty KW. Lentiviral gene transfer of SDF-1alpha to wounds improves diabetic wound healing. J Surg Res 2007;143:35-42.
51. Bett AJ, Prevec L, Graham FL. Packaging capacity and stability of human adenovirus type 5 vectors. J Virol 1993;67:5911-21.
52. Carretero M, Del Río M, García M, et al. A cutaneous gene therapy approach to treat infection through keratinocytetargeted overexpression of antimicrobial peptides. FASEB J 2004;18:1931-3.
53. Chen S, Kapturczak M, Loiler SA, et al. Efficient transduction of vascular endothelial cells with recombinant adenoassociated virus serotype 1 and 5 vectors. Hum Gene Ther 2005;16:235-47.
54. Deodato B, Arsic N, Zentilin L, et al. Recombinant AAV vector encoding human VEGF165 enhances wound healing. Gene Ther 2002;9:777-85.
55. Eming SA, Lee J, Snow RG, et al. Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice-implications for the use of genetically modified keratinocytes to modulate dermal regeneration. J Invest Dermatol 1995;105:756-63.
56. Eming SA, Medalie DA, Tompkins RG, Yarmush ML, Morgan JR. Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft. Hum Gene Ther 1998;9:529-39.
57. Eming SA, Snow RG, Yarmush ML, Morgan JR. Targeted expression of insulin-like growth factor to human keratinocytes: modification of the autocrine control of keratinocyte proliferation. J Invest Dermatol 1996;107:113-20.
58. Eming SA, Whitsitt JS, He L, Krieg T, Morgan JR, Davidson JM. Particle-mediated gene transfer of PDGF isoforms promotes wound repair. J Invest Dermatol 1999;112:297-302.
59. Galeano M, Deodato B, Altavilla D, et al. Effect of recombinant adeno-associated virus vector-mediated vascular endothelial growth factor gene transfer on wound healing after burn injury. Crit Care Med 2003;31:1017-25.
60. Kozarsky KF, Wilson JM. Gene therapy: adenovirus vectors. Curr Opin Genet Dev 1993;3:499-503.
61. Liechty KW, Nesbit M, Herlyn M, Radu A, Adzick NS, Crombleholme TM. Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing. J Invest Dermatol 1999;113:375-83.
62. Lu B, Federoff HJ, Wang Y, Goldsmith LA, Scott G. Topical application of viral vectors for epidermal gene transfer. J Invest Dermatol 1997;108:803-8.
63. Morgan JR, Barrandon Y, Green H, Mulligan RC. Expression of an exogenous growth hormone gene by transplantable human epidermal cells. Science 1987;237:1476-9.
64. Silman NJ, Fooks AR. Biophysical targeting of adenovirus vectors for gene therapy. Curr Opin Mol Ther 2000;2:524-31.
65. Hengge UR, Chan EF, Foster RA, Walker PS, Vogel JC. Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nat Genet 1995;10:161-6.
66. Vogel JC. Nonviral skin gene therapy. Hum Gene Ther 2000;11:2253-9.
67. Eriksson E, Yao F, Svensjö T, et al. In vivo gene transfer to skin and wound by microseeding. J Surg Res 1998;78:85-91.
68. Nanney LB, Paulsen S, Davidson MK, Cardwell NL, Whitsitt JS, Davidson JM. Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair Regen 2000;8:117-27.
69. Yang NS, Sun WH. Gene gun and other non-viral approaches for cancer gene therapy. Nat Med 1995;1:481-3.
70. Dileo J, Miller TE Jr, Chesnoy S, Huang L. Gene transfer to subdermal tissues via a new gene gun design. Hum Gene Ther 2003;14:79-87.
71. Baker LL, Chambers R, DeMuth SK, Villar F. Effects of electrical stimulation on wound healing in patients with diabetic ulcers. Diabetes Care 1997;20:405-12.
72. Gardner SE, Frantz RA, Schmidt FL. Effect of electrical stimulation on chronic wound healing: a meta-analysis. Wound Repair Regen 1999;7:495-503.
73. Lee PY, Chesnoy S, Huang L. Electroporatic delivery of TGF-beta1 gene works synergistically with electric therapy to enhance diabetic wound healing in db/db mice. J Invest Dermatol 2004;123:791-8.
74. Marti G, Ferguson M, Wang J, et al. Electroporative transfection with KGF-1 DNA improves wound healing in a diabetic mouse model. Gene Ther 2004;11:1780-5.
75. Felgner PL, Ringold GM. Cationic liposome-mediated transfection. Nature 1989;337:387-8.
76. Jeschke MG, Barrow RE, Hawkins HK, Tao Z, Perez-Polo JR, Herndon DN. Biodistribution and feasibility of non-viral IGF-I gene transfers in thermally injured skin. Lab Invest 2000;80:151-8.
77. Alexander MY, Akhurst RJ. Liposome-medicated gene transfer and expression via the skin. Hum Mol Genet 1995;4:2279-85.
78. Jeschke MG, Barrow RE, Hawkins HK, et al. IGF-I gene transfer in thermally injured rats. Gene Ther 1999;6:1015-20.
79. Sun L, Xu L, Chang H, et al. Transfection with aFGF cDNA improves wound healing. J Invest Dermatol 1997;108:313-8.
80. Jeschke MG, Klein D. Liposomal gene transfer of multiple genes is more effective than gene transfer of a single gene. Gene Ther 2004;11:847-55.
81. Jeschke MG, Schubert T, Klein D. Exogenous liposomal IGF-I cDNA gene transfer leads to endogenous cellular and physiological responses in an acute wound. Am J Physiol Regul Integr Comp Physiol 2004;286:R958-66.
82. Lynch SE, Nixon JC, Colvin RB, Antoniades HN. Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors. Proc Natl Acad Sci USA 1987;84:7696-700.
83. Sprugel KH, McPherson JM, Clowes AW, Ross R. Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers. Am J Pathol 1987;129: 601-13.
84. Jeschke MG, Herndon DN. The combination of IGF-I and KGF cDNA improves dermal and epidermal regeneration by increased VEGF expression and neovascularization. Gene Ther 2007;14:1235-42.
85. Eriksson E. Gene transfer in wound healing. Adv Skin Wound Care 2000;13(2 Suppl):20-2.
86. Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC, Newman CM. Microbubble-enhanced ultrasound for vascular gene delivery. Gene Ther 2000;7: 2023-7.
87. Shea LD, Smiley E, Bonadio J, Mooney DJ. DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol 1999;17:551-4.
88. Fu H, Hu Y, McNelis T, Hollinger JO. A calcium phosphate-based gene delivery system. J Biomed Mater Res A 2005;74:40-8.
89. Voigt M, Schauer M, Schaefer DJ, Andree C, Horch R, Stark GB. Cultured epidermal keratinocytes on a microspherical transport system are feasible to reconstitute the epidermis in full-thickness wounds. Tissue Eng 1999;5:563-72.
90. Chandler LA, Gu DL, Ma C, et al. Matrix-enabled gene transfer for cutaneous wound repair. Wound Repair Regen 2000;8:473-9.
91. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992;89:5547-51.
92. Breuing K, Eriksson E, Liu P, Miller DR. Healing of partial thickness porcine skin wounds in a liquid environment. J Surg Res 1992;52:50-8.
93. Branski LK, Gauglitz GG, Herndon DN, Jeschke MG. A review of gene and stem cell therapy in cutaneous wound healing. Burns 2009;35:171-80.
94. Gauglitz GG, Jeschke MG. Combined gene and stem cell therapy for cutaneous wound healing. Mol Pharm 2011;8:1471-9.