Pre-clinical evaluation of liposomal gene transfer to improve dermal and epidermal regeneration

Gene Therapy

Volumn 17, Issue 6, 2010, Pages 770-778

  Branski, L K ^a   Masters, O E ^a   Herndon, D N ^a   Mittermayr, R ^b   Redl, H ^b   Traber, D L ^a   Cox, R A ^a   Kita, K ^a   Jeschke, M G ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b AUVA Soziale Unfallversicherung   (Austria)

Author keywords

galactosidase; Autograft; PDGF; Pig; Skin substitute; Wound healing

Indexed keywords

BETA GALACTOSIDASE; COMPLEMENTARY DNA; PLATELET DERIVED GROWTH FACTOR; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIZATION; FEMALE; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LIPOSOMAL GENE DELIVERY SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN AUTOGRAFT; SKIN BIOPSY; SPLIT THICKNESS SKIN GRAFT; SWINE; WOUND HEALING; ANIMAL; BURNS; EPIDERMIS; EVALUATION STUDY; GENE TRANSFER; GENETIC TRANSFECTION; GENETICS; PROCEDURES; REGENERATION; SKIN; SKIN TRANSPLANTATION;

ANIMALS; BURNS; EPIDERMIS; FEMALE; GENE TRANSFER TECHNIQUES; LIPOSOMES; MODELS, ANIMAL; PLATELET-DERIVED GROWTH FACTOR; REGENERATION; SKIN; SKIN TRANSPLANTATION; SWINE; TRANSFECTION; WOUND HEALING;

ANIMALIA; RODENTIA; SUIDAE; SUS;

EID: 77953479950     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.32     Document Type: Article

References (36)

1. Branski LK, Pereira CT, Herndon DN, Jeschke MG. Gene therapy in wound healing: present status and future directions. Gene Ther 2007; 14: 1-10.
2. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341: 738-746.
3. Ammann AJ, Beck LS, DeGuzman L, Hirabayashi SE, Lee WP, McFatridge L et al. Transforming growth factor-beta. Effect on soft tissue repair. Ann NY Acad Sci 1990; 593: 124-134.
4. Miller CR, Bondurant B, McLean SD, McGovern KA, O'Brien DF. Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes. Biochemistry 1998; 37: 12875-12883.
5. Branski LK, Mittermayr R, Herndon DN, Norbury WB, Masters OE, Hofmann M et al. A porcine model of full-thickness burn, excision and skin autografting. Burns 2008; 34: 1119-1127.
6. Meyer W, Schwarz R, Neurand K. The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig. Curr Probl Dermatol 1978; 7: 39-52.
7. Forbes PD. Vascular supply of the skin and hair in swine. In: Montagna W, Dobson RL (eds). Advances in the Biology of Skin: Hair Growth, vol.9. Pergamon: Oxford, 1969, pp 419-432.
8. Heinrich W, Lange PM, Stirtz T, Iancu C, Heidemann E. Isolation and characterization of the large cyanogen bromide peptides from the alpha1-and alpha2-chains of pig skin collagen. FEBS Lett 1971; 16: 63-67.
9. Winter GD. A Study of Wound Healing in the Domestic Pig. PhD thesis, Birbeck College, University of London: London, 1966.
10. Gray GM, White RJ, Williams RH, Yardley HJ. Lipid composition of the superficial stratum corneum cells of pig epidermis. Br J Dermatol 1982; 106: 59-63.
11. Sullivan TP, Eaglstein WH, Davis SC, Mertz P. The pig as a model for human wound healing. Wound Repair Regen 2001; 9: 66-76.
12. Mast BA, Schultz GS. Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Rep Reg 1996; 4: 411-420.
13. Steed DL. Modifying the wound healing response with exogenous growth factors. Clin Plast Surg 1998; 25: 397-405.
14. Robson MC, Smith PD. Topical use of growth factors to enhance healing. In: Falanga V (ed). Cutaneous Wound Healing. Taylor & Francis: London, 2001, pp 379-398.
15. Lynch SE, Nixon JC, Colvin RB, Antoniades HN. Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors. Proc Natl Acad Sci USA 1987; 84: 7696-7700.
16. Noguchi A, Furuno T, Kawaura C, Nakanishi M. Membrane fusion plays an important role in gene transfection mediated by cationic liposomes. FEBS Lett 1998; 433: 169-173.
17. Williams RS, Johnston SA, Riedy M, DeVit MJ, McElligott SG, Sanford JC. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc Natl Acad Sci USA 1991; 88: 2726-2730.
18. Felgner PL, Ringold GM. Cationic liposome-mediated transfec-tion. Nature 1989; 337: 387-388.
19. Jeschke MG, Barrow RE, Hawkins HK, Tao Z, Perez-Polo JR, Herndon DN. Biodistribution and feasibility of non-viral IGF-I gene transfers in thermally injured skin. Lab Invest 2000; 80: 151-158.
20. Eming SA, Whitsitt JS, He L, Krieg T, Morgan JR, Davidson JM. Particle-mediated gene transfer of PDGF isoforms promotes wound repair. J Invest Dermatol 1999; 112: 297-302.
21. Jeschke MG, Barrow RE, Hawkins HK, Yang K, Hayes RL, Lichtenbelt BJ et al. IGF-I gene transfer in thermally injured rats. Gene Ther 1999; 6: 1015-1020.
22. Sun L, Xu L, Chang H, Henry FA, Miller RM, Harmon JM et al. Transfection with aFGF cDNA improves wound healing. J Invest Dermatol 1997; 108: 313-318.
23. Jeschke MG, Schubert T, Klein D. Exogenous liposomal IGF-I cDNA gene transfer leads to endogenous cellular and physiological responses in an acute wound. Am J Physiol Regul Integr Comp Physiol 2004; 286: R958-R966.
24. Jeschke MG, Barrow RE, Hawkins HK, Chrysopoulo MT, Perez-Polo JR, Herndon DN. Effect of multiple gene transfers of insulin like growth factor I complementary DNA gene constructs in rats after thermal injury. Arch Surg 1999; 134: 1137-1141.
25. Jeschke MG, Klein D. Liposomal gene transfer of multiple genes is more effective than gene transfer of a single gene. Gene Ther 2004; 11: 847-855.
26. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci USA 1974; 71: 1207-1210.
27. Senior RM, Griffin GL, Huang JS, Walz DA, Deuel TF. Chemotactic activity of platelet alpha granule proteins for fibroblasts. J Cell Biol 1983; 96: 382-385.
28. Tzeng DY, Deuel TF, Huang JS, Baehner RL. Platelet-derived growth factor promotes human peripheral monocyte activation. Blood 1985; 66: 179-183.
29. Tzeng DY, Deuel TF, Huang JS, Senior RM, Boxer LA, Baehner RL. Platelet-derived growth factor promotes polymorphonuclear leukocyte activation. Blood 1984; 64: 1123-1128.
30. Ansel JC, Tiesman JP, Olerud JE, Krueger JG, Krane JF, Tara DC et al. Human keratinocytes are a major source of cutaneous platelet-derived growth factor. J Clin Invest 1993; 92: 671-678.
31. Liu PY, Liu K, Wang XT, Badiavas E, Rieger-Christ KM, Tang JB et al. Efficacy of combination gene therapy with multiple growth factor cDNAs to enhance skin flap survival in a rat model. DNA Cell Biol 2005; 24: 751-757.
32. Wang XT, Liu PY, Tang JB. PDGF gene therapy enhances expression of VEGF and bFGF genes and activates the NF-kappaB gene in signal pathways in ischemic flaps. Plast Reconstr Surg 2006; 117: 129-139.
33. Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D et al. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen 2004; 12: 497-504.
34. Gu DL, Nguyen T, Gonzalez AM, Printz MA, Pierce GF, Sosnowski BA et al. Adenovirus encoding human platelet-derived growth factor-B delivered in collagen exhibits safety, biodistribution, and immunogenicity profiles favorable for clinical use. Mol Ther 2004; 9: 699-711.
35. Furst W, Banerjee A, Redl H. Comparison of structure, strength and cytocompatibility of a fibrin matrix supplemented either with tranexamic acid or aprotinin. J Biomed Mater Res B Appl Biomater 2006; 82: 109-114.
36. Foss DL, Baarsch MJ, Murtaugh MP. Regulation of hypoxanthine phosphoribosyltransferase, glyceraldehyde-3-phosphate dehy-drogenase and beta-actin mRNA expression in porcine immune cells and tissues. Animal Biotechnol 1998; 9: 67-78.