The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans

Development (Cambridge)

Volumn 141, Issue 3, 2014, Pages 617-628

  Moffat, Laura L ^a   Robinson, Ryan E ^b   Bakoulis, Anastasia ^a   Clark, Scott G ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEVADA   (United States)

Author keywords

C. elegans; Membrane protein trafficking; Neuronal polarity; Wnt signaling

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; FRIZZLED PROTEIN; MEMBRANE PROTEIN; PLR 1 PROTEIN; RING FINGER PROTEIN; ROR PROTEIN; RYK PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; ENDOSOME; LOSS OF FUNCTION MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; SURFACE PROPERTY; UBIQUITINATION; WNT SIGNALING PATHWAY;

C. ELEGANS; MEMBRANE PROTEIN TRAFFICKING; NEURONAL POLARITY; WNT SIGNALING;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL MEMBRANE; CELL MOVEMENT; CELL POLARITY; CONSERVED SEQUENCE; CYTOSOL; DOWN-REGULATION; ENDOSOMES; GREEN FLUORESCENT PROTEINS; LYSINE; MEMBRANE PROTEINS; MUTATION; NEURONS; PROTEIN STRUCTURE, SECONDARY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS; RING FINGER DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; WNT SIGNALING PATHWAY;

EID: 84892766468     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.101600     Document Type: Article

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