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Volumn 67, Issue 4, 2008, Pages 323-333

Lysine conservation and context in TGFβ and Wnt signaling suggest new targets and general themes for posttranslational modification

Author keywords

Dishevelled; Frizzled; Phylogenetics; Smads; Sumoylation; TGF ; Ubiquitination

Indexed keywords

DISHEVELLED PROTEIN; FRIZZLED PROTEIN; LYSINE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 54349091746     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-008-9159-4     Document Type: Article
Times cited : (12)

References (39)
  • 1
    • 38149124000 scopus 로고    scopus 로고
    • Wnt and TGFβ Expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning
    • M Adamska S Degnan K Green M Adamski A Craigie C Larroux B Degnan 2007 Wnt and TGFβ Expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning PLoS ONE 2 e1031
    • (2007) PLoS ONE , vol.2 , pp. 1031
    • Adamska, M.1    Degnan, S.2    Green, K.3    Adamski, M.4    Craigie, A.5    Larroux, C.6    Degnan, B.7
  • 2
    • 33645714061 scopus 로고    scopus 로고
    • The KLH12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-ßcatenin pathway by targeting Dishevelled for degradation
    • S Angers C Thorpe T Biechele S Goldenberg N Zheng M MacCoss R Moon 2006 The KLH12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-ßcatenin pathway by targeting Dishevelled for degradation Nat Cell Biol 8 348 357
    • (2006) Nat Cell Biol , vol.8 , pp. 348-357
    • Angers, S.1    Thorpe, C.2    Biechele, T.3    Goldenberg, S.4    Zheng, N.5    MacCoss, M.6    Moon, R.7
  • 4
    • 33750088147 scopus 로고    scopus 로고
    • Function of the two Xenopus Smad4 s in early frog development
    • C Chang A Brivanlou R Harland 2006 Function of the two Xenopus Smad4 s in early frog development J Biol Chem 281 30794 30803
    • (2006) J Biol Chem , vol.281 , pp. 30794-30803
    • Chang, C.1    Brivanlou, A.2    Harland, R.3
  • 5
  • 6
    • 34748887926 scopus 로고    scopus 로고
    • Crystal structure of activin receptor Type IIB kinase domain from human at 2A resolution
    • S Han P Loulakis M Griffor Z Xie 2007 Crystal structure of activin receptor Type IIB kinase domain from human at 2A resolution Protein Sci 16 2272 2277
    • (2007) Protein Sci , vol.16 , pp. 2272-2277
    • Han, S.1    Loulakis, P.2    Griffor, M.3    Xie, Z.4
  • 7
    • 0037383240 scopus 로고    scopus 로고
    • Genomic clocks and timescales
    • S Hedges S Kumar 2003 Genomic clocks and timescales Trends Genet 19 200 206
    • (2003) Trends Genet , vol.19 , pp. 200-206
    • Hedges, S.1    Kumar, S.2
  • 8
    • 26444486391 scopus 로고    scopus 로고
    • Phosphorylation of βcatenin by cAMP-PK stabilizes βcatenin through inhibition of ubiquitination
    • S Hino C Tanji K Nakayama A Kikuchi 2005 Phosphorylation of βcatenin by cAMP-PK stabilizes βcatenin through inhibition of ubiquitination Mol Cell Biol 25 9063 9072
    • (2005) Mol Cell Biol , vol.25 , pp. 9063-9072
    • Hino, S.1    Tanji, C.2    Nakayama, K.3    Kikuchi, A.4
  • 9
    • 0033524943 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the Type I TGFβ receptor in complex with FKBP12
    • M Huse Y Chen J Massagué J Kuriyan 1999 Crystal structure of the cytoplasmic domain of the Type I TGFβ receptor in complex with FKBP12 Cell 96 425 436
    • (1999) Cell , vol.96 , pp. 425-436
    • Huse, M.1    Chen, Y.2    Massagué, J.3    Kuriyan, J.4
  • 11
    • 44649163272 scopus 로고    scopus 로고
    • The Type I TGFβ receptor is covalently modified and regulated by sumoylation
    • J Kang E Saunier R Akhurst R Derynck 2008 The Type I TGFβ receptor is covalently modified and regulated by sumoylation Nat Cell Biol 10 654 664
    • (2008) Nat Cell Biol , vol.10 , pp. 654-664
    • Kang, J.1    Saunier, E.2    Akhurst, R.3    Derynck, R.4
  • 13
    • 33751543026 scopus 로고    scopus 로고
    • A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signaling that mediates SMAD degradation
    • J Li W Li 2006 A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signaling that mediates SMAD degradation Nat Cell Biol 8 1407 1414
    • (2006) Nat Cell Biol , vol.8 , pp. 1407-1414
    • Li, J.1    Li, W.2
  • 14
    • 0041731797 scopus 로고    scopus 로고
    • Sumo-1/Ubc-9 promotes nuclear accumulation and metabolic stability of Smad4
    • X Lin M Lang Y Liang F Brunicardi X Feng 2003 Sumo-1/Ubc-9 promotes nuclear accumulation and metabolic stability of Smad4 J Biol Chem 278 31043 31048
    • (2003) J Biol Chem , vol.278 , pp. 31043-31048
    • Lin, X.1    Lang, M.2    Liang, Y.3    Brunicardi, F.4    Feng, X.5
  • 15
    • 1842844308 scopus 로고    scopus 로고
    • Repression of Smad4 transcriptional activity by Sumo modification
    • J Long G Wang D He F Liu 2004 Repression of Smad4 transcriptional activity by Sumo modification Biochem J 379 23 29
    • (2004) Biochem J , vol.379 , pp. 23-29
    • Long, J.1    Wang, G.2    He, D.3    Liu, F.4
  • 16
    • 33746211620 scopus 로고    scopus 로고
    • Impact of the N-terminal amino acid on targeted protein degradation
    • T Meinnel A Serero C Giglione 2006 Impact of the N-terminal amino acid on targeted protein degradation Biol Chem 387 839 851
    • (2006) Biol Chem , vol.387 , pp. 839-851
    • Meinnel, T.1    Serero, A.2    Giglione, C.3
  • 17
    • 0042858169 scopus 로고    scopus 로고
    • Differential ubiquitination defines the functional status of Smad4
    • A Morén U Hellman Y Inada T Imamura CH Heldin 2003 Differential ubiquitination defines the functional status of Smad4 J Biol Chem 278 33571 33582
    • (2003) J Biol Chem , vol.278 , pp. 33571-33582
    • Morén, A.1    Hellman, U.2    Inada, Y.3    Imamura, T.4    Heldin, C.H.5
  • 18
    • 20444439172 scopus 로고    scopus 로고
    • Degradation of the tumor suppressor Smad4 by WW and HECT ubiquitin ligases
    • A Morén T Imamura K Miyazono CH Heldin A Moustakas 2005 Degradation of the tumor suppressor Smad4 by WW and HECT ubiquitin ligases J Biol Chem 280 22115 22123
    • (2005) J Biol Chem , vol.280 , pp. 22115-22123
    • Morén, A.1    Imamura, T.2    Miyazono, K.3    Heldin, C.H.4    Moustakas, A.5
  • 20
    • 0032979875 scopus 로고    scopus 로고
    • Molecular evolution of a developmental pathway: Phylogenetic analyses of TGFβ family ligands, receptors and Smad signal transducers
    • S Newfeld R Wisotzkey S Kumar 1999 Molecular evolution of a developmental pathway: phylogenetic analyses of TGFβ family ligands, receptors and Smad signal transducers Genetics 152 783 795
    • (1999) Genetics , vol.152 , pp. 783-795
    • Newfeld, S.1    Wisotzkey, R.2    Kumar, S.3
  • 21
    • 0031833571 scopus 로고    scopus 로고
    • Identification of chromosomal regions involved in dpp function in Drosophila
    • R Nicholls W Gelbart 1998 Identification of chromosomal regions involved in dpp function in Drosophila Genetics 149 203 215
    • (1998) Genetics , vol.149 , pp. 203-215
    • Nicholls, R.1    Gelbart, W.2
  • 22
    • 33747606753 scopus 로고    scopus 로고
    • Early evolution of animal cell signaling and adhesion genes
    • S Nichols W Dirks J Pearse N King 2006 Early evolution of animal cell signaling and adhesion genes Proc Natl Acad Sci USA 103 12451 12456
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12451-12456
    • Nichols, S.1    Dirks, W.2    Pearse, J.3    King, N.4
  • 24
    • 27144449757 scopus 로고    scopus 로고
    • Genetic evidence that Frizzled controls planar cell polarity and Armadillo by a common mechanism
    • M Povelones R Howes M Fish R Nusse 2006 Genetic evidence that Frizzled controls planar cell polarity and Armadillo by a common mechanism Genetics 171 1643 1554
    • (2006) Genetics , vol.171 , pp. 1643-1554
    • Povelones, M.1    Howes, R.2    Fish, M.3    Nusse, R.4
  • 26
    • 34249336767 scopus 로고    scopus 로고
    • Changing venues for tumor suppression: Balancing destruction and localization by monoubiquitylation
    • L Salmena P Pandolfi 2007 Changing venues for tumor suppression: balancing destruction and localization by monoubiquitylation Nat Rev Cancer 7 409 413
    • (2007) Nat Rev Cancer , vol.7 , pp. 409-413
    • Salmena, L.1    Pandolfi, P.2
  • 28
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1domain bound to DNA: Insights on DNA binding in TGFβ signaling
    • Y Shi Y Wang L Jayaraman H Yang J Massagué N Pavletich 1998 Crystal structure of a Smad MH1domain bound to DNA: insights on DNA binding in TGFβ signaling Cell 94 585 594
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1    Wang, Y.2    Jayaraman, L.3    Yang, H.4    Massagué, J.5    Pavletich, N.6
  • 29
    • 0032772791 scopus 로고    scopus 로고
    • Multiple TGFβ receptor related genes in sponge and ancient gene duplications before the parazoan-eumetazoan split
    • H Suga K Ono T Miyata 1999 Multiple TGFβ receptor related genes in sponge and ancient gene duplications before the parazoan-eumetazoan split FEBS Lett 453 346 350
    • (1999) FEBS Lett , vol.453 , pp. 346-350
    • Suga, H.1    Ono, K.2    Miyata, T.3
  • 30
    • 34547781750 scopus 로고    scopus 로고
    • MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0
    • K Tamura J Dudley M Nei S Kumar 2007 MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0 Mol Biol Evol 24 1596 1599
    • (2007) Mol Biol Evol , vol.24 , pp. 1596-1599
    • Tamura, K.1    Dudley, J.2    Nei, M.3    Kumar, S.4
  • 31
    • 0033392501 scopus 로고    scopus 로고
    • The deubiquitinating enzyme Fam interacts with and stabilizes βcatenin
    • S Taya T Yamamoto M Kanai-Azuma S Wood K Kaibuchi 1999 The deubiquitinating enzyme Fam interacts with and stabilizes βcatenin Genes Cells 4 757 767
    • (1999) Genes Cells , vol.4 , pp. 757-767
    • Taya, S.1    Yamamoto, T.2    Kanai-Azuma, M.3    Wood, S.4    Kaibuchi, K.5
  • 32
    • 39449084931 scopus 로고    scopus 로고
    • Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
    • H Tran F Hamada T Schwarz-Romond M Bienz 2008 Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains Genes Dev 22 528 542
    • (2008) Genes Dev , vol.22 , pp. 528-542
    • Tran, H.1    Hamada, F.2    Schwarz-Romond, T.3    Bienz, M.4
  • 34
    • 33750439105 scopus 로고    scopus 로고
    • An extended consensus motif enhances the specificity of substrate modification by Sumo
    • S Yang A Galanis J Witty A Sharrocks 2006 An extended consensus motif enhances the specificity of substrate modification by Sumo EMBO J 25 5083 5093
    • (2006) EMBO J , vol.25 , pp. 5083-5093
    • Yang, S.1    Galanis, A.2    Witty, J.3    Sharrocks, A.4
  • 35
    • 27744535862 scopus 로고    scopus 로고
    • The developmental biology of Dishevelled: An enigmatic protein governing cell fate and cell polarity
    • J Wallingford R Habas 2005 The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity Development 132 4421 4436
    • (2005) Development , vol.132 , pp. 4421-4436
    • Wallingford, J.1    Habas, R.2
  • 38
    • 0027367937 scopus 로고
    • Signaling TGFβ Type II receptors lacking specific domains in the cytoplasmic region
    • R Wieser L Attisano J Wrana J Massagué 1993 Signaling TGFβ Type II receptors lacking specific domains in the cytoplasmic region Mol Cell Biol 13 7239 7247
    • (1993) Mol Cell Biol , vol.13 , pp. 7239-7247
    • Wieser, R.1    Attisano, L.2    Wrana, J.3    Massagué, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.