Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Enomoto, Takashi ^a   Ohashi, Koji ^a   Shibata, Rei ^a   Kambara, Takahiro ^a   Uemura, Yusuke ^a   Yuasa, Daisuke ^a   Kataoka, Yoshiyuki ^a   Miyabe, Megumi ^a   Matsuo, Kazuhiro ^a   Joki, Yusuke ^a   Hayakawa, Satoko ^a   Hiramatsu Ito, Mizuho ^a   Ito, Masanori ^a   Murohara, Toyoaki ^a   Ouchi, Noriyuki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ADIPOCYTOKINE; ADIPOLIN; INSULIN; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 15; KRUPPEL LIKE FACTOR 9; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIETARY INTAKE; GENE OVEREXPRESSION; GENE TARGETING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; TRANSCRIPTION REGULATION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOKINES; ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; OBESITY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84892708903     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083183     Document Type: Article

References (43)

1. Friedman JM (2003) A war on obesity, not the obese. Science 299: 856-858.
2. Matsuzawa Y (2006) Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 3: 35-42.
3. Despres JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444: 881-887.
4. Neels JG, Olefsky JM (2006) Inflamed fat: what starts the fire? J Clin Invest 116: 33-35.
5. Ouchi N, Parker JL, Lugus JJ, Walsh K (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11: 85-97.
6. Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11: 98-107.
7. Moore KJ, Tabas I (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145: 341-355.
8. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91.
9. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, et al. (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221: 286-289.
10. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-737.
11. Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K (2003) Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 14: 561-566.
12. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, et al. (2007) Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 117: 375-386.
13. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, et al. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100: 2473-2476.
14. Ohashi K, Parker JL, Ouchi N, Higuchi A, Vita JA, et al. (2010) Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 285: 6153-6160.
15. Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, et al. (2006) Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 47: 1108-1116.
16. Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, et al. (2005) Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 11: 1096-1103.
17. Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, et al. (2011) Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. J Biol Chem 286: 34552-34558.
18. Wei Z, Peterson JM, Wong GW (2011) Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. J Biol Chem 286: 15652-15665.
19. Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S (2008) Kruppel-like transcription factors: a functional family. Int J Biochem Cell Biol 40: 1996-2001.
20. McConnell BB, Yang VW (2010) Mammalian Kruppel-like factors in health and diseases. Physiol Rev 90: 1337-1381.
21. Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, et al. (2005) Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem 280: 12867-12875.
22. Pei H, Yao Y, Yang Y, Liao K, Wu JR (2011) Kruppel-like factor KLF9 regulates PPARgamma transactivation at the middle stage of adipogenesis. Cell Death Differ 18: 315-327.
23. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, et al. (2001) PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50: 2094-2099.
24. Kilroy G, Burk DH, Floyd ZE (2009) High efficiency lipid-based siRNA transfection of adipocytes in suspension. PLoS One 4: e6940.
25. Ouchi N, Oshima Y, Ohashi K, Higuchi A, Ikegami C, et al. (2008) Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism. J Biol Chem 283: 32802-32811.
26. Shibata R, Ouchi N, Kihara S, Sato K, Funahashi T, et al. (2004) Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem 279: 28670-28674.
27. Enomoto T, Shibata R, Ohashi K, Kambara T, Kataoka Y, et al. (2012) Regulation of adipolin/CTRP12 cleavage by obesity. Biochem Biophys Res Commun 428: 155-159.
28. Wei Z, Lei X, Seldin MM, Wong GW (2012) Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. J Biol Chem 287: 35804-35814.
29. Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, et al. (2008) Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol 28: 3967-3978.
30. Bell-Anderson KS, Funnell AP, Williams H, Mat Jusoh H, Scully T, et al. (2013) Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes 62: 2728-2737.
31. Gray S, Feinberg MW, Hull S, Kuo CT, Watanabe M, et al. (2002) The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem 277: 34322-34328.
32. Yamamoto J, Ikeda Y, Iguchi H, Fujino T, Tanaka T, et al. (2004) A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. J Biol Chem 279: 16954-16962.
33. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, et al. (2007) Regulation of gluconeogenesis by Kruppel-like factor 15. Cell Metab 5: 305-312.
34. Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, et al. (2011) Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion. J Biol Chem 286: 37458-37469.
35. Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830.
36. Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184.
37. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389: 610-614.
38. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, et al. (2002) A central role for JNK in obesity and insulin resistance. Nature 420: 333-336.
39. Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, et al. (2010) Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329: 454-457.
40. Kawamata Y, Imamura T, Babendure JL, Lu JC, Yoshizaki T, et al. (2007) Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin- 1 signaling complex. J Biol Chem 282: 28549-28556.
41. Sabio G, Das M, Mora A, Zhang Z, Jun JY, et al. (2008) A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322: 1539-1543.
42. Kubota N, Terauchi Y, Kubota T, Kumagai H, Itoh S, et al. (2006) Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 281: 8748-8755.
43. Pereira RI, Leitner JW, Erickson C, Draznin B (2008) Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3'-kinase. Life Sci 83: 638-643.