Cancer usurps skeletal muscle as an energy repository

Cancer Research

Volumn 74, Issue 1, 2014, Pages 330-340

  Luo, Yi ^a   Yoneda, Junya ^b   Ohmori, Hitoshi ^a   Sasaki, Takamitsu ^c   Shimbo, Kazutaka ^b   Eto, Sachise ^b   Kato, Yumiko ^b   Miyano, Hiroshi ^b   Kobayashi, Tsuyoshi ^b   Sasahira, Tomonori ^a   Chihara, Yoshitomo ^a   Kuniyasu, Hiroki ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ADVANCED GLYCATION END PRODUCT; AMINO ACID; GLUTAMIC ACID; GLUTAMINE; HIGH MOBILITY GROUP B1 PROTEIN; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; PYRUVATE KINASE; PYRUVATE KINASE M1; UNCLASSIFIED DRUG;

AMINO ACID BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER GROWTH; CELL ENERGY; CLINICAL ARTICLE; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; ENERGY METABOLISM; ENERGY RESOURCE; ENERGY YIELD; ENZYME ACTIVITY; FERMENTATION; HUMAN; HUMAN CELL; LACTATE FERMENTATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

AMINO ACIDS; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GLUTAMINE; HETEROGRAFTS; HMGB1 PROTEIN; HT29 CELLS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; RECOMBINANT PROTEINS;

EID: 84892691174     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-1052     Document Type: Article

References (46)

1. Warburg O. On respiratory impairment in cancer cells. Science 1956;124:269-70.
2. Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011;11: 325-37.
3. Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 2011; 43:969-80.
4. David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010;463:364-8.
5. Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008;452:181-6.
6. Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal 2009;2:ra73.
7. Morifuji M, Ishizaka M, Baba S, Fukuda K, Matsumoto H, Koga J, et al. Comparison of different sources and degrees of hydrolysis of dietary protein: effect on plasma amino acids, dipeptides, and insulin responses in human subjects. J Agric Food Chem 2010;58: 8788-97.
8. Hammer JA III, Rannels DE. Protein turnover in pulmonary macrophages. Utilization of amino acids derived from protein degradation. Biochem J 1981;198:53-65.
9. Kadowaki M, Kanazawa T. Amino acids as regulators of proteolysis. J Nutr 2003;133:2052S-6S.
10. Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett 2010;584:1287-95.
11. Kamaura M, Nishijima K, Takahashi M, Ando T, Mizushima S, Tochikubo O. Lifestyle modification in metabolic syndrome and associated changes in plasma amino acid profiles. Circ J 2010;74:2434-40.
12. Miyagi Y, Higashiyama M, Gochi A, Akaike M, Ishikawa T, Miura T, et al. Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One 2011;6:e24143.
13. Okamoto T, Yamagishi S, Inagaki Y, Amano S, Koga K, Abe R, et al. Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin. FASEB J 2002;16:1928-30.
14. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 2000;405:354-60.
15. Ohmori H, Luo Y, Kuniyasu H. Non-histone nuclear factor HMGB1 as a therapeutic target in colorectal cancer. Expert Opin Ther Targets 2011; 15:183-93.
16. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418:191-5.
17. Gardella S, Andrei C, Ferrera D, Lotti LV, Torrisi MR, Bianchi ME, et al. The nuclear protein HMGB1 is secreted by monocytes via a nonclassical, vesicle-mediated secretory pathway. EMBO Rep 2002;3: 995-1001.
18. Kuniyasu H, Chihara Y, Takahashi T. Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer. Oncol Rep 2003; 10:445-8.
19. Kuniyasu H, Chihara Y, Kondo H. Differential effects between amphoterin and advanced glycation end products on colon cancer cells. Int J Cancer 2003;104:722-7.
20. Ohmori H, Luo Y, Fujii K, Sasahira T, Shimomoto T, Denda A, et al. Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and the metastasis through the expression of high mobility group box 1. Pathobiology 2010;77:210-7.
21. Ioannou S, Voulgarelis M. Toll-like receptors, tissue injury, and tumourigenesis. Mediators Inflamm 2010;2010.pii: 581837.
22. Delgado MA, Deretic V. Toll-like receptors in control of immunological autophagy. Cell Death Differ 2009;16:976-83.
23. Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P, et al. Endogenous HMGB1 regulates autophagy. J Cell Biol 2010;190: 881-92.
24. Wagenmakers AJ. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exerc Sport Sci Rev 1998;26:287-314.
25. Shelton LM, Huysentruyt LC, Seyfried TN. Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model. Int J Cancer 2010;127:2478-85.
26. Shimbo K, Oonuki T, Yahashi A, Hirayama K, Miyano H. Precolumn derivatization reagents for high-speed analysis of amines and amino acids in biological fluid using liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 2009;23:1483-92.
27. Kuniyasu H, Oue N, Wakikawa A, Shigeishi H, Matsutani N, Kuraoka K, et al. Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer. J Pathol 2002;196:163-70.
28. Chihara Y, Fujimoto K, Kondo H, Moriwaka Y, Sasahira T, Hirao Y, et al. Anti-tumor effects of liposome-encapsulated titanium dioxide in nude mice. Pathobiology 2007;74:353-8.
29. Kuniyasu H, Oue N, Sasahira T, Luo Y, Moriwaka Y, Shimomoto T, et al. Reg IV enhances peritoneal metastasis in gastric carcinomas. Cell Prolif 2009;42:110-21.
30. Lee H, Song M, Shin N, Shin CH, Min BS, Kim HS, et al. Diagnostic significance of serum HMGB1 in colorectal carcinomas. PLoS ONE 2012;7:e34318.
31. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6:463-77.
32. Su H, Wang X. p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress. Trends Cardiovasc Med 2011;21:224-8.
33. Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P, et al. The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ 2010;17:666-76.
34. Bluemlein K, Gluckmann M, Gruning NM, Feichtinger R, Kruger A, Wamelink M, et al. Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis. Oncotarget 2012;3:1356-69.
35. Dang CV. PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect. Sci Signal 2009;2:pe75.
36. Dang CV. Links between metabolism and cancer. Genes Dev 2012; 26:877-90.
37. DeBerardinis RJ, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010;29:313-24.
38. Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res 2009;69:7986-93.
39. Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 2008;105:18782-7.
40. Vander Heiden MG. Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 2011;10:671-84.
41. Tomitsuka E, Kita K, Esumi H. An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system-a unique mitochondrial energy metabolism in tumour microenvironments. J Biochem 2012; 152:171-83.
42. Okamoto N, Miyagi Y, Chiba A, Akaike M, Shiozawa M, Imaizumi A, et al. Diagnostic modeling with differences in plasma amino acid profiles between non-cachectic colorectal/breast cancer patients and healthy individuals. Int J Med Med Sci 2009;1:1-8.
43. Tisdale MJ. Molecular pathways leading to cancer cachexia. Physiology 2005;20:340-8.
44. Choudry HA, Pan M, Karinch AM, Souba WW. Branched-chain amino acid-enriched nutritional support in surgical and cancer patients. J Nutr 2006;136:314S-8S.
45. Luo Y, Chihara Y, Fujimoto K, Sasahira T, Kuwada M, Fujiwara R, et al. High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy. Eur J Cancer 2013;49:741-51.
46. Sobin LH, Wittekind C, editors. UICC TNM Classification of malignant tumours. 6th ed. New York: John Wiley & Sons, Inc.; 2003.