Reg IV enhances peritoneal metastasis in gastric carcinomas

Cell Proliferation

Volumn 42, Issue 1, 2009, Pages 110-121

  Kuniyasu, H ^a,c   Oue, N ^b   Sasahira, T ^a   Yi, L ^a   Moriwaka, Y ^a   Shimomoto, T ^a   Fujii, K ^a   Ohmori, H ^a   Yasui, W ^b  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; KERATIN; NITRIC OXIDE; PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; REG IV PROTEIN; SURVIVIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER MODEL; CANCER SURVIVAL; CONTROLLED STUDY; GENE; GENE FUNCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PERITONEAL FLUID LEVEL; PERITONEUM METASTASIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REG IV GENE; STOMACH CARCINOMA;

ANIMALS; BASE SEQUENCE; CELL DIVISION; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; DNA PRIMERS; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LECTINS, C-TYPE; MICE; MICE, INBRED BALB C; MICE, NUDE; PERITONEAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS;

MUS; MUS MUSCULUS;

EID: 58449092403     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2008.00577.x     Document Type: Article

References (42)

1. Jamal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ (2003) Cancer statistics, 2003. CA Cancer J. Clin. 53, 5 26.
2. National Cancer Center, Cancer Information Service 2008) in : Kato H, ed. Cancer Statistics in Japan, 2008 [WWW document]. http://ganjoho.ncc.go.jp/ public/statistics/backnumber/2008-en.html [accessed 11.05.2008]
3. Maehara Y, Moriguchi S, Kakeji Y, Kohnoe S, Korenaga D, Haraguchi M, Sugimachi K (1991) Pertinent risk factors and gastric carcinoma with synchronous peritoneal dissemination or liver metastasis. Surgery 110, 820 823.
4. Moriguchi S, Maehara Y, Korenaga D, Sugimachi K, Nose Y (1992) Risk factors which predict pattern of recurrence after curative surgery for patients with advanced gastric cancer. Surg. Oncol. 1, 341 346.
5. Sugarbaker PH, Yu W, Yonemura Y (2003) Gastrectomy, peritonectomy, and perioperative intraperitoneal chemotherapy: the evolution of treatment strategies for advanced gastric cancer. Semin. Surg. Oncol. 21, 233 248.
6. Vogel I, Kalthoff H (2001) Disseminated tumour cells. Their detection and significance for prognosis of gastrointestinal and pancreatic carcinomas. Virchows Arch. 439, 109 117.
7. Kuniyasu H, Yasui W, Yokozaki H, Akagi M, Akama Y, Kitahara K, Fujii K, Tahara E (1994) Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas. Int. J. Cancer 59, 597 600.
8. Yoneda J, Kuniyasu H, Crispens MA, Price JE, Bucana CD, Fidler IJ (1998) Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice. J. Natl. Cancer Inst. 90, 447 454.
9. Kuniyasu H, Yasui W, Kitadai Y, Yokozaki H, Ito H, Tahara E (1992) Frequent amplification of the c-met gene in scirrhous type stomach cancer. Biochem. Biophys. Res. Commun 189, 227 232.
10. Kuniyasu H, Yasui W, Yokozaki H, Kitadai Y, Tahara E (1993) Aberrant expression of c-met mRNA in human gastric carcinomas. Int. J. Cancer 55, 72 75.
11. Takeda M, Arao T, Yokote H, Komatsu T, Yanagihara K, Sasaki H, Yamada Y, Tamura T, Fukuoka K, Kimura H, Saijo N, Nishio K (2007) AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. Clin. Cancer Res. 13, 3051 3057.
12. Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, Kodama T, Aburatani H (2001) Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Cancer Res. 61, 889 895.
13. Kuniyasu H, Yoshida K, Sasaki T, Sasahira T, Fujii K, Ohmori H (2006) Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. Int. J. Cancer 118, 571 576.
14. Sasaki T, Fujii K, Yoshida K, Shimura H, Sasahira T, Ohmori H, Kuniyasu H (2005a) Peritoneal metastasis inhibition by linoleic acid with activation of PPARγ in human gastrointestinal cancer cells. Virchows Arch. 448, 422 427.
15. Sakakura C, Hasegawa K, Miyagawa K, Nakashima S, Yoshikawa T, Kin S, Nakase Y, Yazumi S, Yamagishi H, Okanoue T, Chiba T, Hagiwara A (2005) Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers. Clin. Cancer Res. 11, 6479 6488.
16. Tsuburaya A, Noguchi Y, Yoshikawa T, Saito A, Doi C, Okamoto T, Fukuzawa K (2002) An anti-apoptosis gene, survivin and telomerase expression in gastric cancer. Hepatogastroenterology 49, 1150 1152.
17. Sasaki N, Morisaki T, Hashizume K, Yao T, Tsuneyoshi M, Noshiro H, Nakamura K, Yamanaka T, Uchiyama A, Tanaka M, Katano M (2001) Nuclear factor-κB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clin. Cancer Res. 7, 4136 4142.
18. Yawata A, Adachi M, Okuda H, Naishiro Y, Takamura T, Hareyama M, Takayama S, Reed JC, Imai K (1998) Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells. Oncogene 16, 2681 2686.
19. Chakraborty C, Katsumata N, Myal Y, Schroedter IC, Brazeau P, Murphy LJ, Shiu RP, Friesen HG (1995) Age-related changes in peptide-23/pancreatitis- associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone. Endocrinology 136, 1843 1849.
20. Lasserre C, Simon MT, Ishikawa H, Diriong S, Nguyen VC, Christa L, Vernier P, Brechot C (1994) Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. Eur. J. Biochem. 224, 29 38.
21. Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (2001) Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim. Biophys. Acta 1518, 287 293.
22. Li A, Crimmins DL, Luo Q, Hartupee J, Landt Y, Ladenson JH, Wilson D, Anant S, Dieckgraefe BK (2003) Expression of a novel regenerating gene product, Reg IV, by high density fermentation in Pichia pastoris: production, purification, and characterization. Protein Expr. Purif. 31, 197 206.
23. Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H (2004) Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. Gene 340, 161 170.
24. Nanakin A, Fukui H, Fujii S, Sekikawa A, Kanda N, Hisatsune H, Seno H, Konda Y, Fujimori T, Chiba T (2007) Expression of the REG IV gene in ulcerative colitis. Lab. Invest. 87, 304 314.
25. Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz. J, Lacasa M, Lesuffleur T (2003) Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int. J. Cancer 103, 185 193.
26. Zhang Y, Lai M, Lv B, Gu X, Wang H, Zhu Y, Shao L, Wang G (2003a) Overexpression of Reg IV in colorectal adenoma. Cancer Lett. 200, 69 76.
27. Bishnupuri KS, Luo Q, Murmu N, Houchen CW, Anant S, Dieckgraefe BK (2006b) Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology 130, 137 149.
28. Bishnupuri KS, Luo Q, Korzenik JR, Henderson JO, Houchen CW, Anant S, Dieckgraefe BK (2006a) Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol. Ther 5, 1714 1720.
29. Mitani Y, Oue N, Matsumura S, Yoshida K, Noguchi T, Ito M, Tanaka S, Kuniyasu H, Kamata N, Yasui W (2007) Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene 26, 4383 4393.
30. Gu Z, Rubin MA, Yang Y, Deprimo SE, Zhao H, Horvath S, Brooks JD, Loda M, Reiter RE (2005) Reg IV: a promising marker of hormone refractory metastatic prostate cancer. Clin. Cancer Res. 11, 2237 2243.
31. Heiskala K, Giles-Komar J, Heiskala M, Andersson LC (2006) High expression of RELP (Reg IV) in neoplastic goblet cells of appendiceal mucinous cystadenoma and pseudomyxoma peritonei. Virchows Arch. 448, 295 300.
32. Pankova-Kholmyansky I, Arber N (2007) Reg IV can serve for early diagnosis and therapy. Cancer Biol. Ther. 6, 123 124.
33. Oue N, Mitani Y, Aung PP, Sakakura C, Takeshima Y, Kaneko M, Noguchi T, Nakayama H, Yasui W (2005) Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J. Pathol. 207, 185 198.
34. Chihara Y, Fujimoto K, Kondo H, Moriwaka Y, Sasahira T, Hirao Y, Kuniyasu H (2007) Anti-tumor effects of liposome-encapsulated titanium dioxide in nude mice. Pathobiology 74, 353 358.
35. Kuniyasu H, Yasui W, Kitahara K, Naka K, Yokozaki H, Akama Y, Hamamoto T, Tahara H, Tahara E (1997) Growth inhibitory effect of interferon-β is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line. Cell Growth Differ. 8, 47 52.
36. Sasaki T, Yoshida K, Kondo H, Ohmori H, Kuniyasu H (2005b) Heme oxygenase-1 accelerates protumoral effects of nitric oxide in cancer cells. Virchows Arch. 446, 525 531.
37. Zhang YW, Ding LS, Lai MD (2003b) Reg gene family and human diseases. World J. Gastroenterol. 9, 2635 2641.
38. Takekura N, Yasui W, Kyo E, Yoshida K, Kameda T, Kitadai Y, Abe K, Umezawa K, Tahara E (1991) Effects of tyrosine kinase inhibitor, erbstatin, on cell growth and growth-factor/receptor gene expression in human gastric carcinoma cells. Int. J. Cancer 47, 938 942.
39. Alkhamesi NA, Ziprin P, Pfistermuller K, Peck DH, Darzi AW (2005) ICAM-1 mediated peritoneal carcinomatosis, a target for therapeutic intervention. Clin. Exp. Metastasis 22, 449 459.
40. Skubitz AP (2002) Adhesion molecules. Cancer Treat. Res. 107, 305 329.
41. Yokozaki H (2000) Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol. Int. 50, 767 777.
42. Mori K, Aoyagi K, Ueda T, Danjoh I, Tsubosa Y, Yanagihara K, Matsuno Y, Sasako M, Sakamoto H, Mafune K, Kaminishi M, Yoshida T, Terada M, Sasaki H (2004) Highly specific marker genes for detecting minimal gastric cancer cells in cytology negative peritoneal washings. Biochem. Biophys. Res. Commun. 313, 931 937.