Neurobiological signatures of alcohol dependence revealed by protein profiling

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Gorini, Giorgio ^a   Roberts, Amanda J ^b   Mayfield, R Dayne ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; DYNAMIN; ISOPROTEIN;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRINKING BEHAVIOR; ENDOCYTOSIS; MALE; MESENCEPHALON; MOUSE; NEUROBIOLOGY; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; RELAPSE;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; BRAIN; CHOICE BEHAVIOR; DRINKING BEHAVIOR; ETHANOL; IMMUNOELECTROPHORESIS, TWO-DIMENSIONAL; MALE; MATCHED-PAIR ANALYSIS; MICE; MICE, INBRED C57BL; PROTEOME; TRANSCRIPTOME;

EID: 84892690936     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082656     Document Type: Article

References (53)

1. Kril JJ, Halliday GM, Svoboda MD, Cartwright H (1997) The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79: 983-998.
2. Sutherland GT, Sheedy D, Kril JJ (2013) Using Autopsy Brain Tissue to Study Alcohol-Related Brain Damage in the Genomic Age. Alcohol Clin Exp Res. doi:10.1111/acer.12243.
3. Gorini G, Bell RL, Mayfield RD (2011) Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. Progress in molecular biology and translational science 98: 293-347. doi:10.1016/B978-0-12-385506-0.00007-7.
4. Dalley JW, Cardinal RN, Robbins TW (2004) Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28: 771-784. doi:10.1016/j.neubiorev.2004.09.006.
5. Sullivan EV, Fama R, Rosenbloom MJ, Pfefferbaum A (2002) A profile of neuropsychological deficits in alcoholic women. Neuropsychology 16: 74-83.
6. Sullivan EV, Pfefferbaum A (2005) Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology (Berl) 180: 583-594. doi:10.1007/s00213-005-2267-6.
7. Nestler EJ (2004) Molecular mechanisms of drug addiction. Neuropharmacology 47 Suppl 1: 24-32. doi:10.1016/j.neuropharm.2004.06.031.
8. Nestler EJ (2005) Is there a common molecular pathway for addiction? Nat Neurosci 8: 1445-1449. doi:10.1038/nn1578.
9. Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, et al. (2004) Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev 27: 739-749. doi:10.1016/j.neubiorev.2003.11.007.
10. Dodd PR, Lewohl JM (1998) Cell death mediated by amino acid transmitter receptors in human alcoholic brain damage: conflicts in the evidence. Ann N Y Acad Sci 844: 50-58.
11. Huntzinger E, Izaurralde E (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12: 99-110. doi:10.1038/nrg2936.
12. Gygi SP, Rochon Y, Franza BR, Aebersold R (1999) Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19: 1720-1730.
13. Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HYK, et al. (2012) Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 148: 1293-1307. doi:10.1016/j.cell.2012.02.009.
14. Greenbaum D, Colangelo C, Williams K, Gerstein M (2003) Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol 4: 117. doi:10.1186/gb-2003-4-9-117.
15. Ponomarev I, Wang S, Zhang L, Harris RA, Mayfield RD (2012) Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. The Journal of neuroscience: the official journal of the Society for Neuroscience 32: 1884-1897. doi:10.1523/JNEUROSCI.3136-11.2012.
16. Lopez MF, Becker HC (2005) Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice. Psychopharmacology 181: 688-696. doi:10.1007/s00213-005-0026-3.
17. Finn DA, Snelling C, Fretwell AM, Tanchuck MA, Underwood L, et al. (2007) Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41). Alcoholism, clinical and experimental research 31: 939-949. doi:10.1111/j.1530-0277.2007.00379.x.
18. Griffin WC 3rd, Lopez MF, Becker HC (2009) Intensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice. Alcohol Clin Exp Res 33: 1893-1900. doi:10.1111/j.1530-0277.2009.01027.x.
19. Fodor IK, Nelson DO, Alegria-Hartman M, Robbins K, Langlois RG, et al. (2005) Statistical challenges in the analysis of two-dimensional difference gel electrophoresis experiments using DeCyder. Bioinformatics 21: 3733-3740. doi:10.1093/bioinformatics/bti612.
20. Vizcaíno JA, Côté RG, Csordas A, Dianes JA, Fabregat A, et al. (2013) The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013. Nucleic Acids Res 41: D1063-1069. doi:10.1093/nar/ gks1262.
21. Zhang B, Horvath S (2005) A general framework for weighted gene coexpression network analysis. Statistical applications in genetics and molecular biology 4: Article17. doi:10.2202/1544-6115.1128.
22. Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9: 559. doi:10.1186/1471-2105- 9-559.
23. D'haene B, Mestdagh P, Hellemans J, Vandesompele J (2012) miRNA expression profiling: from reference genes to global mean normalization. Methods Mol Biol 822: 261-272. doi:10.1007/978-1-61779-427-8-18.
24. Praefcke GJK, McMahon HT (2004) The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol 5: 133-147. doi:10.1038/nrm1313.
25. Ferguson SM, De Camilli P (2012) Dynamin, a membrane-remodelling GTPase. Nat Rev Mol Cell Biol 13: 75-88. doi:10.1038/nrm3266.
26. Phillips TJ, Belknap JK, Hitzemann RJ, Buck KJ, Cunningham CL, et al. (2002) Harnessing the mouse to unravel the genetics of human disease. Genes Brain Behav 1: 14-26.
27. Mayfield RD, Harris RA, Schuckit MA (2008) Genetic factors influencing alcohol dependence. Br J Pharmacol 154: 275-287. doi:10.1038/bjp.2008.88.
28. Rogowska-Wrzesinska A, Le Bihan M-C, Thaysen-Andersen M, Roepstorff P (2013) 2D gels still have a niche in proteomics. J Proteomics. doi:10.1016/j.jprot.2013.01.010.
29. Lewohl JM, Van Dyk DD, Craft GE, Innes DJ, Mayfield RD, et al. (2004) The application of proteomics to the human alcoholic brain. Ann N Y Acad Sci 1025: 14-26. doi:10.1196/annals.1316.002.
30. Etheridge N, Lewohl JM, Mayfield RD, Harris RA, Dodd PR (2009) Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain. Proteomics Clin Appl 3: 730-742. doi:10.1002/prca.200800202.
31. Etheridge N, Mayfield RD, Harris RA, Dodd PR (2011) Identifying changes in the synaptic proteome of cirrhotic alcoholic superior frontal gyrus. Current neuropharmacology 9: 122-128. doi:10.2174/157015911795017164.
32. Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, et al. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31: 1574-1582. doi:10.1038/sj.npp.1300947.
33. Kimpel MW, Strother WN, McClintick JN, Carr LG, Liang T, et al. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. Alcohol 41: 95-132. doi:10.1016/j.alcohol.2007.03.003.
34. McBride WJ, Schultz JA, Kimpel MW, McClintick JN, Wang M, et al. (2009) Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study. Pharmacol Biochem Behav 92: 304-313. doi:10.1016/j.pbb.2008. 12.019.
35. Tapocik JD, Solomon M, Flanigan M, Meinhardt M, Barbier E, et al. (2013) Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence. Pharmacogenomics J 13: 286-296. doi:10.1038/tpj.2012.17.
36. Bell RL, Kimpel MW, Rodd ZA, Strother WN, Bai F, et al. (2006) Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol. Alcohol 40: 3-17. doi:10.1016/j.alcohol.2006.10.001.
37. Bell RL, Kimpel MW, McClintick JN, Strother WN, Carr LG, et al. (2009) Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption. Pharmacol Biochem Behav 94: 131-147. doi:10.1016/j.pbb.2009.07.019.
38. Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, et al. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A 103: 6368-6373. doi:10.1073/pnas.0510188103.
39. Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Adron Harris R, et al. (2011) Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. Alcohol Clin Exp Res 35: 659-670. doi:10.1111/j.1530-0277.2010.01384.x.
40. Gorini G, Ponomareva O, Shores KS, Person MD, Harris RA, et al. (2010) Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. FEBS Lett 584: 845-851. doi:10.1016/j.febslet.2009.12.061.
41. Pietrzykowski AZ, Friesen RM, Martin GE, Puig SI, Nowak CL, et al. (2008) Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron 59: 274-287. doi:10.1016/j.neuron. 2008.05.032.
42. Treistman SN, Martin GE (2009) BK Channels: mediators and models for alcohol tolerance. Trends Neurosci 32: 629-637. doi:10.1016/j.tins.2009.08.001.
43. Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, et al. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 81: 802-813.
44. Liu J, Lewohl JM, Dodd PR, Randall PK, Harris RA, et al. (2004) Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. J Neurochem 90: 1050-1058. doi:10.1111/j.1471-4159.2004.02570.x.
45. Li MD, Wang J (2007) Neuroproteomics and its applications in research on nicotine and other drugs of abuse. Proteomics Clin Appl 1: 1406-1427. doi:10.1002/prca.200700321.
46. Koob GF (2006) The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction 101 Suppl 1: 23-30. doi:10.1111/j.1360-0443. 2006.01586.x.
47. Volkow ND, Ma Y, Zhu W, Fowler JS, Li J, et al. (2008) Moderate doses of alcohol disrupt the functional organization of the human brain. Psychiatry Res 162: 205-213. doi:10.1016/j.pscychresns.2007.04.010.
48. Calabrese V, Testa G, Ravagna A, Bates TE, Stella AM (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochem Biophys Res Commun 269: 397-400. doi:10.1006/bbrc.2000.2311.
49. Pignataro L, Miller AN, Ma L, Midha S, Protiva P, et al. (2007) Alcohol regulates gene expression in neurons via activation of heat shock factor 1. J Neurosci 27: 12957-12966. doi:10.1523/JNEUROSCI.4142-07.2007.
50. Alexander-Kaufman K, Cordwell S, Harper C, Matsumoto I (2007) A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteomics Clin Appl 1: 62-72. doi:10.1002/prca.200600417.
51. Lewohl JM, Nunez YO, Dodd PR, Tiwari GR, Harris RA, et al. (2011) Upregulation of microRNAs in brain of human alcoholics. Alcoholism, clinical and experimental research 35: 1928-1937. doi:10.1111/j.1530-0277.2011.01544.x.
52. Wang J, Yuan W, Li MD (2011) Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/ methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses. Mol Neurobiol 44: 269-286. doi:10.1007/s12035-011-8202-4.
53. Kennedy MJ, Ehlers MD (2006) Organelles and trafficking machinery for postsynaptic plasticity. Annu Rev Neurosci 29: 325-362. doi:10.1146/annurev. neuro.29.051605.112808.