Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: Distribution, temporal variability, and relationship with child attention and hyperactivity

International Journal of Hygiene and Environmental Health

Volumn 217, Issue 2-3, 2014, Pages 405-412

  Fortenberry, Gamola Z ^a   Meeker, John D ^a   Sánchez, Brisa N ^a   Barr, Dana Boyd ^b   Panuwet, Parinya ^b   Bellinger, David ^c   Schnaas, Lourdes ^d   Solano González, Maritsa ^e   Ettinger, Adrienne S ^a,c,f   Hernandez Avila, Mauricio ^g   Hu, Howard ^h   Tellez Rojo, Martha Maria ^e  

^a UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^b EMORY UNIVERSITY   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d INSTITUTO NACIONAL DE PERINATOLOGÍA   (Mexico)

^e INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^f YALE UNIVERSITY   (United States)

^g Ministry of Health   (Mexico)

^h UNIVERSITY OF TORONTO   (Canada)

Author keywords

ADHD; Biomarker; Children; Exposure; Organophosphates; Pesticides

Indexed keywords

2 HYDROXY 3,5,6 TRICHLORPYRIDINE; 3,5,6-TRICHLORO-2-PYRIDINOL; BIOLOGICAL MARKER; CHLORPYRIFOS; CHLORPYRIFOS METHYL; CHLORPYRIFOS-METHYL; DRUG DERIVATIVE; ORGANOPHOSPHATE; PESTICIDE; PYRIDONE DERIVATIVE;

ADULT; AGRICULTURE; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; CHEMICALLY INDUCED DISORDER; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; EXPOSURE; FEMALE; HUMAN; MALE; MEXICO; OCCUPATIONAL EXPOSURE; PREGNANCY; PRENATAL EXPOSURE; PROSPECTIVE STUDY; SEX DIFFERENCE; THIRD TRIMESTER PREGNANCY; URINE; VALIDATION STUDY; YOUNG ADULT;

ADHD; BIOMARKER; CHILDREN; EXPOSURE; ORGANOPHOSPHATES; PESTICIDES;

ADULT; AGRICULTURE; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; CHLORPYRIFOS; FEMALE; HUMANS; MALE; MATERNAL EXPOSURE; MEXICO; OCCUPATIONAL EXPOSURE; PESTICIDES; PREGNANCY; PREGNANCY TRIMESTER, THIRD; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES; PYRIDONES; SEX FACTORS; YOUNG ADULT;

EID: 84892676295     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2013.07.018     Document Type: Article

References (62)

1. Aguiar A., Eubig P.A., Schantz S.L. Attention deficit/hyperactivity disorder: a focused overview for children's environmental health researchers. Environ. Health Perspect. 2010, 118(12):1646-1653. 10.1289/ehp.1002326.
2. American Psychiatric Association Diagnostic and statistical manual of mental disorders 2000, 4th ed., text rev., Washington, DC.
3. Banerjee T., Middleton F., Faraone S. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Pædiatr. 2007, 96(9):1269-1274.
4. Bayley N. Bayley Scales of Infant Development® 1993, BSID®-II. 2nd ed.
5. Berkowitz G., Wetmur J., Birman-Deych E., Obel J., Lapinski R., Godbold J., Wolff M. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ. Health Perspect. 2004, 112(3):388-391.
6. Biederman J., Mick E., Faraone S.V., Braaten E., Doyle A., Spencer T., Johnson M.A. Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. Am. J. Psychiatry 2002, 159(1):36-42.
7. Bouchard M.F., Bellinger D.C., Wright R.O., Weisskopf M.G. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics 2010, 125(6):e1270-e1277. 10.1542/peds.2009-3058.
8. Bradman A., Whyatt R. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the national children's study: a review of monitoring and measurement methodologies. Environ. Health Perspect. 2005, 113(8):1092-1099.
9. Braun J.M., Kahn R.S., Froehlich T., Auinger P., Lanphear B.P. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ. Health Perspect. 2006, 114(12):1904-1909.
10. Braun J.M., Hoffman E., Schwartz J., Sanchez B., Schnaas L., Mercado-Garcia A., Hernandez-Avila M. Assessing windows of susceptibility to lead-induced cognitive deficits in Mexican children. Neurotoxicology 2012, 33(5):1040-1047. 10.1016/j.neuro.2012.04.022.
11. CDC, 2006, NCHS (National Center for Health Statistics). Laboratory procedure manuals. NHANES 1999-2000. 2006a. (accessed December 1, 2010). http://www.cdc/gov/nchs/about/major/nhanes/lab_methods99_00.
12. CDC, 2011. (accessed November 24, 2012). http://www.cdc.gov/ncbddd/adhd/data.html.
13. CDC, 2012. (accessed October 10, 2012). http://www.cdc.gov/biomonitoring/Chlorpyrifos_BiomonitoringSummary.html.
14. Conners C.K., Sitarenios G., Parker J.D., Epstein J.N. The revised conners' parent rating scale (CPRS-R): Factor structure, reliability, and criterion validity. J. Abnorm. Child Psycholo. 1998, 26(4):257-268.
15. Conner Profile, 2000. (accessed October 20, 2012). http://www.psychassessments.com.au/products/26/prod26_report1.pdf.
16. Conner Profile, 2012. (accessed October 20, 2012). http://www.damianbariexca.net/wp-content/docs/Conners%20ADHD%20Report.pdf.
17. Dam K., Seidler F.J., Slotkin T.A. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Dev. Brain Res. 2000, 121(2):179-187. 10.1016/S0165-3806(00)00044-4.
18. De Angelis S., Tassinari R., Maranghi F., Eusepi A., Di Virgilio A., Chiarotti F., Mantovani A. Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice. Toxicol. Sci. 2009, 108(2):311-319.
19. Deb S., Dhaliwal A.J., Roy M. The usefulness of conners' rating scales-revised in screening for attention deficit hyperactivity disorder in children with intellectual disabilities and borderline intelligence. J. Intellect. Disabil. Res. 2008, 52(11):950-965. 10.1111/j.1365-2788.2007.01035.x.
20. Dow, 2012. (accessed October 20, 2012). http://www.chlorpyrifos.com/worldwide-use.htm.
21. Eaton D., Daroff R., Autrup H., Bridges J., Buffler P., Costa L., Spencer P. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit. Rev. Toxicol. 2008, 38(Suppl. 2):1-125.
22. Egeghy P.P., Quackenboss J.J., Catlin S., Ryan P.B. Determinants of temporal variability in NHEXAS-Maryland environmental concentrations, exposures, and biomarkers. J. Expo. Anal. Environ. Epidemiol. 2005, 15(5):388-397. 10.1038/sj.jea.7500415.
23. Engel S.M., Wetmur J., Chen J., Zhu C., Barr D.B., Canfield R.L., Wolff M.S. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ. Health Perspect. 2011, 119(8).
24. Ernst M., Moolchan E.T., Robinson M.L. Behavioral and neural consequences of prenatal exposure to nicotine. J. Am. Acad. Child Adolesc. Psychiatry 2001, 40(6):630-641. 10.1097/00004583-200106000-00007.
25. Eskenazi B., Marks A., Bradman A., Harley K., Barr D., Johnson C., Morga N., Jewell N. Organophosphate pesticide exposure and neurodevelopment in young mexican-american children. Environ. Health Perspect. 2007, 115(5):792-798.
26. Ettinger A.S., Lamadrid-Figueroa H., Tellez-Rojo M.M., Mercado-Garcia A., Peterson K.E., Schwartz J., Hernandez-Avila M. Effect of calcium supplementation on blood lead levels in pregnancy: a randomized placebo-controlled trial. Environ. Health Perspect. 2009, 117(1):26-31. 10.1289/ehp.11868.
27. Garcia S., Seidler F., Slotkin T. Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. Environ. Health Perspect. 2003, 111(3):297-303.
28. Garcia S.J., Seidler F.J., Slotkin T.A. Developmental neurotoxicity of chlorpyrifos: targeting glial cells. Environ. Toxicol. Pharmacol. 2005, 19(3):455-461. 10.1016/j.etap.2004.12.007.
29. Handal A., Harlow S., Breilh J., Lozoff B. Occupational exposure to pesticides during pregnancy and neurobehavioral development of infants and toddlers. Epidemiology 2008, 19(6):851-859.
30. Hernandez-Avila M., Gonzalez-Cossio T., Hernandez-Avila J.E., Romieu I., Peterson K.E., Aro A., et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology (Cambridge, Mass.) 2003, 14(2):206-212. 10.1097/01.ED.E.0000038520.66094.34.
31. Hu H., Tellez-Rojo M.M., Bellinger D., Smith D., Ettinger A.S., Lamadrid-Figueroa H., Hernandez-Avila M. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environ. Health Perspect. 2006, 114(11):1730-1735.
32. Icenogle L.M., Christopher N.C., Blackwelder W.P., Caldwell D.P., Qiao D., Seidler F.J., Levin E.D. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol. Teratol. 2004, 26(1):95-101. 10.1016/j.ntt.2003.09.001.
33. Karlsson S.I. Agricultural pesticides in developing countries. Environment 2004, 46(4):22-41.
34. Landis J.R., Koch G.G. The measurement of observer agreement for categorical data. Biometrics 1977, 33:159-174.
35. Levin E.D., Addy N., Nakajima A., Christopher N.C., Seidler F.J., Slotkin T.A. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Dev. Brain Res. 2001, 130(1):83-89. 10.1016/S0165-3806(01)00215-2.
36. Levin E.D., Addy N., Baruah A., Elias A., Christopher N.C., Seidler F.J., Slotkin T.A. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol. Teratol. 2002, 24(6):733-741. 10.1016/S0892-0362(02)00272-6.
37. Linnet K.M., Dalsgaard S., Obel C., Wisborg K. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am. J. Psychiatry 2003, 160(6):1028-1040.
38. Marks A.R., Harley K., Bradman A., Kogut K., Barr D.B., Johnson C., Eskenazi B. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ. Health Perspect. 2010, 118(12):1768-1774. 10.1289/ehp.1002056.
39. Meeker J.D., Barr D.B., Ryan L., Herrick R.F., Bennett D.H., Bravo R. Temporal variability of urinary levels of non-persistent insecticides in adult men. J. Exposure Anal. Environ. Epidemiol. 2005, 15(3):271-281.
40. Olsson A., Baker S., Nguyen J., Romanoff L., Udunka S., Walker R., Barr D. A liquid chromatography-tandem mass spectrometry multiresidue method for quantification of specific metabolites of organophosphorus pesticides, synthetic pyrethroids, selected herbicides, and deet in human urine. Anal. Chem. 2004, 76(9):2453.
41. Pang Y., MacIntosh D., Camann D., Ryan P.B. Analysis of aggregate exposure to chlorpyrifos in the NHEXAS-Maryland investigation. Environ. Health Perspect. 2002, 110(3):235-240.
42. Panuwet P., Prapamontol T., Chantara S., Thavornyuthikarn P., Montesano M.A., Whitehead R., Barr D. Concentrations of urinary pesticide metabolites in small-scale farmers in Chiang Mai province, Thailand. Sci. Total Environ. 2008, 407(1):655-668.
43. Pearson Assessment, 2012. (accessed October 2012). http://www.pearsonassessments.com/HAIWEB/Cultures/en-us/Productdetail.htm%3FPid=PAa30000.
44. Perera F.P., Rauh V., Whyatt R.M., Tang D., Tsai W.Y., Bernert J.T., Kinney P.L. A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures. Neurotoxicology 2005, 26(4):573-587.
45. Portney L.G., Watkins M.P. Foundations of Clinical Research: Applications to Practice 2000, 560-567. Prentice Hall Inc., New Jersey.
46. Rauh V., Garfinkel R., Perera F., Andrews H., Hoepner L., Barr D., Whyatt R. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 2006, 118(6):e1845-e1859.
47. Rauh V., Arunajadai S., Horton M., Perera F., Hoepner L., Barr D.B., Whyatt R. Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ. Health Perspect. 2011, 119(8).
48. Rauh V.A., Perera F.P., Horton M.K., Whyatt R.M., Bansal R., Hao X., Peterson B.S. Brain anomalies in children exposed prenatally to a common organophosphate pesticide. PNAS 2012, 109(20):7871-7876. 10.1073/pnas.1203396109.
49. Rowland A., Lesesne C., Abramowitz A. The epidemiology of attention-deficit/hyperactivity disorder (ADHD): A public health view. Ment. Retard. Dev. Disabil. Res. Rev. 2002, 8(3):162-170.
50. Salas J., Gonzlez M., Noa M., Prez N., Daz G., Gutirrez R., Osuna I. Organophosphorus pesticide residues in Mexican commercial pasteurized milk. J. Agric. Food Chem. 2003, 51(15):4468-4471.
51. Staller J., Faraone S.V. Attention-deficit hyperactivity disorder in girls: epidemiology and management. CNS Drugs 2006, 20(2):107-123.
52. Téllez-Rojo M.M., Hernández-Avila M., Lamadrid-Figueroa H., Smith D., Hernández-Cadena L., Mercado A., Hu H. Impact of bone lead and bone resorption on plasma and whole blood lead levels during pregnancy. Am. J. Epidemiol. 2004, 160(7):668-678. 10.1093/aje/kwh271.
53. Téllez-Rojo M.M., Bellinger D.C., Arroyo-Quiroz C., Lamadrid-Figueroa H., Mercado-García A., Schnaas-Arrieta L., Hu H. Longitudinal associations between blood lead concentrations lower than 10μg/dL and neurobehavioral development in environmentally exposed children in mexico city. Pediatrics 2006, 118(2):e323-e330. 10.1542/peds.2005-3123.
54. Timchalk C., Busby A., Campbell J., Needham L., Barr D. Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat. Toxicology 2007, 237(1-3):145.
55. U.S.Environmental Protection Agency (U.S.EPA) Interim registration eligibility decision for chlorpyrifos. U.S. EPA 738-R-01-007 February 2002, Available at http://www.epa.gov/oppsrrd1/REDs/chlorpyrifos_ired.pdf (accessed October 2012).
56. U.S. Environmental Protection Agency (U.S. EPA) (2011). (accessed October 2012). http://www.epa.gov/oppsrrd1/REDs/factsheets/chlorpyrifos_fs.htm.
57. Venerosi A., Ricceri L., Scattoni M., Calamandrei G. Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups. Environ. Health 2009, 8:12.
58. Wechsler H. Wechsler Adult Intelligence Scale (WAIS), Spanish Version 1968, Psychological Corporation, San Antonio, TX.
59. Whyatt R.M., Camann D., Perera F.P., Rauh V.A., Tang D., Kinney P.L., Garfinkel R., Andrews H., Hoepner L., Barr D.B. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol. Appl. Pharmacol. 2005, 206(2):246-254. 10.1016/j.taap.2004.11.027.
60. Whyatt R., Garfinkel R., Hoepner L., Andrews H., Holmes D., Williams M., Barr D. A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy. Environ. Health Perspect. 2009, 117(4):559-567.
61. Wilmshurst L., Peele M., Wilmshurst L. Resilience and well-being in college students with and without a diagnosis of ADHD. J. Atten. Disord. 2009.
62. Ye X., Pierik F., Hauser R., Duty S., Angerer J., Park M., Longnecker M. Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the generation R study. Environ. Res. 2008, 108(2):260-267.