Dietary calcium supplements to lower blood lead levels in lactating women: A randomized placebo-controlled trial

Epidemiology

Volumn 14, Issue 2, 2003, Pages 206-212

  Hernandez Avila, Mauricio ^a   Gonzalez Cossio, Teresa ^a   Hernandez Avila, Juan E ^a   Romieu, Isabelle ^a   Peterson, Karen E ^b   Aro, Antonio ^b,c   Palazuelos, Eduardo ^d   Hu, Howard ^b,c  

^a INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d AMERICAN BRITISH COWDRAY MEDICAL CENTER   (Mexico)

Author keywords

Blood lead; Breastfeeding; Calcium supplementation; Randomized clinical trial

Indexed keywords

CALCIUM; CALCIUM CARBONATE; LEAD; PLACEBO;

ADULT; ARTICLE; BODY BURDEN; BONE TISSUE; BREAST FEEDING; CALCIUM INTAKE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HYPOTHESIS; LACTATION; LEAD BLOOD LEVEL; MAJOR CLINICAL STUDY; MEXICO; PREGNANCY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ATOMIC ABSORPTION SPECTROMETRY; BLOOD; BONE; CHEMISTRY; DOUBLE BLIND PROCEDURE; METABOLISM; QUESTIONNAIRE; STATISTICAL MODEL;

ADULT; BONE AND BONES; CALCIUM CARBONATE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LACTATION; LEAD; LINEAR MODELS; PLACEBOS; QUESTIONNAIRES; SPECTROPHOTOMETRY, ATOMIC;

EID: 0038622895     PISSN: 10443983     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001648-200303000-00015     Document Type: Article

References (36)

1. Silbergeld EK. Lead in bone: implications for toxicology during pregnancy and lactation. Environ Health Perspect 1991;91:63-70.
2. Rabinowitz MB. Toxicokinetics of bone lead. Environ Health Perspect 1991;91:33-37.
3. Hu H. Bone lead as a new biologic marker of lead dose: recent findings and implications for public health. Environ Health Perspect 1998;106(suppl 4):961-967.
4. Barry PSI, Mossmann DB. Lead concentration in human tissues. Br J Indust Med 1970;27:339-351.
5. Hu H, Milder F, Burger D. X-Ray Fluorescence: Issues surrounding the application of a new tool for measuring lead burden. Environ Res 1989;49:295-317.
6. Gulson BL, Mahaffey KR, Mizon KJ, Korsch MJ, Cameron MA, Vimpani G. Contribution of tissue lead to blood lead in adult female subjects based on stable lead isotopes methods. J Clin Lab Med 1995;125:703-712.
7. Gulson BL, Jameson CW, Mahaffey KR, Mizon KJ, Korsh MJ, Vimpani G. Pregnancy increases mobilization of lead from maternal skeleton. J Clin Lab Med 1997;130:51-62.
8. Lagerkvist BJ, Ekersydh S, Englyst V, Nordberg GF, Soderberg H Wiklund DE. Increase blood lead and decreased calcium levels during pregnancy, a prospective study of Swedish women living near a smelter. Am J Public Health 1996;86:1247-1252.
9. Téllez-Rojo MM, Hernández-Avila M, González- Cossío, et al. The impact of breastfeeding on the mobilization of lead from bone. Am J Epidemiol 2002;155:420-428.
10. Kalkwarf KJ, Specker BL, Bianchi DC, Ranz J, Ho M. The effect of calcium supplementation on bone density during lactation and after weaning. N Engl J Med 1997;337:523-528.
11. Chan GM, McMurry M, Westover K, Engelbert-Fenton K, Thomas MR. Effects of increased dietary calcium intake upon the calcium and bone mineral status of lactating adolescent and adult women. Am J Clin Nutr 1987;46:319-323.
12. Sargent JD. The role of nutrition in the prevention of lead poisoning in children. Pediatr Ann 1994;23:636-642.
13. Six KM, Goyer RA. Experimental enhancement of lead toxicity by low dietary calcium. J Lab Clin Med 1970;83:933-942.
14. Mahaffey KR, Haseman JD, Goyer RA. Dose-response to lead ingestion in rats on low dietary calcium. J Lab Clin Med 1973;83:92-100.
15. Barton JC, Conrad ME, Harrison L, Nyby S. Effects of calcium on the absorption and retention of lead. J Lab Clin Med 1978;91:366-376.
16. Hernandez-Avila M, Sanin LH, Romieu I, et al. Higher milk intake during pregnancy is associated with lower maternal and umbilical cord lead levels in postpartum women. Environ Res 1997;74:116-121.
17. West WL, Knight EM, Edwards CH, et al. Maternal low level lead and pregnancy outcomes. J Nutr 1994;124:981S-986S.
18. Romieu I, Carreon T, Lopez L, et al. Environmental urban lead exposure and blood lead levels in children of Mexico City. Environ Health Perspect 1995;103:1036-1040.
19. Hernandez-Avila M, Romieu I, Parra S, Hernandez-Avila J, Madrigal H, Willett W. Validity and reproducibility of a food frequency questionnaire to assess dietary intake of women living in Mexico City. Salud Publica Mex 1998;40:133-140.
20. Aro ACA, Todd AC, Amarasiriwardena C, Hu H. Improvement in the calibration of 103CD K x-ray fluorescence systems for measuring bone lead in vivo. Phys Med Biol 1994;39:2263-2271.
21. Hu H, Aro A, Roknitzky A. Bone lead measured by x-ray fluorescence: epidemiological methods and a new biomarker. Environ Health Perspect 1995;103(suppl 1):105-110.
22. Zeger SL, Liang KY. An overview of methods for the analysis of longitudinal data. Stat Med 1992;11:1825-1839.
23. Diggle PJ, Liang KY, Zeger SL. Analysis of Longitudinal Data. New York: Oxford Scientific Publications/Oxford University Press, 1994.
24. Hernandez-Avila M, Gonzalez-Cossio T, Palazuelos E, et al. Dietary and environmental determinants of blood and bone lead levels in lactating postpartum women living in Mexico City. Environ Health Perspect 1996;104:1076-1082.
25. Mahaffey KR, ed. Factors modifying susceptibility to lead toxicity. In: Dietary and Environmental Lead: Human Health Effects. Amsterdam: Elsevier Science, 1985;373-419.
26. Heard MJ, Chamberlain AC. Effect of minerals and food on uptake of lead from the gastrointestinal tract in humans. Hum Toxicol 1982;1:411-415.
27. Ziegler EE, Edwards BB, Jensen RL, Mahaffey KR, Portion SJ. Absorption and retention of lead by infants. Pediatr Res 1978;12:29-34.
28. Sowers MF, Corton G, Shapiro B, et al. Changes in bone density with lactation. JAMA 1993;269:3130-3135.
29. Laskey MA, Prentice A, Hanratty LA, et al. Bone changes after 3 mo of lactation: influence of calcium intake, breast-milk output, and vitamin D-receptor genotype. Am J Clin Nutr 1998;67:685-692.
30. Ritchie LD, Fung EB, Halloran BP, et al. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am J Clin Nutr 1998;67:693-701.
31. Cross NA, Hillman LS, Allen SH, Krause GF. Changes in bone mineral density and markers of bone remodeling during lactation and postweaning in women consuming high amounts of calcium. J Bone Miner Res 1995;10:1312-1320.
32. Sowers M, Randolph L, Shapiro B, Jannaush M. A prospective study of bone density and pregnancy after an extended period of lactation with bone loss. Obstet Gynaecol 1995;85:285-289.
33. Prentice A, Jarjou LM, Stirling DM, Buffenstein R, Fairweather-Tait S. Biochemical markers of calcium and bone metabolism during 18 months of lactation in Gambian women accustomed to a low calcium intake and in those consuming a calcium supplement. J Clin Endocrinol Metab 1998;83:1059-1066.
34. Gulson BL, Mahaffey KR, Jameson CW, et al. Mobilization of lead from the skeleton during the postnatal period is larger than during pregnancy. J Lab Clin Med 1998;131:324-9.
35. Smith R, Phillip AJ. Osteoporosis during pregnancy and its management. Scand J Rheumatol Suppl 1988;107:66-67.
36. Blumsohn A, Herrington K, Hannon RA, Shao P, Eyre DR, Eastell R. The effect of calcium supplementation on the circadian rhythm of bone resorption. J Clin Endocrinol Metab 1994;79:730-735.