Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

Journal of Controlled Release

Volumn 177, Issue 1, 2014, Pages 1-10

  Han, Sifei ^a   Quach, Tim ^a   Hu, Luojuan ^a   Wahab, Anisa ^a   Charman, William N ^a   Stella, Valentino J ^b   Trevaskis, Natalie L ^a   Simpson, Jamie S ^a   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Immunomodulator; Lipid based delivery; Lymph; Lymphatic transport; Mycophenolic acid; Prodrug

Indexed keywords

IMMUNO MODULATORS; LIPID-BASED DELIVERY; LYMPH; LYMPHATIC TRANSPORT; MYCOPHENOLIC ACIDS; PRODRUGS;

BODY FLUIDS; DRUG DELIVERY; ESTERIFICATION; ESTERS; GLYCEROL; HYDROLYSIS; LYMPHOCYTES; RATS;

TRANSPORT PROPERTIES;

1,3 DIPALMITOYL 2 MYCOPHENOLOYL GLYCEROL; MYCOPHENOLIC ACID; OCTADECYL MYCOPHENOLAMIDE; OCTADECYL MYCOPHENOLATE; OCTYL MYCOPHENOLATE; OLEIC ACID; PRODRUG; UNCLASSIFIED DRUG;

ACYLATION AND DEACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTERY CATHETERIZATION; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HYDROLYSIS; DRUG SOLUBILITY; DRUG TARGETING; DRUG TRANSPORT; DRUG UPTAKE; ENZYME STABILITY; ESTERIFICATION; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPH VESSEL; LYMPHATIC SYSTEM; MALE; MESENTERY LYMPH NODE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT;

IMMUNOMODULATOR; LIPID-BASED DELIVERY; LYMPH; LYMPHATIC TRANSPORT; MYCOPHENOLIC ACID; PRODRUG;

ANIMALS; DRUG DELIVERY SYSTEMS; ESTERS; IMMUNOLOGIC FACTORS; LYMPH; LYMPH NODES; LYMPHOCYTES; MALE; MYCOPHENOLIC ACID; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

EID: 84892637908     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.12.031     Document Type: Article

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