Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: Identification of the catalytically active serine, aspartic acid, and histidine residues

Journal of Lipid Research

Volumn 38, Issue 5, 1997, Pages 892-903

  Lohse, Peter ^a   Chahrokh Zadeh, Soheyla ^a   Lohse, Pia ^a   Seidel, Dietrich ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

hydrolase fold; Catalytic triad; Esterase activity; In vitro expression; Lipase consensus sequence; Lipid metabolism; Serine hydrolase; Site directed mutagenesis

Indexed keywords

ACID LIPASE; ASPARTIC ACID; CHOLESTEROL ESTERASE; CHOLESTEROL OLEATE; DIPEPTIDE; GLYCINE; HISTIDINE; LYSOSOME ENZYME; MUTANT PROTEIN; SERINE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID METABOLISM; PRIORITY JOURNAL;

ANIMALS; ASPARTIC ACID; BINDING SITES; DNA, COMPLEMENTARY; HISTIDINE; HUMANS; HYDROLYSIS; LIPASE; MUTAGENESIS, SITE-DIRECTED; RATS; SERINE; SUBSTRATE SPECIFICITY;

EID: 0030983202     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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