The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 2, 2006, Pages 881-891

  Trevaskis, Natalie L ^a   Porter, Christopher J H ^a   Charman, William N ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; FATTY ACID; HALOFANTRINE; LIPID; OLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANNULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TRANSPORT; HEPATOBILIARY SYSTEM; LIPID METABOLISM; LIPOPHILICITY; LYMPH LIPID PRECURSOR POOL; LYMPH VESSEL; LYMPHATIC SYSTEM; MESENTERY; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE;

ANIMALS; BILE; BIOLOGICAL TRANSPORT; DRUG CARRIERS; INTESTINAL ABSORPTION; INTESTINES; LIPIDS; LYMPH; OLEIC ACID; PHENANTHRENES; RATS;

EID: 31144474022     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.094094     Document Type: Article

References (29)

1. Bollman JL, Cava JC, and Grindley JH (1948) Techniques for the collection of lymph from the liver, small intestine and thoracic duct of the rat. J Lab Clin Med 33:1349.
2. Caliph SM, Charman WN, and Porter CJ (2000) Effect of short-, medium- and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J Pharm Sci 89:1073-1084.
3. Charman WN and Stella VJ (1986a) Effect of lipid class and lipid vehicle volume on the intestinal lymphatic transport of DDT. Int J Pharm 33:165-172.
4. Charman WN and Stella VJ (1986b) Estimating the maximum potential for intestinal lymphatic transport of lipophilic drug molecules. Int J Pharm 34:175-178.
5. Charman WN and Stella VJ (1992) Lymphatic Transport of Drugs. CRC Press LLC, Boca Raton, FL.
6. Hussain NM (2000) A proposed model for the assembly of chylomicrons. Atherosclerosis 148:1-15.
7. Kararli TT (1995) Comparison of the gastrointestinal anatomy, physiology and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 16:351-380.
8. Khoo SM, Shackleford DM, Porter CJ, Edwards GA, and Charman WN (2003) Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs. Pharm Res (NY) 20:1460-1465.
9. Mansbach CM 2nd and Arnold A (1986) Steady-state kinetic analysis of triacylglycerol delivery into mesenteric lymph. Am J Physiol 251:G263-G269.
10. Mansbach CM 2nd and Dowell RF (1992) Uptake and metabolism of circulating fatty acids by rat intestine. Am J Physiol 263:G927-G933.
11. Mansbach CM 2nd and Dowell RF (1993) Portal transport of long acyl chain lipids: effect of phosphatidylcholine and low infusion rates. Am J Physiol 264:G1082-G1089.
12. Mansbach CM 2nd and Nevin P (1998) Intracellular movement of triacylglycerols in the intestine. J Lipid Res 39:963-968.
13. Mansbach CM, 2nd and Parthasarathy S (1982) A re-examination of the fate of glyceride-glycerol in neutral lipid absorption and transport. J Lipid Res 23:1009-1019.
14. Mansbach CM and Dowell R (2000) Effect of increasing lipid loads on the ability of the endoplasmic reticulum to transport lipid to the Golgi. J Lipid Res 41:605-612.
15. Nevin P, Koelsch D, and Mansbach CM 2nd (1995) Intestinal triacylglycerol storage pool size changes under differing physiological conditions. J Lipid Res 36:2405-2412.
16. Nilsson A (1968) Intestinal absorption of lecithin and lysolecithin by lymph fistula rats. Biochim Biophys Acta 152:379-390.
17. Noguchi T, Charman WN, and Stella VJ (1985) The effect of drug lipophilicity and lipid vehicles on the lymphatic absorption of various testosterone esters. Int J Pharm 24:173-184.
18. Porter CJ, Charman SA, and Charman WN (1996a) Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion. J Pharm Sci 85:351-356.
19. Porter CJ, Charman SA, Humberstone AJ, and Charman WN (1996b) Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion. J Pharm Sci 85:357-361.
20. Porter CJ and Charman WN (2001) Intestinal lymphatic drug transport: an update. Adv Drug Deliv Rev 50:61-80.
21. Raub TJ, Douglas SL, Melchior GW, Charman WN, and Morozowich W (1992) Methodologies for assessing lymphatic drug transport, in Lymphatic Transport of Drugs (Charman WN and Stella VJ eds) p. 63, CRC Press LLC, Boca Raton, FL.
22. Reininger EJ and Sapirstein LA (1957) Effect of digestion on distribution of blood flow in the rat. Science (Wash DC) 126:1176.
23. Sato Y (1970) The metabolic fate of lysolecithin administered into rat duodenal lumen. Tohoku J Exp Med 100:277-287.
24. Scow RO, Stein Y, and Stein O (1967) Incorporation of dietary lecithin and lysolecithin into lymph chylomicrons in the rat. J Biol Chem 242:4919-4924.
25. Tipton ADt, Frase S, and Mansbach CM 2nd (1989) Isolation and characterization of a mucosal triacylglycerol pool undergoing hydrolysis. Am J Physiol 257:G871-G878.
26. Trevaskis NL, Porter CJ, and Charman WN (2005) Bile increases intestinal lymphatic drug transport in the fasted rat. Pharm Res 22:1863-1870.
27. Tso P, Balint JA, and Simmonds WJ (1977) Role of biliary lecithin in lymphatic transport of fat. Gastroenterology 73:1362-1367.
28. Tso P, Lam J, and Simmonds WJ (1978) The importance of the lysophosphatidylcholine and choline moiety of bile phosphatidylcholine in lymphatic transport of fat. Biochim Biophys Acta 528:364-372.
29. Voshol PJ, Minich DM, Havinga R, Elferink RP, Verkade HJ, Groen AK, and Kuipers F (2000) Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice. Gastroenterology 118:173-182.