The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis

Journal of Biological Chemistry

Volumn 289, Issue 3, 2014, Pages 1723-1731

  Farrand, Lee ^a   Kim, Ji Young ^a,b,c   Byun, Sanguine ^a   Im Aram, Akechai ^a   Lee, Jihoon ^a   Suh, Jeong Yong ^a   Lee, Ki Won ^a   Lee, Hyong Joo ^a   Tsang, Benjamin K ^a,b,c  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF OTTAWA   (Canada)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS-INDUCING FACTORS; CANCER CELL LINES; DOWNSTREAM EFFECTS; INDEPENDENT MODE; OVARIAN CANCER CELLS; OVARIAN CANCERS; TREATMENT OUTCOMES; X-LINKED INHIBITOR OF APOPTOSIS;

CELL CULTURE; CELL DEATH; CHEMOTHERAPY; PLATINUM COMPOUNDS;

ENZYME INHIBITION;

APOPTOSIS INDUCING FACTOR; CISPLATIN; HEPTANE DERIVATIVE; HIRSUTENONE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P53; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; AIFM1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CATECHOL DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; TP53 PROTEIN, HUMAN; UBIQUITIN; XIAP PROTEIN, HUMAN;

ALNUS HIRSUTA; APOPTOSIS; ARTICLE; BARK; CANCER CELL; CELL NUCLEUS; CHEMOSENSITIVITY; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRION; OVARY CANCER; PRIORITY JOURNAL; ACTIVE TRANSPORT; ALDER; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENETICS; METABOLISM; MUTATION; OVARIAN NEOPLASMS; PATHOLOGY; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ALNUS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CATECHOLS; CELL LINE, TUMOR; CELL NUCLEUS; CISPLATIN; DIARYLHEPTANOIDS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MITOCHONDRIA; MUTATION; OVARIAN NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84892634731     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.513879     Document Type: Article

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